Cited by 187Dementia and Cognitive Impairment ResearchHistorical and Modern Theater StudiesAlzheimer's disease research and treatments

Neuropsychological deficits in frontotemporal dementia and Alzheimer's disease: a meta-analytic review

Open access
Hutchinson, A D, Mathias, J L·2007·Journal of Neurology, Neurosurgery & Psychiatry

Abstract

We sought to identify the cognitive tests that best discriminate between Alzheimer's disease (AD) and frontotemporal dementia (FTD). A comprehensive search of all studies examining the cognitive performance of persons diagnosed with AD and FTD, published between 1980 and 2006, was conducted. Ninety-four studies were identified, comprising 2936 AD participants and 1748 FTD participants. Weighted Cohen's d effect sizes, percentage overlap statistics, confidence intervals and fail-safe Ns were calculated for each cognitive test that was used by two or more studies. The most discriminating cognitive tests were measures of orientation, memory, language, visuomotor function and general cognitive ability. Although there were large and significant differences between groups on these measures, there was substantial overlap in the scores of the AD and FTD groups. Age, education, years since diagnosis and diagnostic criteria did not significantly contribute to the group differences. Given the large overlap in the test performance of persons diagnosed with AD and FTD, cognitive tests should be used cautiously and in conjunction with a medical history, behavioural observations, imaging and information from relatives when making differential diagnoses.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1136/jnnp.2006.100669

Cites

161 of 161 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • A normal-range MMSE score is often seen in clinically suspected bvFTD at early stages.

    “A normalrange MMSE score is often seen in clinically suspected bvFTD (Hutchinson and Mathias, 2007) at early stages”

    From Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders (2020) · cites this paper as Hutchinson and Mathias, 2007

    The Discussion reports that participants with FTD had higher MMSE scores than those with Alzheimer’s disease, and suggests the MMSE is less suited to detecting FTD-related deficits. But Table 2 (Method) gives an FTD mean of 22.7; the paper does not establish that normal-range scores are common specifically in early, clinically suspected bvFTD. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Hutchinson, A. D., & Mathias, J. L.
Affiliations
The University of Adelaide (AU)
Corresponding author
Mathias, J L
Venue
Journal of Neurology, Neurosurgery & Psychiatry
Publisher
BMJ
Published
2007-09-01
Volume
78
Issue
9
Pages
917-928
ISSN
0022-3050 (ISSN-L)
OpenAlex
W2157735468
Cited by
187
References
161
Citations by year
2026: 1 · 2025: 6 · 2024: 5 · 2023: 8 · 2022: 12 · 2021: 9 · 2020: 10 · 2019: 8 · 2018: 10 · 2017: 17 · 2016: 10 · 2015: 14 · 2014: 9 · 2013: 12 · 2012: 11
FWCI
6.84
Type
journal article
Language
en
Open access
Locations
  • Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
  • Flinders Academic Commons (Flinders University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
frontotemporal dementia, Alzheimer's disease, neuropsychological deficits, differential diagnosis, cognitive tests, memory, language, visuomotor function, general intelligence, orientation, diagnostic overlap
MeSH terms
Alzheimer Disease, Dementia, Diagnosis, Differential, Humans, Neuropsychological Tests

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review