Neurobehavioral markers of resilience to depression amongst adolescents exposed to child abuse

Dennison, Meg J.; Sheridan, Margaret A.; Busso, Daniel S.; Jenness, Jessica L.; Peverill, Matthew; Rosen, Maya L.; McLaughlin, Katie A.

doi:10.1037/abn0000215

Cited by 117Child Abuse and TraumaChild and Adolescent Psychosocial and Emotional DevelopmentNeural and Behavioral Psychology Studies

Neurobehavioral markers of resilience to depression amongst adolescents exposed to child abuse

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Dennison, Meg J., Sheridan, Margaret A., Busso, Daniel S., Jenness, Jessica L., Peverill, Matthew, Rosen, Maya L., McLaughlin, Katie A.·2016·Journal of Abnormal Psychology

DOI 10.1037/abn0000215PMC PMC5119749

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Abstract

Childhood maltreatment is strongly associated with depression, which is characterized by reduced reactivity to reward. Identifying factors that mitigate risk for depression in maltreated children is important for understanding etiological links between maltreatment and depression as well as improving early intervention and prevention. We examine whether high reward reactivity at behavioral and neurobiological levels is a marker of resilience to depressive symptomology in adolescence following childhood maltreatment. A sample of 59 adolescents (21 with a history of maltreatment; Mean Age = 16.95 years, SD = 1.44) completed an fMRI task involving passive viewing of emotional stimuli. BOLD signal changes to positive relative to neutral images were extracted in basal ganglia regions of interest. Participants also completed a behavioral reward-processing task outside the scanner. Depression symptoms were assessed at the time of the MRI and again 2 years later. Greater reward reactivity across behavioral and neurobiological measures moderated the association of maltreatment with baseline depression. Specifically, faster reaction time (RT) to cues paired with monetary reward relative to those unpaired with reward and greater BOLD signal in the left pallidum was associated with lower depression symptoms in maltreated youth. Longitudinally, greater BOLD signal in the left putamen moderated change in depression scores over time, such that higher levels of reward response were associated with lower increases in depression over time among maltreated youths. Reactivity to monetary reward and positive social images, at both behavioral and neurobiological levels, is a potential marker of resilience to depression among adolescents exposed to maltreatment. These findings add to a growing body of work highlighting individual differences in reactivity to reward as a core neurodevelopmental mechanism in the etiology of depression. (PsycINFO Database Record

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In both groups, lower ventral striatum activation was tied to more depressive symptoms.
“Despite this difference, in both groups decreased activation of the ventral striatum correlated with increased depressive symptoms.”
From The effects of early life stress on reward processing (2018) · cites this paper as Dennison et al., 2016
Findings on positive emotional stimuli diverge: institutionalized children show lower ventral striatal response to positive faces, whereas abused adolescents show greater reactivity to positive social cues.
“While institutionally reared children had decreased ventral striatal response to positive emotional faces (Goff et al., 2013), adolescents with a history of physical and sexual abuse demonstrated increased reactivity to positively valenced social stimuli (Dennison et al., 2016), suggesting a potential difference in the effects of neglect vs abuse.”
