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MALDI-guided SIMS: Multiscale Imaging of Metabolites in Bacterial Biofilms
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“MALDI guided MSI workflows identify phenazines and other metabolites across depth, allowing true overlays of chemotypes and structure [253,254,255].”
From Understanding Pseudomonas aeruginosa Biofilms: Quorum Sensing, c-di-GMP Signaling, and Emerging Antibiofilm Approaches (2026) · cites this paper as [254]
In the citing paper
“A new direction combines MALDI guided MSI with chip-grown P. aeruginosa to analyze quorum signals, phenazines, and structure in parallel [254,274].”
From Understanding Pseudomonas aeruginosa Biofilms: Quorum Sensing, c-di-GMP Signaling, and Emerging Antibiofilm Approaches (2026) · cites this paper as [254]
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Cites
The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm
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Cited by
Kompauer, M., Heiles, S., & Spengler, B. (2017) · Nature Methods · doi:10.1038/nmeth.4071 · Cited by 600
Hobley, L., Harkins, C., MacPhee, C. E., & Stanley-Wall, N. R. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv015 · Cited by 581
Mass Spectrometry Imaging of Biomolecular Information
Spengler, B. (2015) · Analytical Chemistry · doi:10.1021/ac504543v · Cited by 290
Körber, A., Anthony, I. G. M., & Heeren, R. M. A. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.4c05249 · Cited by 88
Harvey, D. J. (2018) · Mass Spectrometry Reviews · doi:10.1002/mas.21530 · Cited by 61
Metadata
- Authors
- Lanni, E. J., Masyuko, R. N., Driscoll, C. M., Aerts, J. T., Shrout, J. D., Bohn, P. W., & Sweedler, J. V.
- Affiliations
- Department of Chemistry and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United States
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-08-26
- Volume
- 86
- Issue
- 18
- Pages
- 9139-9145
- ISSN
- 0003-2700
- 1520-6882
- Cited by
- 96
- References
- 2
- Language
- en
- Funders
- National Institute of General Medical Sciences (U54GM093342)
- Biological and Environmental Research (DE SC0006642)
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- CoChat. (2026). Citation check: MALDI-guided SIMS: Multiscale Imaging of Metabolites in Bacterial Biofilms. https://app.cochat.ai/papers/10.1021/ac5020222
- The paper
- Lanni, E. J., Masyuko, R. N., Driscoll, C. M., Aerts, J. T., Shrout, J. D., Bohn, P. W., & Sweedler, J. V. (2014). MALDI-guided SIMS: Multiscale Imaging of Metabolites in Bacterial Biofilms. Analytical Chemistry. https://doi.org/10.1021/ac5020222
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.