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The Impact of Fatigue on Patients with Multiple Sclerosis
Open accessAbstract
Although fatigue is recognized as a symptom of MS, there have been insufficient methods for evaluating this symptom. We administered the Fatigue Impact Scale to 85 MS patients and 20 hypertensive patients. Neurologic impairment, mental health, and general health status were also assessed. MS patients reported significantly higher fatigue impact than hypertensive patients. Most MS patients reported fatigue as either their worst (14%), or one of their worst (55%) symptoms. Disease classification and neurologic impairment had little bearing on Fatigue Impact Scale scores in the MS sample. The best predictive models for mental health and general health status in the MS sample both included the Fatigue Impact Scale as a significant factor. This study demonstrates that: 1) fatigue is a very prevalent and severe problem in MS, 2) fatigue impact cannot be predicted by clinical measures of neurologic impairment, 3) fatigue has a significant effect on the mental health and general health status of MS patients.
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“is often considered to be the worst symptom of disease (Fisk et al., 1994”
From Systematic review and meta-analysis of interventions for depression and anxiety in persons with multiple sclerosis (2016) · cites this paper as Fisk et al., 1994
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Citations
Cites
Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
Kurtzke, J. F. (1983) · Neurology · doi:10.1212/wnl.33.11.1444 · Cited by 15,011
Krupp, L. B. (1989) · Archives of Neurology · doi:10.1001/archneur.1989.00520460115022 · Cited by 6,172
The Revised UCLA Loneliness Scale: concurrent and discriminant validity evidence
Russell, D., Peplau, L. A., & Cutrona, C. E. (1980) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.39.3.472 · Cited by 5,173
The Sickness Impact Profile: Development and Final Revision of a Health Status Measure
Bergner, M., Bobbitt, R. A., Carter, W. B., & Gilson, B. S. (1981) · Medical Care · doi:10.1097/00005650-198108000-00001 · Cited by 4,619
The structure of psychological distress and well-being in general populations.
Veit, C. T., & Ware, J. E. (1983) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.51.5.730 · Cited by 2,094
Krupp, L., Alvarez, L., LaRocca, N. G., & Lc, S. (1988) · Archives of Neurology · doi:10.1001/archneur.1988.00520280085020 · Cited by 999
Symptomatic fatigue in multiple sclerosis.
Freal, J. E., Kraft, G. H., & Coryell, J. K. (1984) · PubMed · Cited by 526
Affective Disorders in Multiple Sclerosis Review and Recommendations for Clinical Research
Minden, S. L., & Schiffer, R. B. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530010124031 · Cited by 415
Measuring quality of life in clinical trials: a taxonomy and review.
Guyatt, G. H., van Zanten, S. J. V., Feeny, D. H., & Patrick, D. L. (1989) · Europe PMC (PubMed Central) · Cited by 408
Prigatano, G. P. (1984) · Archives of Internal Medicine · doi:10.1001/archinte.1984.00350200121018 · Cited by 300
Research works printed but not linked: 4
- 1987, American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders-Revised
- Ritvo, A model of mental health in patients with multiple sclerosis, Can Psychol, 33, 391
- McNair, 1971, EDITS Manual for the Profile of Mood States
- 10.1037/0022-006x.51.5.730 · DOI
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Sorted by citations
Items 501–600 of 1,001
Association of Central Hypersomnia and Fatigue in Patients With Multiple Sclerosis
Dubessy, A., du Montcel, S. T., Viala, F., Assouad, R., Tiberge, M., Papeix, C., Lubetzki, C., Clanet, M., Arnulf, I., & Stankoff, B. (2021) · Neurology · doi:10.1212/wnl.0000000000012120 · Cited by 23
“Inclusion criteria were (1) diagnosis of MS with relapsing-remitting or primary progressive course, (2) age between 18 and 65, and (3) disability severity defined as a score ≤5.”
BackgroundMethodInfluentialLerdal, A., Celius, E. G., & Moum, T. (2008) · Journal of Advanced Nursing · doi:10.1111/j.1365-2648.2008.04862.x · Cited by 23
Karpatkin, H., & Rzetelny, A. (2012) · International Journal of MS Care · doi:10.7224/1537-2073-14.3.124 · Cited by 23
Stress and memory bias interact to predict depression in multiple sclerosis.
