Proteomic changes in serum of first onset, antidepressant drug-naïve major depression patients
Open accessAbstract
Major depressive disorder (MDD) is a complex and multi-factorial disorder. Although genetic factors and other molecular aspects of MDD have been widely studied, the underlying pathological mechanisms are still mostly unknown. We sought to investigate the pathophysiology of MDD by identifying and characterising serum molecular differences and their correlation to symptom severity in first onset, antidepressant drug-naïve MDD patients. We performed an exploratory molecular profiling study on serum samples of MDD patients and controls using multiplex immunoassay and label-free liquid chromatography mass spectrometry in data independent mode (LC-MSE). We included two independent cohorts of first onset, antidepressant drug-naïve MDD patients (n = 23 and 15) and matched controls (n = 42 and 21) in our study in order to validate the results. The main outcome included the following list of circulatory molecules changing and/or correlating to symptom severity: angiotensin-converting enzyme, acute phase proteins (e.g. ferritin and serotransferrin), brain-derived neurotrophic factor, complement component C4-B, cortisol, cytokines (e.g. macrophage migration inhibitory factor and interleukin-16), extracellular newly identified receptor for advanced glycosylation end products-binding protein, growth hormone and superoxide dismutase-1. This study provides evidence of an increased pro-inflammatory and oxidative stress response, followed by a hyperactivation of the HPA-axis in the acute stages of first onset MDD, as well as a dysregulation in growth factor pathways. These findings help to elucidate MDD related pathways in more detail and further studies may lead to identification of novel drug targets, including components of the inflammatory and oxidative stress response.
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Interleukin 16 protein levels have been reported to be altered in serum samples of MDD patients and to be associated with symptom severity in schizophrenia.
“interleukin 16 protein levels have been reported to be altered in a molecular profiling study on serum samples of MDD patients (Stelzhammer et al., 2014) and to be associated with symptom severity in schizophrenia (Schwarz et al., 2012).”
From Epigenome-wide DNA methylation in unipolar depression: predictive biomarker of antidepressant treatment response? (2024) · cites this paper as Stelzhammer et al., 2014
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Cites
R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,706 · see citing works
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848 · see citing works
Macrophage migration inhibitory factor: a regulator of innate immunity
Calandra, T., & Roger, T. (2003) · Nature reviews. Immunology · doi:10.1038/nri1200 · Cited by 1,782 · see citing works
Raison, C. L., Rutherford, R. E., Woolwine, B. J., Shuo, C., Schettler, P., Drake, D. F., Haroon, E., & Miller, A. H. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.4 · Cited by 1,617 · see citing works
Nemeroff, C. B., Widerlöv, E., Bissette, G., Walléus, H., Karlsson, I., Eklund, K., Kilts, C. D., Loosen, P. T., & Vale, W. (1984) · Science · doi:10.1126/science.6334362 · Cited by 1,485 · see citing works
Sen, S., Duman, R., & Sanacora, G. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.005 · Cited by 1,232 · see citing works
Brunoni, A. R., Lopes, M., & Fregni, F. (2008) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009309 · Cited by 972 · see citing works
Bilici, M., Efe, H., Köroğlu, M. A., Uydu, H. A., Bekaroğlu, M., & Değer, O. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00199-3 · Cited by 718 · see citing works
D, M. F. M., & Kendler, K. S. (2000) · Neuron · doi:10.1016/s0896-6273(00)00112-4 · Cited by 619 · see citing works
Li, G.-Z., Vissers, J., Silva, J. C., Golick, D., Gorenstein, M., & Geromanos, S. (2009) · Proteomics · doi:10.1002/pmic.200800564 · Cited by 553 · see citing works
Maes, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.06.014 · Cited by 544 · see citing works
Engelmann, M., Landgraf, R., & Wotjak, C. T. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.09.001 · Cited by 450 · see citing works
Domenici, E., Willé, D. R., Tozzi, F., Prokopenko, I., Miller, S. L., McKeown, A., Brittain, C. F., Rujescu, D., Giegling, I., Turck, C. W., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009166 · Cited by 347 · see citing works
The psychoneuroimmuno-pathophysiology of cytokine-induced depression in humans
Wichers, M., & Maes, M. (2002) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145702003103 · Cited by 329 · see citing works
Herken, H., Gurel, A., Selek, S., Armutcu, F., Ozen, M. E., Bulut, M., Kap, O., Yumru, M., Savas, H. A., & Akyol, O. (2007) · Archives of Medical Research · doi:10.1016/j.arcmed.2006.10.005 · Cited by 322 · see citing works
Capuron, L., Ravaud, A., & Dantzer, R. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.10.2143 · Cited by 293 · see citing works
A detailed examination of cytokine abnormalities in Major Depressive Disorder
Simon, N. M., McNamara, K., Chow, C. W., Maser, R. S., Papakostas, G. I., Pollack, M. H., Nierenberg, A. A., Fava, M., & Wong, K. K. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.06.004 · Cited by 286 · see citing works
The significance of ferritin in cancer: Anti-oxidation, inflammation and tumorigenesis
Alkhateeb, A. A., & Connor, J. R. (2013) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2013.07.002 · Cited by 246 · see citing works
Smoking, cortisol and nicotine
Steptoe, A., & USSHER, M. H. (2005) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2005.10.011 · Cited by 225 · see citing works
Inflammatory mechanisms in major depressive disorder
Raedler, T. J. (2011) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32834b9db6 · Cited by 213 · see citing works
The blood brain barrier and the role of cytokines in neuropsychiatry.
