Neuropsychological deficits in frontotemporal dementia and Alzheimer's disease: a meta-analytic review
Open accessAbstract
We sought to identify the cognitive tests that best discriminate between Alzheimer's disease (AD) and frontotemporal dementia (FTD). A comprehensive search of all studies examining the cognitive performance of persons diagnosed with AD and FTD, published between 1980 and 2006, was conducted. Ninety-four studies were identified, comprising 2936 AD participants and 1748 FTD participants. Weighted Cohen's d effect sizes, percentage overlap statistics, confidence intervals and fail-safe Ns were calculated for each cognitive test that was used by two or more studies. The most discriminating cognitive tests were measures of orientation, memory, language, visuomotor function and general cognitive ability. Although there were large and significant differences between groups on these measures, there was substantial overlap in the scores of the AD and FTD groups. Age, education, years since diagnosis and diagnostic criteria did not significantly contribute to the group differences. Given the large overlap in the test performance of persons diagnosed with AD and FTD, cognitive tests should be used cautiously and in conjunction with a medical history, behavioural observations, imaging and information from relatives when making differential diagnoses.
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A normal-range MMSE score is often seen in clinically suspected bvFTD at early stages.
“A normalrange MMSE score is often seen in clinically suspected bvFTD (Hutchinson and Mathias, 2007) at early stages”
From Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders (2020) · cites this paper as Hutchinson and Mathias, 2007
The Discussion reports that participants with FTD had higher MMSE scores than those with Alzheimer’s disease, and suggests the MMSE is less suited to detecting FTD-related deficits. But Table 2 (Method) gives an FTD mean of 22.7; the paper does not establish that normal-range scores are common specifically in early, clinically suspected bvFTD. (LLM, conf=0.86)
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- Authors
- Hutchinson, A. D., & Mathias, J. L.
- Affiliations
- The University of Adelaide (AU)
- Corresponding author
- Mathias, J L
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2007-09-01
- Volume
- 78
- Issue
- 9
- Pages
- 917-928
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC2117891
- OpenAlex
- W2157735468
- Cited by
- 187
- References
- 161
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 5 · 2023: 8 · 2022: 12 · 2021: 9 · 2020: 10 · 2019: 8 · 2018: 10 · 2017: 17 · 2016: 10 · 2015: 14 · 2014: 9 · 2013: 12 · 2012: 11
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Flinders Academic Commons (Flinders University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- frontotemporal dementia, Alzheimer's disease, neuropsychological deficits, differential diagnosis, cognitive tests, memory, language, visuomotor function, general intelligence, orientation, diagnostic overlap
- MeSH terms
- Alzheimer Disease, Dementia, Diagnosis, Differential, Humans, Neuropsychological Tests
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