The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
3D Bioprinting of Vessel-like Structures with Multilevel Fluidic Channels
Abstract
In this study, 3D hydrogel-based vascular structures with multilevel fluidic channels (macro-channel for mechanical stimulation and microchannel for nutrient delivery and chemical stimulation) were fabricated by extrusion-based three-dimensional (3D) bioprinting, which could be integrated into organ-on-chip devices that would better simulate the microenvironment of blood vessels. In this approach, partially cross-linked hollow alginate filaments loading fibroblasts and smooth muscle cells were extruded through a coaxial nozzle and then printed along a rotated rod template, and endothelial cells were seeded into the inner wall. Because of the fusion of adjacent hollow filaments, two-level fluidic channels, including a macro-channel in the middle formed from the cylindrical template and a microchannel around the wall resulted from the hollow filaments were formed. By this method, different shapes of vessellike structures of millimeter diameter were printed. The structures printed using 4% alginate exhibited ultimate strength of 0.184 MPa, and L929 mouse fibroblasts encapsulated in the structures showed over 90% survival within 1 week. As a proof of concept, an envisioned load system of both mechanical and chemical stimulation was demonstrated. In addition, a vascular circulation flow system, a cerebral artery surgery simulator, and a cell coculture model were fabricated to demonstrate potential tissue engineering applications of these printed structures.
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Askari, M., Afzali Naniz, M., Kouhi, M., Saberi, A., Zolfagharian, A., & Bodaghi, M. (2021) · Biomaterials Science · doi:10.1039/d0bm00973c · Cited by 369
Tissue Engineering and Regenerative Medicine: Achievements, Future, and Sustainability in Asia
Han, F., Wang, J., Ding, L., Hu, Y., Li, W., Yuan, Z., Guo, Q., Zhu, C., Yu, L., Wang, H., et al. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00083 · Cited by 357
Design, printing, and engineering of regenerative biomaterials for personalized bone healthcare
Jia, Z., Xu, X., Zhu, D., & Zheng, Y. (2023) · Progress in Materials Science · doi:10.1016/j.pmatsci.2023.101072 · Cited by 176
3D printing to innovate biopolymer materials for demanding applications: A review
Li, N., Qiao, D., Zhao, S., Lin, Q., Zhang, B., & Xie, F. (2021) · Materials Today Chemistry · doi:10.1016/j.mtchem.2021.100459 · Cited by 142
Metadata
- Authors
- Gao, Q., Liu, Z., Lin, Z., Qiu, J., Liu, Y., Liu, A., Wang, Y., Xiang, M., Chen, B., Fu, J., & He, Y.
- Venue
- ACS Biomaterials Science & Engineering
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-02-09
- Volume
- 3
- Issue
- 3
- Pages
- 399-408
- ISSN
- 2373-9878 (ISSN-L)
- OpenAlex
- W2577084245
- Cited by
- 267
- References
- 46
- FWCI
- 10.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gao, Q., Liu, Z., Lin, Z., Qiu, J., Liu, Y., Liu, A., Wang, Y., Xiang, M., Chen, B., Fu, J., & He, Y. (2017). 3D Bioprinting of Vessel-like Structures with Multilevel Fluidic Channels. ACS Biomaterials Science & Engineering. https://doi.org/10.1021/acsbiomaterials.6b00643
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