The DOI matches its Crossref record; 25 of the 26 references it cites were found in a registry or an index.
The Impact of Fatigue on Patients with Multiple Sclerosis
Open accessAbstract
Although fatigue is recognized as a symptom of MS, there have been insufficient methods for evaluating this symptom. We administered the Fatigue Impact Scale to 85 MS patients and 20 hypertensive patients. Neurologic impairment, mental health, and general health status were also assessed. MS patients reported significantly higher fatigue impact than hypertensive patients. Most MS patients reported fatigue as either their worst (14%), or one of their worst (55%) symptoms. Disease classification and neurologic impairment had little bearing on Fatigue Impact Scale scores in the MS sample. The best predictive models for mental health and general health status in the MS sample both included the Fatigue Impact Scale as a significant factor. This study demonstrates that: 1) fatigue is a very prevalent and severe problem in MS, 2) fatigue impact cannot be predicted by clinical measures of neurologic impairment, 3) fatigue has a significant effect on the mental health and general health status of MS patients.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“is often considered to be the worst symptom of disease (Fisk et al., 1994”
From Systematic review and meta-analysis of interventions for depression and anxiety in persons with multiple sclerosis (2016) · cites this paper as Fisk et al., 1994
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
Kurtzke, J. F. (1983) · Neurology · doi:10.1212/wnl.33.11.1444 · Cited by 15,011
Krupp, L. B. (1989) · Archives of Neurology · doi:10.1001/archneur.1989.00520460115022 · Cited by 6,172
The Revised UCLA Loneliness Scale: concurrent and discriminant validity evidence
Russell, D., Peplau, L. A., & Cutrona, C. E. (1980) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.39.3.472 · Cited by 5,173
The Sickness Impact Profile: Development and Final Revision of a Health Status Measure
Bergner, M., Bobbitt, R. A., Carter, W. B., & Gilson, B. S. (1981) · Medical Care · doi:10.1097/00005650-198108000-00001 · Cited by 4,619
The structure of psychological distress and well-being in general populations.
Veit, C. T., & Ware, J. E. (1983) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.51.5.730 · Cited by 2,094
Krupp, L., Alvarez, L., LaRocca, N. G., & Lc, S. (1988) · Archives of Neurology · doi:10.1001/archneur.1988.00520280085020 · Cited by 999
Symptomatic fatigue in multiple sclerosis.
Freal, J. E., Kraft, G. H., & Coryell, J. K. (1984) · PubMed · Cited by 526
Affective Disorders in Multiple Sclerosis Review and Recommendations for Clinical Research
Minden, S. L., & Schiffer, R. B. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530010124031 · Cited by 415
Measuring quality of life in clinical trials: a taxonomy and review.
Guyatt, G. H., van Zanten, S. J. V., Feeny, D. H., & Patrick, D. L. (1989) · Europe PMC (PubMed Central) · Cited by 408
Prigatano, G. P. (1984) · Archives of Internal Medicine · doi:10.1001/archinte.1984.00350200121018 · Cited by 300
Research works printed but not linked: 4
- 1987, American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders-Revised
- Ritvo, A model of mental health in patients with multiple sclerosis, Can Psychol, 33, 391
- McNair, 1971, EDITS Manual for the Profile of Mood States
- 10.1037/0022-006x.51.5.730 · DOI
Cited by
Sorted by citations
Items 401–500 of 1,001
Bove, R. M., Musallam, A., Healy, B. C., Houtchens, M. K., Glanz, B. I., Khoury, S. J., Guttmann, C. R. G., Jager, P. L. D., & Chitnis, T. (2013) · BMC Neurology · doi:10.1186/1471-2377-13-73 · Cited by 33
“In a subgroup, the following scales were completed annually: Center for Epidemiological Studies Depression Scale (CES-D [17]), Modified Fatigue Impact Scale (MFIS [18]) for fatigue, and general quality of life (SF-36 [19]).”
MethodWahls, T. L., Scott, M. O., Al-Share, Z., Rubenstein, L. M., Darling, W. G., Carr, L. J., Smith, K. L., Chenard, C. A., LaRocca, N. G., & Snetselaar, L. G. (2018) · Trials · doi:10.1186/s13063-018-2680-x · Cited by 33
“of multiple sclerosis (MS), diminishing quality of life (QOL) and contributing to early exit from the workforce [1, 2].”
