Cited by 125Microbial Metabolites in Food BiotechnologyProbiotics and Fermented FoodsInfant Nutrition and Health

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Consumption of prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis has minor effects on selected immune parameters in polypectomised and colon cancer patients

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Roller, Monika, Clune, Yvonne, Collins, Kevin, Rechkemmer, Gerhard, Watzl, Bernhard·2007·British Journal of Nutrition

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Abstract

Probiotics (PRO) modulate immunity in humans, while the effect of prebiotics (PRE) and synbiotics (SYN) on the human immune system are not well studied yet. The objective of this study was to investigate whether daily intake of a SYN modulates immune functions. In a randomised double-blind, placebo-controlled trial, thirty-four colon cancer patients who had undergone ‘curative resection’ and forty polypectomised patients participated. Subjects of the SYN group daily received encapsulated bacteria (1 × 10 10 colony-forming units of Lactobacillus rhamnosus GG (LGG) and 1 × 10 10 colony-forming units of Bifidobacterium lactis Bb12 (Bb12)) and 10 g of inulin enriched with oligofructose. Controls received encapsulated maltodextrin and 10 g of maltodextrin. Prior to intervention (T1), and 6 (T2) and 12 weeks after the start of the intervention (T3), phagocytic and respiratory burst activity of neutrophils and monocytes, lytic activity of natural killer cells and production of interleukin (IL)-2, IL-10 and IL-12, as well as tumour necrosis factor-α and interferon-γ (IFN-γ) by activated peripheral blood mononuclear cells (PBMC) were measured. In faeces, the concentrations of transforming growth factor-β1 and prostaglandin E 2 were measured. IL-2 secretion by activated PBMC from the polyp group increased significantly between T1 or T2 and T3 ( P < 0·05). In the cancer group, SYN treatment resulted in an increased capacity of PBMC to produce IFN-γ at T3 ( P < 0·05). Other immunity-related parameters were not affected by SYN treatment, neither in the cancer nor in the polyp group. In conclusion, supplementation with this SYN has minor stimulatory effects on the systemic immune system of the two study groups. Further studies in humans should aim to focus on the gut-associated immune system.

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Authors: Roller, M., Clune, Y., Collins, K., Rechkemmer, G., & Watzl, B.
Affiliations: University College Cork (IE)
Technical University of Munich (DE)
Corresponding author: Watzl, Bernhard
ORCID: Watzl, Bernhard
Venue: British Journal of Nutrition
Publisher: Cambridge University Press (CUP)
Published: 2007-03-09
Volume: 97
Issue: 4
Pages: 676-684
ISSN: 0007-1145 (ISSN-L)
1475-2662
DOI: 10.1017/s0007114507450292
OpenAlex: W2151982384
Cited by: 125
References: 54
Citations by year: 2026: 4 · 2025: 4 · 2024: 9 · 2023: 12 · 2022: 5 · 2021: 10 · 2020: 6 · 2019: 6 · 2018: 7 · 2017: 6 · 2016: 7 · 2015: 7 · 2014: 5 · 2013: 8 · 2012: 4
FWCI: 5.85
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified)
Locations: British Journal Of Nutrition (publishedVersion)
PubMed (publishedVersion)
OpenAgrar (submittedVersion)
Funders: Universiteit Hasselt
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords: synbiotics, prebiotics, inulin, fructooligosaccharides, probiotics, Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. lactis BB-12, colon cancer, polypectomy, immune function, cytokines, interferon-gamma, interleukin-2, natural killer cells, neutrophils, monocytes, peripheral blood mononuclear cells, TGF-β1, prostaglandin E2
MeSH terms: Aged, Bifidobacterium, Cells, Cultured, Colonic Neoplasms, Colonic Polyps, Cytotoxicity, Immunologic, Double-Blind Method, Female, Humans, Inulin, Killer Cells, Natural, Male, Middle Aged, Oligosaccharides, Phagocytosis, Cytokines, Respiratory Burst, Probiotics, Lacticaseibacillus rhamnosus

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Consumption of prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis has minor effects on selected immune parameters in polypectomised and colon cancer patients

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