Yarlagadda, A., Alfson, E. D., & Clayton, A. H. (2009) · PubMed Central · Cited by 199 · see citing works
CSF corticotropin-releasing hormone in depressed patients and normal control subjects
Roy, A., Pickar, D., Paul, S. M., Doran, A., Chrousos, G. P., & Gold, P. W. (1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.5.641 · Cited by 183 · see citing works
Proteomics technologies for the global identification and quantification of proteins
Brewis, I. A., & Brennan, P. (2010) · Advances in protein chemistry and structural biology · doi:10.1016/b978-0-12-381264-3.00001-1 · Cited by 171 · see citing works
Schwarz, E., Izmailov, R., Spain, M., Barnes, A., Mapes, J. P., Guest, P. C., Rahmoune, H., Pietsch, S., Leweke, F. M., Rothermundt, M., et al. (2010) · Biomarker Insights · doi:10.4137/bmi.s4877 · Cited by 160 · see citing works
Elevated levels of acute phase plasma proteins in major depression
Joyce, P. R., Hawes, C. R., Mulder, R., Sellman, J. D., Wilson, D. A., & Boswell, D. R. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90065-8 · Cited by 134 · see citing works
Plasma-soluble interleukin-2 and transferrin receptor in schizoprenia and major depression
Maes, M. H. J., Meltzer, H. Y., Buckley, P. F., & Bosmans, E. (1995) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02190412 · Cited by 128 · see citing works
Musil, R., Schwarz, M., Riedel, M. J., Dehning, S., Cerovecki, A., Spellmann, I., Arolt, V., & Müller, N. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.05.047 · Cited by 125 · see citing works
COX-2 inhibitors as antidepressants and antipsychotics: clinical evidence.
Müller, N. (2010) · PubMed · Cited by 122 · see citing works
Stress and Depression: Preclinical Research and Clinical Implications
Bartolomucci, A., & Leopardi, R. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004265 · Cited by 111 · see citing works
Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein
Nielsen, M. J., Petersen, S. V., Jacobsen, C. B., Oxvig, C., Rees, D. C., Møller, H. J., & Moestrup, S. K. (2006) · Blood · doi:10.1182/blood-2006-05-022327 · Cited by 107 · see citing works
Renin–angiotensin-system gene polymorphisms and depression
Saab, Y. B., Gard, P. R., Yeoman, M. S., Mfarrej, B. G., El-Moalem, H. E., & Ingram, M. J. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.04.002 · Cited by 87 · see citing works
Bertenshaw, G. P., Yip, P. F., Seshaiah, P., Zhao, J., Chen, T., Wiggins, W. S., Mapes, J. P., & Mansfield, B. C. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0464 · Cited by 82 · see citing works
Plasma copper, iron, ceruloplasmin and ferroxidase activity in schizophrenia
Wolf, T. L., Kotun, J., & Meador‐Woodruff, J. H. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.05.027 · Cited by 76 · see citing works
Major depression during interferon-α treatment: vulnerability and prevention
Lotrich, F. E. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.4/felotrich · Cited by 71 · see citing works
Neurobiological effects of lumbar puncture stress in psychiatric patients and healthy volunteers
Breier, A. F., Wolkowitz, O. M., Doran, A. R., Bellar, S., & Pickar, D. (1988) · Psychiatry Research · doi:10.1016/0165-1781(88)90050-9 · Cited by 68 · see citing works
Angelucci, F., Aloe, L., Jiménez-Vasquez, P. A., & Mathé, A. A. (2002) · Journal of Ect · doi:10.1097/00124509-200209000-00005 · Cited by 67 · see citing works
Gans, R. O. B. (2006) · Medical Clinics of North America · doi:10.1016/j.mcna.2006.05.002 · Cited by 64 · see citing works
Krishnamurthy, D., Harris, L. W., Levin, Y., Koutroukides, T. A., Rahmoune, H., Pietsch, S., Vanattou‐Saïfoudine, N., Leweke, F. M., Guest, P. C., & Bahn, S. (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.601759 · Cited by 52 · see citing works
Low serum albumin and high ferritin levels in chronichemodialysis patients with major depression
Huang, T., & Lee, C. (2007) · Psychiatry Research · doi:10.1016/j.psychres.2005.07.038 · Cited by 45 · see citing works
Acute phase proteins as biological markers of negative psychopathology in paranoid schizophrenia.
