Attentional bias toward health-threat in health anxiety: a systematic review and three-level meta-analysis
Abstract
Attentional bias toward health-threat may theoretically contribute to the development and maintenance of health anxiety, but the empirical findings have been controversial. This study aimed to synthesize and explore the heterogeneity in a health-threat related attentional bias of health-anxious individuals, and to determine the theoretical model that better represents the pattern of attentional bias in health anxiety. Four databases (Web of Science, PubMed, PsycINFO, and Scopus) were searched for relevant studies, with 17 articles (N = 1546) included for a qualitative review and 16 articles (18 studies) for a three-level meta-analysis (N = 1490). The meta-analytic results indicated that the health anxiety group, compared to the control group, showed significantly greater attentional bias toward health-threat (g = 0.256). Further analyses revealed that attentional bias type, paradigm, and stimuli type were significant moderators. Additionally, compared to the controls, health-anxious individuals displayed significantly greater attention maintenance (g = 0.327) but nonsignificant attention vigilance to health-threat (g = −0.116). Our results provide evidence for the attention maintenance model in health-anxious individuals. The implications for further research and treatment of elevated health anxiety in the context of coronavirus disease-2019 (COVID-19) were also discussed.
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Attentional bias towards health-threat related stimuli is strongly associated with health anxiety in a recent systematic review and meta-analysis.
“A key contribution to this misinterpretation is an attentional bias towards health-threat related stimuli, which has shown to be strongly associated with health anxiety in a recent systematic review and meta-analysis [46].”
From Illness Anxiety Disorder: A Review of the Current Research and Future Directions (2024) · cites this paper as [46]
Cites
PRISMA-P Group, Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., & Stewart, L. A. (2015) · Systematic Reviews · doi:10.1186/2046-4053-4-1 · Cited by 26,223 · see citing works
Conducting Meta-Analyses in <i>R</i> with the <b>metafor</b> Package
Viechtbauer, W. (2010) · Journal of Statistical Software · doi:10.18637/jss.v036.i03 · Cited by 20,464 · see citing works
Cohen, J. (1992) · Psychological Bulletin · doi:10.1037//0033-2909.112.1.155 · Cited by 8,771 · see citing works
Meta-Analytic Procedures for Social Research
Rosenthal, R. (1991) · doi:10.4135/9781412984997 · Cited by 4,635 · see citing works
Threat-related attentional bias in anxious and nonanxious individuals: a meta-analytic study.
Bar-Haim, Y., Lamy, D., Pergamin, L., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.1.1 · Cited by 3,721 · see citing works
The attention system of the human brain: 20 years after
Petersen, S. E., & Posner, M. I. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150525 · Cited by 3,439 · see citing works
Outlier and influence diagnostics for meta-analysis
Viechtbauer, W., & Cheung, M. W.-L. (2010) · Research Synthesis Methods · doi:10.1002/jrsm.11 · Cited by 2,949 · see citing works
Residuals and Influence in Regression.
Atkinson, A. C., Cook, R. D., & Weisberg, S. (1983) · Biometrics · doi:10.2307/2531125 · Cited by 1,904 · see citing works
Doing Meta-Analysis with R: A Hands-On Guide
Harrer, M., Cuijpers, P., Furukawa, T. A., & Ebert, D. D. (2021) · doi:10.1201/9781003107347 · Cited by 1,850 · see citing works
A cognitive-motivational analysis of anxiety.
Mogg, K., & Bradley, B. P. (1998) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(98)00063-1 · Cited by 1,642 · see citing works
Do threatening stimuli draw or hold visual attention in subclinical anxiety?
