Dietary cholesterol: from physiology to cardiovascular risk

Lecerf, Jean-Michel; de Lorgeril, Michel

doi:10.1017/s0007114511000237

Cited by 182Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthNutritional Studies and Diet

Dietary cholesterol: from physiology to cardiovascular risk

Open access

Lecerf, Jean-Michel, de Lorgeril, Michel·2011·British Journal of Nutrition

DOI 10.1017/s0007114511000237

Open this paper in CoChat — free account Open PDF

Abstract

Dietary cholesterol comes exclusively from animal sources, thus it is naturally present in our diet and tissues. It is an important component of cell membranes and a precursor of bile acids, steroid hormones and vitamin D. Contrary to phytosterols (originated from plants), cholesterol is synthesised in the human body in order to maintain a stable pool when dietary intake is low. Given the necessity for cholesterol, very effective intestinal uptake mechanisms and enterohepatic bile acid and cholesterol reabsorption cycles exist; conversely, phytosterols are poorly absorbed and, indeed, rapidly excreted. Dietary cholesterol content does not significantly influence plasma cholesterol values, which are regulated by different genetic and nutritional factors that influence cholesterol absorption or synthesis. Some subjects are hyper-absorbers and others are hyper-responders, which implies new therapeutic issues. Epidemiological data do not support a link between dietary cholesterol and CVD. Recent biological data concerning the effect of dietary cholesterol on LDL receptor-related protein may explain the complexity of the effect of cholesterol on CVD risk.

Integrity signals

Registry

Crossref · 10.1017/s0007114511000237

Cites

79 of 79 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Hamsters fed a hypercholesterolaemic diet supplemented with freeze-dried kefir (milk or soya milk) showed a significant reduction in TAG concentration and in the atherogenic index.
“Hamsters fed a hypercholesterolaemic diet supplemented with freeze-dried kefir (milk or soya milk) showed a significant reduction in TAG concentration and in the atherogenic index (69) .”
From Milk <i>kefir</i> : nutritional, microbiological and health benefits (2017) · cites this paper as [69]
The molecular switches that coordinate LDLR trafficking and turnover in response to nutritional cues, including high dietary cholesterol, remain poorly defined.
“The molecular switches that coordinate LDLR trafficking and turnover in response to nutritional cues, including high dietary cholesterol, remain poorly defined 3-6 .”
From Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover (2026) · cites this paper as [6]
Numerous studies have shown that dietary cholesterol produces a marked reduction in hepatic LDLR levels.
“Numerous studies have shown that dietary cholesterol produces a marked reduction in hepatic LDLR levels 3-6 .”
From Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover (2026) · cites this paper as [6]

