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Matrix Metalloproteinases as New Targets in Alzheimer’s Disease: Opportunities and Challenges
Open accessAbstract
Although matrix metalloproteinases (MMPs) are implicated in the regulation of numerous physiological processes, evidence of their pathological roles have also been obtained in the last decades, making MMPs attractive therapeutic targets for several diseases. Recent discoveries of their involvement in central nervous system (CNS) disorders, and in particular in Alzheimer's disease (AD), have paved the way to consider MMP modulators as promising therapeutic strategies. Over the past few decades, diverse approaches have been undertaken in the design of therapeutic agents targeting MMPs for various purposes, leading, more recently, to encouraging developments. In this article, we will present recent examples of inhibitors ranging from small molecules and peptidomimetics to biologics. We will also discuss the scientific knowledge that has led to the development of emerging tools and techniques to overcome the challenges of selective MMP inhibition.
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“MMPs are known to be linked to extracellular protein degradation including Aβ (72), whereas MMPs upregulated in AD may also confer neuroinflammation, synaptic dysfunction, and neuronal death (73, 74).”
From Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming (2024) · cites this paper as [74]
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Alkanlı, N., Alkanlı, S. S., & Ay, A. (2025) · Springer eBooks · doi:10.1007/978-3-031-40858-8_565-1
Zipfel, P. (2020) · theses.fr (ABES) · doi:10.70675/a2a691b7zbde1z435ezac62ze79e3310bff0
Self-citationFunctional Disability and MMPs in Alzheimer’s Disease
Alkanlı, N., Alkanlı, S. S., & Ay, A. (2026) · Springer eBooks · doi:10.1007/978-3-032-11375-7_565
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Self-citationAI-Assisted SERS Decoding of Dual Enzymatic Activity for Intraoperative Chemical Mapping of Epilepsy
Zhao, J., Chen, Z., Wei, Z., Chen, M., Chen, Y., Liang, X., Liu, C., Wang, R., Zou, X., Yu, J., et al. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c09984
Hussain, R., Sarfraz, H., Chohan, T. A., Khurshid, U., Khan, S. A., Hemlata, Tawfeek, A. M., & Islam, M. S. (2026) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2026.147452
Nagashima, Y. (2026) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6c00496
Metadata
- Authors
- Zipfel, P., Rochais, C., Baranger, K., Rivera, S., & Dallemagne, P.
- Affiliations
- Centre d'Etudes et de Recherche sur le Médicament de Normandie (FR)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Dallemagne, Patrick
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-05-27
- Volume
- 63
- Issue
- 19
- Pages
- 10705-10725
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W3029030457
- Cited by
- 94
- References
- 224
- Citations by year
- 2026: 11 · 2025: 23 · 2024: 20 · 2023: 15 · 2022: 13 · 2021: 10 · 2020: 2
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- green
- arxiv.org
- Licence
- Locations
- Journal of Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- arXiv (Cornell University) (submittedVersion)
- HAL (submittedVersion, other-oa)
- arXiv (Cornell University)
- Funders
- Agence Nationale de la Recherche
- European Regional Development Fund
- Aix-Marseille Universit?
- Centre National de la Recherche Scientifique
- Association France Alzheimer
- R?gion Normandie
- Excellence Initiative of Aix-Marseille Universit?
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
- Keywords
- matrix metalloproteinases, Alzheimer's disease, matrix metalloproteinase inhibitors, therapeutic target, peptidomimetics, small molecule inhibitors, central nervous system disorders
- MeSH terms
- Alzheimer Disease, Central Nervous System, Humans, Drug Delivery Systems, Matrix Metalloproteinases, Peptidomimetics, Matrix Metalloproteinase Inhibitors
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