Sexual Dysfunction in Major Depression

Williams, Katherine; Reynolds, Margaret F.

doi:10.1017/s1092852900026729

Cited by 107Sexual function and dysfunction studiesSexuality, Behavior, and TechnologyAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Sexual Dysfunction in Major Depression

Williams, Katherine, Reynolds, Margaret F.·2006·CNS Spectrums

DOI 10.1017/s1092852900026729

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Abstract

Little is known about the prevalence, typology, and natural course of non—drug-induced sexual dysfunction in patients with depression. Loss of libido has been reported in various studies to affect from 25% to 75% of patients with unipolar depression, and its prevalence appears to be correlated with the severity of depression. Disorders of arousal also appear to be relatively common in both men and women with major depression, of whom ~25% may experience problems with erection or lubrication. The scant available data regarding orgasmic difficulties in patients with depression who have not yet taken antidepressant medication suggest that they are more common than in the general population. The potential causes of sexual dysfunction in patients with depression are complex and little investigated, and future research must distinguish and explore the various biological, psychological, and psychosocial factors that are likely to be involved.

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Approximately 25% of patients with major depression may experience problems with erection or lubrication.
“Approximately 25% of patients with major depression may experience problems with erection or lubrication (531).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [531]

Sexual Dysfunction in the United States: Prevalence and Predictors
Laumann, E. O., Paik, A., & Rosen, R. C. (1999) · JAMA · doi:10.1001/jama.281.6.537 · Cited by 5,119 · see citing works
Associations of Hormones and Menopausal Status With Depressed Mood in Women With No History of Depression
Freeman, E. W., Sammel, M. D., Lin, H., & Nelson, D. B. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.4.375 · Cited by 904 · see citing works
Risk for New Onset of Depression During the Menopausal Transition
Cohen, L. S., Soares, C. N., Vitonis, A. F., Otto, M. W., & Harlow, B. L. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.4.385 · Cited by 836 · see citing works
Distress about sex: a national survey of women in heterosexual relationships.
Bancroft, J., Loftus, J., & Long, J. S. (2003) · Archives of Sexual Behavior · doi:10.1023/a:1023420431760 · Cited by 774 · see citing works
Factors predisposing women to chronic pelvic pain: systematic review
Latthe, P. M., Mignini, L. E., Gray, R. G., Hills, R. K., & Khan, K. S. (2006) · BMJ · doi:10.1136/bmj.38748.697465.55 · Cited by 582 · see citing works
The Relationship Between Depressive Symptoms and Male Erectile Dysfunction: Cross-Sectional Results From the Massachusetts Male Aging Study
Araujo, A. B., Durante, R., Feldman, H. A., Goldstein, I., & McKinlay, J. B. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199807000-00011 · Cited by 576 · see citing works
Incidence and prevalence of the sexual dysfunctions: A critical review of the empirical literature
Spector, I. P., & Carey, M. P. (1990) · Archives of Sexual Behavior · doi:10.1007/bf01541933 · Cited by 557 · see citing works
Sexual dysfunction before antidepressant therapy in major depression
Kennedy, S. H., Dickens, S. E., Eisfeld, B. S., & Bagby, R. M. (1999) · Journal of Affective Disorders · doi:10.1016/s0165-0327(99)00050-6 · Cited by 412 · see citing works
Sexuality during pregnancy and after childbirth
von Sydow, K. (1999) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(98)00106-8 · Cited by 368 · see citing works
Melancholia and Depression
Jackson, S. W. (1986) · Yale University Press eBooks · doi:10.2307/j.ctt1xp3stn · Cited by 335 · see citing works
Melancholia and Depression: From Hippocratic Times to Modern Times
Jackson, S. W. (1986) · Medical Entomology and Zoology · Cited by 326 · see citing works
Increased incidence of depressive symptoms in men with erectile dysfunction
Shabsigh, R., Klein, L. T., Seidman, S., Kaplan, S. A., Lehrhoff, B. J., & Ritter, J. S. (1998) · Urology · doi:10.1016/s0090-4295(98)00292-1 · Cited by 296 · see citing works
The Relation Between Mood and Sexuality in Heterosexual Men
Bancroft, J., Janssen, E., Strong, D., Carnes, L., Vukadinovic, Z., & Long, J. S. (2003) · Archives of Sexual Behavior · doi:10.1023/a:1023409516739 · Cited by 285 · see citing works
Somatic Symptoms in Primary Affective Disorder: Presence and Relationship to the Classification of Depression
Casper, R. C. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790340082012 · Cited by 279 · see citing works
Sexual problems in healthy and depressed persons
Angst, J. (1998) · International Clinical Psychopharmacology · doi:10.1097/00004850-199807006-00001 · Cited by 273 · see citing works
The ELIXIR study: evaluation of sexual dysfunction in 4557 depressed patients in France
Bonierbale, M., Lançon, C., & Tignol, J. (2003) · Current Medical Research and Opinion · doi:10.1185/030079902125001461 · Cited by 249 · see citing works
Correlates of Circulating Androgens in Mid-Life Women: The Study of Women’s Health Across the Nation
Santoro, N., Torréns, J. I., Crawford, S. L., Allsworth, J. E., Finkelstein, J. S., Gold, E. B., Korenman, S. G., Lasley, W. L., Luborsky, J. L., McConnell, D. S., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2063 · Cited by 246 · see citing works
The Menopause and Sexual Functioning: A Review of the Population-Based Studies
Dennerstein, L., Alexander, J. L., & Kotz, K. (2003) · Annual Review of Sex Research · doi:10.1080/10532528.2003.10559811 · Cited by 238 · see citing works
Depression and sexual dysfunction
Baldwin, D. S. (2001) · British Medical Bulletin · doi:10.1093/bmb/57.1.81 · Cited by 217 · see citing works
Sexual dysfunctions in depression
Mathew, R. J., & Weinman, M. L. (1982) · Archives of Sexual Behavior · doi:10.1007/bf01541593 · Cited by 196 · see citing works
Medical and psychiatric symptoms in women with childhood sexual abuse.