1 retracted

RETRACTED: Annexin 2–caveolin 1 complex is a target of ezetimibe and regulates intestinal cholesterol transport
Smart, E. J., Rose, R. A. D., & Farber, S. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400441101 · Cited by 133 · see citing works
Retracted
Niemann-Pick C1 Like 1 Protein Is Critical for Intestinal Cholesterol Absorption
Altmann, S. W., Davis, H. R., Zhu, L.-J., Yao, X., Hoos, L. M., Tetzloff, G. G., Iyer, S. P. N., Maguire, M., Golovko, A., Zeng, M., et al. (2004) · Science · doi:10.1126/science.1093131 · Cited by 1,781 · see citing works
The link between abdominal obesity, metabolic syndrome and cardiovascular disease
Ritchie, S. A., & Connell, J. M. C. (2006) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.07.005 · Cited by 725 · see citing works
Diet, Serum Cholesterol, and Death from Coronary Heart Disease
Shekelle, R. B., Shryock, A. M., Paul, O., Lepper, M. H., Stamler, J., Liu, S., & Raynor, W. J. (1981) · New England Journal of Medicine · doi:10.1056/nejm198101083040201 · Cited by 714 · see citing works
Inhibition of Intestinal Cholesterol Absorption by Ezetimibe in Humans
Sudhop, T., Lütjohann, D., Kodal, A., Igel, M., Tribble, D. L., Shah, S., Perevozskaya, I., & von Bergmann, K. (2002) · Circulation · doi:10.1161/01.cir.0000034044.95911.dc · Cited by 682 · see citing works
LRP: Role in Vascular Wall Integrity and Protection from Atherosclerosis
Boucher, P., Gotthardt, M., Li, W., Anderson, R. G. W., & Herz, J. (2003) · Science · doi:10.1126/science.1082095 · Cited by 581 · see citing works
A Prospective Study of Egg Consumption and Risk of Cardiovascular Disease in Men and Women
Hu, F. B. (1999) · JAMA · doi:10.1001/jama.281.15.1387 · Cited by 477 · see citing works
Dietary cholesterol from eggs increases the ratio of total cholesterol to high-density lipoprotein cholesterol in humans: a meta-analysis
Weggemans, R. M., Zock, P. L., & Katan, M. B. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.5.885 · Cited by 333 · see citing works
Heterogeneity of cholesterol homeostasis in man. Response to changes in dietary fat quality and cholesterol quantity.
McNamara, D. J., Kolb, R., Parker, T. S., Batwin, H., Samuel, P., Brown, C. D., & AHRENS, E. H. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113013 · Cited by 307 · see citing works
Plant Stanol and Sterol Esters in the Control of Blood Cholesterol Levels: Mechanism and Safety Aspects
Plat, J., & Mensink, R. P. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.03.015 · Cited by 307 · see citing works
TEN-YEAR INCIDENCE OF CORONARY HEART DISEASE IN THE HONOLULU HEART PROGRAM
McGee, D., REED, D. M., Yano, K., Kagan, A., & TILLOTSON, J. L. (1984) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113788 · Cited by 264 · see citing works
Review of cholesterol absorption with emphasis on dietary and biliary cholesterol.
Wilson, M. D., & Rudel, L. L. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40109-9 · Cited by 263 · see citing works
Baseline serum cholestanol as predictor of recurrent coronary events in subgroup of Scandinavian simvastatin survival study
Miettinen, T. A., Gylling, H., Strandberg, T. E., & Sarna, S. J. (1998) · BMJ · doi:10.1136/bmj.316.7138.1127 · Cited by 257 · see citing works
Identification of a Receptor Mediating Absorption of Dietary Cholesterol in the Intestine
Hauser, H., Dyer, J. H., Nandy, A., Vega, M. A., Werder, M., Bieliauskaite, E., Weber, F. E., Compassi, S., Gemperli, A. C., Boffelli, D., et al. (1998) · Biochemistry · doi:10.1021/bi982404y · Cited by 249 · see citing works
Cholesterol absorption: regulation of cholesterol synthesis and elimination and within-population variations of serum cholesterol levels
Miettinen, T. A., & Kesäniemi, Y. A. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/49.4.629 · Cited by 216 · see citing works
Noncholesterol Sterols and Cholesterol Lowering by Long-Term Simvastatin Treatment in Coronary Patients
Miettinen, T. A., Strandberg, T. E., & Gylling, H. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.5.1340 · Cited by 208 · see citing works
Increased Hepatobiliary and Fecal Cholesterol Excretion upon Activation of the Liver X Receptor Is Independent of ABCA1
Plösch, T., Kok, T., Bloks, V. W., Smit, M. J., Havinga, R., Chimini, G., Groen, A. K., & Kuipers, F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206522200 · Cited by 207 · see citing works
Egg consumption in relation to cardiovascular disease and mortality: the Physicians' Health Study
Djoussé, L., & Gaziano, J. M. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.4.964 · Cited by 206 · see citing works
Genetic variation and the lipid response to dietary intervention: a systematic review
Masson, L. F., McNeill, G., & Avenell, A. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.5.1098 · Cited by 196 · see citing works
Apolipoprotein E genotype affects plasma lipid response to atorvastatin in a gender specific manner
Pedro‐Botet, J., Schaefer, E. J., Bakker-Arkema, R. G., Black, D. M., Stein, E., Corella, D., & Ordovás, J. M. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(01)00410-5 · Cited by 173 · see citing works
Serum-cholesterol response to dietary cholesterol: a re-evaluation
Hegsted, D. (1986) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/44.2.299 · Cited by 166 · see citing works
Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice
Kruit, J. K., Plösch, T., Havinga, R., Boverhof, R., Groot, P. H. E., Groen, A. K., & Kuipers, F. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.10.006 · Cited by 160 · see citing works
Phytosterols, Cholesterol Absorption and Healthy Diets
Ostlund, R. E. (2007) · Lipids · doi:10.1007/s11745-006-3001-9 · Cited by 159 · see citing works
Eggs, serum cholesterol, and coronary heart disease
Dawber, T. R., Nickerson, R. J., Brand, F. N., & Pool, J. (1982) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/36.4.617 · Cited by 155 · see citing works
Dietary Cholesterol from Eggs Increases Plasma HDL Cholesterol in Overweight Men Consuming a Carbohydrate-Restricted Diet ,2
Mutungi, G., Ratliff, J. C., Puglisi, M. J., Torres‐Gonzalez, M., Vaishnav, U., Leite, J. O. M., Quann, E. E., Volek, J. S., & Fernández, M. L. (2008) · Journal of Nutrition · doi:10.1093/jn/138.2.272 · Cited by 149 · see citing works
Regular egg consumption does not increase the risk of stroke and cardiovascular diseases.
Qureshi, A. I., Suri, M. F. K., Ahmed, S., Nasar, A., Divani, A. A., & Kirmani, J. F. (2007) · PubMed · Cited by 147 · see citing works
New Insights Into the Genetic Regulation of Intestinal Cholesterol Absorption
Lammert, F., & WANG, D. (2005) · Gastroenterology · doi:10.1016/j.gastro.2004.11.017 · Cited by 144 · see citing works
Dietary cholesterol and human coronary heart disease. The epidemiologic evidence.
Stamler, J., & Shekelle, R. B. (1988) · PubMed · Cited by 127 · see citing works
Normal Plasma Cholesterol in an 88-Year-Old Man Who Eats 25 Eggs a Day
Kern, F. (1991) · New England Journal of Medicine · doi:10.1056/nejm199103283241306 · Cited by 125 · see citing works
Illuminating HDL — Is It Still a Viable Therapeutic Target?
Rader, D. J. (2007) · New England Journal of Medicine · doi:10.1056/nejme0707210 · Cited by 119 · see citing works
Cholesterol absorption and synthesis related to low density lipoprotein metabolism during varying cholesterol intake in men with different apoE phenotypes.
Gylling, H., & Miettinen, T. A. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40550-4 · Cited by 119 · see citing works
Intestinal cholesterol absorption
Dawson, P. A., & Rudel, L. L. (1999) · Current Opinion in Lipidology · doi:10.1097/00041433-199908000-00005 · Cited by 119 · see citing works
Effects of dietary cholesterol and fat saturation on plasma lipoproteins in an ethnically diverse population of healthy young men.
Fielding, C. J., Havel, R., Todd, K., Yeo, K. E., Schloetter, M., Weinberg, V., & Frost, P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117705 · Cited by 114 · see citing works
Maintenance of the LDL Cholesterol:HDL Cholesterol Ratio in an Elderly Population Given a Dietary Cholesterol Challenge
Greene, C. M., Zern, T. L., Wood, R. J., Shrestha, S., Aggarwal, D., Sharman, M. J., Volek, J. S., & Fernández, M. L. (2005) · Journal of Nutrition · doi:10.1093/jn/135.12.2793 · Cited by 109 · see citing works
Egg consumption, serum total cholesterol concentrations and coronary heart disease incidence: Japan Public Health Center-based prospective study
Nakamura, Y., Iso, H., Kita, Y., Ueshima, H., Okada, K., Konishi, M., Inoue, M., & Tsugane, S. (2006) · British Journal Of Nutrition · doi:10.1017/bjn20061937 · Cited by 109 · see citing works
Effect of apolipoprotein E polymorphism on serum lipid response to the separate modification of dietary fat and dietary cholesterol
Sarkkinen, E. S., Korhonen, M. J., Erkkilä, A. T., Ebeling, T., & Uusitupa, M. I. J. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.6.1215 · Cited by 109 · see citing works
Comparison of the effects of maximal dose atorvastatin and rosuvastatin therapy on cholesterol synthesis and absorption markers
van Himbergen, T. M., Matthan, N. R., Resteghini, N. A., Otokozawa, S., Ai, M., Stein, E. A., Jones, P. H., & Schaefer, E. J. (2008) · Journal of Lipid Research · doi:10.1194/jlr.p800042-jlr200 · Cited by 108 · see citing works
Low Synthesis and High Absorption of Cholesterol Characterize Type 1 Diabetes
Miettinen, T. A., Gylling, H. K., Tuominen, J. A., Simonen, P. P., & Koivisto, V. A. (2004) · Diabetes Care · doi:10.2337/diacare.27.1.53 · Cited by 99 · see citing works
Egg consumption, serum cholesterol, and cause-specific and all-cause mortality: the National Integrated Project for Prospective Observation of Non-communicable Disease and Its Trends in the Aged, 1980 (NIPPON DATA80)
Nakamura, Y., Okamura, T., Tamaki, S., Kadowaki, T., Hayakawa, T., Kita, Y., Okayama, A., & Ueshima, H. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.1.58 · Cited by 98 · see citing works
Dietary Cholesterol Feeding Suppresses Human Cholesterol Synthesis Measured by Deuterium Incorporation and Urinary Mevalonic Acid Levels
Jones, P. J. H., Pappu, A. S., Hatcher, L. F., Li, Z.-C., Illingworth, D. R., & Connor, W. E. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.10.1222 · Cited by 94 · see citing works