Fox, E., Russo, R., Bowles, R., & Dutton, K. (2001) · Journal of Experimental Psychology: General · doi:10.1037/0096-3445.130.4.681 · Cited by 1,469 · see citing works
Fitting three-level meta-analytic models in R: A step-by-step tutorial
Assink, M., & Wibbelink, C. J. M. (2016) · The Quantitative Methods for Psychology · doi:10.20982/tqmp.12.3.p154 · Cited by 1,330 · see citing works
An information processing model of anxiety: Automatic and strategic processes
Beck, A. T., & Clark, D. A. (1997) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(96)00069-1 · Cited by 1,317 · see citing works
Attentional bias for threat: evidence for delayed disengagement from emotional faces
Fox, E., Russo, R., & Dutton, K. (2002) · Cognition & Emotion · doi:10.1080/02699930143000527 · Cited by 954 · see citing works
Asmundson, G. J. G., & Taylor, S. (2020) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2020.102211 · Cited by 786 · see citing works
Self-citationWarwick, H. M. C., & Salkovskis, P. M. (1990) · Behaviour Research and Therapy · doi:10.1016/0005-7967(90)90023-c · Cited by 587 · see citing works
Attentional bias for positive emotional stimuli: A meta-analytic investigation.
Pool, E. R., Brosch, T., Delplanque, S., & Sander, D. (2015) · Psychological Bulletin · doi:10.1037/bul0000026 · Cited by 425 · see citing works
Risk factors for persistent delinquent behavior among juveniles: A meta-analytic review
Assink, M., van der Put, C. E., Hoeve, M., de Vries, S. L. A., Stams, G. J. J. M., & Oort, F. J. (2015) · Clinical Psychology Review · doi:10.1016/j.cpr.2015.08.002 · Cited by 338 · see citing works
Risk factors for child sexual abuse victimization: A meta-analytic review.
Assink, M., van der Put, C. E., Meeuwsen, M. W. C. M., de Jong, N. M., Oort, F. J., Stams, G. J. J. M., & Hoeve, M. (2019) · Psychological bulletin · doi:10.1037/bul0000188 · Cited by 322 · cited 2× · see citing works
“mv function instead of regtest function to conduct a modified Egger’s test, and a significant slope represents the existence of bias (Assink et al., 2019).”
MethodAnxiety and attention to threat: cognitive mechanisms and treatment with attention bias modification
Mogg, K., & Bradley, B. P. (2016) · Behaviour Research and Therapy · doi:10.1016/j.brat.2016.08.001 · Cited by 313 · see citing works
Unreliability as a threat to understanding psychopathology: The cautionary tale of attentional bias.
Rodebaugh, T. L., Scullin, R. B., Langer, J. K., Dixon, D. J., Huppert, J. D., Bernstein, A., Zvielli, A., & Lenze, E. J. (2016) · Journal of Abnormal Psychology · doi:10.1037/abn0000184 · Cited by 312 · see citing works
Health anxiety in Australia: prevalence, comorbidity, disability and service use
Sunderland, M., Newby, J. M., & Andrews, G. (2013) · British Journal of Psychiatry · doi:10.1192/bjp.bp.111.103960 · Cited by 280 · see citing works
van Eldik, W. M., de Haan, A. D., Parry, L. Q., Davies, P. T., Luijk, M. P. C. M., Arends, L. R., & Prinzie, P. (2020) · Psychological Bulletin · doi:10.1037/bul0000233 · Cited by 273 · see citing works
Attentional bias towards threatening stimuli in children with anxiety: A meta-analysis
Dudeney, J., Sharpe, L., & Hunt, C. (2015) · Clinical Psychology Review · doi:10.1016/j.cpr.2015.05.007 · Cited by 247 · see citing works
Theories and measurement of visual attentional processing in anxiety
Weierich, M. R., Treat, T. A., & Hollingworth, A. (2008) · Cognition and Emotion · doi:10.1080/02699930701597601 · Cited by 245 · see citing works
Vismara, M., Caricasole, V., Starcevic, V., Cinosi, E., Dell'Osso, B., Martinotti, G., & Fineberg, N. A. (2020) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2020.152167 · Cited by 224 · cited 1× · see citing works
“Third, the reference lists of selected papers and relevant review articles (Leonidou & Panayiotou, 2018; Maheu et al., 2021; Vismara et al., 2020) were checked to identify additional studies.”
