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The Impact of Fatigue on Patients with Multiple Sclerosis
Open accessAbstract
Although fatigue is recognized as a symptom of MS, there have been insufficient methods for evaluating this symptom. We administered the Fatigue Impact Scale to 85 MS patients and 20 hypertensive patients. Neurologic impairment, mental health, and general health status were also assessed. MS patients reported significantly higher fatigue impact than hypertensive patients. Most MS patients reported fatigue as either their worst (14%), or one of their worst (55%) symptoms. Disease classification and neurologic impairment had little bearing on Fatigue Impact Scale scores in the MS sample. The best predictive models for mental health and general health status in the MS sample both included the Fatigue Impact Scale as a significant factor. This study demonstrates that: 1) fatigue is a very prevalent and severe problem in MS, 2) fatigue impact cannot be predicted by clinical measures of neurologic impairment, 3) fatigue has a significant effect on the mental health and general health status of MS patients.
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“is often considered to be the worst symptom of disease (Fisk et al., 1994”
From Systematic review and meta-analysis of interventions for depression and anxiety in persons with multiple sclerosis (2016) · cites this paper as Fisk et al., 1994
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“Instrument Test-retest reliability (ICC[3,1]) Internal consistency (Cronbach α) Administration time, min Cutoff score Effect size (Cohen’s d)”
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Key Measurement and Feasibility Characteristics When Selecting Outcome Measures
Elliott, D., Berney, S. C., Harrold, M., & Skinner, E. H. (2015) · Current Physical Medicine and Rehabilitation Reports · doi:10.1007/s40141-015-0099-9 · Cited by 7
“Focus Clinical Frailty Scale (CFS) [67] 1 Physical abilities/ activities 9-point (1 = very fit, 8 = very severely frail, 9 = terminally ill) \5 Stratification for planning interventions, predicting risk of institutional care and death Fatigue Severity Scale (FSS-9) [73] 9 Fatigue experience, cause and impact 7-point (…”
BackgroundOutcome measures for multiple sclerosis
Osborne, L. A., Noble, J. G., Maramba, I. D. C., Jones, K. H., Middleton, R., Lyons, R. A., Ford, D. V., & Reed, P. (2013) · Physical Therapy Reviews · doi:10.1179/1743288x13y.0000000094 · Cited by 7
Manceau, P., Latarche, C., Pittion, S., Edan, G., Seze, J. D., Massart, C., & Debouverie, M. (2014) · BMC Neurology · doi:10.1186/s12883-014-0215-y · Cited by 7
“The score on the Modified Fatigue Impact Scale (MFIS pathological if score ≥35) was noted for each patient.”
BackgroundMethodInfluentialWyrick, S. L., Parker, D., Grabowski, D., Feuling, H., & Ng, A. V. (2008) · Journal of Applied Gerontology · doi:10.1177/0733464808315288 · Cited by 7
Multiple Sclerosis Patients with Markedly Low Intrathecal Antibody Response in Sri Lanka
Gamage, S. M. K., Wijeweera, I., Adikari, S. B., Fink, K., Hillert, J. A., Fogdell‐Hahn, A., & Sominanda, A. (2018) · Multiple Sclerosis International · doi:10.1155/2018/5342936 · Cited by 7
Matešić, I., & Marčinko, I. (2020) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2020.102054 · Cited by 7
Understanding fatigue in multiple sclerosis
Chatterton, H. J., & Spearing, R. (2006) · Physical Therapy Reviews · doi:10.1179/108331906x144154 · Cited by 7
Neuropsychologic Aspects of Multiple Sclerosis
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Hatton, A. L., Williams, K., Chatfield, M. D., Hurn, S. E., Maharaj, J. N., Gane, E. M., Cattagni, T., Dixon, J., Rome, K., Kerr, G., et al. (2022) · Brain Impairment · doi:10.1017/brimp.2022.33 · Cited by 6
“Secondary patient-reported outcomes included the MS Impact Scale (Hobart et al., 2001), MSWalking Scale (Hobart et al., 2003), MS Quality of Life Instrument (Vickrey et al., 1995), Modified Fatigue Impact Scale (Fisk et al., 1992), Medical Outcomes Study Pain Effects Scale (Archibald et al., 1994), Perceived Deficits…”
BackgroundMethodInfluentialStretching is not essential for managing MS spasticity: A randomized controlled trial
Hugos, C. L., Joos, S. K., Perumean‐Chaney, S. E., Cutter, G., & Cameron, M. H. (2023) · Multiple Sclerosis Journal · doi:10.1177/13524585231215960 · Cited by 6
“…Walking Scale-12 (MSWS) measuring the impact of MS on walking, 18 the Modified Fatigue Impact Scale (MFIS) measuring the impact of fatigue, 19 the Pittsburgh Sleep Quality Index (PSQI) measuring sleep quality, 20 the Patient-Reported Outcomes Measurement Information System (PROMIS) Short…”
MethodValet, M., Stoquart, G. G., de Broglie, C., Francaux, M., & Lejeune, T. M. (2020) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.13756 · Cited by 6
“Rate of perceived exertion (RPE) was monitored every 2 minutes using the Borg scale (6-20).”