Walker, E. A., Katon, W. J., Hansom, J., Harrop-Griffiths, J., Holm, L., Jones, M. L., Hickok, L. R., & Jemelka, R. P. (1992) · Psychosomatic Medicine · doi:10.1097/00006842-199211000-00005 · Cited by 193 · see citing works
The Relation Between Mood and Sexuality in Gay Men
Bancroft, J., Janssen, E., Strong, D., & Vukadinovic, Z. (2003) · Archives of Sexual Behavior · doi:10.1023/a:1023461500810 · Cited by 167 · see citing works
Risk factors for postpartum depression: a retrospective investigation at 4-weeks postnatal and a review of the literature.
McCoy, S. J. B., Beal, J. M., Shipman, S. B. M., Payton, M. E., & Watson, G. H. (2006) · PubMed · Cited by 156 · see citing works
Lifetime Psychopathology in Individuals with Low Sexual Desire
Schreiner-Engel, P., & Schiavi, R. C. (1986) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198611000-00002 · Cited by 155 · see citing works
Sexual Functioning Assessed in 4 Double-Blind Placebo- and Paroxetine-Controlled Trials of Duloxetine for Major Depressive Disorder
Delgado, P. L., Brannan, S. K., Mallinckrodt, C. H., Trân, P. V., McNamara, R. K., Wang, F., Watkin, J. G., & Detke, M. J. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0603 · Cited by 135 · see citing works
Nocturnal penile tumescence is diminished in depressed men
Thase, M. E., Reynolds, C. F., Jennings, J. R., Frank, E., Howell, J. R., Houck, P. R., Berman, S., & Kupfer, D. J. (1988) · Biological Psychiatry · doi:10.1016/0006-3223(88)90119-9 · Cited by 99 · see citing works
Hypoactive sexual desire disorder: an underestimated condition in men
MEULEMAN, E. J. H., & van Lankveld, J. J. D. M. (2005) · British Journal of Urology · doi:10.1111/j.1464-410x.2005.05285.x · Cited by 98 · see citing works
Sexual Function in Depressed Men
Nofzinger, E. A. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820130026005 · Cited by 98 · see citing works
Relationships Between Erectile Dysfunction, Depression, and Anxiety in Japanese Subjects
Sugimori, H., Yoshida, K., Tanaka, T., Baba, K., Nishida, T., Nakazawa, R., & Iwamoto, T. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.20354.x · Cited by 88 · see citing works
Mood, depression, and reproductive hormones in the menopausal transition
Schmidt, P. J. (2005) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.09.033 · Cited by 87 · see citing works
SEXUAL DYSFUNCTION IN WOMEN WITH HYPERPROLACTINEMIA: A PILOT STUDY REPORT
Kadıoğlu, P., Yalin, A. S., Tiryakioğlu, Ö., Gazioğlu, N., Oral, G., Şanlı, Ö., Önem, K., & Kadıoğlu, A. (2005) · The Journal of Urology · doi:10.1097/01.ju.0000176456.50491.51 · Cited by 81 · see citing works
Nocturnal penile tumescence in depressed men
Thase, M. E., Reynolds, C. F., Glanz, L. M., Jennings, J. R., Sewitch, D. E., Kupfer, D. J., & Frank, E. (1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.1.89 · Cited by 81 · see citing works
Prospective assessment of sexual function in women treated for recurrent major depression
Cyranowski, J. M., Frank, E., Cherry, C. R., Houck, P. R., & Kupfer, D. J. (2003) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2003.08.003 · Cited by 76 · see citing works
Effect on Sexual Function of Long-Term Treatment With Selective Serotonin Reuptake Inhibitors in Depressed Patients Treated in Primary Care
Ekselius, L., & von Knorring, L. (2001) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200104000-00006 · Cited by 75 · see citing works
Resolution of sexual dysfunction during double-blind treatment of major depression with reboxetine or paroxetine
Baldwin, D. S., Bridgman, K. M., & Buis, C. (2005) · Journal of Psychopharmacology · doi:10.1177/0269881105056666 · Cited by 72 · see citing works
PSYCHIATRIC MORBIDITY IS FREQUENTLY UNDETECTED IN PATIENTS WITH ERECTILE DYSFUNCTION
Mallis, D., Moysidis, K., Nakopoulou, E., Papaharitou, S., Konstantinos Hatzimouratidis, A., & Hatzichristou, D. G. (2005) · The Journal of Urology · doi:10.1097/01.ju.0000176746.73667.3c · Cited by 63 · see citing works
Sexual Function and Satisfaction in the Treatment of Chronic Major Depression With Nefazodone, Psychotherapy, and Their Combination
Zajecka, J., Dünner, D. L., Gelenberg, A. J., Hirschfeld, R. M. A., Kornstein, S. G., Ninan, P. T., Rush, A. J., Thase, M. E., Trivedi, M. H., Arnow, B. A., et al. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n0809 · Cited by 63 · see citing works
Erectile dysfunction: prevalence and relationship to depression, alcohol abuse and panic disorder
Okulate, G. T., Oladokun, O., & Dogunro, A. S. (2003) · General Hospital Psychiatry · doi:10.1016/s0163-8343(03)00015-x · Cited by 58 · see citing works
Gender differences in factors associated with hypoactive sexual desire
Donahey, K. M., & Carroll, R. A. (1993) · Journal of Sex & Marital Therapy · doi:10.1080/00926239308404886 · Cited by 53 · see citing works
Prevalence of Erectile Dysfunction and Active Depression: An Analytic Cross-Sectional Study of General Medical Patients
Kantor, J. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf142 · Cited by 50 · see citing works
Effect of bromocriptine on affect and libido in hyperprolactinemia
KOPPELMAN, M. C. S., Parry, B. L., Hamilton, J. A., Alagna, S. W., & Loriaux, D. L. (1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.8.1037 · Cited by 44 · see citing works
Assessment of sexual functioning in depressed patients treated with mirtazapine: a naturalistic 6-month study
Sáiz-Ruiz, J., Montes, J. M. G., Ibáñez, Á., Díaz, M., Vicente, F., Pelegrín, C., Viñas, R., Árias, F., Carrasco, J. L., & Ferrando, L. (2005) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.706 · Cited by 39 · see citing works
The Effects of Estrogen on Brain Function
Rasgon, N. (2006) · Johns Hopkins University Press eBooks · doi:10.1353/book.3239 · Cited by 25 · see citing works
Androgen Status in Healthy Premenopausal Women with Loss of Libido
Nyunt, A., Stephen, G., Gibbin, J., Durgan, L., Fielding, A., Wheeler, M., & Price, D. (2005) · Journal of Sex & Marital Therapy · doi:10.1080/00926230590475314 · Cited by 18 · see citing works
The aging male: androgens, erectile dysfunction, and depression.
Seidman, S. N. (2003) · PubMed · Cited by 11 · see citing works

