Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype
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Background: Increasing evidence indicates that childhood trauma is a risk factor for schizophrenia and patients with this syndrome have a pro-inflammatory phenotype. We tested the hypothesis that the pro-inflammatory phenotype in schizophrenia is associated with childhood trauma and that patients without a history of such trauma have a similar immune profile to healthy controls. Method: We recruited 40 schizophrenia patients and 40 controls, all of whom completed the Childhood Trauma Questionnaire (CTQ). Using enzyme-linked immunosorbent assay (ELISA) techniques, we measured peripheral levels of interleukin (IL)-1β, IL-6, IL-8 and tumour necrosis factor (TNF)-α. These immune parameters were compared in schizophrenia with childhood trauma, schizophrenia without childhood trauma and healthy controls. Results: Patients with childhood trauma had higher levels of IL-6 and TNF-α than patients without trauma and healthy controls, and TNF-α levels correlated with the extent of the trauma. Patients with no trauma had similar immune profiles to controls. Conclusions: Childhood trauma drives changes, possibly epigenetic, that generate a pro-inflammatory phenotype.
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Patients with schizophrenia and a history of childhood trauma have a pro-inflammatory phenotype.
“patients with schizophrenia and a history of childhood trauma have a pro-inflammatory phenotype (196).”
From Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma (2019) · cites this paper as [196]
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- Authors
- Dennison, U., McKernan, D., Cryan, J., & Dinan, T.
- Affiliations
- University College Cork (IE)
- Corresponding author
- Dennison, U.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2012-02-23
- Volume
- 42
- Issue
- 9
- Pages
- 1865-1871
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2170016495
- Cited by
- 114
- References
- 49
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 2 · 2023: 11 · 2022: 7 · 2021: 10 · 2020: 9 · 2019: 8 · 2018: 9 · 2017: 6 · 2016: 7 · 2015: 15 · 2014: 10 · 2013: 5 · 2012: 2
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion)
- Funders
- GlaxoSmithKline
- Science Foundation Ireland (07/CE/B1368)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- schizophrenia, childhood trauma, pro-inflammatory phenotype, inflammatory cytokines, interleukin-6, TNF-α, IL-1β, interleukin-8, immunological profile, epigenetic modifications, injury severity
- MeSH terms
- Adult, Child, Child Abuse, Enzyme-Linked Immunosorbent Assay, Female, Humans, Inflammation, Male, Middle Aged, Phenotype, Psychotic Disorders, Schizophrenia, Schizophrenic Psychology, Stress, Psychological, Tumor Necrosis Factor-alpha, Interleukin-6, Case-Control Studies, Interleukin-8, Inflammation Mediators, Interleukin-1beta, Parental Death
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