ATP binding cassette transporter G5 and G8 genotypes and plasma lipoprotein levels before and after treatment with atorvastatin
Kajinami, K., Brousseau, M. E., Nartsupha, C., Ordovás, J. M., & Schaefer, E. J. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300278-jlr200 · Cited by 93 · see citing works
Increases in Dietary Cholesterol Are Associated With Modest Increases in Both LDL and HDL Cholesterol in Healthy Young Women
Ginsberg, H. N., Karmally, W., Siddiqui, M., Holleran, S., Tall, A. R., Blaner, W. S., & Ramakrishnan, R. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.2.169 · Cited by 91 · see citing works
Assessment of percent cholesterol absorption in humans with stable isotopes
Bosner, M. S., Ostlund, R., Osofisan, O., Grosklos, J., Fritschle, C., & Lange, L. G. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39690-5 · Cited by 90 · see citing works
Inheritance of cholesterol metabolism of probands with high or low cholesterol absorption
Gylling, H., & Miettinen, T. A. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200155-jlr200 · Cited by 87 · see citing works
Absorption, metabolism, and serum concentrations of cholesterol in vegetarians: effects of cholesterol feeding
Vuoristo, M., & Miettinen, T. A. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/59.6.1325 · Cited by 80 · see citing works
Effects of different doses of atorvastatin on human apolipoprotein B-100, B-48, and A-I metabolism
Lamon‐Fava, S., Diffenderfer, M. R., Barrett, P. H. R., Buchsbaum, A., Matthan, N. R., Lichtenstein, A. H., Dolnikowski, G. G., Horvath, K. V., Asztalos, B. F., Zago, V., et al. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700067-jlr200 · Cited by 80 · see citing works
Dietary linoleic acid increases and palmitic acid decreases hepatic LDL receptor protein and mRNA abundance in young pigs
Mustad, V. A., Ellsworth, J. L., Cooper, A. D., Kris-Etherton, P. M., & Etherton, T. D. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37480-0 · Cited by 80 · see citing works
INGESTION OF EGG RAISES PLASMA LOW DENSITY LIPOPROTEINS IN FREE-LIVING SUBJECTS
Sacks, F., Miller, L., Sutherland, M., Albers, J. J., Salazar, J., Foster, J., Samonds, K., & Kass, E. H. (1984) · The Lancet · doi:10.1016/s0140-6736(84)92168-8 · Cited by 78 · see citing works
Regulation of cholesterol biosynthesis by diet in humans
Jones, P. J. H. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.2.438 · Cited by 77 · see citing works
Effect of dietary cholesterol on plasma cholesterol concentration in subjects following reduced fat, high fibre diet.
Edington, J., Geekie, M., Carter, R., Benfield, L., Fisher, K., Ball, M., & Mann, J. I. (1987) · BMJ · doi:10.1136/bmj.294.6568.333 · Cited by 77 · see citing works
Indices of Cholesterol Metabolism and Relative Responsiveness to Ezetimibe and Simvastatin
Gilchrist, S. C., Xu, F., Vega, G. L., Grundy, S. M., Chandalia, M., Lam, C., Lowe, R. S., Stepanavage, M. E., Musliner, T. A., Cohen, J. C., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1952 · Cited by 74 · see citing works
Aging per se is an independent risk factor for cholesterol gallstone formation in gallstone susceptible mice
Wang, D. Q. ‐. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200078-jlr200 · Cited by 68 · see citing works
The absorption of cholesterol and the sterol balance in the Tarahumara Indians of Mexico fed cholesterol-free and high cholesterol diets
McMurry, M. P., We, C., Lin, D., Cerqueira, M., & Connor, S. (1985) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/41.6.1289 · Cited by 67 · see citing works
Cholesterol absorption efficiency declines at moderate dietary doses in normal human subjects
Ostlund, R. E., Bosner, M. S., & Stenson, W. F. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33387-3 · Cited by 66 · see citing works
Increased dietary cholesterol does not increase plasma low density lipoprotein when accompanied by an energy-restricted diet and weight loss
Harman, N., Leeds, A., & Griffin, B. A. (2008) · European Journal of Nutrition · doi:10.1007/s00394-008-0730-y · Cited by 65 · see citing works
Should we lower cholesterol as much as possible?
Ravnskov, U., ROSCH, P. J., Sutter, M. C., & Houston, M. C. (2006) · BMJ · doi:10.1136/bmj.332.7553.1330 · Cited by 64 · see citing works
Genes, variation of cholesterol and fat intake and serum lipids
Ordovás, J. M., & Schaefer, E. J. (1999) · Current Opinion in Lipidology · doi:10.1097/00041433-199902000-00004 · Cited by 60 · see citing works
Apolipoprotein B gene polymorphisms and serum lipids: meta-analysis of the role of genetic variation in responsiveness to diet
Rantala, M., Rantala, T. T., Savolainen, M. J., Friedlander, Y., & Kesäniemi, Y. A. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.3.713 · Cited by 59 · see citing works
Differential response to low-fat diet between low and normal HDL-cholesterol subjects
Asztalos, B. F., LeFevre, M. L., Wong, L., Foster, T. A., Tulley, R. T., WINDHAUSER, M. M., Zhang, W., & Roheim, P. S. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34470-9 · Cited by 57 · see citing works
Egg intake does not change plasma lipoprotein and coagulation profiles
Vorster, H. H., Benadé, A., Barnard, H. C., Locke, M., Silvis, N., Venter, C., Smuts, C. M., Engelbrecht, G. P., & Marais, M. (1992) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/55.2.400 · Cited by 52 · see citing works
Ineffective decrease of serum cholesterol by simvastatin in a subgroup of hypercholesterolemic coronary patients
Miettinen, T. A., & Gylling, H. K. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(02)00054-0 · Cited by 50 · see citing works
Susceptibility to murine cholesterol gallstone formation is not affected by partial disruption of the HDL receptor SR-BI
Wang, D. Q. ‐., & Carey, M. C. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(02)00194-4 · Cited by 47 · see citing works
Effect of dietary cholesterol in normolipidemic subjects is not modified by nature and amount of dietary fat
Kestin, M., Clifton, P. M., Rouse, I. L., & Nestel, P. J. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/50.3.528 · Cited by 44 · see citing works
Hepatic low-density lipoprotein receptor–related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol
Santo, S. M. S. E., Pires, N. M., Boesten, L. S. M., Gerritsen, G., Bovenschen, N., van Dijk, K. W., Jukema, J. W., Princen, H. M. G., Bensadoun, A., Li, W., et al. (2004) · Blood · doi:10.1182/blood-2003-11-4051 · Cited by 43 · see citing works
Differential absorption of exogenous and endogenous cholesterol in man
Samuel, P., & McNamara, D. J. (1983) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37995-5 · Cited by 42 · see citing works
Food Components that Reduce Cholesterol Absorption
Carr, T. P., & Jesch, E. D. (2006) · Advances in food and nutrition research · doi:10.1016/s1043-4526(06)51003-4 · Cited by 38 · see citing works
Visceral Adipocytes and the Metabolic Syndrome
Tchernof, A. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00324.x · Cited by 37 · see citing works
Visceral Adipocytes and the Metabolic Syndrome
Tchernof, A. (2007) · Nutrition Reviews · doi:10.1301/nr.2007.jun.s24-s29 · Cited by 35 · see citing works
The lipid-lowering effect of ezetimibe in pure vegetarians
Clarenbach, J. J., Reber, M., Lütjohann, D., von Bergmann, K., & Sudhop, T. (2006) · Journal of Lipid Research · doi:10.1194/jlr.p600009-jlr200 · Cited by 34 · see citing works
Regulation of serum cholesterol level in middle-aged and elderly men. Relation of cholesterol absorption and synthesis to lipoprotein metabolism.
Gylling, H., Strandberg, T. E., Tilvis, R. S., & Miettinen, T. A. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.5.694 · Cited by 34 · see citing works
Effect of dietary cholesterol on low density lipoprotein‐receptor, 3‐hydroxy‐3‐methylglutaryl‐CoA reductase, and low density lipoprotein receptor‐related protein mRNA expression in healthy humans
Boucher, P., de Lorgeril, M., Salen, P., Crozier, P., Delaye, J., Vallon, J.-J., GEYSSANT, A., & Dante, R. (1998) · Lipids · doi:10.1007/s11745-998-0321-8 · Cited by 33 · see citing works
Food group and nutrient intakes at baseline in the Multiple Risk Factor Intervention Trial
Tillotson, J., Bartsch, G., Gorder, D. D., Grandits, G., & Stamler, J. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.1.228s · Cited by 31 · see citing works
Markers of absorption and synthesis of cholesterol in men with type 1 diabetes
Gylling, H. K., Laaksonen, D. E., Atalay, M., Hallikainen, M., NISKANEN, L. K., & Miettinen, T. A. (2006) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.697 · Cited by 31 · see citing works
Cholesterol absorption: Influence of body weight and the role of plant sterols
Gylling, H., & Miettinen, T. A. (2005) · Current Atherosclerosis Reports · doi:10.1007/s11883-005-0064-7 · Cited by 30 · see citing works
Serum noncholesterol sterols in children with heterozygous familial hypercholesterolemia undergoing pravastatin therapy
Hedman, M., Miettinen, T. A., Gylling, H., Ketomäki, A., & Antikainen, M. (2006) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2005.08.068 · Cited by 17 · see citing works
Variation in the cholesteryl ester transfer protein (CETP) gene does not influence individual plasma cholesterol response to changes in the nature of dietary fat
Aitken, W., Chisholm, A. W., Duncan, A. W., Harper, M. J., Humphries, S. E., Mann, J. I., Skeaff, C. M., Sutherland, W. H. F., Wallace, A. J., & Williams, S. (2005) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2005.06.007 · Cited by 14 · see citing works
Association of High Total Cholesterol with Coronary Heart Disease Mortality Differs among Subject Populations – Familial Hypercholesterolemia as a Key Concept
Okuyama, H., Ichikawa, Y., Sun, Y., Hamazaki, T., & Lands, W. E. M. (2006) · KARGER eBooks · doi:10.1159/000097804 · Cited by 7 · see citing works
The effect of increased egg consumption on plasma cholesteryl ester transfer activity in healthy subjects
Sutherland, W. H. F., Ball, M., & Walker, H. L. (1997) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600379 · Cited by 7 · see citing works
Phytostérols et risque cardiovasculaire
Lecerf, J. (2007) · Nutrition Clinique et Métabolisme · doi:10.1016/j.nupar.2007.01.004 · Cited by 5 · see citing works
Self-citation