Beeney, J., & Arnett, P. A. (2008) · Neuropsychology · doi:10.1037/0894-4105.22.1.118 · Cited by 23
Foroughipour, M., Taghanaki, H. R. B., Saeidi, M., Khazaei, M., Sasannezhad, P., & Shoeibi, A. (2012) · Acupuncture in Medicine · doi:10.1136/acupmed-2012-010199 · Cited by 23
Stern, M. A. (2005) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2004.06.010 · Cited by 23
Ellison, P. M., Goodall, S., Kennedy, N. C., Dawes, H., Clark, A., Pomeroy, V. M., Duddy, M., Baker, M. R., & Saxton, J. (2021) · Neuropsychology Review · doi:10.1007/s11065-021-09508-1 · Cited by 22
“Studies show that ≥ 75% of people with multiple sclerosis (PwMS) experience fatigue symptoms persistently or sporadically (Lerdal et al., 2007) and over half the MS population describe it as their most severe symptom (Fisk et al., 1994a).”
BackgroundMoraes, A. G., Neri, S. G. R., Motl, R. W., Tauil, C. B., von Glehn, F., Corrêa, É. C., & de David, A. C. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.102948 · Cited by 26
Rahman, M. M., Mim, S. A., Tumpa, M. A. A., Sarker, M. T., Ahmed, M., Alghamdi, B. S. A., Hafeez, A., Alexiou, A. T., Perveen, A., & Ashraf, G. M. (2022) · Cytokine · doi:10.1016/j.cyto.2022.155962 · Cited by 24
Self-Report Assessment of Fatigue in Multiple Sclerosis: A Critical Evaluation
Kos, D., Kerckhofs, E., Ketelaer, P., Duportail, M., Nagels, G., D'hooghe, M. B., & Nuyens, G. (2004) · Occupational Therapy In Health Care · doi:10.1080/j003v17n03_04 · Cited by 22
Pharmacologic Options for the Management of Multiple Sclerosis Symptoms
Schapiro, R. T. (2002) · Neurorehabilitation and neural repair · doi:10.1177/154596802401105162 · Cited by 22
Yıldız, M., Tettenborn, B., & Putzki, N. (2011) · European Neurology · doi:10.1159/000324028 · Cited by 22
Depression and fatigue in relapsing-remitting MS: the role of symptomatic variability
Randolph, J. J., & Arnett, P. A. (2005) · Multiple Sclerosis Journal · doi:10.1191/1352458505ms1133oa · Cited by 22
Fadiga e esclerose múltipla: estudo preliminar de 15 casos através de escalas de auto-avaliação
Mendes, M. F., Tilbery, C. P., & Felipe, E. (2000) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2000000300011 · Cited by 22
LaRocca, N. G., Ritvo, P. G., Miller, D. M., Fischer, J. S., Andrews, H., & Paty, D. W. (1996) · Multiple Sclerosis · doi:10.1007/978-1-4471-1271-6_7 · Cited by 21
Self-citationOxygen Cost During Mobility Tasks and Its Relationship to Fatigue in Progressive Multiple Sclerosis
Devasahayam, A. J., Kelly, L. P., Wallack, E. M., & Ploughman, M. (2019) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2019.03.017 · Cited by 23
Ruotolo, I., Sellitto, G., Ianniello, A., Petsas, N., Castelli, L., Galeoto, G., Berardi, A., Barletta, V. T., Conte, A., & Pozzilli, C. (2022) · Neurological Sciences · doi:10.1007/s10072-022-06080-1 · Cited by 21
“Fatigue is a disabling symptom of multiple sclerosis (MS), a chronic demyelinating disease of the central nervous system [1, 2].”
BackgroundKamudoni, P., Johns, J. R., Cook, K. F., Salem, R., Salek, S., Raab, J., Middleton, R., Henke, C., & Amtmann, D. (2022) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2022.104048 · Cited by 21
Johnson, K., Bamer, A. M., & Fraser, R. (2009) · International Journal of MS Care · doi:10.7224/1537-2073-11.3.137 · Cited by 21
Treatment of Fatigue in Multiple Sclerosis Patients: A Neurocognitive Approach
Catalan, M., Michiel, A. D., Bratina, A., Mezzarobba, S., Pellegrini, L., Marcovich, R., Tamiozzo, F., Servillo, G., Zugna, L., Bosco, A., et al. (2011) · Rehabilitation Research and Practice · doi:10.1155/2011/670537 · Cited by 22
“It is often present in the earliest phase of the disease and it is described as the worst symptom by 40–50 % of patients [2].”
