The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
A Multifunctional Platform for Tumor Angiogenesis-Targeted Chemo-Thermal Therapy Using Polydopamine-Coated Gold Nanorods
Abstract
Image-guided combined chemo-thermal therapy assists in optimizing treatment time, enhancing therapeutic efficiency, and circumventing side effects. In the present study, we developed a chemo-photothermal theranostic platform based on polydopamine (PDA)-coated gold nanorods (GNRs). The PDA coating was thin; however, it significantly suppressed the cytotoxicity of the cetyltrimethylammonium bromide template and allowed high cisplatin loading efficiency, arginine-glycine-aspartic acid (RGD) peptide (c(RGDyC)) conjugation, and chelator-free iodine-125 labeling (RGD- 125 IPt-PDA@GNRs). While loaded cisplatin was released in a pH-sensitive manner, labeled 125 I was outstandingly stable under biological conditions. RGD- 125 IPt-PDA@GNRs had a high specificity for αvβ 3 integrin, and consequently, they could selectively accumulate in tumors, as revealed by single photon emission computed tomography/CT imaging, and in target tumor angiogenic vessels, as shown by high-resolution photoacoustic imaging. As RGD- 125 IPt-PDA@GNRs targets tumor angiogenesis, it is a highly potent tumor therapy. Combined chemo-photothermal therapy with probes could thoroughly ablate tumors and inhibit tumor relapse via a synergistic antitumor effect. Our studies demonstrated that RGD- 125 IPt-PDA@GNRs is a robust platform for image-guided, chemo-thermal tumor therapy with outstanding synergistic tumor killing and relapse inhibition effects.
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Cited by
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Metadata
- Authors
- Zhang, L., Su, H., Cai, J., Cheng, D., Ma, Y., Zhang, J., Zhou, C., Liu, S., Shi, H., Zhang, Y., & Zhang, C.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-11-10
- Volume
- 10
- Issue
- 11
- Pages
- 10404-10417
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2555167393
- Cited by
- 199
- References
- 9
- FWCI
- 13.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Zhang, L., Su, H., Cai, J., Cheng, D., Ma, Y., Zhang, J., Zhou, C., Liu, S., Shi, H., Zhang, Y., & Zhang, C. (2016). A Multifunctional Platform for Tumor Angiogenesis-Targeted Chemo-Thermal Therapy Using Polydopamine-Coated Gold Nanorods. ACS Nano. https://doi.org/10.1021/acsnano.6b06267
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