SARS-CoV-2: Olfaction, Brain Infection, and the Urgent Need for Clinical Samples Allowing Earlier Virus Detection

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Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms

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Human herpesvirus-6 entry into the central nervous system through the olfactory pathway

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The human olfactory transcriptome

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Olfactory sensory neurons mediate ultrarapid antiviral immune responses in a TrkA-dependent manner

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Deep Sequencing of the Murine Olfactory Receptor Neuron Transcriptome

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SARS-CoV-2 is associated with changes in brain structure in UK Biobank

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Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

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Smell dysfunction: a biomarker for COVID‐19

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Experimental Transmission Studies of SARS-CoV-2 in Fruit Bats, Ferrets, Pigs and Chickens

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COVID-19: Specific and Non-Specific Clinical Manifestations and Symptoms: The Current State of Knowledge

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Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age

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Neurobiology of COVID-19

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Anosmia in COVID-19: Underlying Mechanisms and Assessment of an Olfactory Route to Brain Infection

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Central nervous system complications associated with SARS-CoV-2 infection: integrative concepts of pathophysiology and case reports

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Prevalence of Chemosensory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis Reveals Significant Ethnic Differences

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Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2

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Editorial: Nicotine and SARS-CoV-2: COVID-19 may be a disease of the nicotinic cholinergic system

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On the whereabouts of SARS-CoV-2 in the human body: A systematic review

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The chronic neuropsychiatric sequelae of COVID‐19: The need for a prospective study of viral impact on brain functioning

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SERS Based Lateral Flow Immunoassay for Point-of-Care Detection of SARS-CoV-2 in Clinical Samples

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The Loss of Smell and Taste in the COVID-19 Outbreak: a Tale of Many Countries

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The role of Neuropilin-1 in COVID-19

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Cognitive Impairment After COVID-19—A Review on Objective Test Data

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Pathogenesis of Multiple Organ Injury in COVID-19 and Potential Therapeutic Strategies

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Proinflammatory Cytokines in the Olfactory Mucosa Result in COVID-19 Induced Anosmia

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SARS-CoV-2 and the Nervous System: From Clinical Features to Molecular Mechanisms

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Multi-Organ Involvement in COVID-19: Beyond Pulmonary Manifestations

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Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology

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Neurological complications and infection mechanism of SARS-CoV-2

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Multiple Neuroinvasive Pathways in COVID-19

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Potential neuroinvasive pathways of SARS‐CoV‐2: Deciphering the spectrum of neurological deficit seen in coronavirus disease‐2019 (COVID‐19)

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Higher airborne pollen concentrations correlated with increased SARS-CoV-2 infection rates, as evidenced from 31 countries across the globe

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Olfactory and taste disorders in COVID-19: a systematic review

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The olfactory nerve is not a likely route to brain infection in COVID-19: a critical review of data from humans and animal models

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Dysgeusia in COVID-19: Possible Mechanisms and Implications

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ACE2 and SCARF expression in human dorsal root ganglion nociceptors: implications for SARS-CoV-2 virus neurological effects

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Nasal vaccination against SARS-CoV-2: Synergistic or alternative to intramuscular vaccines?

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A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

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Olfactory and gustatory dysfunctions in 100 patients hospitalized for COVID-19: sex differences and recovery time in real-life

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Neurological features of COVID-19 and their treatment: a review

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Lung innervation in the eye of a cytokine storm: neuroimmune interactions and COVID-19

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COVID-19 intranasal vaccines: current progress, advantages, prospects, and challenges

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Evaluation of silver nanoparticles for the prevention of SARS-CoV-2 infection in health workers: In vitro and in vivo

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Relationships between SARS-CoV-2 in Wastewater and COVID-19 Clinical Cases and Hospitalizations, with and without Normalization against Indicators of Human Waste

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Mechanism of Anosmia Caused by Symptoms of COVID-19 and Emerging Treatments

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Anosmia in COVID-19: A Bumpy Road to Establishing a Cellular Mechanism

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Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier?