Flagged first, then by citations

Sorted by citations

Milk <i>kefir</i> : nutritional, microbiological and health benefits
Rosa, D. D., Dias, M. M. S., Grześkowiak, Ł. M., Reis, S. A., Conceição, L. L., & Peluzio, M. D. C. G. (2017) · Nutrition Research Reviews · doi:10.1017/s0954422416000275 · Cited by 463 · see citing works
The SLCO (former SLC21) superfamily of transporters
Hagenbuch, B., & Stieger, B. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.10.009 · Cited by 384 · see citing works
The Influence of Meal Frequency and Timing on Health in Humans: The Role of Fasting
Paoli, A., Tinsley, G. M., Bianco, A., & Moro, T. (2019) · Nutrients · doi:10.3390/nu11040719 · Cited by 381 · see citing works
Dietary cholesterol and cardiovascular disease: a systematic review and meta-analysis
Berger, S., Raman, G., Vishwanathan, R., Jacques, P. F., & Johnson, E. J. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.100305 · Cited by 356 · see citing works
Associations between the human intestinal microbiota, Lactobacillus rhamnosus GG and serum lipids indicated by integrated analysis of high-throughput profiling data
Lahti, L., Salonen, A., Kekkonen, R. A., Salojärvi, J., Jalanka, J., Palva, A., Orešič, M., & de Vos, W. M. (2013) · PeerJ · doi:10.7717/peerj.32 · Cited by 196 · see citing works
Western diets and chronic diseases
Adolph, T. E., & Tilg, H. (2024) · Nature Medicine · doi:10.1038/s41591-024-03165-6 · Cited by 203 · see citing works
Cholesterol reduction mechanisms and fatty acid composition of cellular membranes of probiotic Lactobacilli and Bifidobacteria
Miremadi, F., Ayyash, M. M., Sherkat, F., & Stojanovska, L. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.05.002 · Cited by 166 · see citing works
Importance of Nutrients and Nutrient Metabolism on Human Health.
Chen, Y., Michalak, M., & Agellon, L. B. (2018) · Europe PMC (PubMed Central) · Cited by 153 · see citing works
Nutritional Value and Food Safety of Bivalve Molluscan Shellfish
Wright, A. C., Ying, F., & Baker, G. L. (2018) · Journal of Shellfish Research · doi:10.2983/035.037.0403 · Cited by 150 · see citing works
Red Cabbage Microgreens Lower Circulating Low-Density Lipoprotein (LDL), Liver Cholesterol, and Inflammatory Cytokines in Mice Fed a High-Fat Diet
Huang, H., Jiang, X., Xiao, Z., Yu, L., Pham, Q., Sun, J., Chen, P. C., Yokoyama, W., Yu, L. L., Luo, Y., et al. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b03805 · Cited by 132 · see citing works
Revisiting Human Cholesterol Synthesis and Absorption: The Reciprocity Paradigm and its Key Regulators
Alphonse, P. A. S., & Jones, P. J. H. (2015) · Lipids · doi:10.1007/s11745-015-4096-7 · Cited by 116 · see citing works
Gut dysbiosis, leaky gut, and intestinal epithelial proliferation in neurological disorders: towards the development of a new therapeutic using amino acids, prebiotics, probiotics, and postbiotics
Maguire, M., & Maguire, G. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2018-0024 · Cited by 111 · see citing works
Mechanisms responsible for the hypocholesterolaemic effect of regular consumption of probiotics
dos Reis, S. A., da Conceição, L. L., Rosa, D. D., Siqueira, N. P., & Pelúzio, M. D. C. G. (2016) · Nutrition Research Reviews · doi:10.1017/s0954422416000226 · Cited by 114 · see citing works
An Atomic-Level Perspective of HMG-CoA-Reductase: The Target Enzyme to Treat Hypercholesterolemia
Gesto, D., Pereira, C. M. S. B., Cerqueira, N. M. F. S. A., & Sousa, S. F. (2020) · Molecules · doi:10.3390/molecules25173891 · Cited by 95 · see citing works
Anthocyanin-Rich Juice Lowers Serum Cholesterol, Leptin, and Resistin and Improves Plasma Fatty Acid Composition in Fischer Rats
Gräf, D., Seifert, S., Jaudszus, A., Bub, A., & Watzl, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066690 · Cited by 88 · see citing works
Associations of Dietary Cholesterol, Serum Cholesterol, and Egg Consumption With Overall and Cause-Specific Mortality: Systematic Review and Updated Meta-Analysis
Zhao, B., Gan, L., Graubard, B. I., Männistö, S., Albanes, D., & Huang, J. (2022) · Circulation · doi:10.1161/circulationaha.121.057642 · Cited by 88 · see citing works
Bile Acids Transporters of Enterohepatic Circulation for Targeted Drug Delivery
Durník, R., Sindlerova, L. S., Babica, P., & Jurček, O. (2022) · Molecules · doi:10.3390/molecules27092961 · Cited by 72 · see citing works
Dietary cholesterol and plasma lipoprotein profiles: randomized-controlled trials
Griffin, J. D., & Lichtenstein, A. H. (2013) · Current Nutrition Reports · doi:10.1007/s13668-013-0064-0 · Cited by 64 · see citing works
Egg consumption and cardiovascular risk: a dose–response meta-analysis of prospective cohort studies
Godos, J., Micek, A., Brzostek, T., Toledo, E., Iacoviello, L., Astrup, A. V., Franco, O. H., Galvano, F., Martínez‐González, M. Á., & Grosso, G. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02345-7 · Cited by 65 · see citing works
HC diet inhibited testosterone synthesis by activating endoplasmic reticulum stress in testicular Leydig cells
Yu, C., Jiang, F., Zhang, M., Luo, D., Shao, S., Zhao, J., Gao, L., Zuo, C., & Guan, Q. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14143 · Cited by 63 · see citing works
Effect of Gut Microbiota on Blood Cholesterol: A Review on Mechanisms
Deng, C., Pan, J., Zhu, H., & Chen, Z. (2023) · Foods · doi:10.3390/foods12234308 · Cited by 62 · see citing works
Hypocholesterolaemic effect and anti-hypertensive properties of probiotics and prebiotics: A review
Miremadi, F., Sherkat, F., & Stojanovska, L. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.06.016 · Cited by 60 · see citing works
Pharmacological modulation of cholesterol 7α-hydroxylase (CYP7A1) as a therapeutic strategy for hypercholesterolemia.
Lim, M. Y. C., & Ho, H. K. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115985 · Cited by 59 · see citing works
Computationally Modeling Lipid Metabolism and Aging: A Mini-review
Auley, M. T. M., & Mooney, K. M. (2014) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2014.11.006 · Cited by 53 · see citing works
Egg consumption and human health: an umbrella review of observational studies
Marventano, S., Godos, J., Tieri, M., Ghelfi, F., Titta, L., Lafranconi, A., Gambera, A., Alonzo, E., Sciacca, S., Buscemi, S., et al. (2019) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2019.1648388 · Cited by 53 · see citing works
New radiological insights into the life and death of the Tyrolean Iceman
Gostner, P., Pernter, P., Bonatti, G., Graefen, A., & Zink, A. (2011) · Journal of Archaeological Science · doi:10.1016/j.jas.2011.08.003 · Cited by 52 · see citing works
Pistacia Atlantica Desf., a Source of Healthy Vegetable Oil
Labdelli, A., Zemour, K., Simon, V., Cerny, M., Adda, A., & Merah, O. (2019) · Applied Sciences · doi:10.3390/app9122552 · Cited by 46 · see citing works
