Lactobacillus plantarum strain No. 14 reduces adipocyte size in mice fed high-fat diet

Takemura, Naoki; Okubo, Takuma; Sonoyama, Kei

doi:10.1258/ebm.2010.009377

Cited by 163Probiotics and Fermented FoodsGut microbiota and healthAdipokines, Inflammation, and Metabolic Diseases

Lactobacillus plantarum strain No. 14 reduces adipocyte size in mice fed high-fat diet

Takemura, Naoki, Okubo, Takuma, Sonoyama, Kei·2010·Experimental Biology and Medicine

DOI 10.1258/ebm.2010.009377

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Abstract

Because gut microbiota has recently attracted much attention as an environmental factor involved in the development of obesity, probiotics may be useful in preventing and/or improving obesity and its related disorders. The present study aimed to investigate the effects of Lactobacillus plantarum strain No. 14 (LP14), a bacterial strain reported to decrease body fat percentage in healthy volunteers, on adipocyte size in mice. Female C57BL/6 mice were fed either normal- or high-fat diet and administered intragastrically with LP14 (1 x 10(8) colony-forming units/mouse) or vehicle daily for 11 weeks. High dietary fat intake increased body weight gain, white adipose tissue weight, mean adipocyte size and serum total cholesterol and leptin concentrations, and decreased serum adiponectin concentration. In mice fed the high-fat diet, LP14 administration significantly reduced the mean adipocyte size and tended to reduce the white adipose tissue weight and serum total cholesterol and leptin concentrations as compared with the vehicle-administered mice. All mice had undetectable serum levels of conjugated linoleic acids that reportedly exert antiobesity action. In a separate experiment, LP14 ingestion had no influence on serum triacylglycerol accumulation following olive oil administration in Triton WR1339-treated mice, suggesting that dietary fat absorption is unaffected by LP14. In conclusion, we propose that LP14 may exert a beneficial effect on the onset of diet-induced obesity by reducing the cell size of white adipose tissues, and it seems unlikely that previously reported mechanisms for other bacterial strains are involved in the action of LP14.

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“and beneficial effects in obesity and metabolic syndrome in humans[405,420].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [420]

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Authors: Takemura, N., Okubo, T., & Sonoyama, K.
Affiliations: Hokkaido University (JP)
Graduate School of Life Science
ORCID: Takemura, Naoki
Sonoyama, Kei
Venue: Experimental Biology and Medicine
Publisher: Frontiers Media SA
Published: 2010-07
Volume: 235
Issue: 7
Pages: 849-856
ISSN: 0071-3384 (ISSN-L)
1535-3702
1535-3699
DOI: 10.1258/ebm.2010.009377
OpenAlex: W1996596574
Cited by: 163
References: 41
Citations by year: 2026: 2 · 2025: 5 · 2024: 2 · 2023: 6 · 2022: 11 · 2021: 7 · 2020: 13 · 2019: 9 · 2018: 11 · 2017: 16 · 2016: 11 · 2015: 12 · 2014: 12 · 2013: 20 · 2012: 16
FWCI: 22.54
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Experimental Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Hokkaido University
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords: probiotics, adipocyte size, diet-induced obesity, high-fat diet, white adipose tissue, conjugated linoleic acid, leptin, adiponectin, serum cholesterol, gut microbiota, obesity prevention
MeSH terms: Adipose Tissue, Animals, Body Weight, Cholesterol, Dietary Fats, Female, Mice, Inbred C57BL, Obesity, Triglycerides, Weight Gain, Adipocytes, Leptin, Lactiplantibacillus plantarum, Mice, Adiponectin

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Lactobacillus plantarum strain No. 14 reduces adipocyte size in mice fed high-fat diet

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