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Cited by 355

The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.

Scintillating Nanoparticles as Energy Mediators for Enhanced Photodynamic Therapy

Open access
Kamkaew, Anyanee, Chen, Feng, Zhan, Yonghua, Majewski, Rebecca L., Cai, Weibo·2016·ACS Nano

Abstract

Achieving effective treatment of deep-seated tumors is a major challenge for traditional photodynamic therapy (PDT) due to difficulties in delivering light into the subsurface. Thanks to their great tissue penetration, X-rays hold the potential to become an ideal excitation source for activating photosensitizers (PS) that accumulate in deep tumor tissue. Recently, a wide variety of nanoparticles have been developed for this purpose. The nanoparticles are designed as carriers for loading various kinds of PSs and can facilitate the activation process by transferring energy harvested from X-ray irradiation to the loaded PS. In this review, we focus on recent developments of nanoscintillators with high energy transfer efficiency, their rational designs, as well as potential applications in next-generation PDT. Treatment of deep-seated tumors by using radioisotopes as an internal light source will also be discussed.

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Crossref · 10.1021/acsnano.6b01401

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Metadata

Authors
Kamkaew, A., Chen, F., Zhan, Y., Majewski, R. L., & Cai, W.
Venue
ACS Nano
Published
2016-04-08
Volume
10
Issue
4
Pages
3918-3935
ISSN
  • 1936-0851 (ISSN-L)
  • 1936-086X
OpenAlex
W2332423385
Cited by
355
References
109
FWCI
34.16
Type
journal article
Language
en
Open access
green

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