Cited by 222Gut microbiota and healthProbiotics and Fermented FoodsT-cell and B-cell Immunology

Fecal IgA Levels Are Determined by Strain-Level Differences in Bacteroides ovatus and Are Modifiable by Gut Microbiota Manipulation

Open access
Yang, Chao, Mogno, Ilaria, Contijoch, Eduardo J., Borgerding, Joshua N., Aggarwala, Varun, Li, Zhihua, Siu, Sophia, Grasset, Emilie K. +5 more·2020·Cell Host & Microbe

Published version of a preprint

Abstract

Fecal IgA production depends on colonization by a gut microbiota. However, the bacterial strains that drive gut IgA production remain largely unknown. Here, we assessed the IgA-inducing capacity of a diverse set of human gut microbial strains by monocolonizing mice with each strain. We identified Bacteroides ovatus as the species that best induced gut IgA production. However, this induction varied bimodally across different B. ovatus strains. The high IgA-inducing B. ovatus strains preferentially elicited more IgA production in the large intestine through the T cell-dependent B cell-activation pathway. Remarkably, a low-IgA phenotype in mice could be robustly and consistently converted into a high-IgA phenotype by transplanting a multiplex cocktail of high IgA-inducing B. ovatus strains but not individual ones. Our results highlight the critical importance of microbial strains in driving phenotype variation in the mucosal immune system and provide a strategy to robustly modify a gut immune phenotype, including IgA production.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.chom.2020.01.016

Cites

78 of 78 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Intraspecies variation of gut microbiota can substantially change their effect on hosts.

    “There is now ample evidence that intraspecies variation of gut microbiota can substantially change their effect on hosts, first described for enteric pathogens (for example, Escherichia coli 56 ) but more recently demonstrated for immunomodulatory commensals 57,58 , providing further conceptual support for this notion.”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Yang, C., Mogno, I., Contijoch, E. J., Borgerding, J. N., Aggarwala, V., Li, Z., Siu, S., Grasset, E. K., Helmus, D. S., Dubinsky, M. C., Mehandru, S., Cerutti, A., & Faith, J. J.
Affiliations
  • Icahn School of Medicine at Mount Sinai (US)
  • Karolinska University Hospital (SE)
  • Mount Sinai Hospital (US)
  • Institució Catalana de Recerca i Estudis Avançats (ES)
Corresponding author
Faith, Jeremiah J.
Venue
Cell Host & Microbe
Publisher
Elsevier BV
Published
2020-03
Volume
27
Issue
3
Pages
467-475.e6
ISSN
1931-3128 (ISSN-L)
OpenAlex
W3007217849
Cited by
221
References
78
Citations by year
2026: 22 · 2025: 33 · 2024: 38 · 2023: 29 · 2022: 38 · 2021: 40 · 2020: 21
FWCI
10.38
Type
journal article
Language
en
Open access
Locations
  • Cell Host & Microbe (publishedVersion)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Janssen Research and Development LLC
  • National Institute of General Medical Sciences
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • National Center for Complementary and Integrative Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
fecal IgA, Bacteroides ovatus, strain-level diversity, gut microbiota, mucosal immunity, T cell-dependent B cell activation, microbial transplantation, large intestine
MeSH terms
Gastrointestinal Microbiome, Animals, B-Lymphocytes, Bacteroides, Feces, Germ-Free Life, Humans, Immunoglobulin A, Intestine, Large, Mice, Inbred C57BL, CD4-Positive T-Lymphocytes, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review