Cited by 1,025Multiple Sclerosis Research StudiesCancer survivorship and careFibromyalgia and Chronic Fatigue Syndrome Research

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The Impact of Fatigue on Patients with Multiple Sclerosis

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Fisk, John D., Pontefract, Amanda, Ritvo, Paul G., Archibald, Catherine J., Murray, T.J.·1994·Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

DOI 10.1017/s0317167100048691

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Abstract

Although fatigue is recognized as a symptom of MS, there have been insufficient methods for evaluating this symptom. We administered the Fatigue Impact Scale to 85 MS patients and 20 hypertensive patients. Neurologic impairment, mental health, and general health status were also assessed. MS patients reported significantly higher fatigue impact than hypertensive patients. Most MS patients reported fatigue as either their worst (14%), or one of their worst (55%) symptoms. Disease classification and neurologic impairment had little bearing on Fatigue Impact Scale scores in the MS sample. The best predictive models for mental health and general health status in the MS sample both included the Fatigue Impact Scale as a significant factor. This study demonstrates that: 1) fatigue is a very prevalent and severe problem in MS, 2) fatigue impact cannot be predicted by clinical measures of neurologic impairment, 3) fatigue has a significant effect on the mental health and general health status of MS patients.

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Additional file 5 of Evaluating the impact of patient-reported outcome measures on depression and anxiety levels in people with multiple sclerosis: a study protocol for a randomized controlled trial
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Additional file 4 of Measuring the effects of nurse practitioner (NP)-led care on depression and anxiety levels in people with multiple sclerosis: a study protocol for a randomized controlled trial
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Additional file 3 of Measuring the effects of nurse practitioner (NP)-led care on depression and anxiety levels in people with multiple sclerosis: a study protocol for a randomized controlled trial
Smyth, P. S., Watson, K. E., & Tsuyuki, R. T. (2021) · Figshare · doi:10.6084/m9.figshare.16960219
Additional file 2 of Measuring the effects of nurse practitioner (NP)-led care on depression and anxiety levels in people with multiple sclerosis: a study protocol for a randomized controlled trial
Smyth, P. S., Watson, K. E., & Tsuyuki, R. T. (2021) · Figshare · doi:10.6084/m9.figshare.16960216
Additional file 3 of Prevalence and burden of multiple sclerosis-related fatigue: a systematic literature review
Ramirez, A. O., Keenan, A., Kalau, O., Worthington, E., Cohen, L., & Singh, S. (2021) · Figshare · doi:10.6084/m9.figshare.17120459
Additional file 1 of Measuring the effects of nurse practitioner (NP)-led care on depression and anxiety levels in people with multiple sclerosis: a study protocol for a randomized controlled trial
Smyth, P. S., Watson, K. E., & Tsuyuki, R. T. (2021) · Figshare · doi:10.6084/m9.figshare.16960213
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Additional file 3 of Evaluating the impact of patient-reported outcome measures on depression and anxiety levels in people with multiple sclerosis: a study protocol for a randomized controlled trial
Chu, N. Y., Watson, K. E., Hamarneh, Y. N. A., Yushko, L., Tsuyuki, R. T., & Smyth, P. S. (2023) · Figshare · doi:10.6084/m9.figshare.22612738
Additional file 6 of Evaluating the impact of patient-reported outcome measures on depression and anxiety levels in people with multiple sclerosis: a study protocol for a randomized controlled trial
Chu, N. Y., Watson, K. E., Hamarneh, Y. N. A., Yushko, L., Tsuyuki, R. T., & Smyth, P. S. (2023) · Figshare · doi:10.6084/m9.figshare.22612747
Additional file 2 of Prevalence and burden of multiple sclerosis-related fatigue: a systematic literature review
Ramirez, A. O., Keenan, A., Kalau, O., Worthington, E., Cohen, L., & Singh, S. (2021) · Figshare · doi:10.6084/m9.figshare.17120453
Additional file 1 of Evaluating the impact of patient-reported outcome measures on depression and anxiety levels in people with multiple sclerosis: a study protocol for a randomized controlled trial
Chu, N. Y., Watson, K. E., Hamarneh, Y. N. A., Yushko, L., Tsuyuki, R. T., & Smyth, P. S. (2023) · Figshare · doi:10.6084/m9.figshare.22612732
Additional file 4 of Prevalence and burden of multiple sclerosis-related fatigue: a systematic literature review
Ramirez, A. O., Keenan, A., Kalau, O., Worthington, E., Cohen, L., & Singh, S. (2021) · Figshare · doi:10.6084/m9.figshare.17120462

Authors: Fisk, J. D., Pontefract, A., Ritvo, P. G., Archibald, C. J., & Murray, T. J.
Affiliations: Dalhousie University (CA)
Corresponding author: Fisk, John D.
ORCID: Fisk, John D.
Venue: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Publisher: Cambridge University Press (CUP)
Published: 1994-02
Volume: 21
Issue: 1
Pages: 9-14
ISSN: 0317-1671 (ISSN-L)
2057-0155
DOI: 10.1017/s0317167100048691
OpenAlex: W155259919
Cited by: 1,025
References: 26
Citations by year: 2026: 24 · 2025: 26 · 2024: 34 · 2023: 52 · 2022: 49 · 2021: 63 · 2020: 45 · 2019: 31 · 2018: 46 · 2017: 44 · 2016: 38 · 2015: 56 · 2014: 31 · 2013: 44 · 2012: 38
FWCI: 3.62
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified, 7899 d)
Locations: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques (publishedVersion)
PubMed (publishedVersion)
Funders: Dalhousie University
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Health Sciences › Medicine › Oncology › Cancer survivorship and care
Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Keywords: multiple sclerosis, fatigue, Fatigue Impact Scale, fatigue effects, mental health, health status, neurological deficit, hypertension, symptom burden, disease classification
MeSH terms: Adult, Affect, Aged, Fatigue, Female, Humans, Hypertension, Male, Mental Health, Middle Aged, Multiple Sclerosis, Psychiatric Status Rating Scales, Surveys and Questionnaires

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The Impact of Fatigue on Patients with Multiple Sclerosis

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