Development by Self-Digestion

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605

Oncogenic kinase signalling.

Blume-Jensen, P., & Hunter, T. (2001) · Nature · doi:10.1038/35077225 · Cited by 3,738

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347

Functions of Lysosomes

de Duve, C., & Wattiaux, R. (1966) · Annual Review of Physiology · doi:10.1146/annurev.ph.28.030166.002251 · Cited by 3,033

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

Qu, X., Yu, J., Bhagat, G., Furuya, N., Hibshoosh, H., Troxel, A., Rosen, J., Eskelinen, E.-L., Mizushima, N., Ohsumi, Y., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20039 · Cited by 2,311

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

Yue, Z., Jin, S., Yang, C., Levine, A. J., & Heintz, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436255100 · Cited by 2,116

Molecular dissection of autophagy: two ubiquitin-like systems

Ohsumi, Y. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35056522 · Cited by 1,240

Tor-Mediated Induction of Autophagy via an Apg1 Protein Kinase Complex

Kamada, Y., Funakoshi, T., Shintani, T., Nagano, K., Ohsumi, M., & Ohsumi, Y. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.6.1507 · Cited by 1,145

Influence of TOR kinase on lifespan in C. elegans

Vellai, T., Takacs-Vellai, K., Zhang, Y., Kovacs, A. L., Orosz, L., & Müller, F. (2003) · Nature · doi:10.1038/426620a · Cited by 1,057

Two Distinct Vps34 Phosphatidylinositol 3–Kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting in Saccharomyces cerevisiae

Kihara, A., Noda, T., Ishihara, N., & Ohsumi, Y. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.3.519 · Cited by 1,004

Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L)

Fan, W., Nassiri, A., & Zhong, Q. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016472108 · Cited by 285

Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover

Rikka, S., Quinsay, M. N., Thomas, R. L., Kubli, D. A., Zhang, X., Murphy, A. N., & Gustafsson, Å. B. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2010.146 · Cited by 277

Macroautophagy Regulates Energy Metabolism during Effector T Cell Activation

Hubbard, V. M., Valdor, R., Patel, B., Singh, R., Cuervo, A. M., & Macian, F. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000576 · Cited by 275

Autophagy modulates osteoarthritis‐related gene expression in human chondrocytes

Sasaki, H., Takayama, K., Matsushita, T., Ishida, K., Kubo, S., Matsumoto, T., Fujita, N., Oka, S., Kurosaka, M., & Kuroda, R. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34323 · Cited by 266

Atg9 Cycles Between Mitochondria and the Pre-Autophagosomal Structure in Yeasts

Reggiori, F., Shintani, T., Chong, H., Nair, U., & Klionsky, D. J. (2005) · Autophagy · doi:10.4161/auto.1.2.1840 · Cited by 266

MicroRNA-155 Promotes Autophagy to Eliminate Intracellular Mycobacteria by Targeting Rheb

Wang, J., Yang, K., Zhou, L., MinhaoWu, Wu, Y., Zhu, M., Lai, X., Chen, T., Feng, L., Li, M., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003697 · Cited by 265

Intracellular Inclusions Containing Mutant α1-Antitrypsin Z Are Propagated in the Absence of Autophagic Activity

Kamimoto, T., Shoji, S., Hidvegi, T., Mizushima, N., Umebayashi, K., Perlmutter, D. H., & Yoshimori, T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509409200 · Cited by 259

Listeria monocytogenes Evades Killing by Autophagy During Colonization of Host Cells

Birmingham, C. L., Canadien, V., Gouin, E., Troy, E. B., Yoshimori, T., Cossart, P., Higgins, D. E., & Brumell, J. H. (2007) · Autophagy · doi:10.4161/auto.4450 · Cited by 254

Autophagy promotes synapse development in Drosophila

Shen, W., & Ganetzky, B. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200907109 · Cited by 252

Sodium Selenite Induces Superoxide-Mediated Mitochondrial Damage and Subsequent Autophagic Cell Death in Malignant Glioma Cells