The Bacteroidales produce an N-acylated derivative of glycine with both cholesterol-solubilising and hemolytic activity
Lynch, A., Crowley, E., Casey, E., Cano, R., Shanahan, R., McGlacken, G. P., Marchesi, J. R., & Clarke, D. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-13774-6 · Cited by 44 · see citing works
Dietary Cholesterol in the Elderly Chinese Population: An Analysis of CNHS 2010–2012
Pang, S., Jia, S., Man, Q., Song, S., Li, Y., Song, P., Zhao, W., & Zhang, J. (2017) · Nutrients · doi:10.3390/nu9090934 · Cited by 41 · see citing works
Dysregulation of distal cholesterol biosynthesis in association with relapse and advanced disease in CHC genotype 2 and 3 treated with sofosbuvir and ribavirin
Younossi, Z. M., Stepanova, M., Estep, M., Negro, F., Clark, P. J., Hunt, S., Song, Q., Paulson, M. S., Stamm, L. M., Brainard, D. M., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.08.027 · Cited by 38 · see citing works
Evaluation of the in vitro cholesterol‐lowering activity of the probiotic strain Bacillus coagulans MTCC 5856
Majeed, M. A., Majeed, S., Nagabhushanam, K., Arumugam, S., Beede, K., & Ali, F. H. M. (2018) · International Journal of Food Science & Technology · doi:10.1111/ijfs.13926 · Cited by 38 · see citing works
Monobutyrin Reduces Liver Cholesterol and Improves Intestinal Barrier Function in Rats Fed High-Fat Diets
Nguyen, T. D., Prykhodko, O., Hållenius, F. F., & NYMAN, M. E. (2019) · Nutrients · doi:10.3390/nu11020308 · Cited by 38 · see citing works
Effects of gut microbial therapy on lipid profile in individuals with non-alcoholic fatty liver disease: an umbrella meta-analysis study
Naghipour, A., Amini-Salehi, E., Orang Gorabzarmakhi, M., Shahdkar, M., Fouladi, B., Alipourfard, I., & Sanat, Z. M. (2023) · Systematic Reviews · doi:10.1186/s13643-023-02299-x · Cited by 37 · see citing works
Anti‐obesity peptides from food: Production, evaluation, sources, and commercialization
Hajfathalian, M., Ghelichi, S., & Jacobsen, C. (2025) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.70158 · Cited by 37 · see citing works
Transport of cowpea bean derived peptides and their modulator effects on mRNA expression of cholesterol-related genes in Caco-2 and HepG2 cells
Marques, M. R., Cerda, Á., Fontanari, G. G., Pimenta, D. C., Freitas, R. A. M. S., Hirata, M. H., Hirata, R. D. C., & Arêas, J. A. G. (2018) · Food Research International · doi:10.1016/j.foodres.2018.01.031 · Cited by 34 · see citing works
Assessment of exopolysaccharides, bacteriocins and in vitro and in vivo hypocholesterolemic potential of some Egyptian Lactobacillus spp.
El-Dein, A. N., El-Deen, A. M. N., El‐Shatoury, E. H., Awad, G. E. A., Ibrahim, M. K., Awad, H. M., & Farid, M. A. F. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.01.107 · Cited by 34 · see citing works
NRF3 upregulates gene expression in SREBP2-dependent mevalonate pathway with cholesterol uptake and lipogenesis inhibition
Waku, T., Hagiwara, T., Tamura, N., Atsumi, Y., Urano, Y., Suzuki, M., Iwami, T., Sato, K., Yamamoto, M., Noguchi, N., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103180 · Cited by 30 · see citing works
A Snack Dietary Pattern Increases the Risk of Hypercholesterolemia in Northern Chinese Adults: A Prospective Cohort Study
Na, L., Han, T., Zhang, W., Wu, X., Na, G., Du, S., Li, Y., & Sun, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134294 · Cited by 30 · see citing works
Type 1 diabetes mellitus successfully managed with the paleolithic ketogenic diet
Tóth, C., & Clemens, Z. (2014) · International Journal of Case Reports and Images · doi:10.5348/ijcri-2014124-cr-10435 · Cited by 30 · see citing works
Interindividual variability in the cholesterol-lowering effect of supplementation with plant sterols or stanols
Fumeron, F., Bard, J., & Lecerf, J. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw059 · Cited by 28 · see citing works
Self-citation
Common questions and misconceptions about protein supplementation: what does the scientific evidence really show?
António, J., Evans, C., Ferrando, A. A., Stout, J. R., Antonio, B. B., Cintineo, H. P., Harty, P. S., Arent, S. M., Candow, D. G., Forbes, S. C., et al. (2024) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2024.2341903 · Cited by 31 · see citing works
Dietary Cholesterol Intake and Risk of Gestational Diabetes Mellitus: A Meta-Analysis of Observational Studies
Gao, F., & Cui, C.-Y. (2021) · Journal of the American Nutrition Association · doi:10.1080/07315724.2020.1844605 · Cited by 27 · see citing works
Evaluating computational models of cholesterol metabolism
Paalvast, Y., Kuivenhoven, J. A., & Groen, A. K. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.05.008 · Cited by 25 · see citing works
Effects of Non-Polar Dietary and Endogenous Lipids on Gut Microbiota Alterations: The Role of Lipidomics
Tsiantas, K., Konteles, S. J., Kritsi, E., Sinanoglou, V. J., Tsiaka, T., & Zoumpoulakis, P. G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084070 · Cited by 25 · see citing works
Hungarian Diet and Nutritional Status Survey – The OTAP2009 study. II. Energy and macronutrient intake of the Hungarian population
Nagy, E. S., Bakacs, M., Illés, É., Zentai, A., Lugasi, A., & Martos, É. (2012) · Orvosi Hetilap · doi:10.1556/oh.2012.29376 · Cited by 23 · see citing works
The Association of Dietary Cholesterol and Fatty Acids with Dyslipidemia in Chinese Metropolitan Men and Women
Zhu, Z., Wu, F., Lu, Y., Wang, Z., Zang, J., Yu, H., Guo, C., Jia, X., Shen, X., & Ding, G. (2018) · Nutrients · doi:10.3390/nu10080961 · Cited by 23 · see citing works
Association between long-term air pollution exposure and development of diabetes among community-dwelling adults: Modification of the associations by dietary nutrients
Shin, M.-K., & Kim, K. (2023) · Environment International · doi:10.1016/j.envint.2023.107908 · Cited by 22 · see citing works
Longitudinal association between egg consumption and the risk of cardiovascular disease: interaction with type 2 diabetes mellitus
Jang, J., Shin, M., Kim, O. Y., & Park, K. (2018) · Nutrition and Diabetes · doi:10.1038/s41387-018-0033-1 · Cited by 21 · see citing works
Egg consumption and risk of all-cause and cause-specific mortality in an Italian adult population
Ruggiero, E., Castelnuovo, A. D., Costanzo, S., Persichillo, M., Curtis, A. D., Cerletti, C., Donati, M. B., de Gaetano, G., Iacoviello, L., Bonaccio, M., et al. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02536-w · Cited by 21 · see citing works
25-Hydroxycholesterol-Induced Oxiapoptophagy in L929 Mouse Fibroblast Cell Line
You, J., Lim, H., Seo, J.-Y., Kang, K., Kim, D. K., Oh, J., Seo, Y.-S., Lee, G., Kim, J.-S., Kim, J.-S., et al. (2021) · Molecules · doi:10.3390/molecules27010199 · Cited by 21 · see citing works
Consumption of ultra-processed foods and incidence of dyslipidaemias: the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