BackgroundFadiga na forma remitente recorrente da esclerose múltipla
Mendes, M. F., Tilbery, C. P., BALSIMELL, S., Felipe, E., Moreira, M. A., & Barão-Cruz, A. M. (2000) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2000000300012 · Cited by 21
Relation of quantitative visual and neurologic outcomes to fatigue in multiple sclerosis
Chahin, S., Miller, D. M., Sakai, R. E., Wilson, J. A., Frohman, T. C., Markowitz, C., Jacobs, D. A., Green, A., Calabresi, P. A., Frohman, E. M., et al. (2015) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2015.05.005 · Cited by 21
“Patients with MS note that fatigue interferes with daily activities, may appear after minimal physical activity, and often prevents sustained physical functioning (Fisk et al., 1994; Krupp et al., 1988; Vercoulen et al., 1996).”
BackgroundMethodInfluentialPsychological processes associated with insomnia in patients with multiple sclerosis
Schellaert, V., Labauge, P. M., Lebrun, C., Maudarbocus, K. H., Bernard, J., Blache, J.-B., Ayrignac, X., Dalliere, C. C., Gély-Nargeot, M.-C., & Bayard, S. (2018) · SLEEP · doi:10.1093/sleep/zsy002 · Cited by 22
“Pain and fatigue are key symptoms in MS and have been rated by patients as two of their most important symptoms [37, 38].”
BackgroundAmato, M. P., Goretti, B., Morra, V. B., Gallo, P., Zaffaroni, M., ONOFRJ, M. C., Cocco, E. E., Borriello, G., Zipoli, V., & Trojano, M. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04320-w · Cited by 21
Immersive Virtual Reality and Vestibular Rehabilitation in Multiple Sclerosis: Case Report
García‐Muñoz, C., Cortés-Vega, M.-D., Hernández‐Rodríguez, J., Fernández-Seguín, L. M., Escobio-Prieto, I., & Casuso-Holgado, M. J. (2021) · JMIR Serious Games · doi:10.2196/31020 · Cited by 21
“The patient’s perceived fatigue impact was 61 out of 84 points on the Modified Fatigue Impact Scale (MFIS) [34].”
MethodInfluentialGouveia, A. C. H. B., Dias, S. P., Santos, T., Rocha, H., Coelho, C. R., Ruano, L., Galego, O., Diogo, M. C., Seixas, D., Sá, M. J., et al. (2016) · Acta Neurologica Scandinavica · doi:10.1111/ane.12702 · Cited by 21
Employment status, productivity loss, and associated factors among people with multiple sclerosis
Llorian, E. R., Zhang, W., Khakban, A., Michaux, K. D., Patten, S. B., Traboulsee, A. L., Oh, J., Kolind, S., Prat, A., Tam, R. C., et al. (2023) · Multiple Sclerosis Journal · doi:10.1177/13524585231164295 · Cited by 20
Capturing saccades in multiple sclerosis with a digitized test of rapid number naming
Hainline, C., Rizzo, J., Hudson, T. E., Dai, W., Birkemeier, J., Raynowska, J., Nolan, R. C., Hasanaj, L., Selesnick, I., Frohman, T. C., et al. (2017) · Journal of Neurology · doi:10.1007/s00415-017-8484-1 · Cited by 20
Davenport, L., Cogley, C., Monaghan, R., Gaughan, M., Yap, M., Bramham, J., Tubridy, N. J., McGuigan, C., & O’Keeffe, F. M. (2022) · Journal of Neuropsychology · doi:10.1111/jnp.12283 · Cited by 20
Bruce, J. M., Cozart, J. S., Shook, R. P., Befort, C. A., Siengsukon, C. F., Simon, S. D., LYNCH, S. G., Mahmoud, R., Drees, B. M., Posson, P., et al. (2023) · Multiple Sclerosis Journal · doi:10.1177/13524585231213241 · Cited by 20
Occupational stress and personality traits in multiple sclerosis: A preliminary study
Incerti, C. C., Magistrale, G., Argento, O., Pisani, V., Battista, G. D., Ferraro, E., Caltagirone, C., Benedict, R. H. B., & Nocentini, U. (2015) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2015.06.001 · Cited by 20
Impact of fatigue on the efficacy of rehabilitation in multiple sclerosis
Judica, E., Boneschi, F. M., Ungaro, D., Comola, M., Gatti, R., Comı, G., & Rossi, P. (2011) · Journal of Neurology · doi:10.1007/s00415-010-5851-6 · Cited by 20
“75–95% of patients during the disease course [2–5].”