BackgroundAssessing quality of life in primary biliary cirrhosis
Rannard, A., Buck, D., Jones, D. E. J., James, O., & Jacoby, A. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(03)00323-9 · Cited by 33
Gavrilov, Y. V., Shkilnyuk, G. G., Valko, P. O., Stolyarov, I. D., Ивашкова, Е. В., Ilves, A. G., Nikiforova, I. G., Shchelkova, O. Y., Wasserman, L. I., Vais, E. E., et al. (2018) · Acta Neurologica Scandinavica · doi:10.1111/ane.12993 · Cited by 32
Welton, T., Constantinescu, C. S., Auer, D. P., & Dineen, R. A. (2020) · Brain Connectivity · doi:10.1089/brain.2019.0717 · Cited by 32
“…(Fan et al., 2002), (3) symbol digit modalities test (SDMT; visual information processing speed; Smith, 1982), (4) mod-ified fatigue impact scale (MFIS; Fisk et al., 1994), (5) Neurological Fatigue Index (NFI-MS; Mills et al., 2010), (6) Beck depression inventory 2nd edition (BDI-II; Beck et al.,…”
Linnhoff, S., Koehler, L., Haghikia, A., & Zaehle, T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.935614 · Cited by 36
“Accordingly, the fatigue syndrome can be subdivided into physical, cognitive, and psychosocial fatigue (8).”
BackgroundGhahari, S., & Packer, T. L. (2011) · Disability and Rehabilitation · doi:10.3109/09638288.2011.613518 · Cited by 37
“Interestingly, the no-intervention group, despite statistical significance, none of the improvements (overall FIS or any of its subscales) could be defined as clinically meaningful changes.”
MethodInfluentialDebouverie, M., Pittion‐Vouyovitch, S., Brissart, H., & Guillemin, F. (2008) · Journal of Neurology · doi:10.1007/s00415-008-0761-6 · Cited by 32
Kara, B., Küçük, F., Poyraz, E. C., Tomruk, M. S., & İdıman, E. (2016) · Journal of Back and Musculoskeletal Rehabilitation · doi:10.3233/bmr-150515 · Cited by 32
“This scale consists of three sub-parameters as Timed 25-Foot walk, 9-Hole Peg Test (9-HPT, dominant hand, non-dominat hand), and Paced Auditory Serial Addition Test (PASAT-3” version) [5,6].”
Psychosocial and neurological predictors of mental health in multiple sclerosis patients
Ritvo, P. G., Ftsk, J. D., Archibald, C. J., Murray, T. J., & Field, C. (1996) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(95)00027-5 · Cited by 32
Self-citationCognitive Dysfunction in Multiple Sclerosis
Glanz, B. I., & Houtchens, M. K. (2012) · Wiley eBooks · doi:10.1002/9781119963714.ch10 · Cited by 32
Work Difficulties in People with Multiple Sclerosis
Ponzio, M., Podda, J., Pignattelli, E., Verri, A. P., Persechino, B., Vitturi, B. K., Bandiera, P., Manacorda, T., Inglese, M., Durando, P., et al. (2023) · Journal of Occupational Rehabilitation · doi:10.1007/s10926-023-10149-9 · Cited by 33
“The fatigue construct has been divided into motor, psychosocial, and cognitive or mental dimensions [53].”
BackgroundA Pilot Study on Factors Involved with Work Participation in the Early Stages of Multiple Sclerosis
van der Hiele, K., Middelkoop, H. A. M., Ruimschotel, R. P., Kamminga, N. G. A., & Visser, L. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105673 · Cited by 33
“Fatigue The Fatigue Impact Scale (FIS) [23] was used to assess the impact of fatigue on daily functioning in physical, cognitive, and social dimensions.”
MethodCognitive effects of modafinil in patients with multiple sclerosis: A clinical trial.
Ford-Johnson, L., DeLuca, J., Zhang, J., Elovic, E. P., Lengenfelder, J., & Chiaravalloti, N. D. (2015) · Rehabilitation Psychology · doi:10.1037/a0039919 · Cited by 32
Predictive Models of Cognitive Fatigue in Multiple Sclerosis
Berard, J. A., Smith, A., & Walker, L. A. S. (2018) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acy014 · Cited by 32
Outcome measures for physical fatigue in individuals with multiple sclerosis: a systematic review
Sellitto, G., Morelli, A., Bassano, S., Conte, A., Baione, V., Galeoto, G., & Berardi, A. (2021) · Expert Review of Pharmacoeconomics & Outcomes Research · doi:10.1080/14737167.2021.1883430 · Cited by 32
“Stumbling, tripping, an inability to grasp, and dysarthria are the most significant consequences of fatigue [1] that badly impacts the social and working lives of people with MS [2].”
BackgroundFatigue in Survivors of Autoimmune Encephalitis
Diaz-Arias, L. A., Yeshokumar, A. K., Glassberg, B., Sumowski, J. F., Easton, A., Probasco, J. C., & Venkatesan, A. (2021) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000001064 · Cited by 31
Garis, G., Haupts, M. R., Duning, T., & Hildebrandt, H. (2022) · Neurological Sciences · doi:10.1007/s10072-022-06385-1 · Cited by 35
“Fatigue is a common and disabling symptom of persons with multiple sclerosis [1].”