Kim, E. H., Sohn, S., Kwon, H. J., Kim, S. U., Kim, M.-J., Lee, S.-J., & Choi, K. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4217 · Cited by 251

Autophagy in Spinal Cord Motor Neurons in Sporadic Amyotrophic Lateral Sclerosis

Sasaki, S. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3182160690 · Cited by 249

Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway

Zhou, X., Wang, L., Hasegawa, H., Amin, P., Han, B.-X., Kaneko, S., He, Y., & Wang, F. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914725107 · Cited by 247

The Atg1 Kinase Complex Is Involved in the Regulation of Protein Recruitment to Initiate Sequestering Vesicle Formation for Nonspecific Autophagy in Saccharomyces cerevisiae

Cheong, H., Nair, U., Geng, J., & Klionsky, D. J. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-08-0826 · Cited by 245

Autophagy in bone homeostasis and the onset of osteoporosis

Yin, X., Zhou, C., Li, J., Liu, R., Shi, B., Yuan, Q., & Zou, S. (2019) · Bone Research · doi:10.1038/s41413-019-0058-7 · Cited by 235

Aggregate‐Prone Proteins Are Cleared from the Cytosol by Autophagy: Therapeutic Implications

Williams, A., Jahreiss, L., Sarkar, S., Saiki, S., Menzies, F. M., Ravikumar, B., & Rubinsztein, D. C. (2006) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(06)76003-3 · Cited by 239

Mutation in ATG5 reduces autophagy and leads to ataxia with developmental delay

Kim, M., Sandford, E., Gatica, D., Qiu, Y., Liu, X., Zheng, Y., Schulman, B. A., Xu, J., Semple, I., Ro, S.-H., et al. (2016) · eLife · doi:10.7554/elife.12245 · Cited by 225

How DNA lesions are turned into powerful killing structures: Insights from UV-induced apoptosis

Batista, L. F. Z., Kaina, B., Meneghini, R., & Menck, C. F. M. (2009) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.09.001 · Cited by 234

Age related macular degeneration and drusen: Neuroinflammation in the retina

Buschini, E., Piras, A., Nuzzi, R., & Vercelli, A. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.011 · Cited by 230

Increased autophagy in transgenic mice with a G93A mutant SOD1 gene

Morimoto, N., Nagai, M., Ohta, Y., Miyazaki, K., Kurata, T., Morimoto, M., Murakami, T., Takehisa, Y., Ikeda, Y., Kamiya, T., et al. (2007) · Brain Research · doi:10.1016/j.brainres.2007.06.045 · Cited by 223

The Pancreatitis-induced Vacuole Membrane Protein 1 Triggers Autophagy in Mammalian Cells

Ropolo, A., Grasso, D., Pardo, R., Sacchetti, M. L., Archange, C., Re, A. L., Seux, M., Nowak, J., Gonzalez, C. D., Iovanna, J. L., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706956200 · Cited by 223

PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage

Vasheghani, F., Zhang, Y., Li, Y.-H., Blati, M., Fahmi, H., Lussier, B., Roughley, P., Lagares, D., Endisha, H., Saffar, B., et al. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2014-205743 · Cited by 221

Autophagy mediates pharmacological lifespan extension by spermidineand resveratrol

Morselli, E., Galluzzi, L., Kepp, O., Criollo, A., Maiuri, M. C., Tavernarakis, N., Madeo, F., & Kroemer, G. (2009) · Aging · doi:10.18632/aging.100110 · Cited by 213

Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension.