Morera, A. M., Henry, M., García-Hernández, A., & Fernández-López, L. (2007) · PubMed · Cited by 40 · see citing works
Affinity Depletion of Plasma and Serum for Mass Spectrometry-Based Proteome Analysis
Jaros, J. A. J., Guest, P. C., Bahn, S., & Martins‐de‐Souza, D. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-360-2_1 · Cited by 38 · see citing works
A Combined Study of Cortisol, ACTH and Dexamethasone Concentrations in Major Depression
Charlton, B. G., Leake, A., Wright, C., Griffiths, H. W., & Ferrier, I. N. (1987) · The British Journal of Psychiatry · doi:10.1192/bjp.150.6.791 · Cited by 28 · see citing works
Levin, Y., Jaros, J. A. J., Schwarz, E., & Bahn, S. (2009) · Journal of Proteomics · doi:10.1016/j.jprot.2009.10.013 · Cited by 26 · see citing works
Stelzhammer, V., Rothermundt, M., Guest, P. C., Michael, N., Sondermann, C., Kluge, W. F., Martins‐de‐Souza, D., Rahmoune, H., & Bahn, S. (2011) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201100040 · Cited by 20 · see citing works
Using nonevidence-based approaches to treat patients with alzheimer's disease.
Howe, E. G. (2009) · Europe PMC (PubMed Central) · Cited by 3 · see citing works
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Biomarkers for depression: recent insights, current challenges and future prospects
Strawbridge, R., Young, A. H., & Cleare, A. J. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s114542 · Cited by 415 · see citing works
Nutritional Aspects of Depression
Lang, U. E., Beglinger, C., Schweinfurth, N., Walter, M., & Borgwardt, S. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430229 · Cited by 246 · see citing works
Gadad, B. S., Jha, M. K., Czysz, A., Furman, J. L., Mayes, T. L., Emslie, M. P., & Trivedi, M. H. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.07.001 · Cited by 205 · see citing works
Peripheral Markers of Depression
Nobis, A., Zalewski, D., & Waszkiewicz, N. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9123793 · Cited by 197 · see citing works
The Role of Tryptophan Metabolites in Neuropsychiatric Disorders
Davidson, M., Rashidi, N., Nurgali, K., & Apostolopoulos, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179968 · Cited by 180 · see citing works
Inflammation and neuronal plasticity: a link between childhood trauma and depression pathogenesis
Cattaneo, A., Macchi, F., Plazzotta, G., Veronica, B., Bocchio-Chiavetto, L., Riva, M. A., & Pariante, C. M. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00040 · Cited by 152 · see citing works
Scarr, E., Millan, M. J., Bahn, S., Bertolino, A., Turck, C. W., Kapur, S., Möller, H., & Dean, B. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv042 · Cited by 135 · see citing works
Comes, A. L., Papiol, S., Müeller, T., Geyer, P. E., Mann, M., & Schulze, T. G. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0219-2 · Cited by 101 · see citing works
Perrin, A. J., Horowitz, M. A., Roelofs, J., Zunszain, P. A., & Pariante, C. M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00423 · Cited by 98 · see citing works
Tayeb, A. E. K. A., Poinsignon, V., Chappell, K., Bouligand, J., Becquemont, L., & Verstuyft, C. (2023) · Antioxidants · doi:10.3390/antiox12040942 · Cited by 100 · see citing works
Frye, M. A., Nassan, M. M., Jenkins, G. D., Kung, S., Veldić, M., Palmer, B. A., Feeder, S. E., Tye, S. J., Choi, D., & Biernacka, J. M. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.185 · Cited by 87 · see citing works
The role of macrophages in anti-inflammatory activity of antidepressant drugs
Nazimek, K., Strobel, S. D., Bryniarski, P., Kozlowski, M., Filipczak-Bryniarska, I., & Bryniarski, K. (2016) · Immunobiology · doi:10.1016/j.imbio.2016.07.001 · Cited by 88 · see citing works
Serum proteomic profiles of depressive subtypes
Lamers, F., Bot, M., Jansen, R., Chan, M. K., Cooper, J. D., Bahn, S., & Penninx, B. W. J. H. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.115 · Cited by 84 · see citing works