BackgroundTakasaki, H., & Treleaven, J. M. (2012) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2012.12.013 · Cited by 31
Predictors of psychosocial adjustment in people with physical disease
Kocaman, N., Kutlu, Y., Özkan, M., & Özkan, S. (2007) · Journal of Clinical Nursing · doi:10.1111/j.1365-2702.2006.01809.x · Cited by 31
Fatigue and Cognition in Patients with Relapsing Multiple Sclerosis Treated with Interferon Beta
Melanson, M., Grossberndt, A., Klowak, M., Leong, C., Frost, E. E., Prout, M., Dorze, J.-A. L., Gramlich, C., Doupe, M., Wong, L., et al. (2010) · International Journal of Neuroscience · doi:10.3109/00207454.2010.511732 · Cited by 31
Leuschen, M. P., Filipi, M. L., & Healey, K. M. (2004) · Multiple Sclerosis Journal · doi:10.1191/1352458504ms1114oa · Cited by 31
Nilsagård, Y. E., Denison, E., & Gunnarsson, L. (2006) · Disability and Rehabilitation Assistive Technology · doi:10.1080/09638280500493696 · Cited by 31
“A majority of persons with MS examined in a study reported experiencing more fatigue when exposed to increasing temperatures [25,26], and fatigue per se has been reported to have a negative effect on other symptoms and signs [26].”
BackgroundUkueberuwa, D. M., & Arnett, P. A. (2014) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617714000587 · Cited by 30
The psychosocial and cognitive impact of longstanding ‘benign’ multiple sclerosis
Sayao, A., Bueno, A.-M., Devonshire, V. A., & Tremlett, H. L. (2011) · Multiple Sclerosis Journal · doi:10.1177/1352458511410343 · Cited by 30
“This is in contrast to the situation in the wider ‘general’ MS populations where no correlation was found between fatigue and EDSS.32,33 This may suggest that MS patients with low EDSS scores over the long term are somewhat protected from the development of pathological fatigue, but this hypothesis requires further st…”
ResultInfluentialWhite, A. T., VanHaitsma, T. A., Vener, J. M., & Davis, S. L. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01119.2012 · Cited by 30
“MS, multiple sclerosis; F, females; BMI, body mass index; FIS, Fatigue Impact Scale; EDSS, Expanded Disability Status Scale.”
MethodResultInfluentialAutologous hematopoietic stem cell transplantation improves fatigue in multiple sclerosis
Bose, G., Atkins, H. L., Bowman, M. A., & Freedman, M. S. (2018) · Multiple Sclerosis Journal · doi:10.1177/1352458518802544 · Cited by 30
Modafinil for treatment of fatigue in post-polio syndrome
Vasconcelos, O. M., Prokhorenko, O. A., Salajegheh, M. K., Kelley, K. F., Livornese, K., Olsen, C. H., Vo, A. H., Dalakas, M. C., Halstead, L. S., Jabbari, B., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000261912.53959.b4 · Cited by 30
Treating fatigue in patients with MS
Schwid, S. R., & Murray, T. J. (2005) · Neurology · doi:10.1212/01.wnl.0000159518.42481.5a · Cited by 30
Self-citationWalking ability, balance and accidental falls in persons with Multiple Sclerosis
Nilsagård, Y. E. (2008) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 30
Validation of the Fatigue Impact Scale in Hungarian patients with multiple sclerosis
Losonczi, E., Bencsik, K., Rajda, C., Lencsés, G., Török, M., & Vécsei, L. (2010) · Quality of Life Research · doi:10.1007/s11136-010-9749-7 · Cited by 29
“However, some investigators found no such relationship [1, 26].”
BackgroundMethodHatton, A. L., Dixon, J., Rome, K., Brauer, S., Williams, K., & Kerr, G. (2016) · Trials · doi:10.1186/s13063-016-1337-x · Cited by 29
“Scale (a questionnaire which measures how MS-related fatigue affects everyday life including physical, cognitive and psychosocial functioning [41]); Medical Outcomes Study (MOS) Pain Effects Scale (a MS-specific questionnaire which assesses how pain and disturbing sensations, such as burning or tingling, affect everyd…”
BackgroundFatigue and fluid hydration status in multiple sclerosis: A hypothesis
Cincotta, M. C., Engelhard, M., Stankey, M., & Goldman, M. D. (2016) · Multiple Sclerosis Journal · doi:10.1177/1352458516663854 · Cited by 29
Escudero‐Uribe, S., Hochsprung, A., Heredia-Camacho, B., & Izquierdo‐Ayuso, G. (2017) · Physiotherapy Canada · doi:10.3138/ptc.2016-19 · Cited by 29
“, unable to ride a stationary bicycle); (4) pregnancy; or (5) participation in any exercise programme at our unit in the preceding 3 months.”