Lee, S.-J., Smith, A., Guo, L., Alastalo, T.-P., Li, M., Sawada, H., Liu, X., Chen, Z.-H., Ifedigbo, E., Jin, Y., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201005-0746oc · Cited by 217

Autophagy has a significant role in determining skin color by regulating melanosome degradation in keratinocytes

Murase, D., Hachiya, A., Takano, K., Hicks, R., Visscher, M. O., Kitahara, T., Hase, T., Takema, Y., & Yoshimori, T. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.165 · Cited by 214

Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death

Liu, S., Sarkar, C., Dinizo, M., Faden, A. I., Koh, E. Y., Lipinski, M. M., & Wu, J. (2015) · Cell Death & Disease · doi:10.1038/cddis.2014.527 · Cited by 209

Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age

Kiffin, R., Kaushik, S., Zeng, M., Bandyopadhyay, U., Zhang, C., Massey, A. C., Martinez-Vicente, M., & Cuervo, A. M. (2007) · Journal of Cell Science · doi:10.1242/jcs.001073 · Cited by 213

Autophagy and microtubules - new story, old players

Mackeh, R., Perdiz, D., Lorin, S., Codogno, P., & Poüs, C. (2013) · Journal of Cell Science · doi:10.1242/jcs.115626 · Cited by 212

Autophagic Stress in Neuronal Injury and Disease

Chu, C. T. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000229233.75253.be · Cited by 211

The link between immunity, autoimmunity and endometriosis: a literature update

Zhang, T., De Carolis, C., Man, G. C. W., & Wang, C. C. (2018) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.03.017 · Cited by 196

Rapamycin Promotes Autophagy and Reduces Neural Tissue Damage and Locomotor Impairment after Spinal Cord Injury in Mice

Sekiguchi, A., Kanno, H., Ozawa, H., Yamaya, S., & Itoi, E. (2012) · Journal of Neurotrauma · doi:10.1089/neu.2011.1919 · Cited by 200

Autophagy, ageing and apoptosis: The role of oxidative stress and lysosomal iron

Kurz, T., Terman, A., & Brunk, U. T. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.01.013 · Cited by 199

Down-regulation of autophagy-related protein 5 (ATG5) contributes to the pathogenesis of early-stage cutaneous melanoma

Liu, H., He, Z., von Rütte, T., Yousefi, S., Hunger, R. E., & Simon, H.-U. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005864 · Cited by 188

Generation of cell lines with tetracycline‐regulated autophagy and a role for autophagy in controlling cell size

Hosokawa, N., Hara, Y., & Mizushima, N. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.04.008 · Cited by 194

The Ubiquitin-Proteasome System and the Autophagic-Lysosomal System in Alzheimer Disease

Ihara, Y., Morishima-Kawashima, M., & Nixon, R. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006361 · Cited by 190

Atg17 Regulates the Magnitude of the Autophagic Response

Cheong, H., Yorimitsu, T., Reggiori, F., Legakis, J. E., Wang, C.-W., & Klionsky, D. J. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-10-0894 · Cited by 187

Autophagy in disease: a double-edged sword with therapeutic potential

Martinet, W., Agostinis, P., Vanhoecke, B., Dewaele, M., & de Meyer, G. R. Y. (2009) · Clinical Science · doi:10.1042/cs20080508 · Cited by 186

The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy

Lee, E.-J., & Tournier, C. (2011) · Autophagy · doi:10.4161/auto.7.7.15450 · Cited by 186

Skeletal muscle autophagy and its role in sarcopenia and organismal aging

Jiao, J., & Demontis, F. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.03.009 · Cited by 184

Intralysosomal iron chelation protects against oxidative stress‐induced cellular damage

Kurz, T., Gustafsson, B., & Brunk, U. T. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05321.x · Cited by 175

Protective role of autophagy against Vibrio cholerae cytolysin, a pore-forming toxin from V. cholerae

Gutierrez, M. G., Saka, H. A., Chinen, I., Zoppino, F. C. M., Yoshimori, T., Bocco, J. L., & Colombo, M. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601437104 · Cited by 174

Mitochondrial death effectors: Relevance to sarcopenia and disuse muscle atrophy

Marzetti, E., Hwang, J. C. Y., Lees, H. A., Wohlgemuth, S. E., Dupont-Versteegden, E. E., Carter, C. S., Bernabei, R., & Leeuwenburgh, C. (2010) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.05.007 · Cited by 174