Flagged first, then by citations

2 of the 47 references couldn’t be matched to a known paper.

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Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care
DE HERT, M., CORRELL, C. U., BOBES, J., CETKOVICH‐BAKMAS, M., COHEN, D., ASAI, I., DETRAUX, J., GAUTAM, S., MÖLLER, H., NDETEI, D. M., et al. (2011) · World Psychiatry · doi:10.1002/j.2051-5545.2011.tb00014.x · Cited by 2,488 · see citing works
Hypersexual disorder: A proposed diagnosis for DSM-V
Kafka, M. P. (2010) · Archives of Sexual Behavior · doi:10.1007/s10508-009-9574-7 · Cited by 1,095 · see citing works
The Safety, Tolerability and Risks Associated with the Use of Newer Generation Antidepressant Drugs: A Critical Review of the Literature
Carvalho, A. F., Sharma, M. S., Brunoni, A. R., Vieta, E., & Fava, G. A. (2016) · Psychotherapy and Psychosomatics · doi:10.1159/000447034 · Cited by 650 · see citing works
HIV and depression: 2008 review and update
Rabkin, J. G. (2008) · Current HIV/AIDS Reports · doi:10.1007/s11904-008-0025-1 · Cited by 345 · see citing works
Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment
Hill, M. N., Carrier, E. J., McLaughlin, R. J., Morrish, A. C., Meier, S. E., Hillard, C. J., & Gorzalka, B. B. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05567.x · Cited by 246 · see citing works
Sexual dysfunction in schizophrenia: focus on recent evidence
Baggaley, M. (2008) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.924 · Cited by 191 · see citing works
The impact of severe mental disorders and psychotropic medications on sexual health and its implications for clinical management
Montejo, A. L., Montejo, L., & Baldwin, D. S. (2018) · World Psychiatry · doi:10.1002/wps.20509 · Cited by 191 · see citing works
A critical review of human endotoxin administration as an experimental paradigm of depression.
DellaGioia, N., & Hannestad, J. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.07.014 · Cited by 175 · see citing works
Antidepressants and Sexual Dysfunction: Mechanisms and Clinical Implications
Clayton, A. H., Croft, H. A., & Handiwala, L. (2014) · Postgraduate Medicine · doi:10.3810/pgm.2014.03.2744 · Cited by 152 · see citing works
Assessment of sexuality among middle-aged women using the Female Sexual Function Index
Chedraui, P. A., Pérez-López, F. R., Miguel, G. S., & Ávila, C. (2009) · Climacteric · doi:10.1080/13697130802607727 · Cited by 142 · see citing works
Extended Release Quetiapine Fumarate Monotherapy in Major Depressive Disorder
Cutler, A. J., Montgomery, S., Feifel, D., Lazarus, A. L., Åström, M., & Brecher, M. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04592 · Cited by 137 · see citing works
Depression and anxiety in men with sexual dysfunction: a retrospective study
Rajkumar, R. P., & Kumaran, A. K. (2015) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2015.03.001 · Cited by 121 · see citing works
Effect of Vortioxetine vs. Escitalopram on Sexual Functioning in Adults with Well-Treated Major Depressive Disorder Experiencing SSRI-Induced Sexual Dysfunction
Jacobsen, P. L., Mahableshwarkar, A. R., Chen, Y., Chrones, L., & Clayton, A. H. (2015) · The Journal of Sexual Medicine · doi:10.1111/jsm.12980 · Cited by 118 · see citing works
Psychiatric disorders and sexual dysfunction
Waldinger, M. D. (2015) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63247-0.00027-4 · Cited by 112 · see citing works
Associations between erectile dysfunction and psychological disorders (depression and anxiety): A cross‐sectional study in a Chinese population
Yang, Y., Song, Y., Lü, Y., Xu, Y., Liu, L., & Liu, X. (2019) · Andrologia · doi:10.1111/and.13395 · Cited by 86 · see citing works
Major depression, antidepressant use, and male and female fertility
Evans-Hoeker, E. A., Eisenberg, E., Diamond, M. P., Legro, R. S., Alvero, R. J., Coutifaris, C., Casson, P. R., Christman, G. M., Hansen, K. R., Heping Zhang, D., et al. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.01.029 · Cited by 74 · see citing works
Effects of Estradiol on Learned Helplessness and Associated Remodeling of Hippocampal Spine Synapses in Female Rats
Hajszán, T., Szigeti‐Buck, K., Sallam, N. L., Bober, J., Párducz, Á., MacLusky, N. J., Léránth, C., & Duman, R. S. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.017 · Cited by 73 · see citing works
Antidepressant drugs and sexual dysfunction
Baldwin, D. S., & Foong, T. (2013) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.112.110650 · Cited by 73 · see citing works