BackgroundSuslow, T., Hußlack, A., Kersting, A., & Bodenschatz, C. M. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.05.140 · Cited by 194 · see citing works
A taxometric analysis of health anxiety
Ferguson, E. (2009) · Psychological Medicine · doi:10.1017/s0033291708003322 · Cited by 183 · see citing works
Attentional bias to pain-related information: a meta-analysis of dot-probe studies
Todd, J., van Ryckeghem, D. M. L., Sharpe, L., & Crombez, G. (2018) · Health Psychology Review · doi:10.1080/17437199.2018.1521729 · Cited by 153 · see citing works
The relationship between sense of coherence and post-traumatic stress: a meta-analysis
Schäfer, S. K., Becker, N., King, L., Horsch, A., & Michael, T. (2019) · European Journal of Psychotraumatology · doi:10.1080/20008198.2018.1562839 · Cited by 140 · see citing works
A contemporary conceptual model of hypochondriasis
Abramowitz, J. S., Schwartz, S. A., & Whiteside, S. P. (2002) · Mayo Clinic Proceedings · doi:10.4065/77.12.1323 · Cited by 139 · see citing works
Health anxiety and hypochondriasis in the light of DSM-5
Bailer, J., Kerstner, T., Witthöft, M., Diener, C., Mier, D. U., & Rist, F. (2015) · Anxiety Stress & Coping · doi:10.1080/10615806.2015.1036243 · Cited by 130 · see citing works
Self-citationGupta, R. S., Kujawa, A., & Vago, D. R. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2019.08.006 · Cited by 122 · see citing works
Attentional Bias Toward Illness Threat in Individuals with Elevated Health Anxiety
Owens, K. M. B., Asmundson, G. J. G., Hadjistavropoulos, T., & Owens, T. J. (2004) · Cognitive Therapy and Research · doi:10.1023/b:cotr.0000016930.85884.29 · Cited by 107 · see citing works
Kruijt, A., Parsons, S. D., & Fox, E. (2019) · Journal of Abnormal Psychology · doi:10.1037/abn0000406 · Cited by 103 · see citing works
Tyrer, P. J. (2020) · World Psychiatry · doi:10.1002/wps.20798 · Cited by 97 · see citing works
Maheu, C., Singh, M. D., Tock, W. L., Eyrenci, A., Galica, J., Hébert, M., Frati, F., & Estapé, T. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.644932 · Cited by 91 · see citing works
Acceptance and commitment group therapy (ACT-G) for health anxiety: a randomized controlled trial.
Eilenberg, T., Fink, P., Jensen, J. S., Rief, W., & Frostholm, L. (2016) · Psychological Medicine · doi:10.1017/s0033291715001579 · Cited by 86 · see citing works
Fu, X., & Pérez‐Edgar, K. E. (2018) · Developmental Review · doi:10.1016/j.dr.2018.11.002 · Cited by 85 · see citing works
Shame, guilt, and posttraumatic stress symptoms: A three-level meta-analysis
Shi, C., Ren, Z., Zhao, C., Zhang, T., & Chan, S. H. (2021) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2021.102443 · Cited by 85 · see citing works
Self-citationHaig-Ferguson, A., Cooper, K., Cartwright, E., Loades, M. E., & Daniels, J. (2021) · Behavioural and Cognitive Psychotherapy · doi:10.1017/s1352465820000636 · Cited by 84 · see citing works
Sears, C. R., Quigley, L., Fernandez, A., Newman, K. R., & Dobson, K. S. (2018) · Behavior Research Methods · doi:10.3758/s13428-018-1147-z · Cited by 80 · see citing works
Health anxiety and attentional bias toward virus-related stimuli during the COVID-19 pandemic
Cannito, L., Crosta, A. D., Palumbo, R., Ceccato, I., Anzani, S., Malva, P. L., Palumbo, R., & Domenico, A. D. (2020) · Scientific Reports · doi:10.1038/s41598-020-73599-8 · Cited by 78 · see citing works
