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Cited by 292Photonic Crystals and ApplicationsHydrogels: synthesis, properties, applicationsPolydiacetylene-based materials and applications

Fast Responsive Crystalline Colloidal Array Photonic Crystal Glucose Sensors

Ben-Moshe, Matti, Alexeev, Vladimir L., Asher, Sanford A.·2006·Analytical Chemistry
DOI 10.1021/ac060643i
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Abstract

We developed new photonic crystal polymerized crystalline colloidal array (PCCA) glucose sensing materials, which operate on the basis of formation of cross-links in the hydrogel. These materials are composed of hydrogels that embed an array of approximately 100-nm-diameter monodisperse polystyrene colloids that Bragg diffract light in the visible spectral region. The hydrogels change volume as the glucose concentration varies. This changes the lattice spacing, which changes the wavelength of the diffracted light. In contrast to our previous glucose sensing photonic crystal materials, we no longer require Na+ chelating agents. These photonic crystal materials are being designed for use in glucose sensing contact lens for people with diabetes mellitus. We describe methods to speed up the response kinetics of these PCCA sensing materials. Rapid-response kinetics is achieved by controlling the elasticity and the hydrophilic-hydrophobic balance of the hydrogel system. A more hydrophobic hydrogel composition is obtained by copolymerizing n-hexylacrylate into an acrylamide-bisacrylamide hydrogel. The response rate significantly increases to where it fully responds within 90 s to the average glucose concentrations found in blood (5 mM) and within 300 s to the average glucose concentrations found in tear fluid (0.15 mM). We find unusual temperature-dependent kinetics, which derive from glucose mutarotation in solution. It is shown that alpha-d-glucose is the glucose anomer binding to the boronic acid derivative. Care must be taken in any glucose determination to ensure that the glucose mutarotation equilibrium has been established. We have demonstrated that the sensor is responsive to approximately 0.15 mM glucose concentrations in artificial tear fluid solution.

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  • Contact lens-based sensors were initially introduced utilizing optical detection of tear glucose levels based on the interaction of glucose with concanavalin A or phenylboronic acid derivatives.

    “Contact lens-based sensors were initially introduced utilizing optical detection of tear glucose levels based on the interaction of glucose with concanavalin A or phenylboronic acid derivatives107,108.”

    From Wearable biosensors for healthcare monitoring (2019) · cites this paper as [108]

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Authors
Ben-Moshe, M., Alexeev, V. L., & Asher, S. A.
Affiliations
  • Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260
  • University of Pittsburgh (US)
Corresponding author
Asher, Sanford A.
ORCID
Asher, Sanford A.
Venue
Analytical Chemistry
Publisher
American Chemical Society (ACS)
Published
2006-06-06
Volume
78
Issue
14
Pages
5149-5157
ISSN
  • 0003-2700 (ISSN-L)
  • 1520-6882
DOI
10.1021/ac060643i
OpenAlex
W2091495248
Cited by
292
References
22
Citations by year
2026: 2 · 2025: 7 · 2024: 9 · 2023: 8 · 2022: 17 · 2021: 12 · 2020: 6 · 2019: 7 · 2018: 9 · 2017: 18 · 2016: 18 · 2015: 18 · 2014: 26 · 2013: 25 · 2012: 20
FWCI
10.72
Type
journal article
Language
en
Open access
closed
Locations
  • Analytical Chemistry (publishedVersion)
  • PubMed (publishedVersion)
  • D-Scholarship@Pitt (University of Pittsburgh) (acceptedVersion)
Topics
  • Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Photonic Crystals and Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Chemistry › Organic Chemistry › Polydiacetylene-based materials and applications
Keywords
glucose sensor, photonic crystals, polystyrene colloids, hydrogels, Bragg diffraction, response kinetics, hydrogel elasticity, hydrophilic-hydrophobic balance, boronic acid, diabetes mellitus
MeSH terms
Cross-Linking Reagents, Crystallization, Disaccharides, Glucose, Kinetics, Polymers, Temperature, Time Factors, Biosensing Techniques, Molecular Structure, Hydrogels, Microarray Analysis, Hydrophobic and Hydrophilic Interactions

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