Rapamycin Rescues TDP-43 Mislocalization and the Associated Low Molecular Mass Neurofilament Instability

Caccamo, A., Majumder, S., Deng, J. J., Bai, Y., Thornton, F. B., & Oddo, S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.031278 · Cited by 169

Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells

Vázquez, P., Arroba, A. I., Cecconi, F., de la Rosa, E. J., Boya, P., & De Pablo, F. (2012) · Autophagy · doi:10.4161/auto.8.2.18535 · Cited by 171

C. elegansfeeding defective mutants have shorter body lengths and increased autophagy

Mörck, C., & Pilon, M. (2006) · BMC Developmental Biology · doi:10.1186/1471-213x-6-39 · Cited by 171

Mitochondrial DNA mutations, energy metabolism and apoptosis in aging muscle

Dirks, A. J., Hofer, T., Marzetti, E., Pahor, M., & Leeuwenburgh, C. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.03.002 · Cited by 169

A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease

Rocchi, A., Yamamoto, S., Ting, T., Fan, Y., Sadleir, K., Wang, Y., Zhang, W., Huang, S., Levine, B., Vassar, R., et al. (2017) · PLOS Genetics · doi:10.1371/journal.pgen.1006962 · Cited by 166

Regulation of Autophagy by Neuropathological Protein TDP-43

Bose, J. K., Huang, C.-C., & Shen, C.-K. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.237115 · Cited by 165

Human WIPI‐1 puncta‐formation: A novel assay to assess mammalian autophagy

Proikas-Cezanne, T., Ruckerbauer, S., Stierhof, Y.-D., Berg, C., & Nordheim, A. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.06.040 · Cited by 165

BORC coordinates encounter and fusion of lysosomes with autophagosomes

Jia, R., Guardia, C. M., Pu, J., Chen, Y., & Bonifacino, J. S. (2017) · Autophagy · doi:10.1080/15548627.2017.1343768 · Cited by 160

Ins(1,4,5) P 3 receptor-mediated Ca 2+ signaling and autophagy induction are interrelated

Decuypere, J.-P., Welkenhuyzen, K., Luyten, T., Ponsaerts, R., Dewaele, M., Molgó, J., Agostinis, P., Missiaen, L., De Smedt, H., Parys, J. B., et al. (2011) · Autophagy · doi:10.4161/auto.7.12.17909 · Cited by 159

Microglia change from a reactive to an age-like phenotype with the time in culture

Caldeira, C., Oliveira, A. F., Cunha, C., Vaz, A. R., Falcão, A. S., Fernandes, A., & Brites, D. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00152 · Cited by 156

The Actin Cytoskeleton Is Required for Selective Types of Autophagy, but Not Nonspecific Autophagy, in the Yeast Saccharomyces cerevisiae

Reggiori, F., Monastyrska, I., Shintani, T., & Klionsky, D. J. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-07-0629 · Cited by 155

Cell “Self‐Eating” (Autophagy) Mechanism in Alzheimer's Disease

Funderburk, S. F., Marcellino, B. K., & Yue, Z. (2010) · Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20161 · Cited by 139

Autophagy and misfolded proteins in neurodegeneration

Metcalf, D. J., García-Arencibia, M., Hochfeld, W. E., & Rubinsztein, D. C. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2010.11.003 · Cited by 138

Cocaine-mediated microglial activation involves the ER stress-autophagy axis.