BackgroundSaxton, J., Carter, A., Daley, A., Snowdon, N., Woodroofe, M. N., Petty, J., Roalfe, A. K., Tosh, J. C., & Sharrack, B. (2012) · Contemporary Clinical Trials · doi:10.1016/j.cct.2012.10.011 · Cited by 20
Sehle, A., Vieten, M., Mündermann, A., & Dettmers, C. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00279 · Cited by 22
“INTRODUCTION Fatigue is a frequent symptom in many neurologic diseases (1) and especially common and disabling in patients with multiple sclerosis (MS) (2, 3).”
BackgroundMethodAssociation of cognitive impairment and lesion volumes in multiple sclerosis – A MRI study
Yıldız, M., Tettenborn, B., Radue, E. W., Bendfeldt, K., & Borgwardt, S. (2014) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2014.09.019 · Cited by 20
Valet, M., Lejeune, T. M., Glibert, Y., Hakizimana, J.-C., Pesch, V. V., Sankari, S. E., Detrembleur, C., & Stoquart, G. G. (2017) · International Journal of Rehabilitation Research · doi:10.1097/mrr.0000000000000238 · Cited by 20
“, 2006), whereas others failed to establish such a relationship (Krupp et al., 1988; Fisk et al., 1994).”
BackgroundVienne-Jumeau, A., Oudre, L., Moreau, A., Quijoux, F., Edmond, S., Dandrieux, M., Legendre, E., Vidal, P. P., & Ricard, D. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00261 · Cited by 20
“Group EDSS MSWS FIS WA-pMS 6.5 / 6 83 / 93 56 / 70 WA-pMS 6.5 / 6.5 83 / 95 33 / 68 WA-pMS 6 / 6 20 / 62 0 / 5 WA-pMS 5.5 / 6 78 / 62 42 / 55 WA-pMS 6 / 6 63 / 58 58 / 70 NA-pMS 5 / 4.5 58 / 75 55 / 55 NA-pMS 3.5 / 3.5 88 / 57 55 / 30 NA-pMS 2.5 / 3.5 63 / 82 62 / 78 EDSS, MSWS, and FIS are displayed at M0 / M6.”
MethodInfluentialObjective electrophysiological fatigability markers and their modulation through tDCS
Linnhoff, S., Wolter-Weging, J., & Zaehle, T. (2021) · Clinical Neurophysiology · doi:10.1016/j.clinph.2021.02.391 · Cited by 21
Perfectionism and fatigue in multiple sclerosis
Beshārat, M. A., Pourhosein, R., Rostami, R., & Bazzāziān, S. (2010) · Psychology and Health · doi:10.1080/08870440903464228 · Cited by 22
“Fatigue is one of the most common and disabling symptoms in MS and has been estimated in 53–92% of patients (Bakshi et al., 2000; Colosimo, et al., 1995; Fisk, Pontefract, Ritvo, Archibald, & Murray, 1994); 53% for Colosimo et al. (1995) and 92% for Fisk et al. (1994).”
BackgroundMartínez, I. S., Sánchez, M. C. C., Román, J. L., Martinez, F. I., Guarnizo, E. C., Lallana, J. M., & Zafrilla, P. (2020) · Clinical Therapeutics · doi:10.1016/j.clinthera.2020.03.005 · Cited by 20
The Link Between Energy-Related Sensations and Metabolism: Implications for Treating Fatigue
Filippi, M., Krähenmann, R., & Fissler, P. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.920556 · Cited by 22
“Some instruments also include a motivational component, such as the Multidimensional Fatigue Inventory (MFI; Smets et al., 1995), and a social component, such as the Fatigue Impact Scale (FIS; Fisk et al., 1994).”
BackgroundRisks and benefits of multiple sclerosis therapies: need for continual assessment?
Kieseier, B. C., Wiendl, H., Hartung, H.-P., Leussink, V. I., & Stüve, O. (2011) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32834696dd · Cited by 19
Regional Frontal Perfusion Deficits in Relapsing-Remitting Multiple Sclerosis with Cognitive Decline
Vitorino, R., Hojjat, S., Cantrell, C. G., Feinstein, A., Zhang, L., Lee, L., O'Connor, P. W., Carroll, T., & Aviv, R. I. (2016) · American Journal of Neuroradiology · doi:10.3174/ajnr.a4824 · Cited by 19
Betscher, E., Guenter, W., Langdon, D. W., & Bonek, R. (2020) · Neurologia i Neurochirurgia Polska · doi:10.5603/pjnns.a2020.0080 · Cited by 19
“The MFIS is a modified form of the Fatigue Impact Scale [34].”
