Screening a diverse collection of Artemisia annua germplasm accessions for the antimalarial compound, artemisinin
Abstract
The antimalarial drug artemisinin (ART) is commercially extracted from the medicinal plant Artemisia annua L. Here, we report the screening of 70 A. annua plants representing 14 diverse germplasm accessions sourced from around the world, and identify lines containing >2% ART. These extremely high-yielding individuals have been maintained as vegetative clones, and they represent promising germplasm resources for future A. annua breeding programmes.
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Various hybrid lines with 2% artemisinin (w/w) have been created by conventional breeding methods by crossing A. annua with wild plants having high artemisinin levels.
“For example, various hybrid lines with 2% artemisinin (w/w) have been created by conventional breeding methods by crossing A. annua with wild plants having high artemisinin levels (Cockram et al. 2012).”
From Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches (2021) · cites this paper as Cockram et al. 2012
Cites
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“Concentration of ART in surveys of A. annua accessions is known to be predominantly ,1%, with the highest content reported being 1.4% (Woerdenbag et al., 1994; Delabays et al., 2001; Kumar et al., 2004; Khanuja et al., 2005).”
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“Concentration of ART in surveys of A. annua accessions is known to be predominantly ,1%, with the highest content reported being 1.4% (Woerdenbag et al., 1994; Delabays et al., 2001; Kumar et al., 2004; Khanuja et al., 2005).”
BackgroundInfluentialHigh yields of artemisinin by multi-harvest of Artemisia annua crops
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A Genome-Wide Scenario of Terpene Pathways in Self-pollinated Artemisia annua
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- Authors
- Cockram, J., Hill, C., Burns, C., Arroo, R. R. J., Woolley, J. G., Flockart, I., Robinson, T., Atkinson, C. J., Davies, M. J., Dungey, N., Greenland, A. J., Smith, L. L. M. J., & Bentley, S.
- Affiliations
- National Institute of Agricultural Botany (GB)
- De Montfort University (GB)
- Frontier Agriculture (United Kingdom) (GB)
- East Malling Research (United Kingdom) (GB)
- Humber Teaching NHS Foundation Trust (GB)
- Corresponding author
- Cockram, James
- Venue
- Plant Genetic Resources
- Publisher
- Cambridge University Press (CUP)
- Published
- 2012-07-05
- Volume
- 10
- Issue
- 2
- Pages
- 152-154
- ISSN
- 1479-2621 (ISSN-L)
- 1479-263X
- OpenAlex
- W1974951714
- Cited by
- 19
- References
- 13
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 3
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Plant Genetic Resources (publishedVersion)
- DMU Open Research Archive (De Montfort University) (submittedVersion)
- Greenwich Academic Literature Archive (University of Greenwich) (submittedVersion)
- Funders
- Department for Environment, Food and Rural Affairs, UK Government
- Horticultural Development Company
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Agricultural Productivity and Crop Improvement
- Keywords
- artemisinin, Artemisia annua, germplasm accession, germplasm screening, high-yielding lines, medicinal plant breeding, antimalarial compounds
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