From The effects of early life stress on reward processing (2018) · cites this paper as Dennison et al., 2016

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Childhood Adversity and Neural Development: A Systematic Review
McLaughlin, K. A., Weissman, D., & Bitrán, D. (2019) · Annual Review of Developmental Psychology · doi:10.1146/annurev-devpsych-121318-084950 · Cited by 892 · see citing works
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Child trauma exposure and psychopathology: Mechanisms of risk and resilience
McLaughlin, K. A., & Lambert, H. K. (2017) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2016.10.004 · Cited by 441 · see citing works
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Annual Research Review: Childhood maltreatment, latent vulnerability and the shift to preventative psychiatry – the contribution of functional brain imaging
McCrory, E. J., Gerin, M. I., & Viding, E. (2017) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12713 · Cited by 402 · see citing works
A Systematic Review of Amenable Resilience Factors That Moderate and/or Mediate the Relationship Between Childhood Adversity and Mental Health in Young People
Fritz, J., de Graaff, A. M., Caisley, H., van Harmelen, A., & Wilkinson, P. O. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00230 · Cited by 355 · see citing works
Rethinking Concepts and Categories for Understanding the Neurodevelopmental Effects of Childhood Adversity
Smith, K. E., & Pollak, S. D. (2020) · Perspectives on Psychological Science · doi:10.1177/1745691620920725 · Cited by 351 · see citing works
The effects of early life stress on reward processing
Novick, A. M., Levandowski, M. L., Laumann, L. E., Philip, N. S., Price, L. H., & Tyrka, A. R. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.02.002 · Cited by 192 · see citing works
Mechanisms linking childhood adversity with psychopathology: Learning as an intervention target
McLaughlin, K. A., DeCross, S. N., Jovanović, T., & Tottenham, N. (2019) · Behaviour Research and Therapy · doi:10.1016/j.brat.2019.04.008 · Cited by 198 · see citing works
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Differential Associations of Distinct Forms of Childhood Adversity With Neurobehavioral Measures of Reward Processing: A Developmental Pathway to Depression
Dennison, M., Rosen, M. L., Sambrook, K., Jenness, J. L., Sheridan, M. A., & McLaughlin, K. A. (2017) · Child Development · doi:10.1111/cdev.13011 · Cited by 149 · see citing works
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Impact of Early Life Stress on Reward Circuit Function and Regulation
Hanson, J. L., Williams, A. V., Bangasser, D. A., & Peña, C. J. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.744690 · Cited by 123 · see citing works
An ecological approach to understanding the developing brain: Examples linking poverty, parenting, neighborhoods, and the brain.
Hyde, L. W., Gard, A. M., Tomlinson, R. C., Burt, S. A., Mitchell, C. M., & Monk, C. S. (2020) · American Psychologist · doi:10.1037/amp0000741 · Cited by 111 · see citing works
Brain mechanisms mediating effects of stress on reward sensitivity
Ironside, M., Kumar, P., Kang, M. S., & Pizzagalli, D. A. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.01.016 · Cited by 110 · see citing works
Anxiety, depression, impulsivity, and brain structure in children and adolescents
Merz, E. C., He, X., & Noble, K. G. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.07.020 · Cited by 108 · see citing works
Resilience Following Child Maltreatment: Definitional Considerations and Developmental Variations
Yoon, S., Howell, K. H., Dillard, R., McCarthy, K. S., Napier, T. R., & Pei, F. (2019) · Trauma Violence & Abuse · doi:10.1177/1524838019869094 · Cited by 105 · see citing works
Neuroimaging predictors of onset and course of depression in childhood and adolescence: A systematic review of longitudinal studies
Toenders, Y. J., van Velzen, L. S., Heideman, I. Z., Harrison, B. J., Davey, C. G., & Schmaal, L. (2019) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2019.100700 · Cited by 92 · see citing works
Stress, sensitive periods, and substance abuse
