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Metabolomics Reveal Nanoplastic-Induced Mitochondrial Damage in Human Liver and Lung Cells
Open accessAbstract
Plastic debris in the global biosphere is an increasing concern, and nanoplastic (NPs) toxicity in humans is far from being understood. Studies have indicated that NPs can affect mitochondria, but the underlying mechanisms remain unclear. The liver and lungs have important metabolic functions and are vulnerable to NP exposure. In this study, we investigated the effects of 80 nm NPs on mitochondrial functions and metabolic pathways in normal human hepatic (L02) cells and lung (BEAS-2B) cells. NP exposure did not induce mass cell death; however, transmission electron microscopy analysis showed that the NPs could enter the cells and cause mitochondrial damage, as evidenced by overproduction of mitochondrial reactive oxygen species, alterations in the mitochondrial membrane potential, and suppression of mitochondrial respiration. These alterations were observed at NP concentrations as low as 0.0125 mg/mL, which might be comparable to the environmental levels. Nontarget metabolomics confirmed that the most significantly impacted processes were mitochondrial-related. The metabolic function of L02 cells was more vulnerable to NP exposure than that of BEAS-2B cells, especially at low NP concentrations. This study identifies NP-induced mitochondrial dysfunction and metabolic toxicity pathways in target human cells, providing insight into the possibility of adverse outcomes in human health.
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Cites
Lost at sea: where is all the plastic?
Thompson, R. C., Olsen, Y., Mitchell, R. P., Davis, A., Rowland, S. J., John, A. W. G., McGonigle, D., & Russell, A. E. (2004) · Science · doi:10.1126/science.1094559 · Cited by 7,765
MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights
Pang, Z., Chong, J., Zhou, G., de Lima Morais, D. A., Chang, L., Barrette, M., Gauthier, C., Jacques, P.-É., Li, S., & Xia, J. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab382 · Cited by 3,958
Mitochondrial TCA cycle metabolites control physiology and disease
Martínez-Reyes, I., & Chandel, N. S. (2020) · Nature Communications · doi:10.1038/s41467-019-13668-3 · Cited by 2,813
Future Scenarios of Global Plastic Waste Generation and Disposal
Lebreton, L., & Andrady, A. (2019) · Palgrave Communications · doi:10.1057/s41599-018-0212-7 · Cited by 2,327
The impact of debris on marine life
Gall, S. C., & Thompson, R. C. (2015) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2014.12.041 · Cited by 2,187
Synthetic polymers in the marine environment: A rapidly increasing, long-term threat
Moore, C. J. (2008) · Environmental Research · doi:10.1016/j.envres.2008.07.025 · Cited by 2,112
Nicholson, J. K., & Lindon, J. C. (2008) · Nature · doi:10.1038/4551054a · Cited by 1,886
Microplastics and human health
Vethaak, A. D., & Legler, J. (2021) · Science · doi:10.1126/science.abe5041 · Cited by 1,537
Gomes, A. P., Price, N. L., Ling, A. J. Y., Moslehi, J. J., Montgomery, M. K., Rajman, L., White, J. P., Teodoro, J. S., Wrann, C. D., Hubbard, B. P., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.037 · Cited by 1,482
Toxicity testing in the 21st century: A vision and a strategy
Gibb, S. (2008) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.10.013 · Cited by 1,257
A review of microplastics in table salt, drinking water, and air: direct human exposure
Zhang, Q., Xu, E. G., Li, J., Chen, Q., Ma, L., Zeng, E. Y., & Shi, H. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.9b04535 · Cited by 1,064
Turning microplastics into nanoplastics through digestive fragmentation by Antarctic krill
Dawson, A. L., Kawaguchi, S., King, C. K., Townsend, K. A., King, R., Huston, W. M., & Bengtson Nash, S. M. (2018) · Nature Communications · doi:10.1038/s41467-018-03465-9 · Cited by 1,023
Schirinzi, G. F., Pérez-Pomeda, I., Sanchís, J., Rossini, C., Farré, M., & Barceló, D. (2017) · Environmental Research · doi:10.1016/j.envres.2017.08.043 · Cited by 902
Toxicity of Microplastics and Nanoplastics in Mammalian Systems
Yong, C., Valiyaveettil, S., & Tang, B. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17051509 · Cited by 901
Regulation of cellular glutathione
Deneke, S. M., & Fanburg, B. L. (1989) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1989.257.4.l163 · Cited by 837
Invasions by marine life on plastic debris
Barnes, D. K. A. (2002) · Nature · doi:10.1038/416808a · Cited by 738
Are there nanoplastics in your personal care products?