Scaranni, P. D. O. D. S., Cardoso, L. D. O., Griep, R. H., Lotufo, P. A., Barreto, S. M., & da Fonseca, M. D. J. M. (2022) · British Journal Of Nutrition · doi:10.1017/s0007114522001131 · Cited by 19 · see citing works
Modified dietary fat intake for treatment of gallstone disease in people of any age
Madden, A. M., Smeeton, N., Culkin, A., & Trivedi, D. P. (2024) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012608.pub3 · Cited by 19 · see citing works
Pharmacological modulation of dietary lipid-induced cerebral capillary dysfunction: Considerations for reducing risk for Alzheimer’s disease
Pallebage‐Gamarallage, M. M., Takechi, R., Lam, V., Elahy, M., & Mamo, J. C. L. (2015) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2015.1115820 · Cited by 19 · see citing works
The Impact of Phytosterols on the Healthy and Diseased Brain
Dierckx, T., Bogie, J. F. J., & Hendriks, J. J. A. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180706113844 · Cited by 19 · see citing works
Development of an electrochemical biosensor for non-invasive cholesterol monitoring via microneedle-based interstitial fluid extraction
Kim, J. Y., Kim, M. Y., Han, Y., Lee, G. Y., Kim, D. H., Heo, Y. J., & Park, M. (2024) · Talanta · doi:10.1016/j.talanta.2024.126771 · Cited by 18 · see citing works
The Effects of Cymbopogon citratus (Lemon grass) on the Blood Sugar Level, Lipid Profiles and Hormonal Profiles of Wistar Albino Rats
Adegbegi, A. J., Elliot, S. O., Olamide, O. Y., Omoyemi, A. A., & Funmi, O. S. (2015) · Cited by 18 · see citing works
Assessment of Cholesterol Absorption Inhibitors Nanostructured Aluminosilicate and Cholestyramine Using In Vitro Lipolysis Model
Gershkovich, P., Sivak, O., Contreras-Whitney, S., Darlington, J. W., & Wasan, K. M. (2011) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22770 · Cited by 18 · see citing works
Effect of dietary patterns on cardiovascular risk factors in people with type 2 diabetes. A systematic review and network meta-analysis
Bonekamp, N. E., van Damme, I., Geleijnse, J. M., Winkels, R. M., Visseren, F. L. J., Morris, P. B., & Koopal, C. (2022) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2022.110207 · Cited by 17 · see citing works
Lipids as Nutraceuticals: A Shift in Paradigm
Kumar, S., Sharma, B., Bhadwal, P., Sharma, P., & Agnihotri, N. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811517-6.00003-9 · Cited by 17 · see citing works
The Mechanism of Probiotics in Preventing the Risk of Hypercholesterolemia
Susanti, I., Setiarto, R. H. B., Kahfi, J., Giarni, R., Muhamaludin, Ramadhaningtyas, D. P., & Randy, A. (2023) · Reviews in Agricultural Science · doi:10.7831/ras.11.0_156 · Cited by 16 · see citing works
Erythrocyte Membrane Nanomechanical Rigidity Is Decreased in Obese Patients
Sot, J., García‐Arribas, A. B., Abad‐García, B., Arranz, S., Portune, K. J., Andrade, F., Martín-Nieto, A., Velasco, O., Arana‐Arri, E., Tueros, I., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031920 · Cited by 15 · see citing works
Cardiovascular disease and healthy ageing
Mooney, K. M., & Auley, M. T. M. (2015) · Journal of Integrative Cardiology · doi:10.15761/jic.1000122 · Cited by 15 · see citing works
Prepregnancy Dietary Patterns Are Associated with Blood Lipid Level Changes During Pregnancy: A Prospective Cohort Study in Rio de Janeiro, Brazil
Eshriqui, I., Franco‐Sena, A. B., Farias, D. R., Vilela, A. A. F., Cunha, D. B., Barros, É. G., Emmett, P. M., & Kac, G. (2017) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2016.12.007 · Cited by 14 · see citing works
Lactoferrin Alleviates the Progression of Atherosclerosis in ApoE −/− Mice Fed with High-Fat/Cholesterol Diet Through Cholesterol Homeostasis
Ling, C.-J., Min, Q.-Q., Yang, J., Zhang, Z., Yang, H., Xu, J., & Qin, L. (2019) · Journal of Medicinal Food · doi:10.1089/jmf.2018.4389 · Cited by 14 · see citing works
Influence of obesity on the response to influenza infection and vaccination
Karlsson, E. A., Milner, J. J., Green, W. D., Rebeles, J., Schultz‐Cherry, S., & Beck, M. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813553-2.00010-5 · Cited by 13 · see citing works
Pathophysiological Potentials of NRF3-Regulated Transcriptional Axes in Protein and Lipid Homeostasis
Waku, T., & Kobayashi, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312686 · Cited by 12 · see citing works
Translational characterization of the temporal dynamics of metabolic dysfunctions in liver, adipose tissue and the gut during diet-induced NASH development in Ldlr−/−.Leiden mice
Gart, E., van Duyvenvoorde, W., Snabel, J. M., de Ruiter, C., Attema, J., Caspers, M. P. M., Lek, S., van Heuven, B. J., Speksnijder, A. G. C. L., Giera, M. A., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13985 · Cited by 13 · see citing works
Metabolomic biomarkers of the mediterranean diet in pregnant individuals: A prospective study
Chen, L., Dai, J. M., Fei, Z., Liu, X., Zhu, Y., Rahman, M. L., Lu, R., Mitro, S. D., Yang, J., Hinkle, S. N., et al. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.01.011 · Cited by 12 · see citing works
MTHFD1 promoter hypermethylation increases the risk of hypertension
Xu, M., Li, J., Chen, X., Han, L., Li, L., & Liu, Y. (2018) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2018.1501057 · Cited by 12 · see citing works
In vitro and in vivo hypolipidemic properties of the aqueous extract of Spirulina platensis , cultivated in colored flasks under artificial illumination
Al‐Saman, M. A., Doleib, N. M., Ibrahim, M. R., Nasr, M., Tayel, A. A., & Hamouda, R. A. (2020) · PeerJ · doi:10.7717/peerj.10366 · Cited by 12 · see citing works
A Facile LC-MS Method for Profiling Cholesterol and Cholesteryl Esters in Mammalian Cells and Tissues
Chandramouli, A., & Kamat, S. S. (2024) · Biochemistry · doi:10.1021/acs.biochem.4c00160 · Cited by 11 · see citing works
Emerging functionalities of yeast cell-wall components; the value-added food-grade pre- and post-biotics
Sadeghi, A., Purabdolah, H., Hajinia, F., Shahryari, S., Taheri, F., Ebrahimi, M. T., Assadpour, E., & Jafari, S. M. (2025) · Applied Food Research · doi:10.1016/j.afres.2025.101072 · Cited by 11 · see citing works
Detection of Milk Fat Adulteration in Commercial Butter and Sour Cream
Nurseitova, M., Konuspayev, G. S., Zhakupbeko, A. A., Amutova, F., Omarova, A., Kondybayev, A., Bayandy, G. A., Akhmetsady, N. N., & Faye, B. (2021) · International Journal of Dairy Science · doi:10.3923/ijds.2021.18.28 · Cited by 11 · see citing works
Building blocks of β-sitosterol-γ-oryzanol gels revealed by small-angle neutron scattering and real space modelling
Gilbert, E. P. (2022) · Food & Function · doi:10.1039/d2fo00935h · Cited by 11 · see citing works
High cholesterol diet–induced testicular dysfunction in rats