Psychosocial Aspects of Fertility and Assisted Reproductive Technology
Stanhiser, J., & Steiner, A. Z. (2018) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2018.04.006 · Cited by 74 · see citing works
Coordination of social behaviors by the bed nucleus of the stria terminalis
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Hormones of the hypothalamic-pituitary-gonadal (HPG) axis in male depressive disorders – A systematic review and meta-analysis
Fischer, S., Ehlert, U., & Castro, R. T. A. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100792 · Cited by 66 · see citing works
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Lai, C. (2010) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318205a670 · Cited by 65 · see citing works
Female Sexual Function at Midlife and Beyond
Thomas, H. N., Neal-Perry, G. S., & Hess, R. (2018) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2018.07.013 · Cited by 65 · see citing works
Impact of Antidepressant Drugs on Sexual Function and Satisfaction
Baldwin, D. S., Manson, C., & Nowak, M. (2015) · CNS Drugs · doi:10.1007/s40263-015-0294-3 · Cited by 60 · see citing works
Continuing Medical Education: The Impact of Mental Illness and Psychotropic Medications on Sexual Functioning: The Evidence and Management (CME)
Clayton, A. H., & Balon, R. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01255.x · Cited by 58 · see citing works
Low sexual function and its associated risk factors in pre- and postmenopausal women without clinically significant depression
Verit, F. F., Verit, A., & Billurcu, N. (2009) · Maturitas · doi:10.1016/j.maturitas.2009.07.002 · Cited by 52 · see citing works
Psychological Impact and Sexual Dysfunction in Men with and without Spinal Cord Injury
Cobo‐Cuenca, A. I., Sampietro-Crespo, A., Chamorro, M. V., & Espinosa, N. M. M. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12741 · Cited by 51 · see citing works
Demographic and Psychological Factors Related to Sexual Desire among Heterosexual Women in a Relationship
McCabe, M. P., & Goldhammer, D. L. (2011) · The Journal of Sex Research · doi:10.1080/00224499.2011.569975 · Cited by 44 · see citing works
Excitation-inhibition imbalance in medial preoptic area circuits underlies chronic stress-induced depression-like states
Tao, C., Zhang, G.-W., Sun, W.-J., Huang, J. J., Zhang, L. I., & Tao, H. W. (2024) · Nature Communications · doi:10.1038/s41467-024-52727-2 · Cited by 42 · see citing works
Pharmacological and Clinical Profile of Newer Antidepressants
Dolder, C. R., Nelson, M., & Stump, A. (2010) · Drugs & Aging · doi:10.2165/11537140-000000000-00000 · Cited by 43 · see citing works
Use of selective serotonin reuptake inhibitors reduces fertility in men
Nørr, L., Bennedsen, B. E., Fedder, J., & Larsen, E. R. (2016) · Andrology · doi:10.1111/andr.12184 · Cited by 42 · see citing works
Depression severity is associated with increased risk behaviors and decreased CD4 cell counts
Taniguchi, T., Shacham, E., Önen, N. F., Grubb, J. R., & Overton, E. T. (2014) · AIDS Care · doi:10.1080/09540121.2014.880399 · Cited by 38 · see citing works
A double exposure to social defeat induces sub-chronic effects on sleep and open field behaviour in rats
Kinn, A. M., Grønli, J., Fiske, E., Kuipers, S. D., Ursin, R., Murison, R. C. C., & Portas, C. M. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.07.031 · Cited by 36 · see citing works
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Forbes, M. K., Baillie, A., Eaton, N. R., & Krueger, R. F. (2017) · The Journal of Sex Research · doi:10.1080/00224499.2016.1269306 · Cited by 34 · see citing works
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ter Kuile, M. M., Both, S., & van Uden, J. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01632.x · Cited by 33 · see citing works
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Ghajarzadeh, M., Jalilian, R., Mohammadifar, M., Sahraian, M. A., & Azimi, A. (2014) · PubMed · Cited by 31 · see citing works
Age, Gender, Depression, and Sexual Dysfunction in Taiwan
Chen, K. C., Yeh, T. L., Lee, I. H., Chen, P. S., Huang, H., Yang, Y. K., Shen, W. W., & Lu, R. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01377.x · Cited by 29 · see citing works
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Jeong, J.-Y., Lee, S. K., Kang, Y.-W., Jang, S.-N., Choi, Y. J., & Kim, D.-H. (2011) · International Journal of Impotence Research · doi:10.1038/ijir.2011.32 · Cited by 25 · see citing works
