The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Tumor Microenvironment-Mediated Construction and Deconstruction of Extracellular Drug-Delivery Depots
Open accessAbstract
Protein therapy has been considered the most direct and safe approach to treat cancer. Targeting delivery of extracellularly active protein without internalization barriers, such as membrane permeation and endosome escape, is efficient and holds vast promise for anticancer treatment. Herein, we describe a "transformable" core-shell based nanocarrier (designated CS-NG), which can enzymatically assemble into microsized extracellular depots at the tumor site with assistance of hyaluronidase (HAase), an overexpressed enzyme at the tumor microenvironment. Equipped with an acid-degradable modality, the resulting CS-NG can substantially release combinational anticancer drugs-tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) and antiangiogenic cilengitide toward the membrane of cancer cells and endothelial cells at the acidic tumor microenvironment, respectively. Enhanced cytotoxicity on MDA-MB-231 cells and improved antitumor efficacy were observed using CS-NG, which was attributed to the inhibition of cellular internalization and prolonged retention time in vivo.
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Cites
Nanocarriers as an emerging platform for cancer therapy
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Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
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Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
Fulda, S., & Debatin, K.-M. (2006) · Oncogene · doi:10.1038/sj.onc.1209608 · Cited by 2,312
Protein Therapeutics: A Summary and Pharmacological Classification
Leader, B., Baca, Q. J., & Golan, D. E. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2399 · Cited by 2,161
Overcoming the challenges in administering biopharmaceuticals: Formulation and delivery strategies
Mitragotri, S., Burke, P. A., & Langer, R. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4363 · Cited by 1,702
Tailoring nanocarriers for intracellular protein delivery
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Self-citationBacteria‐Responsive Multifunctional Nanogel for Targeted Antibiotic Delivery
Xiong, M., Li, Y., Bao, Y., Yang, X., Hu, B., & Wang, J. (2012) · Advanced Materials · doi:10.1002/adma.201202847 · Cited by 299
Cited by
A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine
Jahangirian, H., Ghasemian lemraski, E., Webster, T. J., Rafiee-Moghaddam, R., & Abdollahi, Y. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s127683 · Cited by 496
Bridging Bio–Nano Science and Cancer Nanomedicine
Björnmalm, M., Thurecht, K. J., Michael, M., Scott, A. M., & Caruso, F. (2017) · ACS Nano · doi:10.1021/acsnano.7b04855 · Cited by 382
Enzyme-Responsive Nanoparticles for Anti-tumor Drug Delivery
Li, M., Zhao, G., Su, W.-K., & Shuai, Q. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.00647 · Cited by 253
Leveraging Physiology for Precision Drug Delivery
Sun, W., Hu, Q., Ji, W., Wright, G., & Gu, Z. (2017) · Physiological Reviews · doi:10.1152/physrev.00015.2016 · Cited by 169
Self-citationZhu, Q., Chen, X., Xu, X., Zhang, Y., Zhang, C., & Mo, R. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201707371 · Cited by 105
Metadata
- Authors
- Hu, Q., Sun, W., Lu, Y., Bomba, H. N., Ye, Y., Jiang, T., Isaacson, A. J., & Gu, Z.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-01-19
- Volume
- 16
- Issue
- 2
- Pages
- 1118-1126
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2261605287
- Cited by
- 162
- References
- 7
- FWCI
- 9.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Hu, Q., Sun, W., Lu, Y., Bomba, H. N., Ye, Y., Jiang, T., Isaacson, A. J., & Gu, Z. (2016). Tumor Microenvironment-Mediated Construction and Deconstruction of Extracellular Drug-Delivery Depots. Nano Letters. https://doi.org/10.1021/acs.nanolett.5b04343
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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