The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Cell cycle dynamics of NG2 cells in the postnatal and ageing brain
Open accessAbstract
Oligodendrocyte precursors (OLPs or 'NG2 cells') are abundant in the adult mouse brain, where they continue to proliferate and generate new myelinating oligodendrocytes. By cumulative BrdU labelling, we estimated the cell cycle time TC and the proportion of NG2 cells that is actively cycling (the growth fraction) at approximately postnatal day 6 (P6), P60, P240 and P540. In the corpus callosum, TC increased from <2 days at P6 to approximately 9 days at P60 to approximately 70 days at P240 and P540. In the cortex, TC increased from approximately 2 days to >150 days over the same period. The growth fraction remained relatively invariant at approximately 50% in both cortex and corpus callosum - that is, similar numbers of mitotically active and inactive NG2 cells co-exist at all ages. Our data imply that a stable population of quiescent NG2 cells appears before the end of the first postnatal week and persists throughout life. The mitotically active population acts as a source of new oligodendrocytes during adulthood, while the biological significance of the quiescent population remains to be determined. We found that the mitotic status of adult NG2 cells is unrelated to their developmental site of origin in the ventral or dorsal telencephalon. We also report that new oligodendrocytes continue to be formed at a slow rate from NG2 cells even after P240 (8 months of age).
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“This remarkable conclusion still stands, although the rate of increase with time is greater than previously estimated: for every day after birth, TC in the cortical gray matter increases by about two-thirds of a day, not one-third as previously estimated (Psachoulia et al., 2009).”
From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Psachoulia et al., 2009
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“We reported previously that TC in the cortical gray matter increases linearly with age from early postnatal ages until at least P540 (Psachoulia et al., 2009).”
From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Psachoulia et al., 2009
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“Oligodendrocyte precursors (OPs) continue to proliferate and generate myelinating oligodendrocytes (OLs) well into adulthood.”
From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Psachoulia et al., 2009
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Cites
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Fields, R. D. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.04.001 · Cited by 1,337
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Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus
Bergles, D. E., Roberts, J. D. B., Somogyi, P., & Jahr, C. E. (2000) · Nature · doi:10.1038/35012083 · Cited by 1,062
Origin of oligodendrocytes in the subventricular zone of the adult brain
Menn, B., Garcia-Verdugo, J. M., Yaschine, C., Gonzalez-Perez, O., Rowitch, D., & Alvarez-Buylla, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1299-06.2006 · Cited by 972
PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
Rivers, L. E., Young, K. M., Rizzi, M., Jamen, F., Psachoulia, K., Wade, A., Kessaris, N., & Richardson, W. D. (2008) · Nature Neuroscience · doi:10.1038/nn.2220 · Cited by 961
Dawson, M. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00210-0 · Cited by 927
Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity
Nishiyama, A., Komitova, M., Suzuki, R., & Zhu, X. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2495 · Cited by 865
Proliferation and Differentiation of Progenitor Cells Throughout the Intact Adult Rat Spinal Cord
Horner, P. J., Power, A. E., Kempermann, G., Kuhn, H. G., Palmer, T. D., Winkler, J., Thal, L. J., & Gage, F. H. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02218.2000 · Cited by 777
Research works printed but not linked: 3
- Bartzokis, 2009, Neurobiology of Aging
- Hamilton, 2009, Glia
- Geha, 2009, Brain Pathology
Cited by
Sorted by citations
Plasticity in gray and white: neuroimaging changes in brain structure during learning
Zatorre, R. J., Fields, R. D., & Johansen-Berg, H. (2012) · Nature Neuroscience · doi:10.1038/nn.3045 · Cited by 1,685
Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling
Young, K. M., Psachoulia, K., Tripathi, R. B., Dunn, S.-J., Cossell, L., Attwell, D., Tohyama, K., & Richardson, W. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.006 · Cited by 919
“There is considerable uncertainty in these calculations concerning the rate of increase of TC with age; they possibly underestimate the proportion of new OLs that survives because the cell cycle probably slows down (TC increases) more rapidly after P60 than is assumed here (Psachoulia et al., 2009).”
InfluentialHughes, E. G., Kang, S. H., Fukaya, M., & Bergles, D. E. (2013) · Nature Neuroscience · doi:10.1038/nn.3390 · Cited by 808
Kang, S. H., Fukaya, M., Yang, J. K., Rothstein, J. D., & Bergles, D. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.009 · Cited by 815
Oligodendrocyte Development and PlasticityPreprint
Bergles, D. E., & Richardson, W. D. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020453 · Cited by 604
Metadata
- Authors
- Psachoulia, K., Jamen, F., Young, K. M., & Richardson, W. D.
- Affiliations
- University College London (GB)
- Venue
- Neuron Glia Biology
- Publisher
- Cambridge University Press (CUP)
- Published
- 2009-11
- Volume
- 5
- Issue
- 3-4
- Pages
- 57-67
- ISSN
- 1740-925X (ISSN-L)
- 1741-0533
- PMC
- PMC6329448
- OpenAlex
- W2094997319
- Cited by
- 257
- References
- 59
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 8 · 2023: 12 · 2022: 17 · 2021: 20 · 2020: 23 · 2019: 11 · 2018: 15 · 2017: 28 · 2016: 19 · 2015: 19 · 2014: 17 · 2013: 17 · 2012: 9
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuron Glia Biology (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Wellcome Trust
- Alzheimer's Society
- Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- oligodendrocyte precursor cells, cell cycle kinetics, cell cycle duration, growth fraction, postnatal brain development, brain aging, oligodendrocyte myelination, corpus callosum, cerebral cortex, telencephalon, adult neurogenesis, BrdU labeling
- MeSH terms
- Chondroitin Sulfate Proteoglycan 4, Age Factors, Aging, Animals, Antigens, Brain, Bromodeoxyuridine, Cell Count, Cell Cycle, Estrogen Antagonists, Luminescent Proteins, Mice, Transgenic, Oligodendroglia, Proteoglycans, Tamoxifen, Gene Expression Regulation, Developmental, Receptor, Platelet-Derived Growth Factor alpha, Mice
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