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Cited by 79Eating Disorders and BehaviorsNutrition, Health and Food BehaviorRegulation of Appetite and Obesity

Neurobiological features of binge eating disorder

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Balodis, Iris M., Grilo, Carlos M., Potenza, Marc N.·2015·CNS Spectrums
DOI 10.1017/s1092852915000814PMC PMC4658223
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Abstract

Biobehavioral features associated with binge-eating disorder (BED) have been investigated; however, few systematic reviews to date have described neuroimaging findings from studies of BED. Emerging functional and structural studies support BED as having unique and overlapping neural features as compared with other disorders. Neuroimaging studies provide evidence linking heightened responses to palatable food cues with prefrontal areas, particularly the orbitofrontal cortex (OFC), with specific relationships to hunger and reward-sensitivity measures. While few studies to date have investigated non-food-cue responses; these suggest a generalized hypofunctioning in frontostriatal areas during reward and inhibitory control processes. Early studies applying neuroimaging to treatment efforts suggest that targeting neural function underlying motivational processes may prove important in the treatment of BED.

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  • Neuroimaging studies reveal dysfunction in corticostriatal-limbic pathways in BED, particularly in the orbitofrontal cortex, nucleus accumbens, and insula.

    “Neuroimaging studies reveal dysfunction in corticostriatal-limbic pathways, particularly in the orbitofrontal cortex, nucleus accumbens, and insula [132, 133].”

    From Precision obesity medicine: A phenotype-guided framework for pharmacologic therapy across the lifespan (2025) · cites this paper as [132]

    The Food-Cue Reward Processing and Inhibitory Control sections report altered orbitofrontal cortex and insula activity in BED. Generalized Reward Processing reports reduced ventral striatal recruitment, but the copy does not identify the nucleus accumbens specifically as an affected site or establish dysfunction across a corticostriatal-limbic pathway. (LLM, conf=0.84)

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Cited by

Sorted by citations

Authors
Balodis, I. M., Grilo, C. M., & Potenza, M. N.
Affiliations
Yale University (US)
Corresponding author
Balodis, Iris M.
ORCID
Venue
CNS Spectrums
Publisher
Cambridge University Press (CUP)
Published
2015-11-04
Volume
20
Issue
6
Pages
557-565
ISSN
  • 1092-8529 (ISSN-L)
  • 2165-6509
DOI
10.1017/s1092852915000814
PMC
PMC4658223
OpenAlex
W2414464530
Cited by
79
References
14
Citations by year
2026: 7 · 2025: 7 · 2024: 7 · 2023: 8 · 2022: 6 · 2021: 9 · 2020: 14 · 2019: 7 · 2018: 7 · 2017: 4 · 2016: 3
FWCI
0.68
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified)
Locations
  • CNS Spectrums (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Drug Abuse (P20DA027844)
  • National Institute of Diabetes and Digestive and Kidney Diseases (K24DK070052)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
binge eating disorder, neuroimaging, orbitofrontal cortex, food cue reactivity, reward sensitivity, hunger, frontostriatal dysfunction, inhibitory control, motivational processes
MeSH terms
Brain, Cues, Humans, Reward, Binge-Eating Disorder, Neuroimaging

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