Biomarkers for Depression: Recent Insights, Current Challenges and Future Prospects
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Mendes‐Silva, A. P., Pereira, K. S., Araújo, G. T. T., Nicolau, E. D. S., Silva-Ferreira, C. M., Teixeira, A. L., & Diniz, B. S. (2016) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2016.07.017 · Cited by 73 · see citing works
Discovery of serum protein biomarkers in drug-free patients with major depressive disorder
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Enhanced Molecular Aging in Late-Life Depression: the Senescent-Associated Secretory Phenotype
Diniz, B. S., Reynolds, C. F., Sibille, E., Lin, C.-W., Tseng, G., Lotrich, F., Aizenstein, H. J., & Butters, M. A. (2017) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2016.08.018 · Cited by 73 · see citing works
Is there Progress? An Overview of Selecting Biomarker Candidates for Major Depressive Disorder
Young, J. J., Silber, T., Bruno, D., Galatzer‐Levy, I. R., Pomara, N., & Marmar, C. R. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00072 · Cited by 70 · see citing works
Advances in Biomarkers of Major Depressive Disorder
Huang, T., & Lin, C.-C. (2015) · Advances in clinical chemistry · doi:10.1016/bs.acc.2014.11.003 · Cited by 67 · see citing works
Heurich, M., Föcking, M., Mongan, D., Cagney, G., & Cotter, D. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01197-9 · Cited by 66 · see citing works
Inflammatory cytokines, complement factor H and anhedonia in drug-naïve major depressive disorder
Tang, W., Liu, H., Chen, L., Zhao, K., Zhang, Y., Zheng, K., Zhu, C., Zheng, T., Liu, J., Wang, D., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.03.022 · Cited by 53 · see citing works
Diniz, B. S., Lin, C., Sibille, E. L., Tseng, G. C., Lotrich, F. E., Aizenstein, H. J., Reynolds, C. F., & Butters, M. A. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.006 · Cited by 51 · see citing works
Innovative biomarkers in psychiatric disorders: a major clinical challenge in psychiatry
Lozupone, M., Seripa, D., Stella, E., Montagna, M. L., Solfrizzi, V., Quaranta, N. A. A., Veneziani, F., Cester, A., Sardone, R., Bonfiglio, C., et al. (2017) · Expert Review of Proteomics · doi:10.1080/14789450.2017.1375857 · Cited by 51 · see citing works
iTRAQ technology-based identification of human peripheral serum proteins associated with depression
Wang, Q., Su, X., Jiang, X., Dong, X., Fan, Y., Zhang, J., Yu, C., Gao, W., Shi, S., Jiang, J., et al. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.055 · Cited by 49 · see citing works
Sirukumab: A Potential Treatment for Mood Disorders?
Zhou, A. J., Lee, Y. L., Salvadore, G., Hsu, B. L., Fonseka, T. M., Kennedy, S. H., & McIntyre, R. S. (2016) · Advances in Therapy · doi:10.1007/s12325-016-0455-x · Cited by 48 · see citing works
Variation in serum biomarkers with sex and female hormonal status: implications for clinical tests
Ramsey, J. M., Cooper, J. D., Penninx, B. W. J. H., & Bahn, S. (2016) · Scientific Reports · doi:10.1038/srep26947 · Cited by 45 · see citing works
Shi, Y., Song, R., Wang, L., Qi, Y., Zhang, H., Zhu, J., Zhang, X., Tang, X., Zhan, Q., Zhao, Y., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.08.078 · Cited by 48 · see citing works
Mongan, D., Sabherwal, S., Susai, S. R., Föcking, M., Cannon, M. D., & Cotter, D. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.05.036 · Cited by 47 · see citing works
Depression in breast cancer patients: Immunopathogenesis and immunotherapy
Yu, S., Li, W., Tang, L., Fan, X., Yao, S., Zhang, X., Bi, Z., & Cheng, H. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215648 · Cited by 48 · see citing works
Kim, E. Y., Lee, M. Y., Kim, S. H., Ha, K., Kim, K. P., & Ahn, Y. M. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.02.014 · Cited by 44 · see citing works
Sabherwal, S., English, J. A., Föcking, M., Cagney, G., & Cotter, D. (2016) · Expert Review of Proteomics · doi:10.1080/14789450.2016.1252262 · Cited by 40 · see citing works