BackgroundTheory of Mind and Executive Functions are Dissociated in Multiple Sclerosis
Batista, S., Freitas, S., Afonso, A., Macário, C., Sousa, L., Cunha, L., & Santana, I. J. (2017) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acx101 · Cited by 29
Autonomic symptom burden is an independent contributor to multiple sclerosis related fatigue
Skorić, M. K., Crnošija, L., Adamec, I., Barun, B., Gabelić, T., Smoljo, T., Stanić, I., Pavičić, T., Pavlović, I., Drulovic, J. S., et al. (2018) · Clinical Autonomic Research · doi:10.1007/s10286-018-0563-6 · Cited by 29
Exploring the Impact of Fatigue in Progressive Multiple Sclerosis: A Mixed-Methods Analysis
Penner, I., McDougall, F., Brown, T. M., Slota, C., Doward, L. C., Julian, L. J., Belachew, S. M., & Miller, D. M. (2020) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2020.102207 · Cited by 29
The Effect of Coffee and Caffeine Consumption on Patients with Multiple Sclerosis-Related Fatigue
Herden, L., & Weissert, R. (2020) · Nutrients · doi:10.3390/nu12082262 · Cited by 31
Development, standardisation and pilot testing of an online fatigue self-management program
Ghahari, S., Packer, T. L., & Passmore, A. E. (2009) · Disability and Rehabilitation · doi:10.1080/09638280902751956 · Cited by 29
“The fatigue impact scale (FIS) [45] was used to measure the impact of fatigue on individuals’ lives [46].”
MethodThe impact of a recent relapse on patient-reported outcomes in subjects with multiple sclerosis
Healy, B. C., Degano, I. R., Schreck, A., Rintell, D. J., Weiner, H. L., Chitnis, T., & Glanz, B. I. (2012) · Quality of Life Research · doi:10.1007/s11136-011-0108-0 · Cited by 29
Fatigue et sclérose en plaques
Béthoux, F. (2006) · Annales de Réadaptation et de Médecine Physique · doi:10.1016/j.annrmp.2006.04.023 · Cited by 29
The neural basis of fatigue in multiple sclerosis
Novo, A. M., Batista, S., Alves, C. D. L., d’Almeida, O. C., Marques, I. B., Macário, C., Santana, I. J., Sousa, L., Castelo-Branco, M. S., & Cunha, L. (2018) · Neurology Clinical Practice · doi:10.1212/cpj.0000000000000545 · Cited by 30
“Fatigue and depression assessment Fatigue was assessed using the Portuguese version of the Modified Fatigue Impact Scale (MFIS).(17,18) The test contains 21 items and the Portuguese version comprises 2 levels of fatigue: physical (MFISphy) and cognitive (MFIScog).”
MethodUhthoff`s phenomenon 125 years later - what do we know today?
Opara, J. A., Brola, W., Wylęgała, A., & Wylęgała, E. (2016) · PubMed Central · Cited by 29
Fidao, A., De Livera, A., Nag, N., Neate, S., Jelinek, G. A., & Simpson-Yap, S. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2020.102620 · Cited by 31
Blasiis, P. D., Siani, M. F., Fullin, A., Sansone, M., Melone, M. A. B., Sampaolo, S., Signoriello, E., & Lus, G. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.102805 · Cited by 31
Fatigue, Depression, and Anxiety in Patients with COPD, Asthma and Asthma-COPD Overlap
Homętowska, H., Klekowski, J., Świątoniowska-Lonc, N., Jankowska‐Polańska, B., & Chabowski, M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11247466 · Cited by 30
Self care programs and multiple sclerosis: Physical therapeutics treatment - literature review
Demaille-Wlodyka, S., Donzé, C., Givron, P., & Gallien, P. (2011) · Annals of Physical and Rehabilitation Medicine · doi:10.1016/j.rehab.2011.01.003 · Cited by 28
“Des échelles d’incapacité et de fatigue sont associées telles que : l’UK Neurological Disability Scale (UKNDS), Nottingham Extend Activities of Daily Living Index (NEADLI), le Barthel Index, le Standart Day Dependency Record (SDDR), le SF-36, la Modified Fatigue Impact Scale (MFIS) et le Mental Health Inventory (MH…”
BackgroundMethodInfluentialThe Swedish occupational fatigue inventory in people with multiple sclerosis
Johansson, S., Ytterberg, C., Back, B. B. H., Holmqvist, L., & von Koch, L. (2008) · Journal of Rehabilitation Medicine · doi:10.2340/16501977-0236 · Cited by 28
Conte, A., Voti, P. L., Pontecorvo, S., Quartuccio, M. E., Baione, V., Rocchi, L., Cortese, A., Bologna, M., Francia, A., & Berardelli, A. (2015) · Multiple Sclerosis Journal · doi:10.1177/1352458515619780 · Cited by 28
“Post hoc, to investigate differences in the amount of MEP increase during the train in the three groups showed that the percentage increase in the 9th and the 10th MEP in the train significantly differs in the three groups (between-group ANOVA: 9th MEP: F(2, 40) = 3.”