MethodPredictors of fatigue self-management behaviors in adults with multiple sclerosis
Wang, E. Q., Chang, J. H., & Plow, M. A. (2021) · Neurorehabilitation · doi:10.3233/nre-210179 · Cited by 6
“The consequences of MS fatigue can create widespread lifestyle challenges, including decreased ability to maintain employment, restricted participation in leisure activities, and disruption of interpersonal relationships (Fisk et al., 1994; Skerrett & Moss-Morris, 2006; Smith & Arnett, 2005).”
BackgroundFatigue in multiple sclerosis is a diagnostic challenge: A cross-sectional study
Hosseini, S., Yazdchi, M., Sahraian, M. A., Majidi, S., Taher, S., Hassannezhad, S., & Mosaddeghi-Heris, R. (2022) · Journal of Research in Clinical Medicine · doi:10.34172/jrcm.2022.023 · Cited by 7
Cardiopulmonary exercise testing in people with minimally impaired multiple sclerosis
Apollonatou, V., Lykouras, D., Kargiotis, O., Kasdagli, M., Λάγιου, Ό., Papathanasopoulos, P., Spiropoulos, K. V., & Karkoulias, K. (2023) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2023.105016 · Cited by 7
Principais testes utilizados na avaliação de fadiga na esclerose múltipla: revisão sistemática
Filho, H. A., de Carvalho, S. R. D. S., Dias, R. M., & Alvarenga, R. M. P. (2010) · Revista brasileira de neurologia · Cited by 6
Mezini, S., & Soundy, A. (2019) · Behavioral Sciences · doi:10.3390/bs9070070 · Cited by 6
“MSRF is frequently identified as the worst symptom related to MS [13] and associated with negative feeling and psychological distress [1,11,14,15].”
BackgroundLight therapy for multiple sclerosis-associated fatigue: a randomized, controlled phase II trial
Mateen, F. J., Vogel, A. C., Kaplan, T., Hotan, G. C., Grundy, S. J., Holroyd, K. B., Manalo, N. C., Stauder, M. J., & Videnović, A. (2020) · Journal of Neurology · doi:10.1007/s00415-020-09845-w · Cited by 8
The Relationship between Cognitive Dysfunction and Postural Stability in Multiple Sclerosis
Redlicka, J., Zielińska-Nowak, E., Lipert, A., & Miller, E. D. (2021) · Medicina · doi:10.3390/medicina58010006 · Cited by 6
“Generally, fatigue can be influenced in the motoric, psychosocial, and cognitive dimension [3].”
BackgroundValidation of a brief cross-cultural cognitive screening test in Multiple Sclerosis
Delgado‐Álvarez, A., Delgado‐Alonso, C., Goudsmit, M., Gil, M. J., Díez‐Cirarda, M., Valles‐Salgado, M., Montero‐Escribano, P., Hernández-Lorenzo, L., Matías‐Guiu, J., & Matías‐Guiu, J. A. (2022) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2022.104091 · Cited by 6
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FATIGUE AND EXPOSURE TO CIGARETTE SMOKE
Hicks, R. A., Fernandez, C., & Hicks, G. J. (2003) · Psychological Reports · doi:10.2466/pr0.2003.92.3.1040 · Cited by 6
“To do this, we asked a large group of university undergraduates to respond to a questionnaire that included a short form of the Fatigue Impact Scale (2), i.”
BackgroundInterventions for fatigue management after traumatic brain injury
Hicks, E., Senior, H., Purdy, S. C., Barker-Collo, S. L., & Larkins, B. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006448 · Cited by 6
Garis, G., Dettmers, C., Hildebrandt, A., Duning, T., & Hildebrandt, H. (2023) · Neurological Sciences · doi:10.1007/s10072-023-07042-x · Cited by 6
“Fatigue is one of the most frequent symptoms of multiple sclerosis (MS) [1] and is often defined as a subjective feeling of lack of physical and/or mental energy [2] that seriously interferes with a patient’s daily activities.”
