The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Physicochemical Properties Determine Nanomaterial Cellular Uptake, Transport, and Fate
Open accessAbstract
Although a growing number of innovations have emerged in the fields of nanobiotechnology and nanomedicine, new engineered nanomaterials (ENMs) with novel physicochemical properties are posing novel challenges to understand the full spectrum of interactions at the nano-bio interface. Because these could include potentially hazardous interactions, researchers need a comprehensive understanding of toxicological properties of nanomaterials and their safer design. In depth research is needed to understand how nanomaterial properties influence bioavailability, transport, fate, cellular uptake, and catalysis of injurious biological responses. Toxicity of ENMs differ with their size and surface properties, and those connections hold true across a spectrum of in vitro to in vivo nano-bio interfaces. In addition, the in vitro results provide a basis for modeling the biokinetics and in vivo behavior of ENMs. Nonetheless, we must use caution in interpreting in vitro toxicity results too literally because of dosimetry differences between in vitro and in vivo systems as well the increased complexity of an in vivo environment. In this Account, we describe the impact of ENM physicochemical properties on cellular bioprocessing based on the research performed in our groups. Organic, inorganic, and hybrid ENMs can be produced in various sizes, shapes and surface modifications and a range of tunable compositions that can be dynamically modified under different biological and environmental conditions. Accordingly, we cover how ENM chemical properties such as hydrophobicity and hydrophilicity, material composition, surface functionalization and charge, dispersal state, and adsorption of proteins on the surface determine ENM cellular uptake, intracellular biotransformation, and bioelimination versus bioaccumulation. We review how physical properties such as size, aspect ratio, and surface area of ENMs influence the interactions of these materials with biological systems, thereby affecting their hazard potential. We discuss our actual experimental findings and show how these properties can be tuned to control the uptake, biotransformation, fate, and hazard of ENMs. This Account provides specific information about ENM biological behavior and safety issues. This research also assists the development of safer nanotherapeutics and guides the design of new materials that can execute novel functions at the nano-bio interface.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Understanding biophysicochemical interactions at the nano–bio interface
Nel, A. E., Mädler, L., Velegol, D., Xia, T., Hoek, E. M. V., Somasundaran, P., Klaessig, F., Castranova, V., & Thompson, M. (2009) · Nature Materials · doi:10.1038/nmat2442 · Cited by 7,083
Self-citationDetermining the Size and Shape Dependence of Gold Nanoparticle Uptake into Mammalian Cells
Chithrani, B. D., Ghazani, A. A., & Chan, W. C. W. (2006) · Nano Letters · doi:10.1021/nl052396o · Cited by 4,879
Cedervall, T., Lynch, I., Lindman, S., Berggård, T., Thulin, E., Nilsson, H., Dawson, K. A., & Linse, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608582104 · Cited by 3,281
Biodegradable Long-Circulating Polymeric Nanospheres
Gref, R., Minamitake, Y., Peracchia, M. T., Trubetskoy, V., Torchilin, V., & Langer, R. (1994) · Science · doi:10.1126/science.8128245 · Cited by 2,920
Nanoparticle-mediated cellular response is size-dependent
Jiang, W., Kim, B. Y. S., Rutka, J. T., & Chan, W. C. W. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.30 · Cited by 2,776
Chithrani, B. D., & Chan, W. C. W. (2007) · Nano Letters · doi:10.1021/nl070363y · Cited by 2,286
Xia, T., Kovochich, M., Brant, J., Hotze, M., Sempf, J., Oberley, T., Sioutas, C., Yeh, J. I., Wiesner, M. R., & Nel, A. E. (2006) · Nano Letters · doi:10.1021/nl061025k · Cited by 1,918
Self-citationImmunological properties of engineered nanomaterials
Dobrovolskaia, M. A., & McNeil, S. E. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.223 · Cited by 1,823
Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles
