What contributes to depression in Parkinson's disease?
Open accessAbstract
Background. Depression is a common problem in patients with Parkinson's disease, but its mechanism is poorly understood. It is thought that neurochemical changes contribute to its occurrence, but it is unclear why some patients develop depression and others do not. Using a community-based sample of patients with Parkinson's disease, we investigated the contributions of impairment, disability and handicap to depression in Parkinson's disease. Methods. Ninety-seven patients seen in a population-based study on the prevalence of Parkinson's disease completed the Beck Depression Inventory (BDI). Clinical and historical information on symptoms and complications of Parkinson's disease were obtained from the patients by a neurologist. In addition, clinician and patient ratings of disability on the Schwab and England scale were obtained and a quality of life questionnaire was completed. Results. Moderate to severe depression (BDI [ges ] 18) was reported by 19·6% of the patients. Higher depression scores were associated with advancing disease severity, recent self-reported deterioration, higher akinesia scores, a mini-mental score of < 25 and occurrence of falls. Disability as rated by the neurologist accounted for 34% of the variance of depression scores. Self-reported impairment of cognitive function and the feeling of stigmatization accounted for > 50% of the variance of depression scores. Conclusions. Depression in patients with Parkinson's disease is associated with advancing disease severity, recent disease deterioration and occurrence of falls. Regression analysis suggests that depression in Parkinson's disease is more strongly influenced by the patients' perceptions of handicap than by actual disability. The treatment of depression should therefore be targeted independently of treatment of the motor symptoms of Parkinson's disease, and consider the patients' own perception of their disease.
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Depression and anxiety in Parkinson's disease may relate to several factors, including advancing disease severity.
“Depression and anxiety may relate to several factors, including advancing disease severity (Schrag et al. 2001).”
From The clinical symptoms of Parkinson's disease. (2016) · cites this paper as Schrag et al. 2001
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- Authors
- SCHRAG, A., JAHANSHAHI, M., & QUINN, N. P.
- Affiliations
- UCL Queen Square Institute of Neurology (GB)
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2001-01
- Volume
- 31
- Issue
- 1
- Pages
- 65-73
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2105422294
- Cited by
- 242
- References
- 1
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 3 · 2022: 16 · 2021: 9 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 10 · 2016: 7 · 2015: 10 · 2014: 4 · 2013: 10 · 2012: 8
- FWCI
- 8.53
- Type
- journal article
- Language
- en
- Open access
- green
- discovery.ucl.ac.uk
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Parkinson's disease, depression, disability, handicap, disease severity, akinesia, falls, cognitive impairment, stigmatization, quality of life, depression treatment
- MeSH terms
- Aged, Aged, 80 and over, Depressive Disorder, Female, Persons with Disabilities, Disabled Persons, Humans, Male, Middle Aged, Parkinson Disease, Quality of Life, Self Concept, Severity of Illness Index, Disease Progression
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