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Phan, A., IsHak, W. W., Shen, B., Fuess, J., Philip, K. J., Bresee, C. J., Czer, L. S. C., & Schwarz, E. R. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01854.x · Cited by 25 · see citing works
Tuberous sclerosis--what's new?
Osborne, J. P., Merrifield, J., & O'Callaghan, F. J. (2008) · Archives of Disease in Childhood · doi:10.1136/adc.2006.094938 · Cited by 23 · see citing works
Changes in gonadal function at different stages of chronic restraint stress-induced depression animals
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Fabre, L. F., Clayton, A. H., Smith, L. C., Goldstein, I., & Derogatis, L. R. (2012) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2011.02624.x · Cited by 18 · see citing works
From Evidence to Practice: A Comprehensive Analysis of Side Effects in Synthetic Anti-Depressant Therapy
Pannu, A. S., & Goyal, R. K. (2024) · Current Drug Safety · doi:10.2174/0115748863301630240417071353 · Cited by 21 · see citing works
The Spanish Version of the International Index of Erectile Function: Adaptation and Validation
Díaz-Mohedo, E., Sánchez, A. M., Santamaría, F. C., García, E. M., Hernández, S. H., & Hita‐Contreras, F. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20031830 · Cited by 16 · see citing works
Gender specific sexual dysfunction in patients with depression
Liu, X., Feng, Z., Galling, B., Qi, N., Zhu, X., Xiao, L., & Wang, G. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1194228 · Cited by 20 · see citing works
Evaluation of sexual dysfunction and quality of life in patients with severe mental illness: A cross-sectional study from a tertiary care center in Chhattisgarh
Aneja, J., Ghormode, D., Gupta, P. R., & Ratnani, D. (2019) · Industrial Psychiatry Journal · doi:10.4103/ipj.ipj_16_19 · Cited by 16 · see citing works
Developing More Efficacious Antidepressant Medications: Improving and Aligning Preclinical and Clinical Assessment Tools
Cryan, J. F., Sánchez, C., Dinan, T. G., & Borsini, F. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373861-5.00007-2 · Cited by 16 · see citing works
Comparative analysis of postoperative sexual dysfunction and quality of life in type a aortic dissection patients of different ages
Luo, Z.-R., Liao, D.-S., & Chen, L. (2021) · Journal of Cardiothoracic Surgery · doi:10.1186/s13019-021-01468-0 · Cited by 15 · see citing works
The Neurobiology of Psychogenic Erectile Dysfunction in the Spinal Cord
Sakamoto, H. (2010) · Journal of Andrology · doi:10.2164/jandrol.110.010041 · Cited by 15 · see citing works
Sexual Dysfunction Among Patients With Schizophrenia in Southwest Nigeria
Esan, O., & Esan, A. (2018) · Journal of Sex & Marital Therapy · doi:10.1080/0092623x.2018.1447055 · Cited by 15 · see citing works
The effect of acute bupropion on sexual motivation and behavior in the female rat
López, H. H., Wurzel, G., & Ragen, B. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.05.014 · Cited by 15 · see citing works
Sexual Dysfunction Induced by Antidepressants—A Pharmacovigilance Study Using Data from VigiBaseTM
Zeiss, R., Malejko, K., Connemann, B. J., Gahr, M., Durner, V., & Graf, H. (2024) · Pharmaceuticals · doi:10.3390/ph17070826 · Cited by 24 · see citing works
Sexual dysfunction in cervical dystonia and blepharospasm
Marek, M., Grobe‐Einsler, M., Bedarf, J. R., Wabbels, B., & Paus, S. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s175193 · Cited by 13 · see citing works
Sexual health and serotonin 4 receptor brain binding in unmedicated patients with depression—a NeuroPharm study
Rasmussen, A. L., Larsen, S. V., Ozenne, B., Köhler‐Forsberg, K., Stenbæk, D. S., Jørgensen, M. B., Giraldi, A. G. E., & Frøkjær, V. G. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02551-x · Cited by 12 · see citing works
Assessing the effect of Alpinia galanga extract on the treatment of SSRI-induced erectile dysfunction: A randomized triple-blind clinical trial
Akbarzadeh, F., Eslamzadeh, M., Behravan, G., Ebrahimi, A., Emami, S. A., Gilan, A., & Hoseinian, N. S. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1105828 · Cited by 10 · see citing works
DSM-IV Axis I Psychopathology in Males with Non-Paraphilic Hypersexual Disorder
Kafka, M. P. (2015) · Current Addiction Reports · doi:10.1007/s40429-015-0060-0 · Cited by 9 · see citing works
The Interplay of Cross‐Organ Immune Regulation in Inflammation and Cancer