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Povidone-Iodine Use in Sinonasal and Oral Cavities: A Review of Safety in the COVID-19 Era

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and glial cells: Insights and perspectives

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Olfactory Dysfunction in the COVID-19 Outbreak

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COVID‐19 and seizures: Is there a link?

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Expression of ACE2 in airways: Implication for COVID‐19 risk and disease management in patients with chronic inflammatory respiratory diseases

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Smell and taste dysfunction in patients with SARS-CoV-2 infection: A review of epidemiology, pathogenesis, prognosis, and treatment options

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Update on neurological manifestations of COVID-19

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Neurological consequences of COVID-19: what have we learned and where do we go from here?

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Coronaviruses and the Chemical Senses: Past, Present, and Future

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Infection Mechanism of SARS-COV-2 and Its Implication on the Nervous System

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Potential neurological effects of severe COVID-19 infection

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SARS-CoV-2 Infections and ACE2: Clinical Outcomes Linked With Increased Morbidity and Mortality in Individuals With Diabetes

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Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients

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The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication

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Brain imaging and neuropsychological assessment of individuals recovered from a mild to moderate SARS-CoV-2 infection

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Epigenetic regulation of ACE2, the receptor of the SARS-CoV-2 virus1

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Lactoferrin as Antiviral Treatment in COVID-19 Management: Preliminary Evidence

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Mapping of SARS-CoV-2 Brain Invasion and Histopathology in COVID-19 DiseasePreprint

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Spectrum of Headaches Associated With SARS‐CoV‐2 Infection: Study of Healthcare Professionals

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Neurological symptoms in COVID-19: a cross-sectional monocentric study of hospitalized patients

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SARS-CoV-2: is there neuroinvasion?

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Zinc against COVID-19? Symptom surveillance and deficiency risk groups

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Prevalence of Antibodies to SARS-CoV-2 in Italian Adults and Associated Risk Factors

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Rapid diagnosis of SARS-CoV-2 using potential point-of-care electrochemical immunosensor: Toward the future prospects

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Expression of SARS-CoV-2-related receptors in cells of the neurovascular unit: implications for HIV-1 infection

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Long COVID Neuropsychological Deficits after Severe, Moderate, or Mild Infection

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Could Ergothioneine Aid in the Treatment of Coronavirus Patients?

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Neuropathophysiology of coronavirus disease 2019: neuroinflammation and blood brain barrier disruption are critical pathophysiological processes that contribute to the clinical symptoms of SARS-CoV-2 infection

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Long COVID, the Brain, Nerves, and Cognitive Function

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ACE2 Protein Landscape in the Head and Neck Region: The Conundrum of SARS-CoV-2 Infection

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Viral infection and smell loss: The case of COVID‐19

Glezer, I., Bruni‐Cardoso, A., Schechtman, D., & Malnic, B. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15197 · Cited by 69

Central Nervous System Targets and Routes for SARS-CoV-2: Current Views and New Hypotheses

Barrantes, F. J. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00434 · Cited by 65

SARS-CoV-2, an Underestimated Pathogen of the Nervous System

Jakhmola, S., Indari, O., Chatterjee, S., & Jha, H. C. (2020) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-020-00522-7 · Cited by 64

ACE2 & TMPRSS2 Expressions in Head & Neck Tissues: A Systematic Review

Lechien, J. R., Radulesco, T., Calvo‐Henríquez, C., Chiesa-Estomba, C. M., Hans, S., Barillari, M. R., Cammaroto, G., Descamps, G., Hsieh, J. W., Vaira, L. A., et al. (2020) · Head and Neck Pathology · doi:10.1007/s12105-020-01212-5 · Cited by 64

The COVID-19 pandemic and Alzheimer’s disease: mutual risks and mechanisms

Chen, F., Chen, Y., Wang, Y., Ke, Q., & Cui, L. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00316-y · Cited by 63