Verma, A., Uzun, O., Hu, Y., Hu, Y., Han, H.-S., Watson, N., Chen, S., Irvine, D. J., & Stellacci, F. (2008) · Nature Materials · doi:10.1038/nmat2202 · Cited by 1,266
Mechanics of receptor-mediated endocytosis
Gao, H., Shi, W., & Freund, L. B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503879102 · Cited by 1,217
Cellular Uptake, Intracellular Trafficking, and Cytotoxicity of Nanomaterials
Zhao, F., Zhao, Y., Liu, Y., Chang, X., Chen, C., & Zhao, Y. (2011) · Small · doi:10.1002/smll.201100001 · Cited by 1,175
Self-citationThe molecular architecture of the nuclear pore complex
Alber, F., Dokudovskaya, S., Veenhoff, L. M., Zhang, W., Kipper, J., Devos, D., Suprapto, A., Karni-Schmidt, O., Williams, R., Chait, B. T., et al. (2007) · Nature · doi:10.1038/nature06405 · Cited by 1,057
Binding of blood proteins to carbon nanotubes reduces cytotoxicity
Ge, C., Du, J., Zhao, L., Wang, L., Liu, Y., Li, D., Yang, Y., Zhou, R., Zhao, Y., Chai, Z., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105270108 · Cited by 940
Self-citationXia, T., Kovochich, M., Liong, M., Meng, H., Kabehie, S., George, S., Zink, J. I., & Nel, A. E. (2009) · ACS Nano · doi:10.1021/nn900918w · Cited by 933
Self-citationMeng, H., Liong, M., Xia, T., Li, Z., Ji, Z., Zink, J. I., & Nel, A. E. (2010) · ACS Nano · doi:10.1021/nn100690m · Cited by 902
Self-citationStrategies for the intracellular delivery of nanoparticles
Chou, L. Y. T., Ming, K., & Chan, W. C. W. (2011) · Chem. Soc. Rev. · doi:10.1039/c0cs00003e · Cited by 811
Multifunctional Gold Nanoparticle−Peptide Complexes for Nuclear Targeting
Tkachenko, A. G., Xie, H., Coleman, D., Glomm, W., Ryan, J., Anderson, M. F., Franzen, S., & Feldheim, D. L. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0296935 · Cited by 794
Detailed Identification of Plasma Proteins Adsorbed on Copolymer Nanoparticles
Cedervall, T., Lynch, I., Foy, M., Berggård, T., Donnelly, S. C., Cagney, G., Linse, S., & Dawson, K. A. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200700465 · Cited by 777
Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods
Qiu, Y., Liu, Y., Wang, L., Xu, L., Bai, R., Ji, Y., Wu, X., Zhao, Y., Li, Y., & Chen, C. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.06.051 · Cited by 689
Self-citationRole of cell cycle on the cellular uptake and dilution of nanoparticles in a cell population
Kim, J. A., Åberg, C., Salvati, A., & Dawson, K. A. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2011.191 · Cited by 655
Detailed Identification of Plasma Proteins Adsorbed on Copolymer Nanoparticles
Cedervall, T., Lynch, I., Foy, M., Berggård, T., Donnelly, S. C., Cagney, G., Linse, S., & Dawson, K. A. (2007) · Angewandte Chemie · doi:10.1002/ange.200700465 · Cited by 655
Xia, T., Kovochich, M., Liong, M., Zink, J. I., & Nel, A. E. (2008) · ACS Nano · doi:10.1021/nn700256c · Cited by 624
Self-citationWang, H., Zhao, Y., Wu, Y., Hu, Y.-L., Nan, K., Nie, G., & Chen, H. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.07.032 · Cited by 603
Self-citationBorm, P., Klaessig, F. C., Landry, T. D., Moudgil, B., Pauluhn, J., Thomas, K., Trottier, R., & Wood, S. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj084 · Cited by 586
Yan, L., Zheng, Y. B., Zhao, F., Li, S., Gao, X., Xu, B., Weiss, P. S., & Zhao, Y. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15193b · Cited by 539
Self-citationWang, L., Liu, Y., Li, W., Jiang, X., Ji, Y., Wu, X., Xu, L., Qiu, Y., Zhao, K., Wei, T., et al. (2011) · Nano Letters · doi:10.1021/nl103992v · Cited by 514
Self-citationMeng, H., Xue, M., Xia, T., Ji, Z., Tarn, D. Y., Zink, J. I., & Nel, A. E. (2011) · ACS Nano · doi:10.1021/nn200809t · Cited by 509
Self-citationMeng, H., Yang, S., Li, Z., Xia, T., Chen, J., Ji, Z., Zhang, H., Wang, X., Lin, S., Huang, C., et al. (2011) · ACS Nano · doi:10.1021/nn103344k · Cited by 362
Self-citationComparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats
Zhu, M.-T., Feng, W.-Y., Wang, B., Wang, T.-C., Gu, Y.-Q., Wang, M., Wang, Y., Ouyang, H., Zhao, Y.-L., & Chai, Z.-F. (2008) · Toxicology · doi:10.1016/j.tox.2008.02.011 · Cited by 276
Self-citationUltrahigh reactivity provokes nanotoxicity: Explanation of oral toxicity of nano-copper particles