Liu, L., Zhang, M., Jiang, F., Luo, D., Liu, S., Su, Y., Guan, Q., & Yu, C. (2023) · HORMONES · doi:10.1007/s42000-023-00472-4 · Cited by 11 · see citing works
Dysbiosis index and fecal concentrations of sterols, long-chain fatty acids and unconjugated bile acids in dogs with inflammatory protein-losing enteropathy
Cagnasso, F., Suchodolski, J. S., Borrelli, A. L., Borella, F., Bottero, E., Benvenuti, E., Ferriani, R., Tolbert, M. K., Chen, C.-C., Giaretta, P. R., et al. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1433175 · Cited by 10 · see citing works
Dietary cholesterol affects expression of prostatic acid phosphatase in reproductive organs of male rats
Lim, W., Bae, H., Sohn, J. Y., Jeong, W., Kim, S. H., & Song, G. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.11.100 · Cited by 10 · see citing works
Role and Mechanisms Lowering Cholesterol by Dietary of Probiotics and Prebiotics: A Review
Shehata, M. G., El-Sahn, M. A., Sohaimy, S. A. E., & Youssef, M. (2019) · Journal of Applied Sciences · doi:10.3923/jas.2019.737.746 · Cited by 10 · see citing works
Dietary Cholesterol Intake in the Korea National Health and Nutrition Examination Survey (KNHANES) VI (2013–2015)
Park, M., Kweon, S., & Oh, K. (2017) · 대한지역사회영양학회지 · doi:10.5720/kjcn.2017.22.6.520 · Cited by 10 · see citing works
Short-Term Consumption of Probiotic Yogurt Improved HDL-C of Type 2 Diabetes Mellitus Patients: A Double-Blind Randomized Controlled Trial
Lestari, L. A., Ratnasari, D., Azizah, E. F., Farida, I. N., Nuriannisa, F., Yuliani, K., Kusuma, R. J., Huriyati, E., & Kertia, N. (2019) · Romanian Journal of Diabetes Nutrition and Metabolic Diseases · doi:10.2478/rjdnmd-2019-0041 · Cited by 9 · see citing works
A Combination of Single Nucleotide Polymorphisms is Associated with the Interindividual Variability of Cholesterol Bioavailability in Healthy Adult Males
Desmarchelier, C., Wolff, E., Defoort, C., Nowicki, M., Morange, P., Alessi, M., Valéro, R., Nicolay, A., Lairon, D., & Borel, P. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000480 · Cited by 9 · see citing works
NREM-sleep Associated Epileptiform Discharges Disappeared Following a Shift toward the Paleolithic Ketogenic Diet in a Child with Extensive Cortical Malformation
Clemens, Z., Kelemen, A., & Tóth, C. (2015) · American Journal of Medical Case Reports · doi:10.12691/ajmcr-3-7-8 · Cited by 9 · see citing works
Modified dietary fat intake for treatment of gallstone disease
Madden, A. M., Trivedi, D. P., Smeeton, N., & Culkin, A. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012608 · Cited by 9 · see citing works
Phytosterols
Bot, A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-08-100596-5.21626-0 · Cited by 9 · see citing works
The Lipid–Heart Hypothesis and the Keys Equation Defined the Dietary Guidelines but Ignored the Impact of Trans-Fat and High Linoleic Acid Consumption
Newport, M. T., & Dayrit, F. M. (2024) · Nutrients · doi:10.3390/nu16101447 · Cited by 8 · see citing works
Egg phospholipids exert an inhibitory effect on intestinal cholesterol absorption in mice
Lee, Y., Han, C. Y., Bae, M., Park, Y., & Lee, J. (2019) · Nutrition Research and Practice · doi:10.4162/nrp.2019.13.4.295 · Cited by 8 · see citing works
Boots for Achilles: Progesterone's Reduction of Cholesterol Is a Second-Order Adaptation
Amir, D., & Fessler, D. M. T. (2013) · The Quarterly Review of Biology · doi:10.1086/670528 · Cited by 8 · see citing works
Identification of liverCYP51as a gene responsive to circulating cholesterol in a hamster model
Huang, H., Xie, Z., Yokoyama, W., Yu, L. L., & Wang, T. T. Y. (2016) · Journal of Nutritional Science · doi:10.1017/jns.2016.3 · Cited by 8 · see citing works
Effects of Dietary Fatty Acids on Human Health: Focus on Palm oil from Elaeis guineensis Jacq. and Useful Recommendations
Ntsomboh-Ntsefong, G., Constant, L.-L.-N. B., Martin, B. J., Kingsley, T.-M., Albert, D.-M. J., Césaire, K. S. T., Sastile, M. N., Hermine, N.-B., & Youmbi, E. (2016) · Food and public health · Cited by 8 · see citing works
Guideline-conform statin use reduces overall mortality in patients with compensated liver disease
Unger, L. W., Forstner, B., Schneglberger, S., Muckenhuber, M., Eigenbauer, E., Bauer, D. J. M., Scheiner, B., Mandorfer, M., Trauner, M. A., & Reiberger, T. (2019) · Scientific Reports · doi:10.1038/s41598-019-47943-6 · Cited by 8 · see citing works
Composition of Fatty Acids, Tocopherols, Sterols, Total Phenolics, and Antioxidant Activity of Seed Oils of Afzelia xylocarpa and Cassia fistula
Phương, D. L., Thuy, N. T., Long, P. Q., Kuo, P., & Thang, T. D. (2019) · Chemistry of Natural Compounds · doi:10.1007/s10600-019-02659-x · Cited by 7 · see citing works
Controversies and discrepancies in the effect of dietary fat and cholesterol on cardiovascular risk
Leong, W., Ngiam, J. N., Tan, R., Lim, S. L., & Poh, K. K. (2020) · Singapore Medical Journal · doi:10.11622/smedj.2020065 · Cited by 7 · see citing works
Catalytic Generation of Radicals in Supramolecular Systems with Acetylcholine
Potapova, N. V., Kasaikina, O. T., Berezin, M. P., & Plashchina, I. G. (2020) · Kinetics and Catalysis · doi:10.1134/s0023158420050079 · Cited by 7 · see citing works
Relationships between Maternal Dietary Patterns and Blood Lipid Levels during Pregnancy: A Prospective Cohort Study in Shanghai, China
Wang, N., Deng, Z., Wen, L. M., Ding, Y. H., & He, G. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18073701 · Cited by 7 · see citing works
Potential of Medicinal Plants as Hypocholesterolemic Agents in Chicken Meat Production
(2022) · Science Letters · doi:10.47262/sl/10.1.132021028 · Cited by 7 · see citing works
Nutrient and heavy metals composition of dried fish varieties from Bangladesh
Sun, H., Johnson, D. S., & Aluko, R. E. (2024) · LWT · doi:10.1016/j.lwt.2024.117233 · Cited by 6 · see citing works
Formulasi dan Karakteristik Bubur Kacang Merah (Phaseolus vulgaris L.) Instan dengan Pemanis Sukrosa, Isomalto-oligosakarida dan Fibercreme
Putri, R. G., Triwitono, P., & Marsono, Y. (2020) · Jurnal Agritech · doi:10.22146/agritech.46262 · Cited by 6 · see citing works
Biochemical and Haematological Effects and Histopathological Changes caused by Moringa oleifera on Albino Rats
Gasmalbari, E., EL-Kamali, H. H., & Abbadi, O. S. (2020) · Chinese Journal of Medical Research · doi:10.37515/cjmr.091x.3306 · Cited by 6 · see citing works
CHOLESTEROL AND ITS IMPLICATIONS- A REVIEW
Alexander, I., Ugwudike Patrick, O., Ayomide, T. A., & Blessing, N. O. (2021) · Universal Journal of Pharmaceutical Research · doi:10.22270/ujpr.v5i6.513 · Cited by 6 · see citing works
The influence of cholesterol on the generation of radicals in mixed reverse micelles of cationic surfactants with hydroperoxides
Kasaikina, O. T., Potapova, N. V., Круговов, Д. А., & Plashchina, I. G. (2018) · Russian Chemical Bulletin · doi:10.1007/s11172-018-2342-x · Cited by 5 · see citing works