Guo, M.-L., Liao, K., Periyasamy, P., Yang, L., Cai, Y., Callen, S. E., & Buch, S. (2015) · Autophagy · doi:10.1080/15548627.2015.1052205 · Cited by 144

AMPK-independent induction of autophagy by cytosolic Ca2+ increase

Grotemeier, A., Alers, S., Pfisterer, S. G., Paasch, F., Daubrawa, M., Dieterle, A., Viollet, B., Wesselborg, S., Proikas-Cezanne, T., & Stork, B. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.01.015 · Cited by 143

Autophagy in animal development

Allen, E. A., & Baehrecke, E. H. (2020) · Cell Death & Differentiation · doi:10.1038/s41418-020-0497-0 · Cited by 127

Sarcopenia and cachexia: the adaptations of negative regulators of skeletal muscle mass

Sakuma, K., & Yamaguchi, A. (2012) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-011-0052-4 · Cited by 137

Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IκB kinase (IKK)

Qing, G., Yan, P., & Xiao, G. (2006) · Cell Research · doi:10.1038/sj.cr.7310109 · Cited by 140

Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana

Williams, R. A., Tetley, L., Mottram, J. C., & Coombs, G. H. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05274.x · Cited by 140

In Situ Detection of Starvation-induced Autophagy

Martinet, W., De Meyer, G. R. Y., Andries, L., Herman, A. G., & Kockx, M. M. (2006) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.5a6743.2005 · Cited by 139

Toll-like receptor signaling in the lysosomal pathways

Sanjuan, M. A., Milasta, S., & Green, D. R. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00732.x · Cited by 137

Spinal cord injury induces upregulation of Beclin 1 and promotes autophagic cell death

Kanno, H., Ozawa, H., Sekiguchi, A., & Itoi, E. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.09.009 · Cited by 135

Cystatin C in aging and in Alzheimer’s disease

Mathews, P. M., & Levy, E. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.06.003 · Cited by 133

Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice

Sato, S., Uchihara, T., Fukuda, T., Noda, S., Kondo, H., Saiki, S., Komatsu, M., Uchiyama, Y., Tanaka, K., & Hattori, N. (2018) · Scientific Reports · doi:10.1038/s41598-018-21325-w · Cited by 125

Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body

Juhász, G., Puskás, L. G., Komonyi, O., Érdi, B., Maróy, P., Neufeld, T. P., & Sass, M. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402123 · Cited by 121

Membrane proteomics of phagosomes suggests a connection to autophagy

Shui, W., Sheu, L., Liu, J., Smart, B., Petzold, C. J., Hsieh, T.-Y., Pitcher, A., Keasling, J. D., & Bertozzi, C. R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809218105 · Cited by 114

Molecular Processes that Drive Cigarette Smoke–Induced Epithelial Cell Fate of the Lung

Nyunoya, T., Mebratu, Y., Contreras, A., Delgado, M., Chand, H. S., & Tesfaigzi, Y. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0348tr · Cited by 110

Molecular Mechanisms and Regulation of Specific and Nonspecific Autophagy Pathways in Yeast

Nair, U., & Klionsky, D. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.r500016200 · Cited by 107

Caloric restriction and cellular senescence

Fontana, L., Nehme, J., & Demaria, M. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.10.005 · Cited by 104

The interplay between autophagy and mitochondrial dysfunction in oxidative stress-induced cardiac aging and pathology

Wohlgemuth, S. E., Calvani, R., & Marzetti, E. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.03.007 · Cited by 97

Glucocorticoid elevation of dexamethasone-induced gene 2 (Dig2/RTP801/REDD1) protein mediates autophagy in lymphocytes

Molitoris, J. K., McColl, K. S., Swerdlow, S., Matsuyama, M., Lam, M., Finkel, T. H., Matsuyama, S., & Distelhorst, C. W. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.245423 · Cited by 96

Biochemical Isolation and Characterization of the Tubulovesicular LC3-positive Autophagosomal Compartment

Gao, W., Kang, J. H., Liao, Y., Ding, W.-X., Gambotto, A. A., Watkins, S. C., Liu, Y.-J., Stolz, D. B., & Yin, X.-M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.054197 · Cited by 94

Role of autophagy in diabetes and mitochondria

Jung, H. S., & Lee, M. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05614.x · Cited by 92

MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy

Ma, X., Zhang, S., He, L., Rong, Y., Brier, L. W., Sun, Q., Liu, R., Fan, W., Chen, S., Yue, Z., et al. (2017) · Autophagy · doi:10.1080/15548627.2016.1269988 · Cited by 92