Andersen, S. L. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.100140 · Cited by 92 · see citing works
Resilience and young people’s brain structure, function and connectivity: A systematic review
Eaton, S., Cornwell, H., Hamilton-Giachritsis, C. E., & Fairchild, G. F. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.11.001 · Cited by 88 · see citing works
A systematic review of the association between biological markers and environmental stress risk factors for adolescent depression
Zajkowska, Z., Walsh, A. E. L., Zonca, V., Gullett, N., Pedersen, G. A., Kieling, C., Swartz, J. R., Karmacharya, R., Fisher, H. L., Kohrt, B. A., et al. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.04.003 · Cited by 82 · see citing works
The neurobiological effects of childhood maltreatment on brain structure, function, and attachment
Tomoda, A., Nishitani, S., Takiguchi, S., Fujisawa, T. X., Sugiyama, T., & Teicher, M. H. (2024) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-024-01779-y · Cited by 96 · see citing works
High Emotion Differentiation Buffers Against Internalizing Symptoms Following Exposure to Stressful Life Events in Adolescence: An Intensive Longitudinal Study
Nook, E. C., Flournoy, J. C., Rodman, A. M., Mair, P., & McLaughlin, K. A. (2021) · Clinical Psychological Science · doi:10.1177/2167702620979786 · Cited by 73 · see citing works
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A neurocomputational investigation of reinforcement-based decision making as a candidate latent vulnerability mechanism in maltreated children
Gerin, M. I., Puetz, V. B., Blair, J., White, S. F., Sethi, A., Hoffmann, F., Palmer, A. L., Viding, E. M., & McCrory, E. J. P. (2017) · Development and Psychopathology · doi:10.1017/s095457941700133x · Cited by 65 · see citing works
Developmental trajectories to reduced activation of positive valence systems: A review of biological and environmental contributions
Kujawa, A., Klein, D. N., Pegg, S. L., & Weinberg, A. (2020) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2020.100791 · Cited by 61 · see citing works
Life stress, insomnia, and anxiety/depressive symptoms in adolescents: A three-wave longitudinal study
Yang, Y., Liu, X., Liu, Z., Tein, J., & Jia, C.-X. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.11.002 · Cited by 65 · see citing works
Stressful life events moderate the effect of neural reward responsiveness in childhood on depressive symptoms in adolescence
Goldstein, B. L., Kessel, E. M., Kujawa, A., Finsaas, M. C., Davila, J., Hajcak, G., & Klein, D. N. (2019) · Psychological Medicine · doi:10.1017/s0033291719001557 · Cited by 61 · see citing works
A Systematic Review of the Biological Correlates and Consequences of Childhood Maltreatment and Adverse Childhood Experiences
Cooke, E. M., Connolly, E. J., Boisvert, D. L., & Hayes, B. E. (2021) · Trauma Violence & Abuse · doi:10.1177/15248380211021613 · Cited by 57 · see citing works
Neurobiological Markers of Resilience to Early-Life Adversity During Adolescence
Leal, A. S. M., & Silvers, J. A. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.08.004 · Cited by 54 · see citing works
A systematic review of childhood maltreatment and resting state functional connectivity
Gerin, M. I., Viding, E. M., Herringa, R. J., Russell, J. D., & McCrory, E. J. P. (2023) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2023.101322 · Cited by 58 · see citing works
Childhood adversity and impaired reward processing: A meta-analysis
Oltean, L.-E., Șoflău, R., Miu, A. C., & Szentágotai-Tătar, A. (2022) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2022.105596 · Cited by 50 · see citing works
Neurobehavioural mechanisms of threat generalization moderate the link between childhood maltreatment and psychopathology in emerging adulthood
Lange, I., Goossens, L., Bakker, J. M., Michielse, S., van Winkel, R., Lissek, S. M., Leibold, N. K., Marcelis, M. C., Wichers, M., van Os, J., et al. (2019) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.180053 · Cited by 50 · see citing works
Neurocognitive Adaptation and Mental Health Vulnerability Following Maltreatment: The Role of Social Functioning