Hasebe, K., Gray, L. J., Bortolasci, C. C., Panizzutti, B., Mohebbi, M., Kidnapillai, S., Spolding, B., Walder, K. R., Berk, M., Malhi, G. S., et al. (2017) · Acta Neuropsychiatrica · doi:10.1017/neu.2017.2 · Cited by 37 · see citing works
Guest, F. L., Guest, P. C., & Martins‐de‐Souza, D. (2016) · Biomarkers in Medicine · doi:10.2217/bmm-2015-0055 · Cited by 36 · see citing works
Blood-based immune-endocrine biomarkers of treatment response in depression
Chan, M. K., Cooper, J. D., Bot, M., Birkenhäger, T. K., Bergink, V., Drexhage, H. A., Steiner, J. H., Rothermundt, M., Penninx, B. W. J. H., & Bahn, S. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.08.020 · Cited by 35 · see citing works
Proteomic approaches to identify blood-based biomarkers for depression and bipolar disorders
Preece, R. L., Han, S. Y. S., & Bahn, S. (2018) · Expert Review of Proteomics · doi:10.1080/14789450.2018.1444483 · Cited by 37 · see citing works
Salivary proteomics and biomarkers in neurology and psychiatry
Wormwood, K. L., Aslebagh, R., Channaveerappa, D., Dupree, E. J., Borland, M. M., Ryan, J. P., Darie, C. C., & Woods, A. G. (2015) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201400153 · Cited by 36 · see citing works
Kuring, J. K., Mathias, J. L., Ward, L., & Tachas, G. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.10.009 · Cited by 39 · see citing works
Peripheral levels of angiotensins are associated with depressive symptoms in Parkinson's disease
Rocha, N. P., Scalzo, P. L., Barbosa, I. G., de Campos-Carli, S. M., Tavares, L. D., de Souza, M. S., Christo, P. P., Reis, H. J., Silva, A. C. S. E., & Teixeira, A. L. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.07.031 · Cited by 33 · see citing works
Plasma complement component 4 increases in patients with major depressive disorder
Wei, J., Liu, Y., Zhao, L., Yang, X., Ni, P., Wang, Y., Li, T., & Ma, X. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s151238 · Cited by 31 · see citing works
Gadad, B. S., Jha, M. K., Grannemann, B. D., Mayes, T. L., & Trivedi, M. H. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.05.012 · Cited by 30 · see citing works
Proteomic Differences in Blood Plasma Associated with Antidepressant Treatment Response
Turck, C. W., Guest, P. C., Maccarrone, G., Ising, M., Kloiber, S. M., Lucae, S., Holsboer, F., & Martins‐de‐Souza, D. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00272 · Cited by 29 · see citing works
Zhou, M., Liu, Z., Yu, J. H., Li, S., Tang, M., Zeng, L., Wang, H., Xie, H., Peng, L., Huang, H., et al. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.02.010 · Cited by 28 · see citing works
Skibińska, M., Kapelski, P., Dmitrzak‐Węglarz, M., Lepczyńska, N., Pawlak, J., Hauser, J., Szczepankiewicz, A., & Rajewska‐Rager, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10184064 · Cited by 28 · see citing works
Ryan, K. M., Glaviano, A., O'Donovan, S. M., Kolshus, E., Dunne, R. A., Kavanagh, A., Jelovac, A., Noone, M., Tucker, G., Dunn, M. J., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.51 · Cited by 26 · see citing works
Commercialisation of Biomarker Tests for Mental Illnesses: Advances and Obstacles
Chan, M. K., Cooper, J. D., & Bahn, S. (2015) · Trends in biotechnology · doi:10.1016/j.tibtech.2015.09.010 · Cited by 26 · see citing works
Molecular serum signature of treatment resistant depression
Ruland, T., Chan, M. K., Stocki, P., Grosse, L., Rothermundt, M., Cooper, J. D., Arolt, V., & Bahn, S. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4348-0 · Cited by 26 · see citing works
Kim, H.-Y., Rhee, S. J., Lee, H., Han, D., Lee, T. Y., Kim, M., Kim, E. Y., Kwon, J. S., Shin, H., Kim, H., et al. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.113850 · Cited by 25 · see citing works
Luo, X., Fang, Z., Lin, L., Xu, H., Huang, Q., & Zhang, H. (2022) · BMC Psychiatry · doi:10.1186/s12888-022-04410-3 · Cited by 25 · see citing works
