Cited by 501Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

Differential control over cocaine-seeking behavior by nucleus accumbens core and shell

Ito, Rutsuko, Robbins, Trevor W, Everitt, Barry J·2004·Nature Neuroscience

Abstract

Nucleus accumbens (NAc) dopamine is widely implicated in mediating the reinforcing effects of drugs of abuse. However, the precise function of the NAc itself in drug self-administration has been difficult to establish. Here we show a neural double-dissociation of the behavioral processes that underlie cocaine self-administration in rats. Whereas selective excitotoxic lesions of the NAc core had only a minor effect on the acquisition of responding for cocaine under a standard schedule of continuous reinforcement, these lesions profoundly impaired the acquisition of drug-seeking behavior that was maintained by drug-associated conditioned reinforcers and assessed using a second-order schedule of cocaine reinforcement. In contrast, selective excitotoxic lesions of the NAc shell did not impair drug self-administration or the acquisition of cocaine-seeking, but they did attenuate the psychostimulant effects of cocaine. These results further our understanding of how the NAc controls drug-seeking and drug-taking behavior.

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Crossref · 10.1038/nn1217

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Authors
Ito, R., Robbins, T. W., & Everitt, B. J.
Affiliations
University of Cambridge (GB)
Corresponding author
Everitt, Barry J
Venue
Nature Neuroscience
Published
2004-03-21
Volume
7
Issue
4
Pages
389-397
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2014459415
Cited by
501
References
50
Citations by year
2026: 8 · 2025: 7 · 2024: 12 · 2023: 15 · 2022: 10 · 2021: 21 · 2020: 20 · 2019: 17 · 2018: 14 · 2017: 25 · 2016: 20 · 2015: 18 · 2014: 30 · 2013: 31 · 2012: 34
FWCI
10.30
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
nucleus accumbens, nucleus accumbens core, nucleus accumbens shell, cocaine self-administration, cocaine-seeking behavior, second-order schedules, excitotoxic lesions, drug reinforcement, double dissociation
MeSH terms
Animals, Appetitive Behavior, Association Learning, Cocaine, Disease Models, Animal, Dose-Response Relationship, Drug, Male, Nucleus Accumbens, Rats, Inbred Strains, Reinforcement, Psychology, Self Administration, Cocaine-Related Disorders, Rats

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