McCrory, E. J. P., Ogle, J. R., Gerin, M. I., & Viding, E. M. (2019) · Child Maltreatment · doi:10.1177/1077559519830524 · Cited by 42 · see citing works
Neural and Endocrine Correlates of Early Life Abuse in Youth With Depression and Obesity
Sun, K., Watson, K. T., Angal, S., Bakkila, B. F., Gorelik, A. J., Leslie, S. M., Rasgon, N., & Singh, M. K. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00721 · Cited by 39 · see citing works
A review of childhood maltreatment, latent vulnerability and the brain: implications for clinical practice and prevention
Gerin, M. I., Hanson, E., Viding, E. M., & McCrory, E. J. P. (2019) · Adoption & Fostering · doi:10.1177/0308575919865356 · Cited by 35 · see citing works
Social experience calibrates neural sensitivity to social feedback during adolescence: A functional connectivity approach
Rudolph, K., Davis, M. M., Skymba, H. V., Modi, H. H., & Telzer, E. (2020) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2020.100903 · Cited by 35 · see citing works
Neurobiological correlates of resilience during childhood and adolescence – A systematic review
Zhang, L., Rakesh, D., Cropley, V., & Whittle, S. (2023) · Clinical Psychology Review · doi:10.1016/j.cpr.2023.102333 · Cited by 33 · see citing works
Reward Processing Modulates the Association Between Trauma Exposure and Externalizing Psychopathology
Kasparek, S. W., Jenness, J. L., & McLaughlin, K. A. (2020) · Clinical Psychological Science · doi:10.1177/2167702620933570 · Cited by 33 · see citing works
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Machine Learning Analysis of the Relationships Between Gray Matter Volume and Childhood Trauma in a Transdiagnostic Community-Based Sample
Clausen, A. N., Aupperle, R. L., Yeh, H., Waller, D. A., Payne, J., Kuplicki, R., Akeman, E., Paulus, M. P., Bodurka, J., Simmons, K., et al. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.03.001 · Cited by 30 · see citing works
How adverse childhood experiences get under the skin: A systematic review, integration and methodological discussion on threat and reward learning mechanisms
(2024) · doi:10.7554/elife.92700 · Cited by 29 · see citing works
Childhood trauma exposure and reward processing in healthy adults: A functional neuroimaging study
Hendrikse, C. J., du Plessis, S., Luckhoff, H. K., Vink, M., van den Heuvel, L. L., Scheffler, F., Phahladira, L., Smit, R., Asmal, L., Seedat, S., et al. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25051 · Cited by 29 · see citing works
Parenting × Brain Development interactions as predictors of adolescent depressive symptoms and well-being: Differential susceptibility or diathesis-stress?
Deane, C., Vijayakumar, N., Allen, N. B., Schwartz, O., Simmons, J. G., Bousman, C., Pantelis, C., & Whittle, S. (2019) · Development and Psychopathology · doi:10.1017/s0954579418001475 · Cited by 28 · see citing works
The emotion‐elicited late positive potential is stable across five testing sessions
Weinberg, A., Correa, K. A., Stevens, E. S., & Shankman, S. A. (2021) · Psychophysiology · doi:10.1111/psyp.13904 · Cited by 30 · see citing works
Childhood violence exposure and social deprivation predict adolescent amygdala-orbitofrontal cortex white matter connectivity
Goetschius, L. G., Hein, T. C., Mitchell, C. M., Lopez‐Duran, N. L., McLoyd, V. C., Jeanne Brooks-gunn, B., McLanahan, S., Hyde, L. W., & Monk, C. S. (2020) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2020.100849 · Cited by 28 · see citing works
Conceptualizing psychological resilience through resting-state functional MRI in a mentally healthy population: a systematic review
Tai, A. P.-L., Leung, M.-K., Geng, X., & Lau, W. K. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1175064 · Cited by 30 · see citing works
Does reward processing moderate or mediate the link between childhood adversity and psychopathology: A longitudinal study
Kasparek, S. W., Gastón-Panthaki, A., Hanford, L. C., Lengua, L. J., Sheridan, M. A., & McLaughlin, K. A. (2023) · Development and Psychopathology · doi:10.1017/s0954579423000962 · Cited by 29 · see citing works