BackgroundSchakel, W., Bode, C., van de Ven, P. M., van der Aa, H. P. A., Hulshof, C. T. J., van Rens, G. H. M. B., & van Nispen, R. M. A. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-06014-5 · Cited by 5
“The Fatigue Assessment Scale (FAS) [17], Modified Fatigue Impact Scale (MFIS) [18], Patient Health Questionnaire (PHQ-9) [19] and Adaptation to Vision Loss questionnaire (AVL-9) [20, 21] were analyzed with item response theory (IRT) models (i.e. the graded response model) to ensure these measures…”
MethodDelgado-Álvarez, A., Hernández-Lorenzo, L., Nielsen, T. R., Díez-Cirarda, M., Cuevas, C., Montero-Escribano, P., Delgado-Alonso, C., Valles‐Salgado, M., Gil-Moreno, M. J., Matías-Guíu, J., et al. (2024) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2024.105907 · Cited by 5
When fatigue postpartum is also prodromal
Balshi, A., & Bove, R. M. (2024) · Women s Health · doi:10.1177/17455057241309495 · Cited by 5
“11 Fatigue can be experienced far before onset of clear demyelinating symptoms and is considered part of the MS “prodrome.””
Sułkowski, L., Matyja, A., & Matyja, M. (2025) · Medicina · doi:10.3390/medicina61071295 · Cited by 6
“A shortened five-item version (MFIS-5) is available for quick screening, but the full version was preferred in this study for its comprehensive assessment of fatigue [27,28].”
Linnhoff, S., Kadosh, R. C., & Zaehle, T. (2026) · Psychological Medicine · doi:10.1017/s0033291725103024 · Cited by 5
“…utility of the aperiodic exponent, binary logistic mixed-effects regression models were constructed to predict fatigue status (0 = nonfatigued, 1 = fatigued) based on established cutoff scores of MFIS (>18; Fisk et al., 1994) or WEIMuS (>17; Flachenecker et al., 2006) cognitive subscales.”
Wallin, A., Franzén, E., Ekman, U., Piehl, F., & Johansson, S. (2023) · Pilot and Feasibility Studies · doi:10.1186/s40814-023-01265-7 · Cited by 5
“Further outcome measures used were: Frenchay Activities Index [46] for the frequency of social/lifestyle activities; Multiple Sclerosis Impact Scale-29 [47] for the physical and psychological impact of MS; Modified Fatigue Impact Scale [48, 49] for the impact of fatigue; Hospital Anxiety and Depression Scale [50, 51]…”
MethodDevelopment of an integrated conceptual model of multiple sclerosis spasticity
Cameron, M., Bethoux, F., Field-Fote, E., Lenderking, W., Zaiser, E., Cutts, K., Wagner, J., Berwaerts, J., & Steinerman, J. (2023) · Disability and Rehabilitation · doi:10.1080/09638288.2023.2237403 · Cited by 5
“Some patient participants felt that fatigue, which is one of the most common and debilitating symptoms of MS [31, 32], could be caused by pain (subjective experience and physical impact) and soreness from spasticity.”
BackgroundEsbrí, S. F., Tirado, A. S., Mezquita, M. Z., Segura, C. S., & Forn, C. (2023) · Multiple Sclerosis Journal - Experimental Translational and Clinical · doi:10.1177/20552173231196990 · Cited by 5
Le, H. H., Ken-Opurum, J., LaPrade, A., Maculaitis, M. C., & Sheehan, J. J. (2024) · BMC Neurology · doi:10.1186/s12883-023-03423-z · Cited by 5
“Fatigue, one of the most common symptoms of MS, is experienced by about 80% of patients with MS, of whom 55% reported it as one of the worst symptoms experienced, regardless of the level of disability [9].”
BackgroundQuiroz, M. A. D., Chicue-Cuervo, P. C., Garcia-Moreno, L., Gaviria-Carrillo, M., Talero‐Gutiérrez, C., & Palacios‐Espinosa, X. (2025) · Multiple Sclerosis Journal - Experimental Translational and Clinical · doi:10.1177/20552173241312527 · Cited by 5
Bekiari, M., Iakovidis, P., Lytras, D., Chatziprodromidou, I. P., & Dimitros, E. (2021) · International Journal of Physical Education Sports and Health · doi:10.22271/kheljournal.2021.v8.i2c.2050 · Cited by 5
Hubbard, N. A., Araujo, Y. S., Caballero, C., Ouyang, M., Turner, M. P., Himes, L. M., Faghihahmadabadi, S., Thomas, B. P., Hart, J., Huang, H., et al. (2017) · Brain Sciences · doi:10.3390/brainsci7060064 · Cited by 5
“, SF-36 [48], Modified Fatigue Impact Scale (MFIS, [49]); see Table 2 for a complete list of model variables).”