MethodInfluentialWork Participation and Executive Abilities in Patients with Relapsing-Remitting Multiple Sclerosis
van der Hiele, K., van Gorp, D. A. M., Ruimschotel, R. P., Kamminga, N. G. A., Visser, L. H., & Middelkoop, H. A. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129228 · Cited by 22
“The Fatigue Impact Scale was used to measure impact of MSrelated fatigue on daily life [25] resulting in scores for physical, cognitive and social fatigue.”
Modafinil’s Use in Combating Interferon-Induced Fatigue
Martin, K. A., Krahn, L. E., Balan, V., & Rosati, M. J. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9519-0 · Cited by 19
Fatigue in multiple sclerosis is not due to sleep apnoea
Wunderlin, B., Kesselring, J., Ginzler, H., Walser, B., Kühn, M., & Reinhart, W. H. (1997) · European Journal of Neurology · doi:10.1111/j.1468-1331.1997.tb00302.x · Cited by 19
Effect of Modafinil on Fatigue Associated with Neurological Illnesses
Cochran, J. W. (2000) · Journal of Chronic Fatigue Syndrome · doi:10.1300/j092v08n02_06 · Cited by 21
The Patient Experience of Fatigue in Systemic Lupus Erythematosus: A Conceptual Model
Cleanthous, S., Strzok, S., Haier, B., Cano, S., & Morel, T. (2021) · Rheumatology and Therapy · doi:10.1007/s40744-021-00374-0 · Cited by 18
“Research in other chronic inflammatory conditions, where fatigue is a prominent symptom such as multiple sclerosis (MS) [15], indicates that despite the abundance of existing fatigue scales no ‘gold standard’ exists, and fatigue measurement is fundamentally challenged by the lack of a clear definition of the phenomeno…”
BackgroundJawad, A., Baattaiah, B. A., Alharbi, M. D., Chevidikunnan, M. F., & Khan, F. R. (2023) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2023.104838 · Cited by 18
Lamb, A. L., Finlayson, M. L., Mathiowetz, V. G., & Chen, H. Y. (2005) · Clinical Rehabilitation · doi:10.1191/0269215505cr851oa · Cited by 18
Insomnia Symptoms, Subjective Appraisals, and Fatigue: A Multiple Mediation Model
Hare, C. J., Crangle, C. J., Carney, C. E., & Hart, T. L. (2017) · Behavioral Sleep Medicine · doi:10.1080/15402002.2017.1342167 · Cited by 18
Johnson, K. P. (2010) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s6743 · Cited by 18
“Fatigue is highly prevalent among patients with MS,(31,32) reported by approximately 75% of patients(33,34) and noted to be “one of the most distressing symptoms” of MS by 50% of patients.(32,33) As a result, fatigue has a major impact on productivity.”
Vore, M. E., Elgelid, S., Bolger, S., Parsons, C., Quashnoc, R., & Raymor, J. (2011) · International Journal of MS Care · doi:10.7224/1537-2073-13.3.121 · Cited by 18
Brissart, H., Sauvée, M., Latarche, C., Dillier, C., & Debouverie, M. (2010) · European Neurology · doi:10.1159/000322140 · Cited by 17
Turpin, M. J., Asano, M., & Finlayson, M. L. (2015) · International Journal of Qualitative Methods · doi:10.1177/160940691501400206 · Cited by 20
Alteration of motor nerve recovery cycle in multiple sclerosis
Boërio, D., Créange, A., Hogrel, J., & Lefaucheur, J. (2007) · Clinical Neurophysiology · doi:10.1016/j.clinph.2007.04.025 · Cited by 18
Hubbard, N. A., Turner, M. P., Ouyang, M., Himes, L. M., Thomas, B. P., Hutchison, J. L., Faghihahmadabadi, S., Davis, S. L., Strain, J. F., Spence, J. S., et al. (2017) · Human Brain Mapping · doi:10.1002/hbm.23727 · Cited by 17
“Patients completed standard neuropsychological and clinical measures, as well as measures of symptom severity (Modified Fatigue Impact Scale [MFIS; Fisk et al., 1994] and a neurological disability scale [Verdier-Taillefer et al.”
