Cited by 257Neurogenesis and neuroplasticity mechanismsNeonatal and fetal brain pathologyNeuroinflammation and Neurodegeneration Mechanisms

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Cell cycle dynamics of NG2 cells in the postnatal and ageing brain

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Psachoulia, Konstantina, Jamen, Francoise, Young, Kaylene M., Richardson, William D.·2009·Neuron Glia Biology

DOI 10.1017/s1740925x09990354PMC PMC6329448

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Abstract

Oligodendrocyte precursors (OLPs or 'NG2 cells') are abundant in the adult mouse brain, where they continue to proliferate and generate new myelinating oligodendrocytes. By cumulative BrdU labelling, we estimated the cell cycle time TC and the proportion of NG2 cells that is actively cycling (the growth fraction) at approximately postnatal day 6 (P6), P60, P240 and P540. In the corpus callosum, TC increased from <2 days at P6 to approximately 9 days at P60 to approximately 70 days at P240 and P540. In the cortex, TC increased from approximately 2 days to >150 days over the same period. The growth fraction remained relatively invariant at approximately 50% in both cortex and corpus callosum - that is, similar numbers of mitotically active and inactive NG2 cells co-exist at all ages. Our data imply that a stable population of quiescent NG2 cells appears before the end of the first postnatal week and persists throughout life. The mitotically active population acts as a source of new oligodendrocytes during adulthood, while the biological significance of the quiescent population remains to be determined. We found that the mitotic status of adult NG2 cells is unrelated to their developmental site of origin in the ventral or dorsal telencephalon. We also report that new oligodendrocytes continue to be formed at a slow rate from NG2 cells even after P240 (8 months of age).

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Authors: Psachoulia, K., Jamen, F., Young, K. M., & Richardson, W. D.
Affiliations: University College London (GB)
ORCID: Young, Kaylene M.
Richardson, William D.
Venue: Neuron Glia Biology
Publisher: Cambridge University Press (CUP)
Published: 2009-11
Volume: 5
Issue: 3-4
Pages: 57-67
ISSN: 1740-925X (ISSN-L)
1741-0533
DOI: 10.1017/s1740925x09990354
PMC: PMC6329448
OpenAlex: W2094997319
Cited by: 257
References: 59
Citations by year: 2026: 9 · 2025: 14 · 2024: 8 · 2023: 12 · 2022: 17 · 2021: 20 · 2020: 23 · 2019: 11 · 2018: 15 · 2017: 28 · 2016: 19 · 2015: 19 · 2014: 17 · 2013: 17 · 2012: 9
FWCI: 2.82
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
www.cambridge.org/core/terms (unspecified, 148 d)
Locations: Neuron Glia Biology (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eCite Digital Repository (University of Tasmania) (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
Figshare (submittedVersion, cc-by)
Funders: Wellcome Trust
Alzheimer's Society
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology
Medical Research Council
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: oligodendrocyte precursor cells, cell cycle kinetics, cell cycle duration, growth fraction, postnatal brain development, brain aging, oligodendrocyte myelination, corpus callosum, cerebral cortex, telencephalon, adult neurogenesis, BrdU labeling
MeSH terms: Chondroitin Sulfate Proteoglycan 4, Age Factors, Aging, Animals, Antigens, Brain, Bromodeoxyuridine, Cell Count, Cell Cycle, Estrogen Antagonists, Luminescent Proteins, Mice, Transgenic, Oligodendroglia, Proteoglycans, Tamoxifen, Gene Expression Regulation, Developmental, Receptor, Platelet-Derived Growth Factor alpha, Mice

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Cell cycle dynamics of NG2 cells in the postnatal and ageing brain

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