The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
In Vivo High-resolution Ratiometric Fluorescence Imaging of Inflammation Using NIR-II Nanoprobes with 1550 nm Emission
Abstract
Quantitatively imaging the spatiotemporal distribution of biological events in living organisms is essential to understand fundamental biological processes. Self-calibrating ratiometric fluorescent probes enable accurate and reliable imaging and sensing, but conventional probes using wavelength of 400-900 nm suffer from extremely low resolution for in vivo application due to the disastrous photon scattering and tissue autofluorescence background. Here, we develop a NIR-IIb (1500-1700 nm) emissive nanoprobe for high-resolution ratiometric fluorescence imaging in vivo. The obtained nanoprobe shows fast ratiometric response to hypochlorous acid (HOCl) with a detection limit down to 500 nM, through an absorption competition-induced emission (ACIE) bioimaging system between lanthanide-based downconversion nanoparticles and Cy7.5 fluorophores. Additionally, we demonstrate the superior spatial resolution of 1550 nm to a penetration depth of 3.5 mm in a scattering tissue phantom, which is 7.1-fold and 2.1-fold higher than that of 1064 and 1344 nm, respectively. With this nanoprobe, clear anatomical structures of lymphatic inflammation in ratiometric channel are observed with a precise resolution of ∼477 μm. This study will motivate the further research on the development of NIR-II probes for high-resolution biosensing in vivo.
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Cites
Second window for in vivo imaging
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Next-generation in vivo optical imaging with short-wave infrared quantum dots
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Bright quantum dots emitting at ∼1,600 nm in the NIR-IIb window for deep tissue fluorescence imaging
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Sun, C., Li, B., Zhao, M., Wang, S., Lei, Z., Lu, L., Zhang, H., Feng, L., Dou, C., Yin, D., et al. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b10043 · Cited by 582
Self-citationNear-infrared luminescence high-contrast in vivo biomedical imaging
Chen, Y., Wang, S., & Zhang, F. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-022-00002-8 · Cited by 566
Self-citationLiu, Y., Li, Y., Koo, S., Sun, Y., Liu, Y., Liu, X., Pan, Y., Zhang, Z., Du, M., Lu, S., et al. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00553 · Cited by 537
NIR-II light in clinical oncology: opportunities and challenges
Zhang, Z., Du, Y., Shi, X., Wang, K., Qu, Q., Liang, Q., Ma, X., He, K., Chi, C., Tang, J., et al. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-024-00892-0 · Cited by 341
Novel NIR-II organic fluorophores for bioimaging beyond 1550 nm
Li, Y., Liu, Y., Li, Q., Zeng, X., Tian, T., Zhou, W., Cui, Y., Wang, X., Cheng, X., Ding, Q., et al. (2020) · Chemical Science · doi:10.1039/c9sc06567a · Cited by 177
Metadata
- Authors
- Wang, S., Liu, L., Fan, Y., El-Toni, A. M., Alhoshan, M. S., li, D., & Zhang, F.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-03-18
- Volume
- 19
- Issue
- 4
- Pages
- 2418-2427
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2921852197
- Cited by
- 252
- References
- 6
- FWCI
- 13.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, S., Liu, L., Fan, Y., El-Toni, A. M., Alhoshan, M. S., li, D., & Zhang, F. (2019). In Vivo High-resolution Ratiometric Fluorescence Imaging of Inflammation Using NIR-II Nanoprobes with 1550 nm Emission. Nano Letters. https://doi.org/10.1021/acs.nanolett.8b05148
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