THE NERVOUS SYSTEM DAMAGE IN COVID-19 PATIENTS

Викторович, Б. В., Samoilova, E. M., & Baklaushev, V. P. (2020) · Journal of clinical practice · doi:10.17816/clinpract34851 · Cited by 89

WITHDRAWN: SARS-CoV-2 invades cognitive centers of the brain and induces Alzheimer’s-like neuropathologyPreprint

Shen, W., Elahi, M., Logue, J., Yang, P., Baracco, L., Reece, E. A., Wang, B., Li, L., Blanchard, T. G., Han, Z., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.31.478476 · Cited by 59

A Review on the Neurological Manifestations of COVID-19 Infection: a Mechanistic View

Zangbar, H. S., Gorji, A., & Ghadiri, T. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02149-0 · Cited by 57

Anosmia as a presenting symptom of SARS-CoV-2 infection in healthcare workers – A systematic review of the literature, case series, and recommendations for clinical assessment and management

Lechner, M., Chandrasekharan, D. P., Jumani, K., Liu, J., Gane, S. B., Lund, V. J., Philpott, C. M., & Jayaraj, S. M. (2020) · Rhinology Journal · doi:10.4193/rhin20.189 · Cited by 58

Protein expression of angiotensin‐converting enzyme 2, a SARS‐CoV ‐2‐specific receptor, in fetal and placental tissues throughout gestation: new insight for perinatal counseling

Faure‐Bardon, V., Isnard, P., Roux, N., Leruez‐Ville, M., Molina, T. J., Bessières, B., & Ville, Y. G. (2020) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.22178 · Cited by 56

Anosmia: a missing link in the neuroimmunology of coronavirus disease 2019 (COVID-19)

Yazdanpanah, N., Saghazadeh, A., & Rezaei, N. (2020) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0039 · Cited by 58

Gaining Back What Is Lost: Recovering the Sense of Smell in Mild to Moderate Patients After COVID-19

Iannuzzi, L., Salzo, A. E., Angarano, G., Palmieri, V. O., Portincasa, P., Saracino, A., Gelardi, M., Dibattista, M., & Quaranta, N. A. A. (2020) · Chemical Senses · doi:10.1093/chemse/bjaa066 · Cited by 61

A Review on SARS-CoV-2-Induced Neuroinflammation, Neurodevelopmental Complications, and Recent Updates on the Vaccine Development

Karnik, M., Beeraka, N. M., Uthaiah, C. A., Nataraj, S. M., Bettadapura, A. D. S., Aliev, G., & Madhunapantula, S. V. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02399-6 · Cited by 56

Olfactory Cleft Measurements and COVID‐19–Related Anosmia

Altundağ, A., Yıldırım, D., Şanlı, D. E. T., Çayönü, M., Kandemirli, S. G., Şanlı, A. N., Düz, Ö. A., & Saatçi, Ö. (2020) · Otolaryngology · doi:10.1177/0194599820965920 · Cited by 53

COVID-19 Pandemic: A Neurological Perspective

Bishokarma, S. (2020) · Journal of Lumbini Medical College · doi:10.22502/jlmc.v8i1.334 · Cited by 51

Ambulatory COVID-19 Patients Treated with Lactoferrin as a Supplementary Antiviral Agent: A Preliminary Study

Rosa, L., Tripepi, G. L., Naldi, E., Aimati, M., Santangeli, S., Venditto, F., Caldarelli, M., & Valenti, P. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10184276 · Cited by 51

Cellular mechanisms underlying neurological/neuropsychiatric manifestations of COVID‐19

Bodnar, B. H., Patel, K., Ho, W., Luo, J. J., & Hu, W. (2020) · Journal of Medical Virology · doi:10.1002/jmv.26720 · Cited by 51

Co‑expression of peripheral olfactory receptors with SARS‑CoV‑2 infection mediators: Potential implications beyond loss of smell as a COVID‑19 symptom

Kerslake, R., Hall, M., Randeva, H. S., Spandidos, D. A., Chatha, K. K., Kyrou, I., & Karteris, E. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4646 · Cited by 49