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Mediators Linking Childhood Adversities and Trauma to Suicidality in Individuals at Risk for Psychosis
Schmidt, S. J., Schultze‐Lutter, F., Bendall, S., Groth, N., Michel, C., Inderbitzin, N., SCHIMMELMANN, B. G., Hubl, D., & Nelson, B. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00242 · Cited by 27 · see citing works
Influence of childhood adversity, approach motivation traits, and depression on individual differences in brain activation during reward anticipation
DelDonno, S. R., Mickey, B. J., Pruitt, P. J., Stange, J. P., Hsu, D. T., Weldon, A. L., Zubieta, J.-K., & Langenecker, S. A. (2019) · Biological Psychology · doi:10.1016/j.biopsycho.2019.05.009 · Cited by 26 · see citing works
Trauma-associated anterior cingulate connectivity during reward learning predicts affective and anxiety states in young adults
Eckstrand, K., Hanford, L. C., Bertocci, M. A., Chase, H. W., Greenberg, T., Lockovich, J., Stiffler, R., Aslam, H. A., Graur, S., Bebko, G. M., et al. (2018) · Psychological Medicine · doi:10.1017/s0033291718002520 · Cited by 25 · see citing works
Contributions of childhood abuse and neglect to reward neural substrates in adolescence
Yang, R., Yu, Q.-R., Owen, C., Aspe, G. I., & Wiggins, J. (2021) · NeuroImage: Clinical · doi:10.1016/j.nicl.2021.102832 · Cited by 24 · see citing works
A Social Affective Neuroscience Model of Risk and Resilience in Adolescent Depression: Preliminary Evidence and Application to Sexual and Gender Minority Adolescents
Forbes, E. E., Eckstrand, K., Rofey, D. L., & Silk, J. S. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.07.020 · Cited by 22 · see citing works
Functional neuroimaging of resilience to trauma: convergent evidence and challenges for future research
Norbury, A., Seeley, S. H., Pérez-Rodríguez, M. M., & Feder, A. (2023) · Psychological Medicine · doi:10.1017/s0033291723001162 · Cited by 22 · see citing works
Investigation of reward learning and feedback sensitivity in non-clinical participants with a history of early life stress
Wilkinson, M. P., Slaney, C., Mellor, J. R., & Robinson, E. S. J. (2021) · PLoS ONE · doi:10.1371/journal.pone.0260444 · Cited by 22 · see citing works
Anhedonia mediates the relationships between childhood trauma and symptom severity of PTSD and depression, but not of social anxiety
Haim‐Nachum, S., Amsalem, D., Lazarov, A., Zabag, R., Neria, Y., & Sopp, M. R. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.10.107 · Cited by 20 · see citing works
Altered reward and effort processing in children with maltreatment experience: a potential indicator of mental health vulnerability
Armbruster‐Genc, D., Valton, V., Neil, L., Vuong, V., Freeman, Z., Packer, K. C., Kiffin, M. J., Roiser, J. P., Viding, E. M., & McCrory, E. J. P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01284-7 · Cited by 19 · see citing works
Associations between parental conflict and social and monetary reward responsiveness in adolescents with clinical depression
Hill, K. E., Dickey, L., Pegg, S. L., Dao, A., Arfer, K. B., & Kujawa, A. (2022) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-022-00949-7 · Cited by 19 · see citing works
Maltreatment and Emotional Development
Harms, M. B., Leitzke, B. T., & Pollak, S. D. (2019) · Springer eBooks · doi:10.1007/978-3-030-17332-6_28 · Cited by 18 · see citing works
Associations between childhood adversity, cognitive schemas and attenuated psychotic symptoms
LoPilato, A. M., Zhang, Y., Pike, M. R., Addington, J., Bearden, C., Cadenhead, K., Cannon, T. D., Cornblatt, B., Mathalon, D., McGlashan, T., et al. (2020) · Early Intervention in Psychiatry · doi:10.1111/eip.13017 · Cited by 14 · see citing works
Pubertal timing and functional neurodevelopmental alterations independently mediate the effect of family conflict on adolescent psychopathology
Petrican, R., Miles, S., Rudd, L., Wasiewska, W., Graham, K. S., & Lawrence, A. D. (2021) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2021.101032 · Cited by 16 · see citing works
Identifying resting state differences salient for resilience to chronic pain based on machine learning multivariate pattern analysis.