Lees, A., Mogg, K., & Bradley, B. P. (2005) · Cognition & Emotion · doi:10.1080/02699930441000184 · Cited by 76 · see citing works
Bailey, R., & Adrian Wells, A. (2015) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2015.05.005 · Cited by 70 · see citing works
The psychology of pandemics: preparing for the next global outbreak of infectious disease
Bakshi, A. J., Deshmukh, J., & Kumar, S. (2021) · British Journal of Guidance and Counselling · doi:10.1080/03069885.2021.1949809 · Cited by 70 · see citing works
Albery, I. P., Spada, M. M., & Nikčević, A. V. (2021) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.2639 · Cited by 59 · see citing works
Witthöft, M., Kerstner, T., Ofer, J., Mier, D., Rist, F., Diener, C., & Bailer, J. (2016) · Clinical Psychological Science · doi:10.1177/2167702615593474 · Cited by 49 · see citing works
Self-citationHeterogeneity of the Anxiety-Related Attention Bias: A Review and Working Model for Future Research
Dennis‐Tiwary, T. A., Roy, A. K., Denefrio, S., & Myruski, S. (2019) · Clinical Psychological Science · doi:10.1177/2167702619838474 · Cited by 49 · see citing works
Lecci, L., & Cohen, D. J. (2002) · Health Psychology · doi:10.1037/0278-6133.21.2.147 · Cited by 48 · see citing works
Consciousness and the attention schema: Why it has to be right
Graziano, M. S. A. (2020) · Cognitive Neuropsychology · doi:10.1080/02643294.2020.1761782 · Cited by 44 · see citing works
Jasper, F., & Witthöft, M. (2011) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2011.08.004 · Cited by 39 · see citing works
Self-citationSpecificity and modifiability of cognitive biases in hypochondriasis.
Gropalis, M., Bleichhardt, G., Hiller, W., & Witthöft, M. (2013) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0028493 · Cited by 38 · cited 2× · see citing works
“…IAD or hypochondriasis) showed greater attentional bias toward health-threat, compared to those with self-reported low health anxiety (Owens et al., 2004; Witthöft et al., 2013; Witthöft, Rist, & Bailer, 2008) or healthy controls (Gropalis et al., 2013; Mier et al., 2017; Witthöft et al., 2016).”
ResultSelf-citationLeonidou, C., & Panayiotou, G. (2018) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2018.06.001 · Cited by 38 · see citing works
Karademas, E. C., Christopoulou, S., Dimostheni, A., & Pavlu, F. (2008) · Personality and Individual Differences · doi:10.1016/j.paid.2007.11.007 · Cited by 37 · see citing works
Witthöft, M., Rist, F., & Bailer, J. (2007) · Cognitive Therapy and Research · doi:10.1007/s10608-007-9159-5 · Cited by 34 · see citing works
Self-citationWitthöft, M., Mier, D. U., Ofer, J., Müller, T., Rist, F., Kirsch, P., Bailer, J., & Diener, C. (2013) · Neuropsychobiology · doi:10.1159/000345545 · Cited by 28 · see citing works
Self-citationRosen, D. K., Price, R. B., & Silk, J. S. (2019) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2019.04.003 · Cited by 25 · see citing works
Tyrer, P. J., Wang, D., Crawford, M., Dupont, S., Cooper, S., Nourmand, S., Lazarevic, V., Philip, A., & Tyrer, H. (2020) · Psychological Medicine · doi:10.1017/s003329172000046x · Cited by 23 · see citing works
Mier, D., Bailer, J., Ofer, J., Kerstner, T., Zamoscik, V., Rist, F., Witthöft, M., & Diener, C. (2017) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.160081 · Cited by 20 · see citing works
Self-citationNorbye, A. D., Abelsen, B., Førde, O. H., & Ringberg, U. (2020) · Psychological Medicine · doi:10.1017/s0033291720004122 · Cited by 20 · see citing works
