Combined role of childhood maltreatment, family history, and gender in the risk for alcohol dependence
Open accessAbstract
Background: Studies of the relationship between childhood maltreatment and alcohol dependence have not controlled comprehensively for potential confounding by co-occurring maltreatments and other childhood trauma, or determined whether parental history of alcohol disorders operates synergistically with gender and maltreatment to produce alcohol dependence. We addressed these issues using national data. Method: Face-to-face surveys of 27 712 adult participants in a national survey. Results: Childhood physical, emotional and sexual abuse, and physical neglect were associated with alcohol dependence (p<0.001), controlling for demographics, co-occurring maltreatments and other childhood trauma. Attributable proportions (APs) due to interaction between each maltreatment and parental history revealed significant synergistic relationships for physical abuse in the entire sample, and for sexual abuse and emotional neglect in women (APs, 0.21, 0.31, 0.26 respectively), indicating that the odds of alcohol dependence given both parental history and these maltreatments were significantly higher than the additive effect of each alone (p<0.05). Conclusions: Childhood maltreatments independently increased the risk of alcohol dependence. Importantly, results suggest a synergistic role of parental alcoholism: the effect of physical abuse on alcohol dependence may depend on parental history, while the effects of sexual abuse and emotional neglect may depend on parental history among women. Findings underscore the importance of early identification and prevention, particularly among those with a family history, and could guide genetic research and intervention development, e.g. programs to reduce the burden of childhood maltreatment may benefit from addressing the negative long-term effects of maltreatments, including potential alcohol problems, across a broad range of childhood environments.
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History of ELS/CT is associated with risk behavior patterns, such as substance abuse and suicide attempts in later life.
“Similarly, history of ELS/CT has been associated with risk behavior patterns, such as substance abuse and suicide attempts in later life (30–35).”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [33]
The Results section reports that childhood maltreatment was associated with adult alcohol dependence, supporting the substance-use part of the claim, though the study addresses alcohol dependence specifically rather than substance abuse generally. The Methods section mentions a caregiver’s suicide attempt as a childhood experience, not the respondent’s suicide attempt later in life; the paper does not support that outcome. (LLM, conf=0.88)
Experimental — accuracy not yet measuredChildhood trauma is associated with higher rates of risky alcohol use, earlier drinking onset, and alcohol use disorder diagnosis.
“as well as increased rates of risky alcohol use, younger drinking onset, and alcohol use disorder (AUD) diagnosis (3–7).”
From Impact of Childhood Trauma on Executive Function in Adolescence—Mediating Functional Brain Networks and Prediction of High-Risk Drinking (2020) · cites this paper as [4]
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Impact of Exposure to Childhood Maltreatment on Transitions to Alcohol Dependence in Women and Men
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- Authors
- Fenton, M. C., Geier, T., Keyes, K., Skodol, A. E., Grant, B. F., & Hasin, D. S.
- Affiliations
- Columbia University (US)
- University of Wisconsin System (US)
- New York State Psychiatric Institute (US)
- University of Arizona (US)
- National Institute on Alcohol Abuse and Alcoholism (US)
- Corresponding author
- Hasin, D. S.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2012-08-10
- Volume
- 43
- Issue
- 5
- Pages
- 1045-1057
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- PMC
- PMC3767412
- OpenAlex
- W2155682005
- Semantic Scholar
- 3b4b20e786cf2611988abffef6264cf1f7025df1
- Cited by
- 112
- References
- 67
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 13 · 2022: 7 · 2021: 5 · 2020: 12 · 2019: 14 · 2018: 6 · 2017: 9 · 2016: 12 · 2015: 7 · 2014: 8 · 2013: 7
- FWCI
- 8.00
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1f31da026689-01)
- National Institute on Alcohol Abuse and Alcoholism (U01AA018111, K05AA014223)
- National Institute on Drug Abuse (F31-DA026689, R01DA018652)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Health › Intimate Partner and Family Violence
- Keywords
- child abuse, alcoholism, parental alcoholism, family history (medicine), gender differences, physical abuse, sexual abuse, emotional neglect, physical neglect, childhood trauma, attributable proportion, synergistic interaction, alcohol use disorder risk
- MeSH terms
- Adolescent, Adult, Alcoholism, Child, Child Abuse, Data Collection, Female, Humans, Interview, Psychological, Life Change Events, Male, Middle Aged, Risk Factors, Sex Factors, United States, Effect Modifier, Epidemiologic, Prevalence, Child of Impaired Parents, Genetic Predisposition to Disease, Young Adult
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