Dou, J., Jiang, J., Xue, Y., Jiang, X., Jiang, Y., Xiao, P., & Xu, J. (2025) · MedComm · doi:10.1002/mco2.70249 · Cited by 9 · see citing works
Serotonin 1A receptors and sexual behavior in a genetic model of depression
Schijven, D., Sousa, V. C., Roelofs, J., Olivier, B., & Olivier, J. D. A. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.12.012 · Cited by 8 · see citing works
Evolution of sexual functioning of men through treated and untreated depression
Laforgue, E., Busnel, G., Lauzeille, D., Grall‐Bronnec, M., Cabelguen, C., Bulteau, S., Vanelle, J., Jolliet, P., Sauvaget, A., & Victorri‐Vigneau, C. (2021) · L Encéphale · doi:10.1016/j.encep.2021.06.008 · Cited by 7 · see citing works
Sexual Activity After Dysvascular Lower Extremity Amputation
Henderson, A. W., Norvell, D. C., Turner, A., Williams, R. M., Hakimi, K., & Czerniecki, J. (2016) · Rehabilitation Psychology · doi:10.1037/rep0000087 · Cited by 4 · see citing works
Review of Duloxetine and Venlafaxine in Depression
Zerjav-Lacombe, S., Tse, G., & Scott, M. J. W. (2009) · Canadian Pharmacists Journal / Revue des Pharmaciens du Canada · doi:10.3821/1913-701x-142.3.144 · Cited by 6 · see citing works
Prevalence of sexual dysfunction and its association with psychological symptoms in drug-naive major depressive disorder patients in West China
Jiang, F., Liu, Z., Wu, X., Tan, A., Qin, X., Su, R.-C., Li, H., Wang, H., Xiao, J. F., & Zhou, B. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1291988 · Cited by 5 · see citing works
Different Evaluations Exist between Men with Erectile Dysfunction and Their Female Partners When Using Erectile Hardness Model: An Interesting, Observational, and Cross‐Sectional Field Survey
Gao, J., Zhang, Y., Li, H., Gao, P., & Zhang, X. (2020) · BioMed Research International · doi:10.1155/2020/2302348 · Cited by 5 · see citing works
Sexual motivation in male rats is modulated by tropomyosin receptor kinase B (TrkB).
Hawley, W. R., & Mosura, D. E. (2018) · Behavioral Neuroscience · doi:10.1037/bne0000286 · Cited by 4 · see citing works
Sexualleben remittierter depressiver Patientinnen
Baranyi, A., Stepan, A., & Rothenhäusler, H. (2009) · Der Nervenarzt · doi:10.1007/s00115-009-2818-x · Cited by 4 · see citing works
Sexual functioning in patients with major depressive disorder in randomized placebo-controlled studies of extended release quetiapine fumarate
Clayton, A. H., Locklear, J. C., Svedsäter, H., & McIntyre, R. S. (2013) · CNS Spectrums · doi:10.1017/s1092852913000631 · Cited by 4 · see citing works
Risk assessment of the top 60 drugs for drug-related sexual dysfunction: a disproportion analysis from the Food and Drug Administration adverse event reporting system
Wu, L., Rao, M., Chen, Y., & Wang, H. (2025) · The Journal of Sexual Medicine · doi:10.1093/jsxmed/qdaf227 · Cited by 3 · see citing works
Impact of sexual dysfunction on quality of life among anxiety disorder patients
Fons, C. E. (2008) · Cited by 3 · see citing works
Impact of minimally invasive mitral valve surgery on sexual dysfunction in male patients
Yan, L., Tang, M., Dai, X.-F., Chen, L., & Fang, G. (2022) · Journal of Cardiothoracic Surgery · doi:10.1186/s13019-022-01814-w · Cited by 3 · see citing works
The clinical utility of newer antidepressant agents: Understanding the role in management of MDD
Waters, K. (2022) · Mental Health Clinician · doi:10.9740/mhc.2022.10.309 · Cited by 3 · see citing works
Psychosexual Dysfunctions in Male Patients With Diagnosis of Depression and/or Anxiety Disorders Attending Psychiatry Outpatient Clinic in Chhatrapati Shivaji Subharti Hospital, Meerut
Biswas, R. K., Choudhary, S., & Kumar, V. (2023) · Journal of Psychosexual Health · doi:10.1177/26318318231157242 · Cited by 3 · see citing works
Contemporary Vistas in Geriatric Sexuality
Mathur, S., Manohar, S., Chandran, S., Raman, R., Pereira, P., & Rao, T. S. (2019) · Journal of Psychosexual Health · doi:10.1177/2631831819862889 · Cited by 3 · see citing works
Efficacy and Safety of Toludesvenlafaxine Hydrochloride Sustained-Release Tablets on Somatic Symptoms of Major Depressive Disorder: A Prospective, Single-Arm, Multicenter Clinical Study
Wang, Y., He, M., Zhang, H., Luo, Y., Sun, X., Yao, Z., Tang, H., Yan, R., Du, X., Li, Z., et al. (2025) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s513481 · Cited by 2 · see citing works
Serotonergic activity estimated by EEG loudness-dependent auditory evoked potentials as a predictor of sexual SSRI side effects
