The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Size-Dependent Heating of Magnetic Iron Oxide Nanoparticles
Abstract
The ability to generate heat under an alternating magnetic field (AMF) makes magnetic iron oxide nanoparticles (MIONs) an ideal heat source for biomedical applications including cancer thermoablative therapy, tissue preservation, and remote control of cell function. However, there is a lack of quantitative understanding of the mechanisms governing heat generation of MIONs, and the optimal nanoparticle size for magnetic fluid heating (MFH) applications. Here, we show that MIONs with large sizes (>20 nm) have a specific absorption rate (SAR) significantly higher than that predicted by the widely used linear theory of MFH. The heating efficiency of MIONs in both the superparamagnetic and ferromagnetic regimes increased with size, which can be accurately characterized with a modified dynamic hysteresis model. In particular, the 40 nm ferromagnetic nanoparticles have an SAR value approaching the theoretical limit under a clinically relevant AMF. An in vivo study further demonstrated that the 40 nm MIONs could effectively heat tumor tissues at a minimal dose. Our experimental results and theoretical analysis on nanoparticle heating offer important insight into the rationale design of MION-based MFH for therapeutic applications.
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Cites
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Soetaert, F., Korangath, P., Serantes, D., Fiering, S., & Ivkov, R. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.025 · Cited by 406
Stimuli‐Responsive Nanoparticles for Controlled Drug Delivery in Synergistic Cancer Immunotherapy
Zhang, J., Lin, Y., Lin, Z., Wei, Q., Qian, J., Ruan, R., Jiang, X., Hou, L., Song, J., Ding, J., et al. (2022) · Advanced Science · doi:10.1002/advs.202103444 · Cited by 292
Vitrification and Nanowarming of Kidneys
Sharma, A., Rao, J. S., Han, Z., Gangwar, L., Namsrai, B., Gao, Z., Ring, H. L., Magnuson, E., Etheridge, M., Wowk, B., et al. (2021) · Advanced Science · doi:10.1002/advs.202101691 · Cited by 105
Vitrification and Rewarming of Magnetic Nanoparticle‐Loaded Rat Hearts
Gao, Z., Namsrai, B., Han, Z., Joshi, P., Rao, J. S., Ravikumar, V., Sharma, A., Ring, H. L., Idiyatullin, D., Magnuson, E. C., et al. (2022) · Advanced Materials Technologies · doi:10.1002/admt.202100873 · Cited by 78
Wang, L., Shi, Y., Jiang, J., Li, C., Zhang, H., Zhang, X., Jiang, T., Wang, L., Wang, Y., & Feng, L. (2022) · Small · doi:10.1002/smll.202203678 · Cited by 71
Metadata
- Authors
- Tong, S., Quinto, C. A., Zhang, L., Mohindra, P., & Bao, G.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-06-21
- Volume
- 11
- Issue
- 7
- Pages
- 6808-6816
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2625059079
- Cited by
- 401
- References
- 46
- FWCI
- 16.53
- Type
- journal article
- Language
- en
- Open access
- closed
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