MENG, H., CHEN, Z., XING, G., YUAN, H., CHEN, C., ZHAO, F., ZHANG, C., & ZHAO, Y. (2007) · Toxicology Letters · doi:10.1016/j.toxlet.2007.09.015 · Cited by 262
Self-citationChirality of Glutathione Surface Coating Affects the Cytotoxicity of Quantum Dots
Li, Y., Zhou, Y., Wang, H., Perrett, S., Zhao, Y., Tang, Z., & Nie, G. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201008206 · Cited by 239
Self-citationZhu, M.-T., Wang, B., Wang, Y., Yuan, L., Wang, H.-J., Wang, M., Ouyang, H., Chai, Z.-F., Feng, W.-Y., & Zhao, Y.-L. (2011) · Toxicology Letters · doi:10.1016/j.toxlet.2011.03.021 · Cited by 222
Self-citationZhao, Y., Xing, G., & Chai, Z. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.77 · Cited by 220
Self-citationZhu, M.-T., Feng, W.-Y., Wang, Y., Wang, B., Wang, M., Ouyang, H., Zhao, Y.-L., & Chai, Z.-F. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfn245 · Cited by 211
Self-citationWang, X., Xia, T., Addo Ntim, S., Ji, Z., Lin, S., Meng, H., Chung, C.-H., George, S., Zhang, H., Wang, M., et al. (2011) · ACS Nano · doi:10.1021/nn2033055 · Cited by 200
Self-citationStatistical analysis of nanoparticle dosing in a dynamic cellular system
Summers, H. D., Rees, P., Holton, M. D., Rowan Brown, M., Chappell, S. C., Smith, P. J., & Errington, R. J. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2010.277 · Cited by 172
Wang, X., Xia, T., Ntim, S. A., Ji, Z., George, S., Meng, H., Zhang, H., Castranova, V., Mitra, S., & Nel, A. E. (2010) · ACS Nano · doi:10.1021/nn102112b · Cited by 166
Self-citationBio-distribution and metabolic paths of silica coated CdSeS quantum dots
Chen, Z., Chen, H., Meng, H., Xing, G., Gao, X., Sun, B., Shi, X., Yuan, H., Zhang, C., & Liu, R. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.03.022 · Cited by 155
Self-citationHolt, B. D., Dahl, K. N., & Islam, M. F. (2011) · Small · doi:10.1002/smll.201100437 · Cited by 112
Exosomes as Extrapulmonary Signaling Conveyors for Nanoparticle‐Induced Systemic Immune Activation
Zhu, M., Li, Y., Shi, J., Feng, W., Nie, G., & Zhao, Y. (2011) · Small · doi:10.1002/smll.201101708 · Cited by 110
Self-citationRNA delivery into mitochondria.
Entelis, N., Kolesnikova, O., Martin, R., & Tarassov, I. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00135-1 · Cited by 78
Intracellular organelle-targeted non-viral gene delivery systems
Won, Y.-W., Lim, K. S., & Kim, Y. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.01.013 · Cited by 75
Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents
Miao, Q., Xu, D., Wang, Z., Xu, L., Wang, T., Wu, Y. F., Lovejoy, D. B., Kalinowski, D. S., Richardson, D. R., Nie, G., et al. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.06.012 · Cited by 47
Self-citation
Cited by
Cellular uptake of nanoparticles: Journey inside the cell
Behzadi, S., Serpooshan, V., Tao, W., Hamaly, M. A., Alkawareek, M. Y., Dreaden, E. C., Brown, D., Alkilany, A. M., Farokhzad, O. C., & Mahmoudi, M. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00636a · Cited by 2,859
Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles
Foroozandeh, P., & Aziz, A. A. (2018) · Nanoscale Research Letters · doi:10.1186/s11671-018-2728-6 · Cited by 1,377
Diverse Applications of Nanomedicine
Pelaz, B., Alexiou, C., Alvarez-Puebla, R. A., Alves, F., Andrews, A. M., Ashraf, S., Balogh, L. P., Ballerini, L., Bestetti, A., Brendel, C., et al. (2017) · ACS Nano · doi:10.1021/acsnano.6b06040 · Cited by 1,350
Self-citationThe toxicity of nanoparticles and their interaction with cells: an in vitro metabolomic perspective
Awashra, M., & Młynarz, P. (2023) · Nanoscale Advances · doi:10.1039/d2na00534d · Cited by 319
McIlwraith, H. K., Kim, J., Helm, P., Bhavsar, S. P., Metzger, J. S., & Rochman, C. M. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.1c02922 · Cited by 295
Metadata
- Authors
- Zhu, M., Nie, G., Meng, H., Xia, T., Nel, A., & Zhao, Y.
- Venue
- Accounts of Chemical Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-08-14
- Volume
- 46
- Issue
- 3
- Pages
- 622-631
- ISSN
- 0001-4842 (ISSN-L)
- 1520-4898
- OpenAlex
- W2078944426
- Cited by
- 803
- References
- 43
- FWCI
- 17.67
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