Hernandez, L. M., Yousefi, N., & Tufenkji, N. (2017) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.7b00187 · Cited by 700
Recent advances in toxicological research of nanoplastics in the environment: A review
Shen, M., Zhang, Y., Zhu, Y., Song, B., Zeng, G., Hu, D., Wen, X., & Ren, X. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.05.102 · Cited by 686
Xu, M., Halimu, G., Zhang, Q., Song, Y., Fu, X., Li, Y., Li, Y., & Zhang, H. (2019) · Science of The Total Environment · doi:10.1016/j.scitotenv.2019.133794 · Cited by 659
Self-citationThe emerging role and targetability of the TCA cycle in cancer metabolism
Anderson, N. M., Mucka, P., Kern, J. G., & Feng, H. (2018) · Protein & Cell · doi:10.1007/s13238-017-0451-1 · Cited by 556
The endoplasmic reticulum–mitochondria connection: One touch, multiple functions
Marchi, S., Patergnani, S., & Pinton, P. (2014) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.10.015 · Cited by 475
Polystyrene nanoparticles internalization in human gastric adenocarcinoma cells
Forte, M., Iachetta, G., Tussellino, M., Carotenuto, R., Prisco, M., De Falco, M., Laforgia, V., & Valiante, S. (2016) · Toxicology in Vitro · doi:10.1016/j.tiv.2015.11.006 · Cited by 443
Wu, P., Lin, S., Cao, G., Wu, J., Jin, H., Wang, C., Wong, M. H., Yang, Z., & Cai, Z. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.129361 · Cited by 428
Self-citationReview on plastic wastes in marine environment – Biodegradation and biotechnological solutions
A., G. K., K., A., M., H., K., S., & G., D. (2020) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2019.110733 · Cited by 406
Mitochondrial control of immunity: beyond ATP
Mehta, M. M., Weinberg, S. E., & Chandel, N. S. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.66 · Cited by 396
Wang, Y.-L., Lee, Y.-H., Hsu, Y.-H., Chiu, I.-J., Huang, C. C.-Y., Huang, C.-C., Chia, Z.-C., Lee, C.-P., Lin, Y.-F., & Chiu, H.-W. (2021) · Environmental Health Perspectives · doi:10.1289/ehp7612 · Cited by 383
Lv, L., He, L., Jiang, S., Chen, J., Zhou, C., Qu, J., Lu, Y., Hong, P., Sun, S., & Li, C. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.138449 · Cited by 374
Xu, D., Ma, Y., Han, X., & Chen, Y. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.126092 · Cited by 360
Kwak, J. I., & An, Y.-J. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.124034 · Cited by 359
Fernandez-Checa, J. C., Kaplowitz, N., Garcia-Ruiz, C., Colell, A., Miranda, M., Mari, M., Ardite, E., & Morales, A. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.1.g7 · Cited by 333
Potential health impact of environmental micro‐ and nanoplastics pollution
Chang, X., Xue, Y., Li, J., Zou, L., & Tang, M. (2020) · Journal of Applied Toxicology · doi:10.1002/jat.3915 · Cited by 328
Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny
Jeong, B., Baek, J. Y., Koo, J., Park, S., Ryu, Y.-K., Kim, K.-S., Zhang, S., Chung, C., Dogan, R., Choi, H.-S., et al. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.127815 · Cited by 312
Trevisan, R., Voy, C., Chen, S., & Di Giulio, R. T. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.9b02003 · Cited by 309
The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling
Sullivan, L. B., Martinez-Garcia, E., Nguyen, H., Mullen, A. R., Dufour, E., Sudarshan, S., Licht, J. D., Deberardinis, R. J., & Chandel, N. S. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.05.003 · Cited by 304
Zhou, Z., Luo, M., Chen, X., Yin, Y., Xiong, X., Wang, R., & Zhu, Z.-J. (2020) · Nature Communications · doi:10.1038/s41467-020-18171-8 · Cited by 290
Wang, X., Zheng, H., Zhao, J., Luo, X., Wang, Z., & Xing, B. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.9b07016 · Cited by 288
Fumarate induces redox-dependent senescence by modifying glutathione metabolism
Zheng, L., Cardaci, S., Jerby, L., MacKenzie, E. D., Sciacovelli, M., Johnson, T. I., Gaude, E., King, A., Leach, J. D. G., Edrada-Ebel, R., et al. (2015) · Nature Communications · doi:10.1038/ncomms7001 · Cited by 281
The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore
Rottenberg, H., & Hoek, J. B. (2017) · Aging Cell · doi:10.1111/acel.12650 · Cited by 275
Nanoplastics impact on marine biota: A review
Gonçalves, J. M., & Bebianno, M. J. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.116426 · Cited by 234