BackgroundMethodInfluentialRandolph, J. J., Arnett, P. A., Higginson, C. I., & Voss, W. D. (2000) · Archives of Clinical Neuropsychology · doi:10.1016/s0887-6177(99)00030-x · Cited by 28
Bomyea, J. A., Lang, A. J., Delano‐Wood, L., Jak, A. J., Hanson, K. L., Sorg, S. F., Clark, A. L., & Schiehser, D. M. (2016) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12799 · Cited by 27
Olfactory function and cognition in relapsing–remitting and secondary-progressive multiple sclerosis
Carotenuto, A., Costabile, T., Moccia, M., Falco, F., Scala, M. R., Russo, C. V., Saccà, F., Rosa, A. D., Lanzillo, R., & Morra, V. B. (2018) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2018.09.024 · Cited by 27
Carlozzi, N. E., Boileau, N. R., Murphy, S. L., Braley, T. J., & Kratz, A. L. (2019) · Journal of Health Psychology · doi:10.1177/1359105319877448 · Cited by 29
“…of the highest ranked problems for persons with fibromyalgia (FM) (Bennett et al., 2007; Mease et al., 2008; Wolfe et al., 1995a, 1995b) and multiple sclerosis (MS) (Finlayson et al., 1998; Fisk et al., 1994; Freal et al., 1984; Krupp et al., 1988; Merkelbach et al., 2002; Yorkston et al., 2012).”
BackgroundEffect of using of a lower-extremity exoskeleton on disability of people with multiple sclerosis
McGibbon, C. A., Sexton, A., Gryfe, P., Dutta, T., Jayaraman, A., Deems-Dluhy, S., Novak, A. C., Fabara, E. E., Adans-Dester, C. P., & Bonato, P. (2021) · Disability and Rehabilitation Assistive Technology · doi:10.1080/17483107.2021.1874064 · Cited by 27
Perceived Fatigue Impact and Cognitive Variability in Multiple Sclerosis
Riegler, K. E., Cadden, M. H., Guty, E. T., Bruce, J. M., & Arnett, P. A. (2021) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617721000230 · Cited by 27
Productivity loss among people with early multiple sclerosis: A Canadian study
Llorian, E. R., Zhang, W., Khakban, A., Patten, S. B., Traboulsee, A. L., Oh, J., Kolind, S., Prat, A., Tam, R. C., & Lynd, L. D. (2022) · Multiple Sclerosis Journal · doi:10.1177/13524585211069070 · Cited by 27
Spreadbury, J. H., Young, A., & Kipps, C. (2022) · Journal of Medical Internet Research · doi:10.2196/31929 · Cited by 28
Rostaminia, S., Mayberry, A., Ganesan, D., Marlin, B. M., & Gummeson, J. (2017) · Proceedings of the ACM on Interactive Mobile Wearable and Ubiquitous Technologies · doi:10.1145/3090088 · Cited by 27
“…is also important to understand how to improve quality of life for cancer patients [18, 50], parkinson’s patients [35], multiple sclerosis patients [26, 44], as well as increase awareness of mental state among the general public and improve regulation of the levels of stress in our daily lives…”
BackgroundHugos, C. L., Chen, Z., Chen, Y., Turner, A. P., Haselkorn, J. K., Chiara, T., McCoy, S. C., Bever, C. T., Cameron, M. H., BOURDETTE, D. N., et al. (2017) · Multiple Sclerosis Journal · doi:10.1177/1352458517745723 · Cited by 27
Cehelyk, E. K., Harvey, D. Y., Grubb, M. L., Jalel, R., El-Sibai, M. S., Markowitz, C., Berger, J. R., Hamilton, R. H., & Chahin, S. (2018) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2018.10.112 · Cited by 30
“Pearson correlation analyses and chi-square tests were used to study the association between key variables and two measures of performance on the BCNT: (1) overall performance, calculated as the average difference in RTs between conditions, collapsed across cycles, i.e. the interference effect and slope of the interfe…”
MethodInfluentialBallroom dance for persons with multiple sclerosis: a pilot feasibility study
Ng, A. V., Bunyan, S. L., Suh, J., Huenink, P., Gregory, T., Gambon, S., & Miller, D. M. (2019) · Disability and Rehabilitation · doi:10.1080/09638288.2018.1516817 · Cited by 28
“Symptomatic fatigue was measured with the Fatigue Impact Scale [28] where higher scores represent worse fatigue.”
