Cited by 116Dementia and Cognitive Impairment ResearchNutritional Studies and DietFatty Acid Research and Health

Nutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group

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Yassine, Hussein N, Samieri, Cécilia, Livingston, Gill, Glass, Kimberly, Wagner, Maude, Tangney, Christy, Plassman, Brenda L, Ikram, M Arfan +19 more·2022·The Lancet Healthy Longevity

Abstract

Observational studies suggest that nutritional factors have a potential cognitive benefit. However, systematic reviews of randomised trials of dietary and nutritional supplements have reported largely null effects on cognitive outcomes and have highlighted study inconsistencies and other limitations. In this Personal View, the Nutrition for Dementia Prevention Working Group presents what we consider to be limitations in the existing nutrition clinical trials for dementia prevention. On the basis of this evidence, we propose recommendations for incorporating dietary patterns and the use of genetic, and nutrition assessment tools, biomarkers, and novel clinical trial designs to guide future trial developments. Nutrition-based research has unique challenges that could require testing both more personalised interventions in targeted risk subgroups, identified by nutritional and other biomarkers, and large-scale and pragmatic study designs for more generalisable public health interventions across diverse populations.

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  1. [57]Hoevenaar-Blom MP, Richard E, Moll van Charante EP, Association of targeting vascular risk factors with a reduction in dementia incidence in old age: secondary analysis of the prevention of dementia by intensive vascular care (preDIVA) randomized clinical trial. JAMA Neurol 2021; 78: 1527– 28. 34633434 PMC8506299

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Authors
Yassine, H. N., Samieri, C., Livingston, G., Glass, K., Wagner, M., Tangney, C., Plassman, B. L., Ikram, M. A., Voigt, R. M., Gu, Y., O'Bryant, S., Minihane, A. M., Craft, S., Fink, H. A., Judd, S., Andrieu, S., Bowman, G. L., Richard, E., Albensi, B., Meyers, E., Khosravian, S., Solis, M., Carrillo, M., Snyder, H., Grodstein, F., Scarmeas, N., & Schneider, L. S.
Affiliations
  • University of Southern California (US)
  • University of East Anglia (GB)
Corresponding author
Yassine, Hussein N
Venue
The Lancet Healthy Longevity
Publisher
Elsevier BV
Published
2022-07
Volume
3
Issue
7
Pages
e501-e512
ISSN
2666-7568 (ISSN-L)
OpenAlex
W4283818777
Cited by
116
References
76
Citations by year
2026: 24 · 2025: 32 · 2024: 35 · 2023: 17 · 2022: 8
FWCI
14.99
Type
journal article
Language
en
Open access
Locations
  • The Lancet Healthy Longevity (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, cc-by)
  • UEA Digital Repository (University of East Anglia) (acceptedVersion)
  • PubMed Central (acceptedVersion, cc-by)
  • HAL (submittedVersion, cc-by)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
  • UCL Discovery (University College London) (submittedVersion)
  • Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion, cc-by)
  • Pure Amsterdam UMC (submittedVersion, cc-by)
  • Radboud Repository (Radboud University) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion, other-oa)
Funders
  • Novo Nordisk
  • Nestec (R01AG055122)
  • American Chemical Society (PCT/EP2017/065340, PCT/EP2017/082148, PCT/EP2018/058701, PCT/EP2018/064813, R01 AG043398)
  • Biogen
  • Alzheimer's Association
  • Eli Lilly and Company
  • Novartis
  • National Institutes of Health
  • National Institute on Aging (R01AG054434, R01AG055770, R01AG067063, R13AG069386)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
dementia prevention, nutrition, dietary habits, dietary supplements, cognitive function, clinical trial design, biomarkers, genetic risk factors, nutrition assessment tools, personalized interventions, public health interventions
MeSH terms
Dementia, Diet, Humans, Nutritional Status, Biomarkers, Dietary Supplements

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