Systems Genomics Support for Immune and Inflammation Hypothesis of Depression
Sharma, A. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160106155331 · Cited by 24 · see citing works
Kim, E. Y., Ahn, H., Lee, M. Y., Yu, J., Yeom, J., Jeong, H., Min, H., Lee, H. J., Kim, K., & Ahn, Y. M. (2020) · Biomedicines · doi:10.3390/biomedicines8110455 · Cited by 23 · see citing works
Mojiri-Forushani, H., Khajehali, E., Adelipour, M., & Mohammadi, A. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-08219-x · Cited by 24 · see citing works
Ziani, P. R., Feiten, J. G., Goularte, J. F., Colombo, R., Antqueviezc, B., Géa, L. P., & Rosa, A. R. (2022) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2022.20.2.211 · Cited by 24 · see citing works
Levchenko, А., Nurgaliev, T., Kanapin, A. A., Samsonova, A. A., & Gainetdinov, R. R. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03990 · Cited by 20 · see citing works
Fluoxetine ameliorates depressive symptoms by regulating lncRNA expression in the mouse hippocampus
Zhang, C.-L., 昆明650201，中国, 中., State Key Laboratory of Phytochemistry and Plant Resources in West China, Y. K. L. O. N. M. C., Li, Y.-J., Lu, S., Zhang, T., Xiao, R., Luo, H.-R., 呼和浩特010110，中国, 内., 中国科学院大学，北京100049，中国, et al. (2021) · Zoological Research · doi:10.24272/j.issn.2095-8137.2020.294 · Cited by 20 · see citing works
Rodrigues, J. E., Martinho, A., Santos, V., Santa, C., Madeira, N. G. G. F., Martins, M. J., Pato, C. N., Macedo, A., & Manadas, B. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105460 · Cited by 21 · see citing works
Zhou, F., Zhou, L., Guo, T., Wang, N., Hao, H., Zhou, Y., & Yu, D. (2017) · Oncotarget · doi:10.18632/oncotarget.22233 · Cited by 20 · see citing works
Han, S. Y. S., Cooper, J. D., Özcan, S., Rustogi, N., Penninx, B. W. J. H., & Bahn, S. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0623-2 · Cited by 19 · see citing works
Associations between SNPs and immune-related circulating proteins in schizophrenia
Chan, M. K., Cooper, J. D., Heilmann‐Heimbach, S., Frank, J., Witt, S. H., Nöthen, M. M., Steiner, J. H., Rietschel, M., & Bahn, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-12986-0 · Cited by 19 · see citing works
Shin, D., Rhee, S. J., Lee, J., Yeo, I., Do, M., Joo, E.-J., Jung, H. Y., Roh, S., Lee, S., Kim, H.-Y., et al. (2021) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00058 · Cited by 18 · see citing works
Han, S. Y. S., Tomasik, J., Rustogi, N., Lago, S. G., Barton‐Owen, G., Eljasz, P., Cooper, J. D., Özcan, S., Olmert, T., Farrag, L. P., et al. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.08.011 · Cited by 17 · see citing works
Point-of-Care Testing and Personalized Medicine for Metabolic Disorders
Guest, F. L., & Guest, P. C. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7614-0_6 · Cited by 16 · see citing works
Dean, B., Tsatsanis, A., Lam, L. Q., Scarr, E., & Duce, J. A. (2018) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2018.1555377 · Cited by 16 · see citing works
Bidoki, N. H., Zera, K. A., Nassar, H., Drag, L. L., Mlynash, M., Osborn, E., Musabbir, M., Kim, D. E., Mendez, M. P., Lansberg, M. G., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.08.002 · Cited by 16 · see citing works
DeAtley, K. L., Colgrave, M. L., Cánovas, Á., Wijffels, G. L., Ashley, R. L., Silver, G. A., Rincón, G., Medrano, J. F. F., Islas‐Trejo, A., Fortes, M. R. S., et al. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.7b00875 · Cited by 15 · see citing works
Proteomic Markers for Depression
Silva-Costa, L. C., Carlson, P. T., Guest, P. C., de Almeida, V., & Martins‐de‐Souza, D. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-05542-4_10 · Cited by 15 · see citing works
Yang, F., Wang, H., Chen, H., Ran, D., Tang, Q., Weng, P., Sun, Y., & Jiang, W. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.06.020 · Cited by 14 · see citing works
Can Molecular Biology Propose Reliable Biomarkers for Diagnosing Major Depression?
