CoChat
Sign Up
Cited by 76Tea Polyphenols and EffectsPhytochemicals and Antioxidant ActivitiesCoffee research and impacts

Effects of regular ingestion of black tea on haemostasis and cell adhesion molecules in humans

Hodgson, JM, Puddey, IB, Mori, TA, Burke, V, Baker, RI, Beilin, LJ·2001·European Journal of Clinical Nutrition
DOI 10.1038/sj.ejcn.1601231
Open this paper in CoChat — free account

Abstract

Objective To assess the effects in humans of regular ingestion of black tea on haemostasis-related variables and cell adhesion molecules.Design Twenty-two subjects were recruited from the general population to a randomised-controlled crossover study. Subjects stopped drinking tea, apart from that provided, for the duration of the study. During a 4-week baseline period all subjects drank 5 cups/day (250 ml) of hot water. The effects of 5 cups/day of black tea for 4 weeks were then compared with hot water. Platelet aggregation in response to three doses of collagen and ADP, plasma concentrations of coagulation and fibrinolytic factors (fibrinogen, factor VII, tPA, PAI-1) and plasma concentrations of cell adhesion molecules (soluble P-selectin, E-selectin, ICAM-1, VCAM-1) were assessed twice, one week apart, at the end of each period. Twenty-four hour urinary concentration of 4-O-methylgallic acid (4OMGA), assessed once at the end of each period, was used as a marker of black tea polyphenol intake.Results The 24 h urinary excretion of 4OMGA was increased during regular ingestion of black tea in comparison to hot water (P<0.0001). Black tea resulted in lower soluble P-selectin (P=0.01) in comparison to hot water, but did not influence other adhesion molecules. Soluble P-selectin was significantly correlated with mean collagen-stimulated platelet aggregation at baseline (r=0.61, P=0.003), and during regular ingestion of hot water (r=0.70, P<0.0001) and black tea (r=0.51, P=0.01). However, platelet aggregation was not different between the black tea and hot water periods for collagen- or ADP-stimulated aggregation at any dose. Coagulation and fibrinolytic factors were also not different between periods.Conclusions The effect of black tea on soluble P-selectin provides a potential mechanism for cardiovascular benefits of regular ingestion of tea.Sponsorship This study was supported by grants from the Tea Trade Health Research Association and the National Heart Foundation of Australia.

Integrity signals

Registry

Crossref · 10.1038/sj.ejcn.1601231

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The concept that systemic chronic low-grade inflammation raises risk for metabolic syndrome and type 2 diabetes rests on observations of higher inflammation marker levels in people with those conditions.

    “The concept of systemic, chronic, but low-grade inflammation as a risk factor for the metabolic syndrome and for type 2 diabetes is based on the observation of elevated blood levels of inflammation-associated markers in people with incident type 2 diabetes or with the metabolic syndrome (2,3) .”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [3]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Hodgson, J., Puddey, I., Mori, T., Burke, V, Baker, R., & Beilin, L.
Affiliations
The University of Western Australia (AU)
Corresponding author
Hodgson, JM
Venue
European Journal of Clinical Nutrition
Publisher
Springer Science and Business Media LLC
Published
2001-10-01
Volume
55
Issue
10
Pages
881-886
ISSN
  • 0954-3007 (ISSN-L)
  • 1476-5640
DOI
10.1038/sj.ejcn.1601231
OpenAlex
W2330159460
Cited by
76
References
47
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2022: 3 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 5 · 2012: 6
FWCI
3.31
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • European Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (University of Western Australia) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
Keywords
black tea, hemostasis, adhesion molecules, platelet aggregation, soluble P-selectin, E-selectin, ICAM-1, VCAM-1, coagulation factors, fibrinolysis, tea polyphenols, cardiovascular health, ADP
MeSH terms
Adult, Aged, Female, Gallic Acid, Homeostasis, Humans, Male, Middle Aged, Platelet Aggregation, Tea, Biomarkers, Cell Adhesion Molecules, Cross-Over Studies, P-Selectin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review