MethodEgg, R., Högl, B., Glatzl, S., Beer, R., & Berger, T. (2002) · Multiple Sclerosis Journal · doi:10.1191/1352458502ms793oa · Cited by 27
Spießhoefer, J., Regmi, B., Senol, M., Jörn, B., Gorol, O., Elfeturi, M., Walterspacher, S., Giannoni, A., Kahles, F., Gloeckl, R., et al. (2024) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202309-1572oc · Cited by 28
“Participants completed clinical questionnaires to determine dyspnea on exertion (the modi fi ed Medical Research Council dyspnea scale, the Borg dyspnea scale (19), and the Clinical Respiratory Questionnaire (20)) and fatigue (the modi fi ed Fatigue Severity Index (21)).”
MethodFatigue in inflammatory bowel diseases: Relationship with age and disease activity
Pellino, G., Sciaudone, G., Caserta, V., Candilio, G., Fatico, G. S. D., Gagliardi, S., Landino, I., Patturelli, M., Riegler, G., CAPRIO, E. L. D., et al. (2014) · International Journal of Surgery · doi:10.1016/j.ijsu.2014.08.379 · Cited by 26
“With our exploratory, pilot study we were able to demonstrate that IBD-associated fatigue affects the life of IBD patients, similarly to other chronic diseases [30,43].”
BackgroundMethodDoes fatigue occur in MS patients without disability?
Alvarenga-Filho, H., Alvarenga, R. M. P., de Carvalho, S. R. D. S., Clemente, H. N., Vasconcelos, C. C. F., & Dias, R. M. (2014) · International Journal of Neuroscience · doi:10.3109/00207454.2014.909415 · Cited by 26
“The majority of our knowledge regarding the subjective experience of fatigue in MS originates from the studies that applied self-questionnaires [8, 9].”
BackgroundMethodResultInfluentialJarosz, K., Zborowska, A., & Młynarska, A. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19148625 · Cited by 28
Aging with a Disability: Physical Impairment, Pain, and Fatigue
Widerström-Noga, E. G., & Finlayson, M. L. (2010) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2009.12.010 · Cited by 26
“Up to 60% of people who have multiple sclerosis, SCI, and post-polio syndrome experience fatigue severe enough to interfere with daily activities.(34,36,70,79,80)”
Smith, C. E., & Hale, L. A. (2007) · Physical Therapy Reviews · doi:10.1179/108331907x174970 · Cited by 26
White, A. T., & Petajan, J. H. (2004) · Clinical Neurophysiology · doi:10.1016/j.clinph.2004.05.002 · Cited by 26
“All subjects completed the Fatigue Impact Scale (FIS) at each test session to evaluate total and physical fatigues (Fisk et al., 1994).”
MethodBol, Y., Duits, A. A., Vertommen-Mertens, C. E. R., Hupperts, R. M. M., Romberg-Camps, M. J. L., Verhey, F. R. J., & Vlaeyen, J. W. S. (2010) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2009.11.011 · Cited by 28
“Although several previous studies did not find any association between disease severity, as measured with the EDSS, and fatigue [38–41], our study revealed that disease severity was an independent contributor to physical fatigue only, which is in line with other findings [7].”
ResultNeuropsychiatric changes during the COVID-19 pandemic in multiple sclerosis patients
Demir, C. F., Bilek, F., & Balgetir, F. (2020) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20200122 · Cited by 26
Pathogenesis and management of multiple sclerosis revisited
Shah, A., Panchal, V. S., Patel, K. B., Alimohamed, Z., Kaka, N., Sethi, Y., & Patel, N. (2022) · Disease-a-Month · doi:10.1016/j.disamonth.2022.101497 · Cited by 28
Neuropsychological correlates of multiple sclerosis across the lifespan
Nunan-Saah, J., Paulraj, S., Waubant, E., Krupp, L., & Gomez, R. (2015) · Multiple Sclerosis · doi:10.1177/1352458515586088 · Cited by 28
de Carvalho, M. L. L., Motta, R., Konrad, G., Battaglia, M. A., & Brichetto, G. (2011) · Multiple Sclerosis Journal · doi:10.1177/1352458511415748 · Cited by 25
“Richards et al.27 found that, during a language task and after visual stimulation, EMFs increased the amount of alpha activity generated by patients with MS.”
