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Cited by 1Bone Tissue Engineering MaterialsElectrospun Nanofibers in Biomedical Applicationsbiodegradable polymer synthesis and properties

Biomimetic HA-Reinforced PCL/PLA Fibrous Structures via Solution Blow Spinning: Cocoon-Inspired Design for Bone Regeneration

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Almeida, Carolina L., Figueiredo, Lucas R. F., Melo, José D. D., Medeiros, Eliton S.·2025·ACS Omega
DOI 10.1021/acsomega.5c06418PMC PMC12771151
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Abstract

sp. moths, were produced by solution blow spinning (SBS) using biodegradable polymers such as polycaprolactone (PCL) and poly-(lactic acid) (PLA), selected for their distinct melting temperatures, enabling the fabrication of hot-pressed fiber-reinforced composites, with the addition of hydroxyapatite (HA) microparticles, due to its osteoconductive capacity. Cocoons were analyzed using scanning electron microscopy (SEM), tensile tests, Fourier-transform infrared spectroscopy (FTIR), and thermogravimetry (TG) and differential scanning calorimetry (DSC). The results showed that cocoons consist of fibroin dispersed in a sericin matrix, interspersed with HA particles, forming a fibrous multilayered structure. To replicate this structure, fibrous layers were produced using a multinozzle SBS system that spun PLA (fibrous phase) and PCL (matrix). A hot-press process at varying temperatures and spun layers was applied to melt PCL while preserving the fibrous morphology of PLA. Characterization of the bioinspired structures followed the same techniques used for the cocoons, revealing similar morphology with PLA fibers in a PCL-HA matrix. Mechanical strength varied, with the six-layer fibrous membrane, pressed at 90 °C for 30 min, exhibiting the highest strength. Overall, this research demonstrates the potential of developing bioinspired nanocomposites with customized properties based on the structure of moth cocoons.

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  • SBS technique has advantages over electrospinning of simple operation, low cost, high safety, ability to fabricate thicker membranes, and broad raw material availability.

    “Compared with electrospinning, the SBS technique has the advantages of simple operation, low cost, high safety, the ability to fabricate thicker membranes, and broad raw material availability [208].”

    From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [208]

    The Introduction describes how SBS forms fibers and mentions electrospinning, while the Methods describe a multinozzle SBS setup and stacked fiber mats; neither section compares the techniques on operation, cost, safety, membrane thickness, or raw-material availability. Searches for those claimed advantages found no passage in our copy that makes the comparison. (LLM, conf=0.76)

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Cited by

Sorted by citations

Authors
Almeida, C. L., Figueiredo, L. R. F., Melo, J. D. D., & Medeiros, E. S.
Affiliations
  • Universidade Federal da Paraíba (BR)
  • Universidade Federal do Rio Grande do Norte (BR)
Corresponding author
  • Melo, José D. D.
  • Medeiros, Eliton S.
ORCID
Venue
ACS Omega
Publisher
American Chemical Society (ACS)
Published
2025-11-21
Volume
10
Issue
48
Pages
58555-58565
ISSN
2470-1343 (ISSN-L)
DOI
10.1021/acsomega.5c06418
PMC
PMC12771151
OpenAlex
W4416462261
Cited by
1
References
1
Citations by year
2026: 1
FWCI
0.24
Type
journal article
Language
en
Open access
Licence
Locations
  • ACS Omega (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • PubMed Central (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Conselho Nacional de Desenvolvimento Cient??fico e Tecnol??gico (305065/2022-0, 406973/2022-9, 409994/2023-5)
  • Minist??rio da Ci??ncia, Tecnologia, Inova????es e Comunica????es
  • Coordena????o de Aperfei??oamento de Pessoal de N??vel Superior (88882.344748/2019-01)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Keywords
solution blow spinning, biomimetic materials, polycaprolactone, polylactic acid, hydroxyapatite, fiber-reinforced composites, bone regeneration, hot pressing, silk fibroin, sericin, mechanical strength

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