BackgroundMethodDymecka, J., Gerymski, R., Татаруч, Р., & Bidzan, M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11061716 · Cited by 20
Petruzzello, S. J., & Motl, R. W. (2011) · Mental health and physical activity · doi:10.1016/j.mhpa.2011.04.002 · Cited by 17
Mental fatigue impairs pre-attentive processing: A MMN study
Yang, B., Xiao, W. L., Liu, X., Wu, S., & Miao, D. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.08.080 · Cited by 17
How Patients With Multiple Sclerosis Perceive Cognitive Slowing
Roberg, B. L., Bruce, J. M., Lovelace, C. T., & LYNCH, S. G. (2012) · The Clinical Neuropsychologist · doi:10.1080/13854046.2012.733413 · Cited by 17
“Modified Fatigue Impact Scale-5 (MFIS-5; Fisk et al., 1994).”
MethodManaging fatigue in adults with multiple sclerosis
Hourihan, S. J. (2015) · Nursing Standard · doi:10.7748/ns.29.43.51.e9654 · Cited by 18
Pust, G. E. A., Pöttgen, J., Randerath, J., Lau, S., Heesen, C., Gold, S. M., & Penner, I. (2019) · Journal of Neurology · doi:10.1007/s00415-019-09311-2 · Cited by 17
Roppolo, M., Mulasso, A., Gollin, M., Bertolotto, A., & Ciairano, S. (2013) · Mental health and physical activity · doi:10.1016/j.mhpa.2013.05.002 · Cited by 17
Fatigue – concepts for physiotherapy management and measurement
O'Connell, C., & Stokes, E. (2007) · Physical Therapy Reviews · doi:10.1179/108331907x223100 · Cited by 17
“Three months after completing the study, the impact of fatigue, as measured by the Modified Fatigue Impact Scale (MFIS), was significantly reduced.”
BackgroundInfluentialEffects of motor-motor and motor-cognitive tasks on balance in patients with multiple sclerosis
Mercan, F., Kara, B., Tiftikçioğlu, B. İ., Mercan, E., & Sertpoyraz, F. M. (2016) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2016.03.015 · Cited by 17
“This scale includes 40 questions and assesses the amount of fatigue affected by the person’s activities of daily living (ADL) (Fisk et al., 1994).”
BackgroundHughes, A. J., Turner, A. P., Alschuler, K. N., Atkins, D. C., Beier, M. L., Amtmann, D., & Ehde, D. M. (2016) · Behavioral Sleep Medicine · doi:10.1080/15402002.2016.1173553 · Cited by 17
Managing fatigue: clinical correlates, assessment procedures and therapeutic strategies.
Penner, I., & Calabrese, P. (2010) · PubMed · Cited by 17
Wang, Z., Liu, M., Cai, Z., Ding, Q., Hu, Y., & Cui, L. (2020) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2020.1779299 · Cited by 17
Fatigue: a common but poorly understood symptom in neurological and non-neurological diseases
Penner, I., Grothe, M., & Chan, A. (2025) · Nature Reviews Neurology · doi:10.1038/s41582-025-01153-z · Cited by 20
“Other scales, such as the Fatigue Impact Scale 10 (FIS), were initially designed with far too many items; in this case, the number of items was subsequently reduced to create the Modified Fatigue Impact Scale 11 (MFIS).”
Pupil response speed as a marker of cognitive fatigue in early Multiple Sclerosis☆
Guillemin, C., Hammad, G. H., Read, J., Requier, F., Charonitis, M., Delrue, G., Vandeleene, N., Lommers, É., Maquet, P., & Collette, F. (2022) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2022.104001 · Cited by 18
“Concerning eye blinks, an increased number of long blinks was observed at the end of the task, and pwMS tend to show more blinks than HC.(3) This might relate to the necessity for both groups to lubricate the eyes when cognitive demand is prolonged and fatigue arises(15), while the increased need for blinking in patie…”
BackgroundInfluentialInteroceptive and metacognitive facets of fatigue in multiple sclerosis
Rouault, M., Pereira, I., Galioulline, H., Fleming, S. M., Stephan, K. E., & Manjaly, Z. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.16048 · Cited by 21
“Fatigue is fundamentally disabling for patients and profoundly affects their quality of life (Fisk et al., 1994).”