BackgroundInfluentialPerceived Met and Unmet Health-Care Needs in a Community Population with Multiple Sclerosis
Patten, S. B., Williams, J. V. A., Lavorato, D. H., Terriff, D., Metz, L. M., Berzins, S., & Bulloch, A. G. M. (2012) · International Journal of MS Care · doi:10.7224/1537-2073-14.1.2 · Cited by 25
Effects of whole body vibration on hormonal & functional indices in patients with multiple sclerosis
Eftekhari, E., Ebrahimi, A., & Etemadifar, M. (2015) · The Indian Journal of Medical Research · doi:10.4103/0971-5916.169210 · Cited by 25
“After the training, the participants in the experimental group expressed no significant changes in the MFIS scores.”
Dymecka, J., & Bidzan, M. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15122678 · Cited by 25
Browne, R. W., Jakimovski, D., Ziliotto, N., Kühle, J., Bernardi, F., Weinstock‐Guttman, B., Zivadinov, R., & Ramanathan, M. K. (2019) · Journal of clinical lipidology · doi:10.1016/j.jacl.2019.06.003 · Cited by 24
Fatigue in Multiple Sclerosis Is Associated With Childhood Adversities
Pust, G. E. A., Dettmers, C., Randerath, J., Rahn, A. C., Heesen, C., Schmidt, R., & Gold, S. M. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00811 · Cited by 26
Coping with Multiple Sclerosis: Considerations and Interventions
McNulty, K. (2007) · Springer eBooks · doi:10.1007/978-0-387-48670-3_14 · Cited by 25
Kratz, A. L., Ehde, D. M., Hanley, M. A., Jensen, M. P., Osborne, T. L., & Kraft, G. H. (2015) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2015.10.093 · Cited by 24
“The specific aims were: (1) to determine the relative frequency and severity of eight symptoms in persons with MS; (2) to determine the extent to which MS subtype and disease progression relate to the frequency and severity of symptoms; and (3) to estimate the associations between symptom severity and both community i…”
BackgroundSimple index of functional connectivity at rest in Multiple Sclerosis fatigue
Buyukturkoglu, K., Porcaro, C., Cottone, C., Cancelli, A., Inglese, M., & Tecchio, F. (2017) · Clinical Neurophysiology · doi:10.1016/j.clinph.2017.02.010 · Cited by 24
“Fatigue levels were scored using the modified Fatigue Impact Scale (mFIS, (Fisk et al. , 1994)). mFIS identifies the physical, cognitive and psychosocial components of fatigue.”
MethodSchakel, W., Bode, C., van de Ven, P. M., van der Aa, H. P. A., Hulshof, C. T. J., van Rens, G. H. M. B., & van Nispen, R. M. A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224340 · Cited by 24
“Fatigue was defined as a latent variable with two indicators: severity as measured by the Fatigue Assessment Scale (FAS) [21] and impact on daily life as measured by the Modified Fatigue Impact Scale (MFIS) [22].”
MethodInfluentialPortaccio, E., Bellinvia, A., Razzolini, L., Pastò, L., Goretti, B., Niccolai, C., Fonderico, M., Zaffaroni, M., Pippolo, L., Moiola, L., et al. (2022) · Neurology · doi:10.1212/wnl.0000000000200115 · Cited by 24
Multiple Sclerosis Fatigue is Associated with Reduced Psychomotor Vigilance
Rotstein, D., O'Connor, P. W., Lee, L., & Murray, B. J. (2012) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100013196 · Cited by 24
Kuspinar, A., Finch, L. E., Pickard, A. S., & Mayo, N. E. (2013) · Quality of Life Research · doi:10.1007/s11136-013-0604-5 · Cited by 24
“Fatigue which affects 75–90 % of patients with MS [78–81] is not included in the EQ-5D or the HUI measures.”
BackgroundFatigue in primary biliary cirrhosis: a possible role of comorbidities
Biagini, M. R., Tozzi, A., Milani, S., Grippo, A., Amantini, A., Capanni, M., Galli, A., & Surrenti, C. (2008) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e3282f1cbda · Cited by 24
Does Fatigue Complaint Reflect Memory Impairment in Multiple Sclerosis?
Jougleux, C., Duhin, E., Deken, V., Outteryck, O., Vermersch, P., & Zéphir, H. (2014) · Multiple Sclerosis International · doi:10.1155/2014/692468 · Cited by 24
Pilot study of participating in a fatigue management programme for clients with multiple sclerosis
Twomey, F., & Robinson, K. (2010) · Disability and Rehabilitation · doi:10.3109/09638281003656578 · Cited by 26
Cognitive impact of anticholinergic medication in MS: Adding insult to injury?