You, B., Wen, H., & Jackson, T. (2021) · Psychophysiology · doi:10.1111/psyp.13921 · Cited by 15 · see citing works
WITHDRAWN:Childhood violence exposure and social deprivation predict adolescent amygdala-orbitofrontal cortex white matter connectivity
Goetschius, L. G., Hein, T. C., Mitchell, C. M., Lopez‐Duran, N. L., McLoyd, V. C., Jeanne, McLanahan, S., Hyde, L. W., & Monk, C. S. (2020) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2020.100822 · Cited by 15 · see citing works
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Cortical and subcortical morphological alterations in postpartum depression
Yang, W., Jiang, Y., Ma, L., Xiao, M., Liu, M., Ren, Z., Zhang, Y., & Hu, L. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114414 · Cited by 15 · see citing works
Autobiographical memory as a latent vulnerability mechanism following childhood maltreatment: Association with future depression symptoms and prosocial behavior
Puetz, V. B., Viding, E. M., Hoffmann, F., Gerin, M. I., Sharp, M. L., Rankin, G., Maguire, E. A., Mechelli, A., & McCrory, E. J. P. (2020) · Development and Psychopathology · doi:10.1017/s0954579420000504 · Cited by 17 · see citing works
Medial Prefrontal Cortex Activity to Reward Outcome Moderates the Association Between Victimization Due to Sexual Orientation and Depression in Youth
Eckstrand, K., Silk, J. S., Nance, M., Wallace, M. L., Buckley, N., Lindenmuth, M., Flores, L. E., Alarcón, G., Quevedo, K. M., Phillips, M. L., et al. (2022) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2022.08.009 · Cited by 14 · see citing works
How childhood adversity affects components of decision making
Smith, K. E., Xu, Y.-Y., & Pollak, S. D. (2025) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106027 · Cited by 10 · see citing works
Early life interpersonal stress and depression: Social reward processing as a potential mediator.
Palacios-Barrios, E. E., Patel, K., & Hanson, J. (2023) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110887 · Cited by 13 · see citing works
Emerging ecophenotype: reward anticipation is linked to high-risk behaviours after sexual abuse
Pechtel, P., Harris, J. R., Karl, A., Clunies-Ross, C., Bower, S., Moberly, N. J., Pizzagalli, D. A., & Watkins, E. R. (2022) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsac030 · Cited by 13 · see citing works
How Early Life Adversity Transforms the Learning Brain
Hauser, M. D. (2020) · Mind Brain and Education · doi:10.1111/mbe.12277 · Cited by 10 · see citing works
How biopsychosocial depressive risk shapes behavioral and neural responses to social evaluation in adolescence
Stretton, J., Walsh, N., Mobbs, D., Schweizer, S., van Harmelen, A., Lombardo, M. V., Goodyer, I. M., & Dalgleish, T. (2021) · Brain and Behavior · doi:10.1002/brb3.2005 · Cited by 9 · see citing works
Functional brain plasticity following childhood maltreatment: A longitudinal fMRI investigation of autobiographical memory processing
Puetz, V. B., Viding, E. M., Maguire, E. A., Mechelli, A., Armbruster‐Genc, D., Sharp, M. L., Rankin, G., Gerin, M. I., & McCrory, E. J. P. (2021) · Development and Psychopathology · doi:10.1017/s0954579421001292 · Cited by 9 · see citing works
Abnormal amygdala volume moderates parenting and anxiety symptoms in children and adolescents with anxiety disorder
Liu, J., Wang, L., Zhang, L., Ding, Y., Zhang, X., Hu, Z., & Zhao, X. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.05.012 · Cited by 9 · see citing works
Functional brain network organization and multidomain resilience to neighborhood disadvantage in youth.