BackgroundPapeix, C., Gambotti, L., Assouad, R., Ewenczyck, C., Tanguy, M., Pineau, F., Houis, M.-C., Mazevet, D., Maillart, É., & Lubetzki, C. (2015) · Multiple Sclerosis Journal - Experimental Translational and Clinical · doi:10.1177/2055217315608864 · Cited by 16
Predictors of Fatigue Impact in Persons With Long-Standing Multiple Sclerosis
Morrison, J. D., & Stuifbergen, A. M. (2016) · Journal of Neuroscience Nursing · doi:10.1097/jnn.0000000000000208 · Cited by 19
Kassie, S. A., Alia, J., & Hyland, L. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-049041 · Cited by 18
Genetic Variants of the BAFF Gene and Risk of Fatigue Among Patients With Primary Sjögren’s Syndrome
Flessa, C., Zampeli, E., Evangelopoulos, M., Natsis, V., Bodewes, I. L. A., Huijser, E., Versnel, M. A., Moutsopoulos, H. Μ., & Mavragani, C. P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.836824 · Cited by 16
Impact of Armodafinil on Cognition in Multiple Sclerosis
Bruce, J. M., Hancock, L. M., Roberg, B. L., Brown, A., Henkelman, E., & LYNCH, S. G. (2012) · Cognitive and Behavioral Neurology · doi:10.1097/wnn.0b013e31826df7fd · Cited by 15
Physiopathologie et traitement de la fatigue dans la sclérose en plaques
Boërio, D., Lefaucheur, J. P., Hogrel, J., & Créange, A. (2006) · Revue Neurologique · doi:10.1016/s0035-3787(06)75017-2 · Cited by 16
Association Between Glutamate Blockade and Fatigue in Patients With Multiple Sclerosis
Nourbakhsh, B., Revirajan, N., & Waubant, E. L. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.2332 · Cited by 16
Edwards, K. A., Molton, I. R., Smith, A. E., Ehde, D. M., Bombardier, C. H., Battalio, S. L., & Jensen, M. P. (2016) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2016.02.025 · Cited by 16
Multiple Sclerosis: Etiology and Treatment Strategies
Namaka, M., Turcotte, D., Leong, C., Grossberndt, A., & Klassen, D. (2008) · The Consultant Pharmacist · doi:10.4140/tcp.n.2008.886 · Cited by 16
The fatigue and quality of life in patients with chronic pulmonary diseases
Szymańska–Chabowska, A., Juzwiszyn, J., Tański, W., Świątkowski, F., Kobecki, J., & Chabowski, M. (2021) · Science Progress · doi:10.1177/00368504211044034 · Cited by 16
“87 for the total scale and its subscales.(12,13) The MFIS scale has been validated for Polish conditions.”
BackgroundTorkhani, E., Dematte, E., SLAWINSKI, J. S., Csillik, A. S., Gay, M., Bensmaïl, D., Heinzlef, O., & de Marco, G. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.767784 · Cited by 14
Sexual problems in MS: Sex differences and their impact on quality of life
Kaplan, T., Feldman, T., Healey, B., Behn, M., Glanz, B. I., & Chitnis, T. (2023) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2023.104672 · Cited by 15
Sociodemographic and Clinical Determinants of Fatigue in Multiple Sclerosis
Maier, S., Bajkó, Z., Roşescu, R., Bărcuţean, L., Sărmășan, E., Voidăzan, S. T., & Bălașa, R. (2023) · Life · doi:10.3390/life13112132 · Cited by 18
“A total score of ≤ 38 points is considered no fatigue impact, 39–58 points is considered a low fatigue impact, and ≥ 59 points is considered a high fatigue impact on the quality of life [17,20].”
BackgroundSedaghati, P., Alghosi, M., & Hosseini, F. (2023) · BMC Neurology · doi:10.1186/s12883-023-03464-4 · Cited by 18
“In addition to the limitation in MS individuals’ activities of daily living and social lives from fatigue, it also hurts cognitive functions, decreasing attention and concentration [6].”
BackgroundDrulovic, J. S., Bursac, L. O., Milojković, D., Kisić-Tepavčević, D., Gazibara, T. M., & Pekmezovic, T. D. (2012) · Disability and Rehabilitation · doi:10.3109/09638288.2012.704122 · Cited by 15
“Additionally, 15–55% of all MS patients consider fatigue as their most disabling symptom [2,3].”
BackgroundSulbutiamine shows promising results in reducing fatigue in patients with multiple sclerosis
Sevim, S., Kaleağası, H., & Taşdelen, B. (2017) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2017.05.010 · Cited by 15
“The FIS tool is composed of three subscales that describe how the fatigue impacts cognitive (10 items), physical (10 items) and psychosocial functioning (20 items) (Fisk et al., 1994b; Armutlu et al., 2007).”