Cruce, R., Vosoughi, R., & Freedman, M. S. (2012) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2012.05.002 · Cited by 24
Motor fatigability after low-intensity hand grip exercises in persons with multiple sclerosis
Severijns, D., Lemmens, M., Thoelen, R., & Feys, P. (2016) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2016.08.007 · Cited by 24
The split hand in amyotrophic lateral sclerosis: a possible role for the neuromuscular junction
de Carvalho, M. A., & Swash, M. (2019) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2019.1606245 · Cited by 24
Fatigue of cholestasis and the serotoninergic neurotransmitter system in the rat†
Çelik, T., Gören, M. Z., Çınar, K., Gürdal, H., Önder, F. O., Tan, A., Bebi̇toğlu, B. T., Bozdayi, M. A., Bozkaya, H., Uzunalımoǧlu, Ö., et al. (2005) · Hepatology · doi:10.1002/hep.20617 · Cited by 24
“7,8 Several functions of the central nervous system have been suggested to contribute to the genesis of fatigue in cholestasis: (1) the defective release of corticotrophin-releasing hormone,8-10 (2) an imbalance of manganese homeostasis in the brain,4 and (3) altered serotoninergic neurotransmission.”
BackgroundLatinsky‐Ortiz, E. M., & Strober, L. B. (2022) · Health & Social Care in the Community · doi:10.1111/hsc.13800 · Cited by 27
“2.3.3 | Disease Symptomatology (Assessment of secondary factors associated with MS) The Modified Fatigue Impact Scale (MFIS), a modified version of the FIS (Fisk et al., 1994), consists of 21 items derived from interviews with MS patients concerning how fatigue impacts their lives.”
BackgroundMethodInfluentialThe Complex Interplay Between Trait Fatigue and Cognition in Multiple Sclerosis
Guillemin, C., Lommers, É., Delrue, G., Gester, E., Maquet, P., & Collette, F. (2022) · Psychologica Belgica · doi:10.5334/pb.1125 · Cited by 23
Leodori, G., Mancuso, M., Maccarrone, D., Tartaglia, M., Ianniello, A., Certo, F., Baione, V., Ferrazzano, G., Malimpensa, L., Belvisi, D., et al. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106073 · Cited by 25
“(Fisk et al., 1994) Clinical characteristics of patients are summarized in Table 1.”
BackgroundMethodBiological outcome measurements for behavioral interventions in multiple sclerosis
Fischer, A., Heesen, C., & Gold, S. M. (2011) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285611405252 · Cited by 23
“Biology of MS-related fatigue Both physical and mental fatigue are experienced by up to two thirds of MS patients and are often perceived as the most debilitating symptoms [Stuke et al. 2009; Fisk et al. 1994].”
Gait pattern changes after six‐minute walk test in persons with multiple sclerosis
Escudero‐Uribe, S., Hochsprung, A., & Izquierdo‐Ayuso, G. (2018) · Physiotherapy Research International · doi:10.1002/pri.1741 · Cited by 24
Fuchs, T. A., Vaughn, C. B., Benedict, R. H. B., Weinstock‐Guttman, B., Choudhery, S., Carolus, K., Rooney, P., Ashton, K., Ramasamy, D. P., Jakimovski, D., et al. (2018) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2018.11.005 · Cited by 24
Giunti, G., Rivera-Romero, O., Kool, J., Bansi, J., Sevillano, J. L., Granja-Domínguez, A., Izquierdo‐Ayuso, G., & Giunta, D. H. (2020) · JMIR Research Protocols · doi:10.2196/18196 · Cited by 24
Metadata
- Authors
- Fisk, J. D., Pontefract, A., Ritvo, P. G., Archibald, C. J., & Murray, T. J.
- Affiliations
- Dalhousie University (CA)
- Corresponding author
- Fisk, John D.
- ORCID
- Fisk, John D.
- Venue
- Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
- Publisher
- Cambridge University Press (CUP)
- Published
- 1994-02
- Volume
- 21
- Issue
- 1
- Pages
- 9-14
- ISSN
- 0317-1671 (ISSN-L)
- 2057-0155
- OpenAlex
- W155259919
- Cited by
- 1,025
- References
- 26
- Citations by year
- 2026: 24 · 2025: 26 · 2024: 34 · 2023: 52 · 2022: 49 · 2021: 63 · 2020: 45 · 2019: 31 · 2018: 46 · 2017: 44 · 2016: 38 · 2015: 56 · 2014: 31 · 2013: 44 · 2012: 38
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Dalhousie University
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Keywords
- multiple sclerosis, fatigue, Fatigue Impact Scale, fatigue effects, mental health, health status, neurological deficit, hypertension, symptom burden, disease classification
- MeSH terms
- Adult, Affect, Aged, Fatigue, Female, Humans, Hypertension, Male, Mental Health, Middle Aged, Multiple Sclerosis, Psychiatric Status Rating Scales, Surveys and Questionnaires
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
