A meta-analysis of neuropsychological, social cognitive, and olfactory functioning in the behavioral and language variants of frontotemporal dementia
Abstract
Background: Though meta-analyses of neuropsychological and social cognitive deficits in behavioral variant frontotemporal dementia (bvFTD) have been conducted, no study has comprehensively characterized and compared the neuropsychological, social cognitive, and olfactory profiles in the behavioral and language variants of FTD. Methods: Our search yielded 470 publications meeting inclusion criteria representing 11 782 FTD patients and 19 451 controls. For each domain, we calculated Hedges’ g effect sizes, which represent the mean difference between the patient and control group divided by the pooled standard deviation. The heterogeneity of these effects was assessed with Cochran's Q-statistic using a random-effects model. Meta-regressions were employed to analyze the influence of demographic and disease characteristics. Results: Though semantic variant primary progressive aphasia patients showed the greatest impairment across all task types, the three groups showed similar cognitive effect sizes once contributions from the language subdomain were excluded from analysis. Contrary to expectation, the magnitude of deficits in executive functioning, social cognition and olfaction were comparable between the three subgroups. Among indices, a metric of executive errors distinguished the behavioral variant of FTD from the language phenotypes. Conclusions: These data indicate that social cognitive and traditional executive functioning measures may not capture differences between FTD syndromes. These results have important implications for the interpretation of neuropsychological assessments, particularly when applied to the differential diagnosis of FTD. It is hoped that these findings will guide clinical and research assessments and spur new studies focused on improving the measurement of FTD syndromes.
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FTD presents with high levels of heterogeneity in behavioral, clinical, and neuropathological markers.
“FTD presents with high levels of heterogeneity in behavioral, clinical, and neuropathological markers (Boeve et al., 2022; Peet et al., 2021; Rohan et al., 2019).”
From Multiclass characterization of frontotemporal dementia variants via multimodal brain network computational inference (2023) · cites this paper as Rohan et al., 2019
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Neuropsychology Assessment in Dementia and Neurodegenerative Disease
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- Authors
- Kamath, V., Chaney, G.-A. S., DeRight, J., & Onyike, C. U.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Kamath, Vidyulata
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2018-12-06
- Volume
- 49
- Issue
- 16
- Pages
- 2669-2680
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2904209082
- Cited by
- 35
- References
- 65
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 8 · 2021: 7 · 2020: 1 · 2019: 2
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (KL2TR001077)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- frontotemporal dementia, behavioral variant frontotemporal dementia, semantic dementia, neuropsychological deficits, social cognition, olfactory dysfunction, executive function, differential diagnosis, effect size
- MeSH terms
- Aged, Agnosia, Aphasia, Diagnosis, Differential, Female, Humans, Language, Male, Middle Aged, Neuropsychological Tests, Social Behavior, Executive Function, Emotional Intelligence, Frontotemporal Dementia
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