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Cited by 202

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Reprogramming Tumor-Associated Macrophages by Nanoparticle-Based Reactive Oxygen Species Photogeneration

Shi, Changrong, Liu, Ting, Guo, Zhide, Zhuang, Rongqiang, Zhang, Xianzhong, Chen, Xiaoyuan·2018·Nano Letters
DOI 10.1021/acs.nanolett.8b03568
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Abstract

Without coordinated strategies to mitigate the immunosuppressive nature of the tumor microenvironment, cancer immunotherapy generally offers limited clinical benefit for established tumors. Tumor-associated macrophages (TAMs) are the critical driver of this immunosuppressive tumor microenvironment, which also promotes tumor metastasis. Here we successfully reprogrammed TAMs to an antitumor M1 phenotype using precision nanoparticle-based reactive oxygen species photogeneration, which demonstrated superior efficiency and efficacy over lipopolysaccharide stimulation. Meanwhile, antigen presentation and T-cell-priming by TAMs were enhanced by inhibiting lysosomal proton pump and proteolytic activity or by promoting tumor associated antigen release in the cytoplasm. The reprogrammed TAMs orchestrate cytotoxic lymphocyte (CTL) recruitment in the tumor and direct memory T-cells toward tumoricidal responses. This strategy could effectively eradicate tumors, inhibit metastasis, and further prevent their recurrence, which holds tremendous promise to realize potent cancer immunotherapy.

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Metadata

Authors
Shi, C., Liu, T., Guo, Z., Zhuang, R., Zhang, X., & Chen, X.
Venue
Nano Letters
Publisher
American Chemical Society (ACS)
Published
2018-10-19
Volume
18
Issue
11
Pages
7330-7342
ISSN
  • 1530-6984 (ISSN-L)
  • 1530-6992
DOI
10.1021/acs.nanolett.8b03568
OpenAlex
W2896596725
Cited by
202
References
14
FWCI
8.28
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Reprogramming Tumor-Associated Macrophages by Nanoparticle-Based Reactive Oxygen Species Photogeneration. https://app.cochat.ai/papers/10.1021/acs.nanolett.8b03568
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Shi, C., Liu, T., Guo, Z., Zhuang, R., Zhang, X., & Chen, X. (2018). Reprogramming Tumor-Associated Macrophages by Nanoparticle-Based Reactive Oxygen Species Photogeneration. Nano Letters. https://doi.org/10.1021/acs.nanolett.8b03568

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