Authors: Lecerf, J.-M., & de Lorgeril, M.
Affiliations: Institut Pasteur de Lille (FR)
Corresponding author: Lecerf, Jean-Michel
ORCID: Lecerf, Jean-Michel
Venue: British Journal of Nutrition
Publisher: Cambridge University Press (CUP)
Published: 2011-03-09
Volume: 106
Issue: 1
Pages: 6-14
ISSN: 0007-1145 (ISSN-L)
1475-2662
DOI: 10.1017/s0007114511000237
OpenAlex: W2079096694
Cited by: 182
References: 79
Citations by year: 2026: 6 · 2025: 7 · 2024: 14 · 2023: 16 · 2022: 10 · 2021: 18 · 2020: 20 · 2019: 12 · 2018: 19 · 2017: 11 · 2016: 11 · 2015: 13 · 2014: 8 · 2013: 13 · 2012: 2
FWCI: 1.45
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified)
Locations: British Journal Of Nutrition (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: dietary cholesterol, cardiovascular risk, serum cholesterol, cholesterol absorption, enterohepatic circulation, bile acids, phytosterols, cholesterol biosynthesis, LDL receptor-related protein, hyper-responders
MeSH terms: Cardiovascular Diseases, Cholesterol, Cholesterol, Dietary, Humans, Intestinal Absorption, Phytosterols, Risk Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dietary cholesterol: from physiology to cardiovascular risk

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks