Cited by 102Cancer-related molecular mechanisms researchRNA Research and SplicingRNA regulation and disease

Involvement of long noncoding RNAs in diseases affecting the central nervous system

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Pastori, Chiara, Wahlestedt, Claes·2012·RNA Biology

Abstract

DNA sequences associated with protein-coding genes have been the primary focus of most genetic analyses of complex human diseases. Although we are rapidly gaining a comprehensive view of the etiology of certain central nervous system disorders, major gaps in our understanding persist. Recent studies have uncovered that many human genomic sequences are transcribed but not translated, generating an astounding diversity of noncoding RNAs (ncRNAs). This awareness should be taken into account when studying human diseases and may have profound implications on the development of novel biomarkers as well as therapies.

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Authors
Pastori, C., & Wahlestedt, C.
Affiliations
University of Miami (US)
Corresponding author
Wahlestedt, Claes
Venue
RNA Biology
Published
2012-06
Volume
9
Issue
6
Pages
860-870
ISSN
  • 1547-6286 (ISSN-L)
  • 1555-8584
OpenAlex
W1990595903
Cited by
100
References
138
Citations by year
2024: 2 · 2023: 3 · 2022: 8 · 2021: 12 · 2020: 9 · 2019: 11 · 2018: 10 · 2017: 5 · 2016: 12 · 2015: 10 · 2014: 8 · 2013: 10
FWCI
0.67
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • RNA Biology (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (R01MH084880)
  • National Institute of Neurological Disorders and Stroke (R01NS063974)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords
long non-coding RNA, central nervous system disorders, non-coding RNA, biomarkers, therapeutic target, neurodegenerative diseases, neurodevelopmental disorders
MeSH terms
Animals, Brain Neoplasms, Gene Expression Regulation, Humans, Gene Expression, Genomic Imprinting, Neurodegenerative Diseases, Chromosome Disorders, RNA, Long Noncoding

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