Bright, Magnetic NIR-II Quantum Dot Probe for Sensitive Dual-Modality Imaging and Intensive Combination Therapy of Cancer
Abstract
Improving the effectiveness of cancer therapy will require tools that enable more specific cancer targeting and improved tumor visualization. Theranostics have the potential for improving cancer care because of their ability to serve as both diagnostics and therapeutics; however, their diagnostic potential is often limited by tissue-associated light absorption and scattering. Herein, we develop CuInSe 2 @ZnS:Mn quantum dots (QDs) with intrinsic multifunctionality that both enable the accurate localization of small metastases and act as potent tumor ablation agents. By leveraging the growth kinetics of a ZnS shell on a biocompatible CuInSe 2 core, Mn doping, and folic acid functionalization, we produce biocompatible QDs with high near-infrared (NIR)-II fluorescence efficiency up to 31.2%, high contrast on magnetic resonance imaging (MRI), and preferential distribution in 4T1 breast cancer tumors. MRI-enabled contrast of these nanoprobes is sufficient to timely identify small metastases in the lungs, which is critically important for preventing cancer spreading and recurrence. Further, exciting tumor-resident QDs with NIR light produces both fluorescence for tumor visualization through radiative recombination pathways as well as heat and radicals through nonradiative recombination pathways that kill cancer cells and initiate an anticancer immune response, which eliminates tumor and prevents tumor regrowth in 80% of mice.
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A multifunctional QD with CISe core, ZnS shell, manganese doping, and folic acid functionalization possesses high near-infrared (NIR)-II fluorescence efficiency of up to 31.2% and high contrast on magnetic resonance imaging (MRI).
“With CISe as the core, ZnS as the shell, manganese doping, and folic acid functionalization, a multifunctional QD has recently been produced. It possesses high near-infrared (NIR)-II fluorescence efficiency of up to 31.2% and high contrast on magnetic resonance imaging (MRI).105”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [105]
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- Authors
- Li, Y., Zhang, P., Tang, W., McHugh, K. J., Kershaw, S. V., Jiao, M., Huang, X., Kalytchuk, S., Perkinson, C. F., Yue, S., Qiao, Y., Zhu, L., Jing, L., Gao, M., & Han, B.
- Affiliations
- Chinese Academy of Sciences (CN)
- State Key Laboratory of Luminescent Materials and Devices (CN)
- Rice University (US)
- City University of Hong Kong (HK)
- Qingdao University of Science and Technology (CN)
- Regional Centre of Advanced Technologies and Materials (CZ)
- Massachusetts Institute of Technology (US)
- Beijing University of Chemical Technology (CN)
- Corresponding author
- Jing, Lihong
- ORCID
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-04-20
- Volume
- 16
- Issue
- 5
- Pages
- 8076-8094
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W4224239775
- Cited by
- 98
- References
- 76
- Citations by year
- 2026: 18 · 2025: 30 · 2024: 21 · 2023: 21 · 2022: 8
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Nano (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Technology of the People's Republic of China (2018YFA0208800)
- Youth Innovation Promotion Association of the Chinese Academy of Sciences (2018042)
- Cancer Prevention and Research Institute of Texas (RR190056)
- National Natural Science Foundation of China (22177115, 81671755, 81720108024)
- Beijing National Laboratory for Molecular Sciences
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence Properties of Advanced Materials
- Keywords
- NIR-II fluorescence, theranostics, dual-modality imaging, magnetic resonance imaging contrast, folic acid functionalization, breast cancer metastasis, photothermal therapy, photodynamic therapy, tumor ablation, cancer immunotherapy, 4T1 breast cancer, lung metastasis, nanoprobes
- MeSH terms
- Animals, Magnetic Resonance Imaging, Neoplasms, Sulfides, Zinc Compounds, Quantum Dots, Mice
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