The DOI matches its Crossref record; 52 of the 54 references it cites were found in a registry or an index.
Consumption of prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis has minor effects on selected immune parameters in polypectomised and colon cancer patients
Open accessAbstract
Probiotics (PRO) modulate immunity in humans, while the effect of prebiotics (PRE) and synbiotics (SYN) on the human immune system are not well studied yet. The objective of this study was to investigate whether daily intake of a SYN modulates immune functions. In a randomised double-blind, placebo-controlled trial, thirty-four colon cancer patients who had undergone ‘curative resection’ and forty polypectomised patients participated. Subjects of the SYN group daily received encapsulated bacteria (1 × 10 10 colony-forming units of Lactobacillus rhamnosus GG (LGG) and 1 × 10 10 colony-forming units of Bifidobacterium lactis Bb12 (Bb12)) and 10 g of inulin enriched with oligofructose. Controls received encapsulated maltodextrin and 10 g of maltodextrin. Prior to intervention (T1), and 6 (T2) and 12 weeks after the start of the intervention (T3), phagocytic and respiratory burst activity of neutrophils and monocytes, lytic activity of natural killer cells and production of interleukin (IL)-2, IL-10 and IL-12, as well as tumour necrosis factor-α and interferon-γ (IFN-γ) by activated peripheral blood mononuclear cells (PBMC) were measured. In faeces, the concentrations of transforming growth factor-β1 and prostaglandin E 2 were measured. IL-2 secretion by activated PBMC from the polyp group increased significantly between T1 or T2 and T3 ( P < 0·05). In the cancer group, SYN treatment resulted in an increased capacity of PBMC to produce IFN-γ at T3 ( P < 0·05). Other immunity-related parameters were not affected by SYN treatment, neither in the cancer nor in the polyp group. In conclusion, supplementation with this SYN has minor stimulatory effects on the systemic immune system of the two study groups. Further studies in humans should aim to focus on the gut-associated immune system.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In this sense, administration of B. animalis subsp. lactis BB-12 together with Lactobacillus rhamnosus GG and inulin improved the immune functions in resected CRC patients (126).”
From Bifidobacteria and Their Health-Promoting Effects (2017) · cites this paper as [126]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
Gibson, G. R., & Roberfroid, M. B. (1995) · Journal of Nutrition · doi:10.1093/jn/125.6.1401 · Cited by 7,659
Manual of Clinical Laboratory Immunology
Rose, N. R., Hamilton, R. G., & Detrick, B. (1992) · Cited by 1,253
Prostaglandins as modulators of immunity
Harris, S. G., Padilla, J., Koumas, L., Ray, D. M., & Phipps, R. P. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(01)02154-8 · Cited by 1,168
Thomson, A. W. (1994) · Cited by 1,114
Manual of Clinical Laboratory Immunology
Balows, A. (1997) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(97)00145-4 · Cited by 855
Furrie, E., Macfarlane, S., Kennedy, A., Cummings, J. H., Walsh, S. V., O’Neil, D. A., & Macfarlane, G. T. (2005) · Gut · doi:10.1136/gut.2004.044834 · Cited by 766
A fresh look at tumor immunosurveillance and immunotherapy
Smyth, M. J., Godfrey, D. I., & Trapani, J. A. (2001) · Nature Immunology · doi:10.1038/86297 · Cited by 747
Altered eicosanoid levels in human colon cancer.
Rigas, B., Goldman, I. S., & Levine, L. (1993) · PubMed · Cited by 569
Gill, H. S., Rutherfurd, K. J., Cross, M. L., & Gopal, P. K. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.6.833 · Cited by 485 · cited 1×
“Consumption of probiotics changed the relative proportions of leucocyte subsets and enhanced phagocytic activity as well as natural killer (NK) cell cytotoxicity (Gill et al. 2001; Olivares et al. 2006).”
Lindsay, J. O. (2006) · Gut · doi:10.1136/gut.2005.074971 · Cited by 471
Research works printed but not linked: 1
- 10.1079/BJN/2002541 · DOI
Cited by
Sorted by citations
The gut microbiota influences anticancer immunosurveillance and general health
Routy, B., Gopalakrishnan, V., Daillère, R., Zitvogel, L., Wargo, J. A., & Kroemer, G. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0006-2 · Cited by 523
Bifidobacteria and Their Health-Promoting Effects
Hidalgo-Cantabrana, C., Delgado, S., Ruiz, L., Ruas-Madiedo, P., Sánchez, B., & Margolles, A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0010-2016 · Cited by 490
Next generation probiotics in disease amelioration
Chang, C., Lin, T., Tsai, Y., Wu, T.-R., Lai, W.-F., Lu, C., & Lai, H. (2019) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2018.12.011 · Cited by 398
McLoughlin, R. F., Berthon, B. S., Jensen, M. E., Baines, K. J., & Wood, L. G. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.156265 · Cited by 308
Importance of probiotics in the prevention and treatment of colorectal cancer
Eslami, M., Yousefi, B., Kokhaei, P., Hemati, M., Nejad, Z. R., Arabkari, V., & Namdar, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28473 · Cited by 285
Metadata
- Authors
- Roller, M., Clune, Y., Collins, K., Rechkemmer, G., & Watzl, B.
- Affiliations
- University College Cork (IE)
- Technical University of Munich (DE)
- Corresponding author
- Watzl, Bernhard
- ORCID
- Watzl, Bernhard
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2007-03-09
- Volume
- 97
- Issue
- 4
- Pages
- 676-684
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2151982384
- Cited by
- 125
- References
- 54
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 9 · 2023: 12 · 2022: 5 · 2021: 10 · 2020: 6 · 2019: 6 · 2018: 7 · 2017: 6 · 2016: 7 · 2015: 7 · 2014: 5 · 2013: 8 · 2012: 4
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- OpenAgrar (submittedVersion)
- Funders
- Universiteit Hasselt
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- synbiotics, prebiotics, inulin, fructooligosaccharides, probiotics, Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. lactis BB-12, colon cancer, polypectomy, immune function, cytokines, interferon-gamma, interleukin-2, natural killer cells, neutrophils, monocytes, peripheral blood mononuclear cells, TGF-β1, prostaglandin E2
- MeSH terms
- Aged, Bifidobacterium, Cells, Cultured, Colonic Neoplasms, Colonic Polyps, Cytotoxicity, Immunologic, Double-Blind Method, Female, Humans, Inulin, Killer Cells, Natural, Male, Middle Aged, Oligosaccharides, Phagocytosis, Cytokines, Respiratory Burst, Probiotics, Lacticaseibacillus rhamnosus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