Bezek, J. L., Tillem, S., Suarez, G. L., Burt, S. A., Vazquez, A. Y., Michael, C., Sripada, C., Kump, K. L., & Hyde, L. W. (2024) · American Psychologist · doi:10.1037/amp0001279 · Cited by 8 · see citing works
Exposure to community violence as a mechanism linking neighborhood socioeconomic disadvantage and neural responses to reward
Westerman, H. B., Suarez, G. L., Richmond‐Rakerd, L. S., Nusslock, R., Klump, K. L., Burt, S. A., & Hyde, L. W. (2024) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsae029 · Cited by 8 · see citing works
Emotionaler Missbrauch in Kindheit und Jugend – Biologische Einbettung und klinische Implikationen
Hoffmann, F., & Heim, C. C. (2024) · Praxis der Kinderpsychologie und Kinderpsychiatrie · doi:10.13109/prkk.2024.73.1.4 · Cited by 9 · see citing works
Heightened response to positive facial cues as a potential marker of resilience following childhood adversity
Gerin, M. I., Viding, E. M., Neil, L., Armbruster‐Genc, D., Freeman, Z., Sharp, M. L., Phillips, H., & McCrory, E. J. P. (2024) · European Journal of Psychotraumatology · doi:10.1080/20008066.2024.2309783 · Cited by 9 · see citing works
A prospective longitudinal study of multidomain resilience among youths with and without maltreatment histories
Wang, S. S., Walsh, K., & Li, J. J. (2023) · Development and Psychopathology · doi:10.1017/s0954579423000032 · Cited by 7 · see citing works
Life stress and suicidality mediated by insomnia and depressive symptoms in adolescents: a three-wave longitudinal study
Liu, X., Yang, Y., Liu, Z., & Jia, C.-X. (2023) · SLEEP · doi:10.1093/sleep/zsad121 · Cited by 7 · see citing works
Reward anticipation buffers neuroendocrine and cardiovascular responses to acute psychosocial stress in healthy young adults
Hu, W., & Yang, J. (2021) · Stress · doi:10.1080/10253890.2021.1923690 · Cited by 7 · see citing works
How adverse childhood experiences get under the skin: A systematic review, integration and methodological discussion on threat and reward learning mechanisms
Ruge, J., Ehlers, M. R., Kastrinogiannis, A., Klingelhöfer-Jens, M., Koppold, A., Abend, R., & Lonsdorf, T. B. (2023) · doi:10.31234/osf.io/nfpbj · Cited by 7 · see citing works
Childhood maltreatment is associated with lower exploration and disrupted prefrontal activity and connectivity during reward learning in volatile environments
Armbruster‐Genc, D., Neil, L., Valton, V., Phillips, H., Rankin, G., Sharp, M. L., Rapley, J. M., Viding, E. M., Roiser, J. P., & McCrory, E. J. P. (2024) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.14095 · Cited by 8 · see citing works
Adolescent Depressive Symptom Trajectories From Before to After the COVID-19 Pandemic
Gataviņš, M. M., Tran, K. T., Visoki, E., Moore, T. M., Hoffman, K. W., Shilton, T., Schultz, L. M., Almasy, L. A., Mancini, A. D., & Barzilay, R. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.45987 · Cited by 6 · see citing works
Stress and Reward: A Multimodal Assessment of Resilience after Childhood Sexual Abuse
Pechtel, P., Belleau, E. L., Kaiser, R. H., Whitton, A. E., Beltzer, M., Clegg, R. A., Goer, F., Vitaliano, G. D., Teicher, M. H., & Pizzagalli, D. A. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100498 · Cited by 6 · see citing works
A six-year longitudinal study examining chronicity and timing of maltreatment effects on risk-related functional connectivity change across adolescence
Lindenmuth, M., Chen, Y., Lee, T., Melville, N., Casas, B. R., & Kim‐Spoon, J. (2025) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2025.101577 · Cited by 5 · see citing works
Common and distinct neural underpinnings of the association between childhood maltreatment and depression and aggressive behavior