BackgroundPatel, V., & Feinstein, A. (2017) · Cognitive and Behavioral Neurology · doi:10.1097/wnn.0000000000000138 · Cited by 5
“Of particular concern is fatigue, which occurs in 50% to 90% of people with MS (Benito-León et al, 2007; Kaynak et al, 2006; Stanton et al, 2006; Strober, 2015; Van Der Werf et al, 1998) and is rated by 55% of them as one of their most challenging symptoms (Fisk et al, 1994a).”
BackgroundMethodGasper, J. M., Lewis, M. A., Kroeger, A. K., Muz, B., LaRocca, N. G., & Frankel, D. (2020) · International Journal of MS Care · doi:10.7224/1537-2073.2019-020 · Cited by 5
Ślusarz, R., Olkiewicz, J., Bonek, R., Filipska, K., Biercewicz, M., & Wiśniewski, A. (2021) · International Journal of Medical Sciences · doi:10.7150/ijms.61964 · Cited by 5
Exercise in Multiple Sclerosis – An Integral Component of Disease Management
Döring, A., Pfueller, C. F., Paul, F., & Dörr, J. (2012) · Advances in predictive, preventive and personalised medicine · doi:10.1007/978-94-007-5866-7_12 · Cited by 5
Checklist Individual Strength to measure severe fatigue in immune thrombocytopenia
van Dijk, W. E. M., Penson, A., Kuijlaars, I. A. R., Suijker, M. H., van Galen, K. P. M., Knoop, H., & Schutgens, R. E. G. (2022) · British Journal of Haematology · doi:10.1111/bjh.18031 · Cited by 5
Short-Form Prediction of WAIS-R Scores in a Sample of Individuals Diagnosed With Multiple Sclerosis
Mendella, P. D., McFadden, L., Regan, J., & Medlock, L. (2000) · Applied Neuropsychology · doi:10.1207/s15324826an0702_6 · Cited by 5
Preparing entry-level practitioners for evidence-based practice
Villeneuve, M. A., & Maranda, S. (2005) · Journal of the Canadian Health Libraries Association / Journal de l Association de bilbiothèques de la santé du Canada · doi:10.5596/c05-009 · Cited by 5
“[24]) To identify perceived impact of fatigue on”
BackgroundYaldizli, Ö., Baranwal, M., Vago, S., Kreuzfelder, E., Limmroth, V., & Putzki, N. (2009) · European Neurology · doi:10.1159/000236375 · Cited by 5
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Silverman, S. C., Yang, B., Mata-Greve, F., Sajeev, N., Samiee, S., Norton, J., & Hugos, C. L. (2024) · International Journal of MS Care · doi:10.7224/1537-2073.2024-012 · Cited by 4
Validación psicométrica de la Escala de gravedad de fatiga en médicos residentes mexicanos
Duarte, R. E., Velasco, E., Sosa, J. J. S., & Lagunes, L. I. R. (2018) · Educación Médica · doi:10.1016/j.edumed.2017.11.006 · Cited by 4
Fatigue und Fatigability bei Multipler Sklerose – Leistungsbeurteilung
Dettmers, C., Schmidt, R., & Jöbges, M. (2020) · Die Rehabilitation · doi:10.1055/a-1199-2594 · Cited by 4
Akbar, N., & Finlayson, M. L. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.102911 · Cited by 4
Oliver, B. J., Walsh, K., Messier, R., Mehta, F., Cabot, A., Klawiter, E. C., Pagnotta, P., Solomon, A. J., England, S. E., & for the MS-CQI Investigators (2021) · Population Health Management · doi:10.1089/pop.2021.0040 · Cited by 4
Brain Atrophy and Physical and Cognitive Disability in Multiple Sclerosis
Casanova, I., de Silanes, C. L., Torres, L. D., Eimil, M., Gil, M. J., Oyanguren, B., Terrero, R., Sabín, J., Diaz, B. P., Saiz, M. A. D. M. B. S. B., et al. (2021) · Basic and Clinical Neuroscience Journal · doi:10.32598/bcn.2021.1893.1 · Cited by 4
“We also obtained the Beck Depression Inventory-II (BDI-II) (Sacco et al., 2016)and the Multiple Sclerosis Fatigue Scale (Fisk et al., 1994; Casanova et al., 2000).”
