Involvement of long noncoding RNAs in diseases affecting the central nervous system
Open accessAbstract
DNA sequences associated with protein-coding genes have been the primary focus of most genetic analyses of complex human diseases. Although we are rapidly gaining a comprehensive view of the etiology of certain central nervous system disorders, major gaps in our understanding persist. Recent studies have uncovered that many human genomic sequences are transcribed but not translated, generating an astounding diversity of noncoding RNAs (ncRNAs). This awareness should be taken into account when studying human diseases and may have profound implications on the development of novel biomarkers as well as therapies.
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LncRNA may become a therapeutic target for treating GARDs.
“LncRNA may thus become a therapeutic target for treating GARDs.[246]”
From RNA delivery biomaterials for the treatment of genetic and rare diseases (2019) · cites this paper as [246]
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- Authors
- Pastori, C., & Wahlestedt, C.
- Affiliations
- University of Miami (US)
- Corresponding author
- Wahlestedt, Claes
- Venue
- RNA Biology
- Publisher
- Informa UK Limited
- Published
- 2012-06
- Volume
- 9
- Issue
- 6
- Pages
- 860-870
- ISSN
- 1547-6286 (ISSN-L)
- 1555-8584
- PMC
- PMC3495748
- OpenAlex
- W1990595903
- Cited by
- 100
- References
- 138
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 8 · 2021: 12 · 2020: 9 · 2019: 11 · 2018: 10 · 2017: 5 · 2016: 12 · 2015: 10 · 2014: 8 · 2013: 10
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- RNA Biology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH084880)
- National Institute of Neurological Disorders and Stroke (R01NS063974)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- long non-coding RNA, central nervous system disorders, non-coding RNA, biomarkers, therapeutic target, neurodegenerative diseases, neurodevelopmental disorders
- MeSH terms
- Animals, Brain Neoplasms, Gene Expression Regulation, Humans, Gene Expression, Genomic Imprinting, Neurodegenerative Diseases, Chromosome Disorders, RNA, Long Noncoding
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