Fermentation supernatants of Lactobacillus delbrueckii inhibit growth of human colon cancer cells and induce apoptosis through a caspase 3–dependent pathway
Open accessAbstract
Probiotic bacteria are known to exert a wide range of beneficial effects on their animal hosts. Therefore, the present study explored the effect of the supernatants obtained from Lactobacillus delbrueckii fermentation (LBF) on colon cancer. The results indicated that the proliferation of LBF solution‑treated colon cancer SW620 cells was arrested and accumulated in the G1 phase in a concentration‑dependent manner. The LBF solution efficiently induced apoptosis through the intrinsic caspase 3‑depedent pathway, with a corresponding decreased expression of Bcl‑2. The activity of matrix metalloproteinase 9, which is associated with the invasion of colon cancer cells, was also decreased in the LBF‑treated cells. In conclusion, the results demonstrate the antitumor effect of LBF in vitro and may contribute to the development of novel therapies for the treatment of colon cancer.
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The enhanced effect of S. salivarius CP163 and S. salivarius CP208 included the induction of colon cancer cells as partially mediated by activation of caspase-2.
“The stimulation of the death of colon cancer cells via intrinsic caspase-3 was observed after inducing a response from probiotic strains of L. delbrueckii and L. acidophilus [56,57], indicating that the enhanced effect of probiotic strains of S. salivarius CP163 and S. salivarius CP208 included the induction of colon cancer cells as partially mediated by activation of caspase-2.”
From Bioprophylactic potential of novel human colostrum probiotics via apoptotic induction of colon cancer cells and cell immune activation (2022) · cites this paper as [56]
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- Authors
- WAN, Y., XIN, Y., ZHANG, C., WU, D., DING, D., TANG, L., OWUSU, L., BAI, J., & LI, W.
- Affiliations
- Dalian Medical University (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
- Corresponding author
- LI, WEILING
- Venue
- Oncology Letters
- Publisher
- Spandidos Publications
- Published
- 2014-03-10
- Volume
- 7
- Issue
- 5
- Pages
- 1738-1742
- ISSN
- 1792-1074 (ISSN-L)
- 1792-1082
- PMC
- PMC3997687
- OpenAlex
- W2085597352
- Cited by
- 76
- References
- 16
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 6 · 2023: 13 · 2022: 8 · 2021: 5 · 2020: 8 · 2019: 10 · 2018: 2 · 2017: 3 · 2016: 9 · 2015: 3
- FWCI
- 7.17
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Oncology Letters (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- BD
- National Key Research and Development Program of China (2007CB513006)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Cancer Research and Treatments
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- Lactobacillus delbrueckii, fermentation supernatant, colon cancer, apoptosis, caspase-3, Bcl-2, G1 cell cycle arrest, MMP-9, anticancer activity, probiotics, SW620 cells
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