Taste and Smell Dysfunction in COVID-19 Patients

Abalo-Lojo, J. M., Pouso-Diz, J. M., & González, F. (2020) · Annals of Otology Rhinology & Laryngology · doi:10.1177/0003489420932617 · Cited by 49

Effects of Antimalarial Drugs on Neuroinflammation-Potential Use for Treatment of COVID-19-Related Neurologic Complications

Ong, W., Go, M., Wang, D. Y., Cheah, I. K.-M., & Halliwell, B. B. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02093-z · Cited by 49

COVID-19 Neurological Manifestations and Underlying Mechanisms: A Scoping Review

Wenting, A., Gruters, A. A. A., van Os, Y., Verstraeten, S., Valentijn, S. A. M., Ponds, R., & de Vugt, M. E. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00860 · Cited by 51

Long COVID, neuropsychiatric disorders, psychotropics, present and future

Tang, S. W., Leonard, B. E., & Helmeste, D. M. (2022) · Acta Neuropsychiatrica · doi:10.1017/neu.2022.6 · Cited by 45

The Effect of COVID-19 on NF-κB and Neurological Manifestations of Disease

Davies, D. A., Adlimoghaddam, A., & Albensi, B. C. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02438-2 · Cited by 47

Olfactory and gustatory dysfunctions in COVID-19 patients: A systematic review and meta-analysis

Hoang, M. P., Kanjanaumporn, J., Aeumjaturapat, S., Chusakul, S., Seresirikachorn, K., & Snidvongs, K. (2019) · Asian Pacific Journal of Allergy and Immunology · doi:10.12932/ap-210520-0853 · Cited by 46

SARS-CoV-2 Brain Regional Detection, Histopathology, Gene Expression, and Immunomodulatory Changes in Decedents with COVID-19

Serrano, G. E., Walker, J. E., Tremblay, C., Piras, I. S., Huentelman, M. J., Belden, C. M., Goldfarb, D., Shprecher, D., Atri, A., Adler, C. H., et al. (2022) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlac056 · Cited by 45

The potential role of the carotid body in COVID-19

Porzionato, A., Emmi, A., Stocco, E., Barbon, S., Rafael Boscolo-berto, A., Macchi, V., & De, R. (2020) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00309.2020 · Cited by 44

Pathophysiological relationship between COVID-19 and olfactory dysfunction: A systematic review

Lima, M. H. D. L. C., Cavalcante, A. L. B., & Leão, S. C. (2021) · Brazilian Journal of Otorhinolaryngology · doi:10.1016/j.bjorl.2021.04.001 · Cited by 43

Anosmia in COVID-19: Underlying Mechanisms and Assessment of an Olfactory Route to Brain Infection

Butowt, R., & von Bartheld, C. S. (2021) · The Neuroscientist · doi:10.1177/1073858420956905 · Cited by 345

Elevated ACE-2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication

Chen, M., Shen, W., Rowan, N. R., Kulaga, H. M., Hillel, A. T., Ramanathan, M., & Lane, A. P. (2020) · European Respiratory Journal · doi:10.1183/13993003.01948-2020 · Cited by 246

SARS-CoV-2 receptor and entry genes are expressed by sustentacular cells in the human olfactory neuroepithelium

Fodoulian, L., Tuberosa, J., Rossier, D., Boillat, M., Kan, C., Pauli, V., Egervari, K., Lobrinus, J. A., Landis, B. N., Carleton, A., et al. (2020) · doi:10.1101/2020.03.31.013268 · Cited by 286

Anosmia in COVID-19: Underlying Mechanisms and Assessment of an Olfactory Route to Brain Infection (Russian translation)

Butowt, R., & von Bartheld, C. S. (2021) · Juvenis scientia · doi:10.32415/jscientia_2021_7_5_28-59 · Cited by 2

Olfactory Receptivity and COVID-19: A probable rapid testing solution

Gupta, R. (2020) · Journal of computational methods in molecular design