Ivanets, N. N., Svistunov, A. А., Chubarev, V. N., Kinkulkina, M. A., Tikhonova, Y. G., Syzrantsev, N. S., Sologova, S. S., Ignatyeva, N. V., Mutig, K., & Tarasov, V. V. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666201124110437 · Cited by 14 · see citing works
Decreased Plasma Levels of Angiotensin-Converting Enzyme Among Patients With Bipolar Disorder
Sanches, M., Colpo, G. D., Cuellar, V. A., Bockmann, T., Rogith, D., Soares, J. C., & Teixeira, A. L. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.617888 · Cited by 14 · see citing works
Tunç, S., Atagün, M. İ., Başbuğ, H. S., & Erel, Ö. (2019) · Psychiatry and Clinical Psychopharmacology · doi:10.1080/24750573.2019.1584489 · Cited by 14 · see citing works
Chan, M. K., Cooper, J. D., Bot, M., Steiner, J. H., Penninx, B. W. J. H., & Bahn, S. (2015) · Neuroendocrinology · doi:10.1159/000442208 · Cited by 14 · see citing works
Neuropsychiatric disorders: An immunological perspective
Aw, E., Zhang, Y., Yalçın, E., Herrmann, U., & Carroll, M. C. (2021) · Advances in immunology · doi:10.1016/bs.ai.2021.09.002 · Cited by 13 · see citing works
Schiele, M. A., Crespo Salvador, O., Lipovsek, J., Schwarte, K., Schlosser, P., Zwanzger, P., Arolt, V., Baune, B. T., Köttgen, A., & Domschke, K. (2024) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyae045 · Cited by 13 · see citing works
Enzymatic biomarkers of oxidative stress in patients with depressive disorders. A systematic review
Lievanos-Ruiz, F. J., & Fenton-Navarro, B. (2024) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2024.110788 · Cited by 12 · see citing works
Apolipoprotein D as a Potential Biomarker in Neuropsychiatric Disorders
del Valle, E., Rubio-Sardón, N., Menéndez-Pérez, C., Martínez‐Pinilla, E., & Navarro, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115631 · Cited by 12 · see citing works
Association study of MIF promoter polymorphisms with suicide completers in the Japanese population
Shimmyo, N., Hishimoto, A., Otsuka, I., Okazaki, S., Boku, S., Mouri, K., Horai, T., Takahashi, M., Ueno, Y., Shirakawa, O., et al. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s130855 · Cited by 11 · see citing works
Carboni, L. (2014) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201400139 · Cited by 10 · see citing works
Ferritin disorder in the plasma and hippocampus associated with major depressive disorder
Wang, Y., Li, Y., Wu, Z., Chen, Z., Yu, H., He, Y., Tian, Y., Lan, T., Bai, M., Chen, X., et al. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.03.059 · Cited by 10 · see citing works
Neuroproteomic profiling of human body fluids
Månberg, A., Schwenk, J. M., & Nilsson, P. (2015) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201500065 · Cited by 10 · see citing works
Aldosterone Action on Brain and Behavior
Murck, H. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00052-3 · Cited by 10 · see citing works
Association between suicide attempts and anemia in late-life depression inpatients
Li, J., Wang, L., Wang, Z., Zhao, F., Sun, Y., Lu, Y., & Yang, L. (2024) · BMC Geriatrics · doi:10.1186/s12877-023-04649-9 · Cited by 9 · see citing works
A Complete Proteomic Workflow to Study Brain-Related Disorders via Postmortem Tissue
Reis‐de‐Oliveira, G., Fioramonte, M., & Martins‐de‐Souza, D. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8994-2_31 · Cited by 9 · see citing works
Guo, Q., Si, Y. J., Shen, Y. L., Chen, X., Yang, M., Fang, D. Z., & Lin, J. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01766-7 · Cited by 8 · see citing works
Iron metabolism dysfunction in neuropsychiatric disorders: Implications for therapeutic intervention
Duarte-Silva, E. P., Maes, M. H. J., & Peixoto, C. A. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115343 · Cited by 9 · see citing works
Abulseoud, O. A., Yehia, A., Egol, C., Nettey, V. N., Aly, M. H., Qu, Y., Skolnik, A. B., Grill, M. F., Sen, A., & Schneekloth, T. D. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1035986 · Cited by 8 · see citing works
Wu, J., Wang, Z., Xu, H., Yang, L., Liu, J., Zheng, Y., Kang, C., Wang, X., Shi, J., Zhao, N., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1156481 · Cited by 8 · see citing works
Woo, H. I., Park, J., Lim, S., Kim, D. K., & Lee, S. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02702-y · Cited by 8 · see citing works