Li, Y., Zhang, T., Hou, X., Chen, X., & Mao, Y. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06485-0 · Cited by 5 · see citing works
Sensitivity to psychosocial influences at age 3 predicts mental health in middle childhood
McDermott, C. L., Taylor, K., Sharp, S. D. S., Lydon‐Staley, D. M., Leonard, J., & Mackey, A. P. (2024) · Developmental Science · doi:10.1111/desc.13531 · Cited by 4 · see citing works
Childhood emotional neglect and depression in emerging adults: Exploring the roles of rumination and resilience
Zhong, X. B., Li, S., & Zhou, W. (2025) · Acta Psychologica · doi:10.1016/j.actpsy.2025.105272 · Cited by 4 · see citing works
Ventral striatal-cingulate resting-state functional connectivity in healthy adolescents relates to later depression symptoms in adulthood
Giacco, A. C. D., Morales, A. M., Jones, S. A., Barnes, S. J., & Nagel, B. J. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.08.028 · Cited by 4 · see citing works
The Family System Amidst Complex Trauma: A Driving Force to Enhance Resilience and Reduce Depression in Young Adults
Daniels, A. D., Bryan, J. A., Liles, S., & Carney, J. V. (2022) · The Family Journal · doi:10.1177/10664807221104115 · Cited by 4 · see citing works
Integration of Equity and Diversity Frameworks to Advance Biological Psychiatry
Arredondo, M. M., Garcini, L. M., & McLaughlin, K. A. (2022) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2022.08.004 · Cited by 4 · see citing works
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Neuroimaging resilience to trauma: convergent evidence and challenges for future researchPreprint
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Authors: Dennison, M. J., Sheridan, M. A., Busso, D. S., Jenness, J. L., Peverill, M., Rosen, M. L., & McLaughlin, K. A.
Affiliations: University of Washington (US)
University of North Carolina at Chapel Hill (US)
Harvard University (US)
Corresponding author: McLaughlin, Katie A.
ORCID: Dennison, Meg J.
Sheridan, Margaret A.
Busso, Daniel S.
Jenness, Jessica L.
Peverill, Matthew
Rosen, Maya L.
McLaughlin, Katie A.
Venue: Journal of Abnormal Psychology
Publisher: American Psychological Association (APA)
Published: 2016-11
Volume: 125
Issue: 8
Pages: 1201-1212
ISSN: 0021-843X (ISSN-L)
1939-1846
DOI: 10.1037/abn0000215
PMC: PMC5119749
OpenAlex: W2549830953
Cited by: 117
References: 71
Citations by year: 2026: 6 · 2025: 14 · 2024: 13 · 2023: 13 · 2022: 11 · 2021: 18 · 2020: 15 · 2019: 13 · 2018: 9 · 2017: 4 · 2016: 1
FWCI: 12.05
Type: journal article
Language: en
Update notices: correction (2016-11-17)
Open access: hybrid
doi.org
Licence: other-oa
www.apa.org/pubs/journals/resources/open-access.aspx (am, 371 d)
Locations: Journal of Abnormal Psychology (publishedVersion, other-oa)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
Smith ScholarWorks (Smith College) (submittedVersion)
Minerva Access (University of Melbourne) (submittedVersion)
UNC Libraries
Funders: National Institutes of Health (K01-MH092526, R01-MH103291, R01-106482, K01-MH092555, T32-HD057822)
Charles H. Hood Foundation
Jacobs Foundation
One Mind Institute
Topics: Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: child abuse, depression, resilience, reward reactivity, adolescents, basal ganglia, globus pallidus, putamen, BOLD signal, monetary rewards, emotional stimuli
MeSH terms: Adolescent, Basal Ganglia, Brain Mapping, Child Abuse, Depression, Female, Humans, Magnetic Resonance Imaging, Male, Reaction Time, Reward, Resilience, Psychological

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Neurobehavioral markers of resilience to depression amongst adolescents exposed to child abuse

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