Development by Self-Digestion

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605

Oncogenic kinase signalling.

Blume-Jensen, P., & Hunter, T. (2001) · Nature · doi:10.1038/35077225 · Cited by 3,738

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347

Functions of Lysosomes

de Duve, C., & Wattiaux, R. (1966) · Annual Review of Physiology · doi:10.1146/annurev.ph.28.030166.002251 · Cited by 3,033

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

Qu, X., Yu, J., Bhagat, G., Furuya, N., Hibshoosh, H., Troxel, A., Rosen, J., Eskelinen, E.-L., Mizushima, N., Ohsumi, Y., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20039 · Cited by 2,311

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

Yue, Z., Jin, S., Yang, C., Levine, A. J., & Heintz, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436255100 · Cited by 2,116

Molecular dissection of autophagy: two ubiquitin-like systems

Ohsumi, Y. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35056522 · Cited by 1,240

Tor-Mediated Induction of Autophagy via an Apg1 Protein Kinase Complex

Kamada, Y., Funakoshi, T., Shintani, T., Nagano, K., Ohsumi, M., & Ohsumi, Y. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.6.1507 · Cited by 1,145

Influence of TOR kinase on lifespan in C. elegans

Vellai, T., Takacs-Vellai, K., Zhang, Y., Kovacs, A. L., Orosz, L., & Müller, F. (2003) · Nature · doi:10.1038/426620a · Cited by 1,057

Two Distinct Vps34 Phosphatidylinositol 3–Kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting in Saccharomyces cerevisiae

Kihara, A., Noda, T., Ishihara, N., & Ohsumi, Y. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.3.519 · Cited by 1,004

The FBXW7-SHOC2-Raptor Axis Controls the Cross-Talks between the RAS-ERK and mTORC1 Signaling Pathways

Xie, C.-M., Tan, M., Lin, X.-T., Wu, D., Jiang, Y., Tan, Y., Li, H., Ma, Y., Xiong, X., & Sun, Y. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.052 · Cited by 49

Autophagy participates in isoliquiritigenin-induced melanin degradation in human epidermal keratinocytes through PI3K/AKT/mTOR signaling

Yang, Z., Zeng, B., Pan, Y., Huang, P., & Wang, C. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.10.070 · Cited by 48

Live imaging and single-cell analysis reveal differential dynamics of autophagy and apoptosis

Xu, Y., Yuan, J., & Lipinski, M. M. (2013) · Autophagy · doi:10.4161/auto.25080 · Cited by 47

Human cytomegalovirus protein pUL38 prevents premature cell death by binding to ubiquitin-specific protease 24 and regulating iron metabolism

Sun, Y., Bao, Q., Xuan, B., Xu, W., Pan, D., Li, Q., & Qian, Z. (2018) · Journal of Virology · doi:10.1128/jvi.00191-18 · Cited by 43

Altered signal transduction pathways and induction of autophagy in human myotonic dystrophy type 1 myoblasts

Beffy, P., Del Carratore, R., Masini, M., Furling, D., Puymirat, J., Masiello, P., & Simili, M. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.08.010 · Cited by 42

Candida albicans autophagy, no longer a bystander: Its role in tolerance to ER stress-related antifungal drugs

Yu, Q., Jia, C., Dong, Y., Zhang, B., Xiao, C., Chen, Y., Wang, Y., Li, X., Wang, L., Zhang, B., et al. (2015) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2015.02.008 · Cited by 42

Tubeimoside-1, a triterpenoid saponin, induces cytoprotective autophagy in human breast cancer cells in vitro via Akt-mediated pathway

Jiang, S.-L., Guan, Y.-D., Chen, X.-S., Ge, P., Wang, X.-L., Lao, Y.-Z., Xiao, S.-S., Zhang, Y., Yang, J.-M., Xu, X.-J., et al. (2019) · Acta Pharmacologica Sinica · doi:10.1038/s41401-018-0165-9 · Cited by 37

Radiocontrast-induced nephropathy is attenuated by autophagy through regulation of apoptosis and inflammation

Ko, G. J., Bae, S. Y., Hong, Y.-A., Pyo, H. J., & Kwon, Y. J. (2016) · Human & Experimental Toxicology · doi:10.1177/0960327115604198 · Cited by 31

Transcription factors and cognate signalling cascades in the regulation of autophagy

Chandra, V., Bhagyaraj, E., Parkesh, R., & Gupta, P. (2016) · Biological Reviews · doi:10.1111/brv.12177 · Cited by 26

Down-regulation of the ubiquitin–proteasome proteolysis system by amino acids and insulin involves the adenosine monophosphate-activated protein kinase and mammalian target of rapamycin pathways in rat hepatocytes

Chotechuang, N., Azzout-Marniche, D., Bos, C., Chaumontet, C., Gaudichon, C., & Tomé, D. (2011) · Amino Acids · doi:10.1007/s00726-010-0765-2 · Cited by 24

Origin and function of the stalk-cell vacuole in Dictyostelium

Uchikawa, T., Yamamoto, A., & Inouye, K. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.01.014 · Cited by 20

Chapter 19 Monitoring Autophagy in Magnaporthe oryzae

Liu, X., Liu, T., & Lin, F. (2008) · Methods in Enzymology · doi:10.1016/s0076-6879(08)03219-9 · Cited by 19

Expression of cFLIPL Determines the Basal Interaction of Bcl‐2 With Beclin‐1 and Regulates p53 Dependent Ubiquitination of Beclin‐1 During Autophagic Stress

Ranjan, K., & Pathak, C. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25474 · Cited by 19

Investigating the Association between the Autophagy Markers LC3B, SQSTM1/p62, and DRAM and Autophagy-Related Genes in Glioma

Danish, F., Qureshi, M. A., Mirza, T., Amin, W., Sufiyan, S., Naeem, S., Arshad, F., & Mughal, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25010572 · Cited by 16

Entosis Acts as a Novel Way within Sertoli Cells to Eliminate Spermatozoa in Seminiferous Tubule

Ahmed, N., Yang, P., Huang, Y., Chen, H., Liu, T., Wang, L., Nabi, F., Liu, Y., & Chen, Q. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00361 · Cited by 15