The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
pH/Glucose Dual Responsive Metformin Release Hydrogel Dressings with Adhesion and Self-Healing via Dual-Dynamic Bonding for Athletic Diabetic Foot Wound Healing
Abstract
In view of the lack of a specific drug-sustained release system that is responsive to chronic wounds of the type II diabetic foot, and the demands for frequent movement at the foot wound, pH/glucose dual-responsive metformin-released adhesion-enhanced self-healing easy-removable antibacterial antioxidant conductive hemostasis multifunctional phenylboronic acid and benzaldehyde bifunctional polyethylene glycol- co -poly(glycerol sebacic acid)/dihydrocaffeic acid and l -arginine cografted chitosan (PEGS-PBA-BA/CS-DA-LAG, denoted as PC) hydrogel dressings were constructed based on the double dynamic bond of the Schiff-base and phenylboronate ester. It was further demonstrated that the PC hydrogel promotes wound healing by reducing inflammation and enhancing angiogenesis in a rat type II diabetic foot model. In addition, the addition of metformin (Met) and graphene oxide (GO), as well as their synergy, were confirmed to better promote wound repair in vivo . In summary, adhesion-enhanced self-healing multifunctional PC/GO/Met hydrogels with stimuli-responsive metformin release ability and easy removability have shown a promoting effect on the healing of chronic athletic diabetic wounds and provide a local-specific drug dual-response release strategy for the treatment of type II diabetic feet.
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Citations
Cites
Functional Hydrogels as Wound Dressing to Enhance Wound Healing
Liang, Y., He, J., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c04206 · Cited by 3,135
Self-citationArginine metabolism: nitric oxide and beyond
WU, G., & MORRIS, S. M. (1998) · Biochemical Journal · doi:10.1042/bj3360001 · Cited by 2,811
Tonnesen, M. G., Feng, X., & Clark, R. A. F. (2000) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1046/j.1087-0024.2000.00014.x · Cited by 1,463
Catechol-functionalized chitosan/pluronic hydrogels for tissue adhesives and hemostatic materials
Ryu, J. H., Lee, Y., Kong, W. H., Kim, T. G., Park, T. G., & Lee, H. (2011) · Biomacromolecules · doi:10.1021/bm200464x · Cited by 677
Wang, R., Li, J., Chen, W., Xu, T., Yun, S., Xu, Z., Xu, Z., Sato, T., Chi, B., & Xu, H. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201604894 · Cited by 471
Self-citationShan, M., Gong, C., Li, B., & Wu, G. (2017) · Polymer Chemistry · doi:10.1039/c7py00519a · Cited by 151
Cited by
Anti‐inflammatory hydrogel dressings and skin wound healing
Huang, C., Dong, L., Zhao, B., Lu, Y., Huang, S., Yuan, Z., Luo, G., Xu, Y., & Qian, W. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.1094 · Cited by 445
Antibacterial adhesive self-healing hydrogels to promote diabetic wound healing
Chen, J., He, J., Yang, Y., Qiao, L., Hu, J., Zhang, J., & Guo, B. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.04.041 · Cited by 359
Self-citationLiang, Y., Xu, H., Li, Z., Zhangji, A., & Guo, B. (2022) · Nano-Micro Letters · doi:10.1007/s40820-022-00928-z · Cited by 313
Self-citationLi, H., Li, B., Lv, D., Li, W., Lu, Y., & Luo, G. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114778 · Cited by 142
Stimuli‐Responsive Hydrogels for Antibacterial Applications
Hao, Z., Li, X., Zhang, R., & Zhang, L. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400513 · Cited by 135
Metadata
- Authors
- Liang, Y., Li, M., Yang, Y., Qiao, L., Xu, H., & Guo, B.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-01-31
- Volume
- 16
- Issue
- 2
- Pages
- 3194-3207
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W4210568695
- Cited by
- 876
- References
- 6
- FWCI
- 69.39
- Type
- journal article
- Language
- en
- Open access
- closed
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