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Targeted Bioimaging and Photodynamic Therapy of Cancer Cells with an Activatable Red Fluorescent Bioprobe
Abstract
A new red-emissive bioprobe TPE-red-2AP2H was developed by taking advantage of the unique emission feature of tetraphenylethylene and a cancer cell-specific peptide. By responding to the target protein and the acidic microenvironment of tumor cells, activated fluorescence bioimaging was achieved with high signal-to-noise ratio and without involving mutiple washing steps. Apart from targeting the membrane-anchored LAPTM4B proteins, TPE-red-2AP2H was successfully utilized to trace the intracellular movement of LAPTM4B protein. The generation of (1)O2 under visible light irradiation makes this bioprobe also promising for targeted-photodynamic therapy. By discriminating the expression level of the target protein, TPE-red-2AP2H can respond to the progression status of tumors with different photodynamic therapy effect.
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Metadata
- Authors
- Hu, F., Huang, Y., Zhang, G., Zhao, R., Yang, H., & Zhang, D.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-07-17
- Volume
- 86
- Issue
- 15
- Pages
- 7987-7995
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2314933196
- Cited by
- 285
- References
- 66
- FWCI
- 17.14
- Type
- journal article
- Language
- en
- Open access
- closed
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