Ketilsdottir, G. D., Ip, C.-T., Frøkjær, V. G., Giraldi, A. G. E., Jørgensen, M. B., & Jensen, K. H. R. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.11.002 · Cited by 2 · see citing works
Chronic Administration of Imipramine Normalizes Decreased Sexual Motivation and Increased Predisposition to Catalepsy Induced by Propylthiouracil in Rats
Tikhonova, M. A., Amstislavskaya, T. G., & Kulikov, V. A. (2009) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-009-9134-6 · Cited by 2 · see citing works
The Elephant in the Bedroom: Sexual Functioning in Military Populations
Wilcox, S. L., Schuyler, A. C., & Hassan, A. M. (2015) · 2015 APHA Annual Meeting & Expo (Oct. 31 - Nov. 4, 2015) · doi:10.13140/rg.2.1.4474.0648 · Cited by 2 · see citing works
Of Gods and Devils
Ellis, T. (2016) · Method & Theory in the Study of Religion · doi:10.1163/15700682-12341377 · Cited by 1 · see citing works
Sex and the Military: A model for provider education
Wilcox, S. L., Whitsett, D. P., & Finney, K. (2016) · Contemporary Behavioral Health Care · doi:10.15761/cbhc.1000114 · Cited by 1 · see citing works
Role of Medicinal Plants in Combating Anti-depressant Induced Male Infertility
Raval, M., Gori, P., Patel, S. G., & Vyas, N. Y. (2022) · Current Traditional Medicine · doi:10.2174/2215083808666220321144217 · Cited by 1 · see citing works
A study of sexual dysfunction in females having major depressive disorder
Sharma, S. (2024) · International Journal of Sexual and Reproductive Health Care · doi:10.17352/ijsrhc.000042 · Cited by 1 · see citing works
Sexual Dysfunction in Alopecia Areata: A Systematic Review
Krajewski, P. K., Złotowska, A., Szepietowski, J. C., & Saceda‐Corralo, D. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14082602 · Cited by 1 · see citing works
The Cortisol/DHEA Ratio and Sexual Function in Women with and without a History of Depression
Dundon, C. M. (2014) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont) · Cited by 1 · see citing works
La lesión medular como factor de riesgo dedisfunción sexual en el varón
García-Moreno, A.-M. L. (2013) · doi:10.14201/gredos.122996 · Cited by 1 · see citing works
The endocannabinoid system and female sexual arousal
Klein, C. (2011) · cIRcle (University of British Columbia) · doi:10.14288/1.0103333 · Cited by 1 · see citing works
Kirjallisuuskatsaus masentuneen aikuisen seksuaaliongelmista ja -ohjauksesta
Tiainen, T., & Valkonen, A. (2010) · Theseus (Ammattikorkeakoulujen)
World Psychiatryis indexed in PubMed, Current Contents/Clinical Medicine, Current Contents/Social and Behavioral Sciences, Science Citation Index, and EMBASE Âñåìèðíàÿ Ïñèõèàòðè÷åñêàÿ Àññîöèàöèÿ (ÂÏÀ)
Maj, M., Ïðåçèäåíò, È., Tasman, A., & Herrman, H. (2011)
Evidence Linking the Structure and Function of the Internal Pudendal Artery to Erectile Function: Impact of Aging, Hypertension, Antihypertensive Treatments and Lifestyle Modifications
Hannan, J. L. (2009) · QSpace (Queen's University Library)
Sex and Lifestyle
Gillman, M., & Egger, G. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-810401-9.00026-7
008 Examining Clinician Attitudes on Sexual Health Assessment after an Educational Intervention
Benyounes, J. (2019) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2019.03.465
Sexuelle Gesundheit und Lebensstil
Gillman, M., Sagner, M., & Egger, G. J. (2017) · Elsevier eBooks · doi:10.1016/b978-3-437-23274-9.00026-5
Part II: Statistics in practice: Statistics overview
Rodriguez, R. W., & Touchette, D. R. (2020) · JACCP JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY · doi:10.1002/jac5.1214
A study of the potential effect of Depression on Male Sexual Functioning
Kumar, V., & Shinde, B. B. (2020) · Indian Journal of Mental Health(IJMH) · doi:10.30877/ijmh.7.1.2020.59-65
Sexualität und Intimität bei depressiven Erkrankungen
Ebert, A. (2021) · Nervenheilkunde · doi:10.1055/a-1637-9009
P.0401 Self-reported sexual function in depressed patients and serotonin 4 receptor brain binding – a Positron Emission Tomography study
Rasmussen, A. L., Larsen, S. V., Stenbæk, D. S., Jørgensen, M. B., Giraldi, A. G. E., & Frøkjær, V. G. (2021) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2021.10.375
PREVALENCE OF SEXUAL DYSFUNCTION IN MALE PATIENTS WITH DEPRESSION: A CROSS-SECTIONAL STUDY
(2021) · International Journal of Biology Pharmacy and Allied Sciences · doi:10.31032/ijbpas/2021/10.1.1018
KAJIAN EFEK SAMPING ANTIDEPRESAN TERHADAP FUNGSI SEKSUAL
Manda, V., & Damayanti, A. (2023) · JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY · doi:10.30649/pst.v3i2.49

