The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Clearance Pathways and Tumor Targeting of Imaging Nanoparticles
Open accessAbstract
A basic understanding of how imaging nanoparticles are removed from the normal organs/tissues but retained in the tumors is important for their future clinical applications in early cancer diagnosis and therapy. In this review, we discuss current understandings of clearance pathways and tumor targeting of small-molecule- and inorganic-nanoparticle-based imaging probes with an emphasis on molecular nanoprobes, a class of inorganic nanoprobes that can escape reticuloendothelial system (RES) uptake and be rapidly eliminated from the normal tissues/organs via kidneys but can still passively target the tumor with high efficiency through the enhanced permeability permeability and retention (EPR) effect. The impact of nanoparticle design (size, shape, and surface chemistry) on their excretion, pharmacokinetics, and passive tumor targeting were quantitatively discussed. Synergetic integration of effective renal clearance and EPR effect offers a promising pathway to design low-toxicity and high-contrast-enhancement imaging nanoparticles that could meet with the clinical translational requirements of regulatory agencies.
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Cites
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Modulating Pharmacokinetics, Tumor Uptake and Biodistribution by Engineered Nanoparticles
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Cited by
Analysis of nanoparticle delivery to tumours
Wilhelm, S., Tavares, A. J., Dai, Q., Ohta, S., Audet, J., Dvorak, H. F., & Chan, W. C. W. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.14 · Cited by 5,218
Diverse Applications of Nanomedicine
Pelaz, B., Alexiou, C., Alvarez-Puebla, R. A., Alves, F., Andrews, A. M., Ashraf, S., Balogh, L. P., Ballerini, L., Bestetti, A., Brendel, C., et al. (2017) · ACS Nano · doi:10.1021/acsnano.6b06040 · Cited by 1,350
In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles
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Glomerular barrier behaves as an atomically precise bandpass filter in a sub-nanometre regime
Du, B., Jiang, X., Das, A., Zhou, Q., Yu, M., Jin, R., & Zheng, J. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2017.170 · Cited by 587
Self-citationShahbazi, M.-A., Faghfouri, L., Ferreira, M. P. A., Figueiredo, P., Maleki, H., Sefat, F., Hirvonen, J., & Santos, H. A. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00283a · Cited by 523
Metadata
- Authors
- Yu, M., & Zheng, J.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-07-14
- Volume
- 9
- Issue
- 7
- Pages
- 6655-6674
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2418560736
- Cited by
- 886
- References
- 8
- FWCI
- 39.16
- Type
- journal article
- Language
- en
- Open access
- green
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