BackgroundMethodFatigue Can Be Objectively Measured in Multiple Sclerosis
Gümüş, H. (2018) · Nöro Psikiyatri Arşivi · doi:10.29399/npa.23396 · Cited by 15
“It consists of 5 of the 21 items of MFIS that most strongly correlate with the total MFIS score (12, 16, 17).”
BackgroundManagement of Fatigue in Neurological disorders
Khan, F., & Amatya, B. (2018) · The Journal of the International Society of Physical and Rehabilitation Medicine · doi:10.4103/ijprm.ijprm_5_18 · Cited by 17
Zaehle, T. (2021) · Brain Sciences · doi:10.3390/brainsci11040467 · Cited by 15
“Thus, to overcome the subjective nature of fatigue measures and the associated limitations for diagnosis and intervention of MS-related fatigue, we and others [25,30] proposed a generalized fatigue taxonomy that is disease nonspecific and universally applicable.”
BackgroundThe impact of ocrelizumab on health-related quality of life in individuals with multiple sclerosis
Glanz, B. I., Zurawski, J. D., Casady, E. C., Shamah, R., Weiner, M., Chitnis, T., Weiner, H. L., & Healy, B. C. (2021) · Multiple Sclerosis Journal - Experimental Translational and Clinical · doi:10.1177/20552173211007523 · Cited by 15
Patient reported outcomes in benign multiple sclerosis
Hviid, L. E., Healy, B. C., Rintell, D. J., Chitnis, T., Weiner, H. L., & Glanz, B. I. (2011) · Multiple Sclerosis Journal · doi:10.1177/1352458511398370 · Cited by 15
Diamond, B. J., Johnson, S. K., Kaufman, M., Shiflett, S. C., & Graves, L. (2013) · EXPLORE · doi:10.1016/j.explore.2012.12.001 · Cited by 15
How Does Fatigue Affect Communication?
Hartelius, L., Burge, Å., Johansson, A., Ljungsfors, A., Mattsson, A., Winkworth, A. L., & Andersen, O. (2004) · International Journal of MS Care · doi:10.7224/1537-2073-6.2.39 · Cited by 15
Siniscalchi, A., Gallelli, L., Tolotta, G. A., Loiacono, D., & Sarro, G. D. (2010) · Clinical Therapeutics · doi:10.1016/j.clinthera.2010.10.012 · Cited by 15
Carnitine for fatigue in multiple sclerosis
Tejani, A. M., Wasdell, M. B., Spiwak, R. P., Rowell, G., & Nathwani, S. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007280.pub2 · Cited by 15
Cochrane, G. D., Christy, J. B., & Motl, R. W. (2021) · Physical Therapy · doi:10.1093/ptj/pzab168 · Cited by 14
Danciut, I., Rae, C. L., Rashid, W., Scott, J., Bozzali, M., Iancu, M., Garfinkel, S. N., Bouyagoub, S., Dowell, N. G., Langdon, D. W., et al. (2024) · Brain Communications · doi:10.1093/braincomms/fcae292 · Cited by 15
Metadata
- Authors
- Fisk, J. D., Pontefract, A., Ritvo, P. G., Archibald, C. J., & Murray, T. J.
- Affiliations
- Dalhousie University (CA)
- Corresponding author
- Fisk, John D.
- ORCID
- Fisk, John D.
- Venue
- Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
- Publisher
- Cambridge University Press (CUP)
- Published
- 1994-02
- Volume
- 21
- Issue
- 1
- Pages
- 9-14
- ISSN
- 0317-1671 (ISSN-L)
- 2057-0155
- OpenAlex
- W155259919
- Cited by
- 1,025
- References
- 26
- Citations by year
- 2026: 24 · 2025: 26 · 2024: 34 · 2023: 52 · 2022: 49 · 2021: 63 · 2020: 45 · 2019: 31 · 2018: 46 · 2017: 44 · 2016: 38 · 2015: 56 · 2014: 31 · 2013: 44 · 2012: 38
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Dalhousie University
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Keywords
- multiple sclerosis, fatigue, Fatigue Impact Scale, fatigue effects, mental health, health status, neurological deficit, hypertension, symptom burden, disease classification
- MeSH terms
- Adult, Affect, Aged, Fatigue, Female, Humans, Hypertension, Male, Mental Health, Middle Aged, Multiple Sclerosis, Psychiatric Status Rating Scales, Surveys and Questionnaires
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