J -Aggregates of Cyanine Dye for NIR-II in Vivo Dynamic Vascular Imaging beyond 1500 nm
Abstract
Light in the second near-infrared window, especially beyond 1500 nm, shows enhanced tissue transparency for high-resolution in vivo optical bioimaging due to decreased tissue scattering, absorption, and autofluorescence. Despite some inorganic luminescent nanoparticles have been developed to improve the bioimaging around 1500 nm, it is still a great challenge to synthesize organic molecules with the absorption and emission toward this region. Here, we present J -aggregates with 1360 nm absorption and 1370 nm emission formed by self-assembly of amphiphilic cyanine dye FD-1080 and 1,2-dimyristoyl- sn -glycero-3-phosphocholine. Molecular dynamics simulations were further employed to illustrate the self-assembly process. Superior spatial resolution and high signal-to-background ratio of J -aggregates were demonstrated for noninvasive brain and hindlimb vasculature bioimaging beyond 1500 nm. The efficacy evaluation of the clinically used hypotensor is successfully achieved by high-resolution in vivo dynamic vascular imaging with J -aggregates.
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FD-1080 cyanine dye coassembled with dipalmitoylphosphatidylcholine (DMPC) lipid via a film dispersion method allowed preparation of nanoparticles with an average size of 110 nm.
“FD-1080 cyanine dye coassembled with dipalmitoylphosphatidylcholine (DMPC) lipid via a film dispersion method allowed one to prepare nanoparticles with an average size of 110 nm.”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [113]
The fluorescence lifetime of FD-1080/DMPC nanoparticles was shortened from 312 to 172 ps.
“The fluorescence lifetime was shortened from 312 to 172 ps.”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [113]
Steady-state absorption and fluorescence spectra of FD-1080/DMPC nanoparticles revealed a small (10 nm) Stokes shift and a large red shift (300 nm) compared to the FD-1080 monomer, with spectral peaks located at 1360 and 1370 nm, respectively.
“Steady-state absorption and fluorescence spectra of FD-1080/DMPC nanoparticles revealed a small (10 nm) Stokes shift and a large red shift (300 nm) as compared to the FD-1080 monomer with spectral peak located at 1360 and 1370 nm, respectively.113”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [113]
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- Authors
- Sun, C., Li, B., Zhao, M., Wang, S., Lei, Z., Lu, L., Zhang, H., Feng, L., Dou, C., Yin, D., Xu, H., Cheng, Y., & Zhang, F.
- Affiliations
- Fudan University (CN)
- Shanghai Jiao Tong University (CN)
- Tongji University (CN)
- Corresponding author
- Zhang, Fan
- ORCID
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-11-20
- Volume
- 141
- Issue
- 49
- Pages
- 19221-19225
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2989893681
- Cited by
- 582
- References
- 61
- Citations by year
- 2026: 58 · 2025: 76 · 2024: 81 · 2023: 92 · 2022: 107 · 2021: 78 · 2020: 89
- FWCI
- 24.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of the American Chemical Society (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Technology of the People's Republic of China (2017YFA0207303)
- Science and Technology Commission of Shanghai Municipality (17JC1400100, 19490713100)
- National Natural Science Foundation of China (21725502)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Keywords
- J-aggregates, cyanine dyes, NIR-II imaging, self-assembly, amphiphilic dyes, phosphatidylcholine, molecular dynamics simulation, cerebral vasculature, tissue transparency
- MeSH terms
- Animals, Carbocyanines, Carotid Arteries, Dimyristoylphosphatidylcholine, Fluorescent Dyes, Rats, Inbred SHR, Spectroscopy, Near-Infrared, Nanoparticles, Molecular Dynamics Simulation, Hydrophobic and Hydrophilic Interactions, Optical Imaging
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