MethodAre near visual signs and symptoms in multiple sclerosis compatible with convergence insufficiency?
Gil‐Casas, A., Pinero, D. P., & Molina‐Martín, A. (2021) · Clinical and Experimental Optometry · doi:10.1080/08164622.2021.1961566 · Cited by 4
Lees, S., Dicker, M., Ku, J. E., Chaganti, V., Mew-Sum, M., Wang, N., Smith, A., Oldmeadow, C. J., Goon, W. L., Bevan, M., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-051509 · Cited by 4
Romano, S., Caltagirone, C., & Nocentini, U. (2012) · Springer eBooks · doi:10.1007/978-88-470-2676-6_3 · Cited by 4
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Xu, Y., Lizarondo, L. M., Zhao, Y., Quan, C., & Cao, Y. (2023) · International Journal of Evidence-Based Healthcare · doi:10.1097/xeb.0000000000000389 · Cited by 4
“6 – 8 Fisk et al. 9 showed that the symptoms of MS can affect both mental health and general health, and consequently, the disease requires greater attention from health care workers.”
BackgroundSuperficial brain stimulation in multiple sclerosis
Schlaeger, R., Hardmeier, M., & Fuhr, P. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53497-2.00046-2 · Cited by 4
Eibner, C., Vardavas, R., Nowak, S. A., Liu, J., & Rao, P. (2019) · RAND Corporation eBooks · doi:10.7249/rr4246 · Cited by 4
DePauw, E. M., Rouhani, M., Flanagan, A. M., & Ng, A. V. (2021) · Multiple Sclerosis Journal - Experimental Translational and Clinical · doi:10.1177/20552173211028875 · Cited by 4
Memory in Polish multiple sclerosis patients - correlations with mood and fatigue
Betscher, E., Guenter, W., & Bonek, R. (2021) · Psychiatria Polska · doi:10.12740/pp/125747 · Cited by 6
Potential Benefits of Nintendo Wii Fit Among People with Multiple Sclerosis
Plow, M. A., & Finlayson, M. L. (2013) · International Journal of MS Care · doi:10.7224/1537-2073-15.s1.13 · Cited by 4
Brichetto, G., Rinaldi, S., Spallarossa, P., Battaglia, M. A., & de Carvalho, M. L. L. (2013) · Neurorehabilitation · doi:10.3233/nre-130933 · Cited by 4
Treatment of neuropsychiatric syndromes in multiple sclerosis
Patten, S. B. (2005) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.5.3.413 · Cited by 4
Trajectory of fatigue severity in natalizumab treated multiple sclerosis patients
Yıldız, M., Tettenborn, B., & Borgwardt, S. (2012) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2012.08.039 · Cited by 4
“Fatigue is one of the most debilitating symptoms in multiple clerosis (MS) [1].”
BackgroundPsychometric Features of the Persian Version of the Fatigue Impact Scale in Iranian Stroke Patients
Saneii, S. H., Heidari, M., Zaree, M., & Akbarfahimi, M. (2020) · Journal of Advances in Medical and Biomedical Research · doi:10.30699/jambs.28.127.111 · Cited by 4
“There are a lot of fatigue assessment tools available, such as the fatigue severity scale (FSS) (10), fatigue impact scale (FIS) (11), fatigue assessment scale (FAS) (12), and fatigue scale for motor and cognitive functions (FSMC) (13).”
BackgroundMethodUnderstanding fatigue in multiple sclerosis : from a psychological perspective
Bol, Y. (2010) · Research Publications (Maastricht University) · doi:10.26481/dis.20100305yb · Cited by 4
Leodori, G., Mancuso, M., Maccarrone, D., Tartaglia, M., Ianniello, A., Baione, V., Ferrazzano, G., Malimpensa, L., Belvisi, D., Berardelli, A., et al. (2024) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2024.106146 · Cited by 3
Cognitive reserve in multiple sclerosis: The role of depression and fatigue
Stein, C., O’Keeffe, F. M., Brosnan, M. B., Flynn, C., McGuigan, C., & Bramham, J. (2025) · Multiple Sclerosis Journal · doi:10.1177/13524585251338757 · Cited by 3
Glanz, B. I., Chitnis, T., Weiner, H. L., & Healy, B. C. (2025) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2025.106786 · Cited by 3
Karanfil, E., Salcı, Y., Balkan, A. F., Sütçü, G., & Tuncer, A. (2023) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2023.104522 · Cited by 3
Angelis, F. D., Nistri, R., & Wright, S. L. (2024) · CNS Drugs · doi:10.1007/s40263-024-01132-w · Cited by 3
“For example, the fatigue impact scale (FIS) is widely used to quantify the effect of fatigue on physical, cognitive and psychosocial functioning [56].”