Autophagy Is Activated in Injured Neurons and Inhibited by Methylprednisolone After Experimental Spinal Cord Injury

Chen, H.-C., Fong, T.-H., Lee, A.-W., & Chiu, W.-T. (2012) · Spine · doi:10.1097/brs.0b013e318221e859 · Cited by 90

Autophagy is activated by proteasomal inhibition and involved in aggresome clearance in cultured astrocytes

Jänen, S. B., Chaachouay, H., & Richter‐Landsberg, C. (2010) · Glia · doi:10.1002/glia.21047 · Cited by 87

Intracellular survival of Shigella

Ogawa, M., & Sasakawa, C. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00652.x · Cited by 89

Developmental expression of LC3α and β: Absence of fibronectin or autophagy phenotype in LC3β knockout mice

Cann, G. M., Guignabert, C., Ying, L., Deshpande, N., Bekker, J. M., Wang, L., Zhou, B., & Rabinovitch, M. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21392 · Cited by 84

AMP-activated protein kinase conducts the ischemic stress response orchestra

Young, L. H. (2008) · Circulation · doi:10.1161/circulationaha.107.713115 · Cited by 82

Podocyte autophagic activity plays a protective role in renal injury and delays the progression of podocytopathies

Zeng, C., Fan, Y., Wu, J., Shi, S., Chen, Z., Zhong, Y., Zhang, C., Zen, K., & Liu, Z. (2014) · The Journal of Pathology · doi:10.1002/path.4382 · Cited by 80

Autophagy Promotes Peripheral Nerve Regeneration and Motor Recovery Following Sciatic Nerve Crush Injury in Rats

Huang, H.-C., Chen, L., Zhang, H.-X., Li, S.-F., Liu, P., Zhao, T.-Y., & Li, C.-X. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0672-9 · Cited by 80

Chapter 5 Autophagic Clearance of Aggregate‐Prone Proteins Associated with Neurodegeneration

Sarkar, S., Ravikumar, B., & Rubinsztein, D. C. (2009) · Methods in Enzymology · doi:10.1016/s0076-6879(08)04005-6 · Cited by 79

Age-related changes in the function of autophagy in rat kidneys

Cui, J., Bai, X.-Y., Shi, S., Cui, S., Hong, Q., Cai, G., & Chen, X. (2012) · AGE · doi:10.1007/s11357-011-9237-1 · Cited by 75

Selective inhibition of IFNG-induced autophagy by Mir155 - and Mir31 -responsive WNT5A and SHH signaling

Holla, S., Kurowska-Stolarska, M., Bayry, J., & Balaji, K. N. (2014) · Autophagy · doi:10.4161/auto.27225 · Cited by 76

Microalgae Produce Antioxidant Molecules with Potential Preventive Effects on Mitochondrial Functions and Skeletal Muscular Oxidative Stress

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Mitochondrial longevity pathways

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Loss of autophagy promotes murine acetaminophen hepatotoxicity

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Detection of WIPI1 mRNA as an indicator of autophagosome formation

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Cannabidiol post-treatment alleviates rat epileptic-related behaviors and activates hippocampal cell autophagy pathway along with antioxidant defense in chronic phase of pilocarpine-induced seizure

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Autophagy and ageing: Insights from invertebrate model organisms

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Beneficial effects of dietary restriction in aging brain

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Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function

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Alternative Macroautophagic Pathways

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The Implications of Autophagy in Alzheimer’s Disease

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SNF4Aγ, the Drosophila AMPK γ subunit is required for regulation of developmental and stress-induced autophagy

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Autophagy in Alzheimer’s disease

Moreira, P. I., Santos, R. X., Zhu, X., Lee, H.-G., Smith, M. A., Casadesus, G., & Perry, G. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.84 · Cited by 55

Monitoring Autophagy in Yeast

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Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease

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Pik3c3 deletion in pyramidal neurons results in loss of synapses, extensive gliosis and progressive neurodegeneration

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