Biodegradable, Tissue Adhesive Polyester Blends for Safe, Complete Wound Healing
Open accessAbstract
Pressure-sensitive adhesives typically used for bandages are nonbiodegradable, inhibiting healing, and may cause an allergic reaction. Here, we investigated the effect of biodegradable copolymers with promising thermomechanical properties on wound healing for their eventual use as biodegradable, biocompatible adhesives. Blends of low molecular weight (LMW) and high molecular weight (HMW) poly(lactide- co -caprolactone) (PLCL) are investigated as tissue adhesives in comparison to a clinical control. Wounds treated with PLCL blend adhesives heal completely with similar vascularization, scarring, and inflammation indicators, yet require fewer dressing changes due to integration of the PLCL adhesive into the wound. A blend of LMW and HMW PLCL produces an adhesive material with significantly higher adhesive strength than either neat polymer. Wound adhesion is comparable to a polyurethane bandage, utilizing conventional nonbiodegradable adhesives designed for extremely strong adhesion.
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PLCL applications include wound healing, vascular transplantation, bone and cartilage repair, and drug delivery systems.
“These applications include wound healing, vascular transplantation, bone and cartilage repair, and even drug delivery systems [14–20].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [14]
The Results (page unavailable) explicitly describe PLCL use in wound healing applications. The paper does not identify PLCL applications in vascular transplantation, bone or cartilage repair, or drug delivery; its measurements of wound revascularization do not establish vascular transplantation as an application. (LLM, conf=0.88)
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- Authors
- Daristotle, J. L., Erdi, M., Lau, L. W., Zaki, S. T., Srinivasan, P., Balabhadrapatruni, M., Ayyub, O. B., Sandler, A. D., & Kofinas, P.
- Affiliations
- University of Maryland, College Park (US)
- Children's National (US)
- Corresponding author
- Kofinas, Peter
- Venue
- ACS Biomaterials Science & Engineering
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-07-29
- Volume
- 7
- Issue
- 8
- Pages
- 3908-3916
- ISSN
- 2373-9878 (ISSN-L)
- PMC
- PMC8594560
- OpenAlex
- W3186272611
- Cited by
- 34
- References
- 37
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 7 · 2023: 7 · 2022: 5
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- ACS Biomaterials Science & Engineering (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (F31EB025735, R01EB019963)
- University of Maryland
- Topics
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Keywords
- tissue adhesives, wound healing, biodegradable adhesives, pressure-sensitive adhesives, bandages, adhesion strength, vascularization, scar formation, inflammation, dressing changes, biocompatibility
- MeSH terms
- Adhesives, Bandages, Polyesters, Tissue Adhesives, Wound Healing
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