The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Identification of Receptor Binding to the Biomolecular Corona of Nanoparticles
Open accessAbstract
Biomolecules adsorbed on nanoparticles are known to confer a biological identity to nanoparticles, mediating the interactions with cells and biological barriers. However, how these molecules are presented on the particle surface in biological milieu remains unclear. The central aim of this study is to identify key protein recognition motifs and link them to specific cell-receptor interactions. Here, we employed an immuno-mapping technique to quantify epitope presentations of two major proteins in the serum corona, low-density lipoprotein and immunoglobulin G. Combining with a purpose-built receptor expression system, we show that both proteins present functional motifs to allow simultaneous recognition by low-density lipoprotein receptor and Fc-gamma receptor I of the corona. Our results suggest that the "labeling" of nanoparticles by biomolecular adsorption processes allows for multiple pathways in biological processes in which they may be "mistaken" for endogenous objects, such as lipoproteins, and exogenous ones, such as viral infections.
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Cites
Principles of nanoparticle design for overcoming biological barriers to drug delivery
Blanco, E., Shen, H., & Ferrari, M. (2015) · Nature Biotechnology · doi:10.1038/nbt.3330 · Cited by 7,002
Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake
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Self-citationImmunological properties of engineered nanomaterials
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Mapping protein binding sites on the biomolecular corona of nanoparticles
Kelly, P. M., Åberg, C., Polo, E., O'Connell, A., Cookman, J., Fallon, J., Krpetić, Ž., & Dawson, K. A. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.47 · Cited by 360
Self-citationHadjidemetriou, M., Al-Ahmady, Z., Mazza, M., Collins, R. F., Dawson, K., & Kostarelos, K. (2015) · ACS Nano · doi:10.1021/acsnano.5b03300 · Cited by 358
Self-citationCryptic Epitopes of Albumin Determine Mononuclear Phagocyte System Clearance of Nanomaterials
Mortimer, G. M., Butcher, N. J., Musumeci, A. W., Deng, Z. J., Martin, D. J., & Minchin, R. F. (2014) · ACS Nano · doi:10.1021/nn405830g · Cited by 154
Mapping of Molecular Structure of the Nanoscale Surface in Bionanoparticles
Herda, L. M., Hristov, D. R., Lo Giudice, M. C., Polo, E., & Dawson, K. A. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.6b12297 · Cited by 100
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Cited by
On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles
Dilliard, S. A., Cheng, Q., & Siegwart, D. J. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2109256118 · Cited by 1,018
Bridging Bio–Nano Science and Cancer Nanomedicine
Björnmalm, M., Thurecht, K. J., Michael, M., Scott, A. M., & Caruso, F. (2017) · ACS Nano · doi:10.1021/acsnano.7b04855 · Cited by 382
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Beyond the protein corona—Lipids matter for biological response of nanocarriers
Müller, J., Prozeller, D., Ghazaryan, A., Kokkinopoulou, M., Mailänder, V., Morsbach, S., & Landfester, K. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.02.036 · Cited by 79
Protein Corona Formation on Lipid Nanoparticles Negatively Affects the NLRP3 Inflammasome Activation
Debnath, M., Forster, J., Ramesh, A., & Kulkarni, A. (2023) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.3c00329 · Cited by 60
Metadata
- Authors
- Lara, S., Alnasser, F., Polo, E., Garry, D., Lo Giudice, M. C., Hristov, D. R., Rocks, L., Salvati, A., Yan, Y., & Dawson, K. A.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-01-31
- Volume
- 11
- Issue
- 2
- Pages
- 1884-1893
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2582641787
- Cited by
- 243
- References
- 10
- FWCI
- 9.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lara, S., Alnasser, F., Polo, E., Garry, D., Lo Giudice, M. C., Hristov, D. R., Rocks, L., Salvati, A., Yan, Y., & Dawson, K. A. (2017). Identification of Receptor Binding to the Biomolecular Corona of Nanoparticles. ACS Nano. https://doi.org/10.1021/acsnano.6b07933
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