Proteomics insight into psychiatric disorders: an update on biological fluid biomarkers
Giusti, L., Ciregia, F., Mazzoni, M. R., & Lucacchini, A. (2016) · Expert Review of Proteomics · doi:10.1080/14789450.2016.1230499 · Cited by 8 · see citing works
Tomasović, S., Sremec, J., Košćak, J., Klepac, N., Draganić, P., & Bielen, I. (2016) · PubMed · Cited by 6 · see citing works
Bai, L., Zou, W., Wang, L., Yu, X., Lou, H., Dai, X., Teng, W., Yu, W., Li, M., Cao, H., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28889 · Cited by 5 · see citing works
Park, J., Kang, Y., Han, K., Tae, W., Kang, U., Chu, H., & Ham, B. (2022) · Psychiatry Investigation · doi:10.30773/pi.2022.0100 · Cited by 4 · see citing works
Supti, K. F., Asaduzzaman, M., Suhee, F. I., Shahriar, M., Islam, S. M. A., Bhuiyan, M., Qusar, M. S., & Islam, M. (2023) · Clinical Pathology · doi:10.1177/2632010x231220841 · Cited by 4 · see citing works
Distinct behavioural and neurovascular signatures induced by acute and chronic stress in rats
Simões, D. M., Carreira, J., Henriques, A., Gaspar, R., Sanches, E. S., Baptista, F. I., & Silva, A. P. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115706 · Cited by 3 · see citing works
Gulbaz, Z.-U.-A., Mirza, S., Naveed, S., Azeem, M. W., Husain, N., & Cheema, M. I. (2025) · Psychiatric Quarterly · doi:10.1007/s11126-025-10223-w · Cited by 2 · see citing works
Proteomic Studies of Psychiatric Disorders
Guest, P. C. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7614-0_4 · Cited by 2 · see citing works
Aging, Cerebrovascular Burden, and Cognitive Decline
Cho, K. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.89854 · Cited by 2 · see citing works
LC-MSE for Qualitative and Quantitative Proteomic Studies of Psychiatric Disorders
Fioramonte, M., Guest, P. C., & Martins‐de‐Souza, D. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-52479-5_7 · Cited by 2 · see citing works
Al-Habash, I. H., Alshaeb, A., Srpanova, V. B., Alempijevic, D. M., Marković, M. K., Concato, M., Radaelli, D., & D’Errico, S. (2025) · Current Neuropharmacology · doi:10.2174/011570159x344453241129073214 · Cited by 1 · see citing works
Interleukin-16 is increased in dialysis patients but is not a cardiovascular risk factor
Brösecke, F., Pfau, A. C., Ermer, T., Ribeiro, A. B. D. T. M., Rubenbauer, L., Rao, V., Burlein, S., Genser, B., Reichel, M., Aronson, P. S., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-61808-7 · Cited by 1 · see citing works
Ramsey, J. M. (2015) · Apollo (University of Cambridge) · doi:10.17863/cam.268
Investigating neurobiological mechanisms linking depression and inflammation
Hasebe, K. (2017) · Figshare
- Authors
- Stelzhammer, V., Haenisch, F., Chan, M. K., Cooper, J. D., Steiner, J., Steeb, H., Martins-de-Souza, D., Rahmoune, H., Guest, P. C., & Bahn, S.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Bahn, Sabine
- ORCID
- Venue
- The International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-06-05
- Volume
- 17
- Issue
- 10
- Pages
- 1599-1608
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- OpenAlex
- W2117492847
- Cited by
- 105
- References
- 45
- Citations by year
- 2025: 4 · 2024: 6 · 2023: 7 · 2022: 9 · 2021: 13 · 2020: 8 · 2019: 5 · 2018: 9 · 2017: 14 · 2016: 19 · 2015: 10 · 2014: 1
- FWCI
- 10.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The International Journal of Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- major depressive disorder, first-episode depression, serum proteomics, biomarkers, symptom severity, inflammation, oxidative stress, hypothalamic-pituitary-adrenal axis, cortisol, cytokines, macrophage migration inhibitory factor, interleukin-16, angiotensin-converting enzyme, ferritin, brain-derived neurotrophic factor, complement C4B, growth hormone, superoxide dismutase 1
- MeSH terms
- Adult, Analysis of Variance, Blood Proteins, Chromatography, Liquid, Complement System Proteins, Major Depressive Disorder, Depressive Disorder, Major, Female, Humans, Hydrocortisone, Immunoassay, Peptidyl-Dipeptidase A, Male, Middle Aged, Psychiatric Status Rating Scales, Mass Spectrometry, Statistics as Topic, Case-Control Studies, Cytokines, Proteomics
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