Attentional bias toward personally relevant health-threat words
Lee, H. R., Turkel, J. E., Cotter, S. P., Milliken, J. M., Cougle, J. R., Goetz, A. R., & Lesnick, A. M. (2012) · Anxiety Stress & Coping · doi:10.1080/10615806.2012.713474 · Cited by 18 · see citing works
Attentional biases in illness anxiety: Null findings from the dot probe paradigm
Jacoby, R. J., Wheaton, M. G., & Abramowitz, J. S. (2016) · Journal of Obsessive-Compulsive and Related Disorders · doi:10.1016/j.jocrd.2016.04.007 · Cited by 11 · see citing works
Effects of Dispositional Coping Strategy and Level of Health Anxiety on Attentional Bias
Kim, S., Kim, K., & Lee, J.-H. (2014) · Social Behavior and Personality An International Journal · doi:10.2224/sbp.2014.42.7.1183 · Cited by 9 · see citing works
Selective Attention and Health Anxiety: Ill-Health Stimuli are Distracting for Everyone
Shields, C., & Murphy, K. A. (2011) · Cognitive Therapy and Research · doi:10.1007/s10608-011-9351-5 · Cited by 9 · see citing works
Ștefan, S., Zorila, A., & Brie, E. (2019) · Cognition & Emotion · doi:10.1080/02699931.2019.1645643 · Cited by 8 · see citing works
Zhang, Y., Wang, P., Ma, Y., Yang, X., Meng, F., Broadley, S., Sun, J., & Li, Z. (2021) · World Journal of Psychiatry · doi:10.5498/wjp.v11.i3.73 · Cited by 7 · see citing works
Leonidou, C., & Panayiotou, G. (2020) · Journal of Health Psychology · doi:10.1177/1359105320967435 · Cited by 3 · see citing works
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Illness Anxiety Disorder: A Review of the Current Research and Future Directions
Kikas, K., Werner-Seidler, A., Upton, E., & Newby, J. (2024) · Current Psychiatry Reports · doi:10.1007/s11920-024-01507-2 · Cited by 31 · see citing works
“A key contribution to this misinterpretation is an attentional bias towards health-threat related stimuli, which has shown to be strongly associated with health anxiety in a recent systematic review and meta-analysis [46].”
BackgroundInterpretation bias in health anxiety: a systematic review and meta-analysis
Du, X., Witthöft, M., Zhang, T., Shi, C., & Ren, Z. (2023) · Psychological Medicine · doi:10.1017/s0033291722003427 · Cited by 30 · see citing works
Self-citationGehrt, T. B., Macoveanu, J., Bailey, C. J., Fisher, P. M., Pallesen, K. J., & Frostholm, L. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.12.138 · Cited by 8 · see citing works
- Authors
- Shi, C., Taylor, S., Witthöft, M., Du, X., Zhang, T., Lu, S., & Ren, Z.
- Affiliations
- Central China Normal University (CN)
- University of British Columbia (CA)
- Johannes Gutenberg University Mainz (DE)
- Corresponding author
- Ren, Zhihong
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2022-01-10
- Volume
- 52
- Issue
- 4
- Pages
- 604-613
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W4205977150
- Cited by
- 32
- References
- 68
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 12 · 2023: 5 · 2022: 3
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Key Program of Institute of Wuhan Studies of Jianghan University (IWHS20201007)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
- Keywords
- health anxiety, attentional bias, health hazards, sustained attention, COVID-19 pandemic, anxiety maintenance
- MeSH terms
- Attentional Bias, COVID-19, Anxiety, Anxiety Disorders, Humans
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