Sexual dysfunction secondary to depressive disorders.
Bartlik, B. D., Kocsis, J. H., Legere, R., Villaluz, J., Kossoy, A., & Gelenberg, A. J. (1999) · PubMed · Cited by 34 · see citing works
Frequency Of Sexual Dysfunction In Treated and Untreated Depressed Male Patients
Al-Jiboori, S. D. A. (2017) · AL-QADISIYAH MEDICAL JOURNAL · doi:10.28922/qmj.2007.3.4.128-138
A study to assess sexual dysfunction in patients with major depressive disorder
Maru, R. K., Jadhav, B., Shah, B. R., & Dhavale, H. S. (2019) · Open Journal of Psychiatry & Allied Sciences · doi:10.5958/2394-2061.2019.00006.5 · Cited by 4 · see citing works
Sexual dysfunction among drug-naïve depressive disorder patient in a multidisciplinary teaching hospital
Magh, S., Singh, R., & Puia, L. (2018) · Journal of Medical Society · doi:10.4103/jms.jms_8_17
Association of Major Depression With Sexual Dysfunction in Men
Fabre, L. F., Clayton, A. H., Smith, L. C., Goldstein, I., & Derogatis, L. R. (2013) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.12010004 · Cited by 27 · see citing works

Authors: Williams, K., & Reynolds, M. F.
Affiliations: Stanford Medicine (US)
Corresponding author: Williams, Katherine
ORCID: Williams, Katherine
Venue: CNS Spectrums
Publisher: Cambridge University Press (CUP)
Published: 2006
Volume: 11
Issue: S9
Pages: 19-23
ISSN: 1092-8529 (ISSN-L)
2165-6509
DOI: 10.1017/s1092852900026729
OpenAlex: W125145245
Cited by: 107
References: 47
Citations by year: 2026: 1 · 2025: 8 · 2024: 5 · 2023: 9 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 7 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 6 · 2013: 6 · 2012: 2
FWCI: 0.97
Type: journal article
Language: en
Open access: closed
Licence: www.cambridge.org/core/terms (unspecified, 3232 d)
Locations: CNS Spectrums (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
Social Sciences › Psychology › Clinical Psychology › Sexuality, Behavior, and Technology
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: sexual dysfunction, major depressive disorder, low libido, arousal disorders, erectile dysfunction, dyspareunia, orgasmic dysfunction, depression severity, prevalence, psychosocial factors, biological factors
MeSH terms: Antidepressive Agents, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Erectile Dysfunction, Male, Sexual Dysfunction, Physiological, Prevalence, Sexual Dysfunctions, Psychological

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Sexual Dysfunction in Major Depression

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