Halimu, G., Zhang, Q., Liu, L., Zhang, Z., Wang, X., Gu, W., Zhang, B., Dai, Y., Zhang, H., Zhang, C., et al. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128485 · Cited by 221
Self-citationCortés, C., Domenech, J., Salazar, M., Pastor, S., Marcos, R., & Hernández, A. (2020) · Environmental Science: Nano · doi:10.1039/c9en00523d · Cited by 219
Lim, S. L., Ng, C. T., Zou, L., Lu, Y., Chen, J., Bay, B. H., Shen, H.-M., & Ong, C. N. (2019) · Nanotoxicology · doi:10.1080/17435390.2019.1640913 · Cited by 217
Xanthine dehydrogenase/xanthine oxidase and oxidative stress
Chung, H. Y., Baek, B. S., Song, S. H., Kim, M. S., Huh, J. I., Shim, K. H., Kim, K. W., & Lee, K. H. (1997) · AGE · doi:10.1007/s11357-997-0012-2 · Cited by 191
Sendra, M., Saco, A., Yeste, M. P., Romero, A., Novoa, B., & Figueras, A. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2019.121788 · Cited by 182
Liu, X., Zhao, Y., Dou, J., Hou, Q., Cheng, J., & Jiang, X. (2022) · Nano Letters · doi:10.1021/acs.nanolett.1c04184 · Cited by 175
Ding, Y., Zhang, R., Li, B., Du, Y., Li, J., Tong, X., Wu, Y., Ji, X., & Zhang, Y. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.116974 · Cited by 164
Ruenraroengsak, P., & Tetley, T. D. (2015) · Particle and Fibre Toxicology · doi:10.1186/s12989-015-0091-7 · Cited by 163
Energy metabolism controls phenotypes by protein efficiency and allocation
Chen, Y., & Nielsen, J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1906569116 · Cited by 156
Mitochondria and T2D: Role of Autophagy, ER Stress, and Inflammasome
Rocha, M., Apostolova, N., Díaz‐Rúa, R., Muntané, J., & Víctor, V. M. (2020) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2020.03.004 · Cited by 151
Zhang, H., Shao, X., Zhao, H., Li, X., Wei, J., Yang, C., & Cai, Z. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.8b07281 · Cited by 150
Self-citationWang, S., Liu, M., Wang, J., Jingshan, H., & Wang, J. (2020) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2020.111403 · Cited by 140
Cederbaum, A. I. (2014) · Redox Biology · doi:10.1016/j.redox.2014.11.008 · Cited by 136
Large-scale targeted metabolomics method for metabolite profiling of human samples
Cao, G., Song, Z., Hong, Y., Yang, Z., Song, Y., Chen, Z., Chen, Z., & Cai, Z. (2020) · Analytica Chimica Acta · doi:10.1016/j.aca.2020.05.053 · Cited by 104
Self-citationMetabolic disorders of purine metabolism affecting the nervous system
Jinnah, H. A., Sabina, R. L., & Berghe, G. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-444-59565-2.00052-6 · Cited by 96
Limits of human lung function at high altitude
Schoene, R. B. (2001) · Journal of Experimental Biology · doi:10.1242/jeb.204.18.3121 · Cited by 91
Pyroglutamic acidosis by glutathione regeneration blockage in critical patients with septic shock
Gamarra-Morales, Y., Santiago, F. C., Molina‐López, J., Castaño, J., Herrera‐Quintana, L., Domínguez, Á., & Planells, E. (2019) · Critical Care · doi:10.1186/s13054-019-2450-5 · Cited by 79
Song, Y., Li, R., Zhang, Y., Wei, J., Chen, W., Chung, C. K. A., & Cai, Z. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.10.171 · Cited by 73
Self-citationZhang, H., Liang, Y., Wu, P., Shi, X., Zhang, G., & Cai, Z. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.0c08273 · Cited by 31
Self-citationLi, Z., Hou, J., Deng, Y., Zhi, H., Wu, W., Yan, B., Chen, T., Tu, J., Zhu, Z., Wu, W., et al. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.152918 · Cited by 30
Song, Y., & Villeneuve, D. L. (2021) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5197 · Cited by 30
Self-citationAdverse outcome pathways and in vitro toxicology strategies for microplastics hazard testing
Halappanavar, S. S., & Mallach, G. (2021) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2021.09.002 · Cited by 28
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Lee, S. (2026) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2025.2584495 · Cited by 8
Metadata
- Authors
- Lin, S., Zhang, H., Wang, C., Su, X.-L., Song, Y., Wu, P., Yang, Z., Wong, M.-H., Cai, Z., & Zheng, C.
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-08-25
- Volume
- 56
- Issue
- 17
- Pages
- 12483-12493
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- OpenAlex
- W4293104570
- Cited by
- 391
- References
- 61
- FWCI
- 15.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
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