Sundström, B., Johansson, S., & Wallin, A. (2024) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2024.106210 · Cited by 3
A psychological model of predictive factors of distress following long COVID
Brown, S. A., Holland, J. F., Gaynor, K., Bramham, J., O’Keeffe, F. M., O'Flanagan, S., Savinelli, S., Mallon, P. W. G., Feeney, E. R., Kenny, G., et al. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.12.049 · Cited by 4
Multiple sclerosis-associated fatigue
Krupp Lauren, B., & Serafin Dana, J. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9781139023986.059 · Cited by 3
Fatigue better understanding, better therapy?
Schläger, R., & Penner, K. (2006) · Schweizer Archiv für Neurologie und Psychiatrie · doi:10.4414/sanp.2006.01680 · Cited by 3
Multiple Sclerosis: Clinical Features, Immunopathogenesis, and Treatment
Lizarraga, A., & Sheremata, W. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-51220-4_2 · Cited by 3
Chung, Y. H., Jeong, A., Kim, B. J., Park, K., & Min, J. (2022) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2022.103811 · Cited by 3
Esbrí, S. F., Tirado, A. S., Sanchís-Segura, C., & Forn, C. (2022) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2022.104182 · Cited by 4
Wooliscroft, L., McCoy, S. L., Hildebrand, A. D., Rooney, W. D., Oken, B., Spain, R., Kuehl, K. S., BOURDETTE, D. N., & Cameron, M. H. (2023) · BMJ Open · doi:10.1136/bmjopen-2022-061539 · Cited by 3
“To measure fatigue, we will use the Modified Fatigue Impact Scale, 46 a multidimensional questionnaire of fatigue developed for pwMS.”
MethodMoazen, M., Mousavi-Shirazi-Fard, Z., Mazloom, Z., Izadi, S., & Ghaseminasab-Parizi, M. (2023) · Nutritional Neuroscience · doi:10.1080/1028415x.2023.2233175 · Cited by 4
“This questionnaire has been derived from the original 40-item fatigue impact scale [17] which has been modi fi ed by the multiple sclerosis quality-of-life inventory (MSQLI) panel.”
MethodBlanchard, C. C. V., Pérez, B. D. D., Tindall, T., Clarkson, K., Felmban, G., Scheffler, G., Periam, R., Lankappa, S. T., Constantinescu, C. S., das Nair, R., et al. (2023) · Open Medicine · doi:10.1515/med-2023-0814 · Cited by 3
“It is a modi fi ed form of the Fatigue Impact Scale [41] and was developed following interviews with people with MS who discussed how fatigue had impacted their daily lives.”
Influential
Metadata
- Authors
- Fisk, J. D., Pontefract, A., Ritvo, P. G., Archibald, C. J., & Murray, T. J.
- Affiliations
- Dalhousie University (CA)
- Corresponding author
- Fisk, John D.
- ORCID
- Fisk, John D.
- Venue
- Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
- Publisher
- Cambridge University Press (CUP)
- Published
- 1994-02
- Volume
- 21
- Issue
- 1
- Pages
- 9-14
- ISSN
- 0317-1671 (ISSN-L)
- 2057-0155
- OpenAlex
- W155259919
- Cited by
- 1,025
- References
- 26
- Citations by year
- 2026: 24 · 2025: 26 · 2024: 34 · 2023: 52 · 2022: 49 · 2021: 63 · 2020: 45 · 2019: 31 · 2018: 46 · 2017: 44 · 2016: 38 · 2015: 56 · 2014: 31 · 2013: 44 · 2012: 38
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Dalhousie University
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Keywords
- multiple sclerosis, fatigue, Fatigue Impact Scale, fatigue effects, mental health, health status, neurological deficit, hypertension, symptom burden, disease classification
- MeSH terms
- Adult, Affect, Aged, Fatigue, Female, Humans, Hypertension, Male, Mental Health, Middle Aged, Multiple Sclerosis, Psychiatric Status Rating Scales, Surveys and Questionnaires
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